记者 沈思怡 昨天，奉贤区举办2025贤商大会，近450名来自奉贤各行各业的企业家、商会代表在这场一年一度 的民营经济大会上齐聚一堂。现场，奉贤区对十大领航贤商、十大先锋贤商、十大青创贤商、优秀创新 创业案例等相关企业代表进行表彰。 奉贤是上海民营经济最活跃的区域之一。2024年，奉贤全区民营企业数量占企业总数近九成，贡献 了超六成规上工业产值、过半的税收以及超六成就业岗位。 这场大会上，既有在奉贤深耕多年、加码增资的"老朋友"，也有带着前沿技术与全球视野前来 的"新朋友"。他们的故事为解码奉贤民营经济的韧性与活力提供了鲜活样本。 生态引"新朋友"落子布局 耀速科技是一家专注于类器官芯片技术的公司，核心团队成员出自美国顶尖科研院所。2024年，团 队正式回国布局，将上海研发运营中心落子在奉贤临港南桥科技城。虽然企业成立时间不久，却已频频 受到行业巨头青睐。无论是跨国制药公司、国内头部药企，还是手握新药研发外包全球订单的CRO （合同研究组织）公司，都把合作的橄榄枝递向耀速的核心产品"器官芯片"。 通俗地说，器官芯片就是"在芯片上造器官"，它是一种含有活细胞和微流控芯片的生物工程装置， 可模拟真实器官的结构和功 ...

Core Insights - The experimental animal industry in China is undergoing a transformation, focusing on animal welfare and the development of specialized products for experimental animals [1][2] - The industry is moving towards self-research and development of animal welfare products, establishing a complete industrial chain from breeding to drug testing [1] Group 1: Industry Transformation - The experimental animal industry is evolving to prioritize animal welfare, with products like toys and comfort items being developed to reduce stress and anxiety in animals [1] - The market for animal comfort products is significant, with estimates exceeding 100 million yuan, indicating a growing demand for such items [1] Group 2: Technological Advancements - The company, 集萃药康, is utilizing advanced technologies such as CRISPR/Cas9 for gene modification and AI for creating virtual mice to enhance research capabilities [2] - The company has developed around 30,000 strains of experimental mice, positioning itself among the global leaders in this field [2] Group 3: Research and Development Focus - The focus on animal welfare is seen as essential for obtaining reliable experimental data, emphasizing the importance of healthy and well-cared-for animals in research [1][2] - The company is also exploring cutting-edge fields such as organ-on-a-chip and brain-machine interfaces, indicating a commitment to innovation in biomedical research [2]

Core Insights - Nanjing Biomedicine Valley has introduced over 50 innovative products and technologies that are first in the world or country, highlighting its role as a key player in the biomedicine industry [1] - The region is focusing on precision medicine and niche areas such as brain science and gene therapy, aiming to establish a comprehensive innovation ecosystem [2][3] - Two new class 1 drugs have been approved this year, marking a significant achievement for the Nanjing Biomedicine Valley [3][4] Industry Overview - The global biomedicine industry is accelerating towards precision diagnosis and treatment, with Nanjing Biomedicine Valley positioning itself in niche markets [2] - The region has established a full industrial chain in gene and cell therapy, including gene testing, diagnostics, and CAR-T cell therapy [3] - The Nanjing Biomedicine Valley has attracted over 1,300 companies, with 7 companies successfully listed and 6 class 1 drugs approved [5] Innovation and Development - The Nanjing Biomedicine Valley is enhancing its innovation capabilities by collaborating with universities and establishing technology transfer centers [6] - A total of 84 billion yuan fund support plan has been launched to facilitate the transformation of scientific achievements from universities [6] - The region is focusing on building a robust innovation ecosystem that integrates innovation chains, industry chains, capital chains, and talent chains [7] Recent Achievements - The approval of two class 1 drugs, Enze Shou and Ji Ke Shu, represents a milestone for the biomedicine valley, with the former being the first targeted drug for platinum-resistant ovarian cancer in China [3][4] - The establishment of the Jiangsu Brain Intelligence Technology Innovation Center aims to make breakthroughs in brain science over the next five years [2] - The Nanjing Biomedicine Valley has successfully facilitated the listing of companies and the approval of innovative drugs, showcasing its supportive environment for biomedicine enterprises [5][6]

Core Insights - The collaboration between Georgia Institute of Technology and Vanderbilt University has led to the development of the world's first micro "lung chip" with an integrated immune system, which can actively defend against pathogens and has the potential to revolutionize disease research and replace animal testing [1][3] Group 1: Technology and Innovation - The new lung chip is designed to simulate lung functions and includes a functional immune system, allowing it to realistically mimic the lung's response to infections, inflammation, and self-repair processes [3] - Previous attempts to integrate an immune system into organ chips faced technical challenges, such as the short lifespan of immune cells and difficulties in simulating their circulation and interaction within the body. The research team has optimized technology to achieve long-term survival and defense functionality of immune cells within the chip [3] Group 2: Research Applications - The lung chip has demonstrated immune responses similar to those in humans during experiments with influenza virus, showcasing its ability to accurately replicate real pathological processes [3] - This innovation opens new avenues for preclinical research, allowing for a deeper understanding of the interactions between immune responses and viral infections, as well as the evaluation of antiviral drug efficacy [3] Group 3: Future Prospects - The new lung chip can be utilized to study diseases such as asthma, cystic fibrosis, lung cancer, and tuberculosis. Future plans include integrating immune organs to simulate the collaboration between the lungs and the systemic immune system [4] - The long-term goal is to achieve personalized medicine by constructing chips using patients' own cells to predict the most effective treatment strategies [4]

Core Insights - The collaboration between Georgia Institute of Technology and Vanderbilt University has led to the development of the world's first micro "lung chip" with an integrated immune system, which can actively defend against pathogens, potentially revolutionizing disease research and reducing reliance on animal testing [1][2] Group 1: Technological Breakthrough - The new lung chip is capable of simulating the immune response to infections, inflammation, and self-repair processes, overcoming previous technical challenges related to the survival and functionality of immune cells within the chip [1] - The chip demonstrated a highly similar immune response to human lungs during influenza virus attack experiments, accurately replicating the pathological processes [1] Group 2: Research Applications - This innovative lung chip opens new avenues for preclinical research, allowing for a deeper understanding of the interactions between immune responses and viral infections, as well as the evaluation of antiviral drug efficacy [2] - The chip can be utilized to study various diseases, including asthma, cystic fibrosis, lung cancer, and tuberculosis, and there are plans to integrate immune organs to simulate the collaboration between the lungs and the systemic immune system [2] Group 3: Future Goals - The long-term objective is to achieve personalized medicine by constructing chips using patients' own cells to predict the most effective treatment strategies [2]

Core Concept - Organ chips represent a significant advancement in biomedical research, utilizing human cells to create miniaturized organ models for drug testing and disease research, offering a more accurate alternative to traditional animal models [4][6][7]. Group 1: Technology Overview - Organ chips are built on a foundation of microfluidic technology, integrating human cells and biological materials to simulate organ functions and responses [2][3]. - The first fully functional organ chip, the "lung chip," was developed around 2009, and research in this field has been ongoing for over a decade in China [3][5]. - These chips can replicate complex physiological environments, allowing for precise drug testing and disease modeling [3][6]. Group 2: Advantages Over Traditional Methods - Organ chips significantly reduce the reliance on animal testing, addressing ethical concerns and providing more relevant data for human biology [4][6]. - They offer a high-throughput capability, enabling extensive data analysis and reducing the time required for drug testing from 90-180 days to just 6 days for 100 compounds [6][7]. - The cost of using organ chips is only 10% to 20% of traditional animal models, making them a cost-effective solution for drug development [7]. Group 3: Market Potential - The global organ chip market is projected to grow at a compound annual growth rate (CAGR) of 31.2% from 2024 to 2030, indicating strong future demand for this technology [8]. Group 4: Challenges Ahead - Despite the promising potential of organ chips, the transition from scientific research to practical application faces challenges that need to be addressed [9].

Core Insights - The "2025 Guangzhou Medical and Health Industry Expo" will be held from August 22 to 24 at the China Import and Export Fair Complex, organized by the Guangzhou Municipal Government and relevant health authorities [1] - The expo will cover an exhibition area of 30,000 square meters, featuring 3 pavilions and 18 exhibition areas, showcasing cutting-edge technologies such as gene editing, cell therapy, organoids, organ-on-a-chip, nuclear medicine, 3D printing, biomanufacturing, and synthetic biology [1] - The event aims to encompass the entire industry chain, including R&D, transformation, production, clinical application, third-party services, and financial support [1] Industry Participation - The expo has attracted participation from health administrative departments from various regions including Anhui, Sichuan, Fujian, Chongqing, and Xinjiang [1] - Top research institutions such as Guangzhou laboratories and technology transfer centers from universities, along with over 50 local tertiary hospitals, have been invited to exhibit [1] Corporate Involvement - Notable exhibitors include large pharmaceutical companies like China Resources, Sinopharm, and Guangzhou Pharmaceutical, as well as innovative firms such as BeiGene, CanSino, and Yipin Hong [1] - Telecommunications companies like China Telecom, China Unicom, and China Mobile are also participating in the expo [1]

Group 1 - The 33rd Guangzhou Expo will showcase over 130 robots in a newly established robot performance area, highlighting the integration of resources from the Greater Bay Area [1] - The expo will feature four thematic exhibition areas, including new productivity, rural revitalization, silver economy, and quality of life, covering a total exhibition area of approximately 180,000 square meters, representing a year-on-year growth of over 50% [1] - The 9th China (Guangzhou) International Elderly Health Industry Expo will focus on technology and resources from Hong Kong and Macau, featuring a dedicated smart robot area with various innovative robots [1] Group 2 - The 2025 Guangzhou Medical and Health Industry Expo will have a 30,000 square meter exhibition area, attracting over 400 participating units, showcasing cutting-edge technologies such as gene editing and cell therapy [2] - The expo will facilitate cross-border medical cooperation through a special session for Hong Kong and Macau medical devices, promoting the integration of advanced medical technologies into the mainland market [2] - The consumption assistance exhibition area will serve as a platform to promote domestic circulation, with participation from 80 cities and over 320 enterprises, connecting local agricultural products with Greater Bay Area consumers [2]

Core Insights - The traditional reliance on animal testing in drug development is being challenged by advancements in organoids, organ-on-a-chip technology, and AI simulations, marking a new era in life sciences and pharmaceutical research [1][3] - The FDA has mandated the gradual elimination of mandatory animal testing for monoclonal antibodies and has incorporated organoids and organ-on-a-chip solutions into its regulatory framework [1] - The first fully automated AI organoid system in Asia was showcased at a forum in Shanghai, highlighting the city's potential to leverage this "black technology" for biomedicine [1][4] Organoid and Organ-on-a-Chip Technology - Organoids mimic the structure and function of real organs, such as brain and intestinal organoids, and have been recognized as a top technology by Science magazine in 2013 [2] - Organ-on-a-chip technology combines organoids with microfluidic chips to simulate physiological environments, with over 60 companies globally involved in this sector, projected to reach a market size of $620 million by 2029 [2] Market Growth and Applications - The organoid industry is expected to maintain a compound annual growth rate (CAGR) of over 20% in the coming years, enhancing drug screening efficiency and reducing costs and risks in drug development [3] - Personalized medicine is a significant development direction for organoids, allowing for the creation of patient-specific organoids to simulate disease states for tailored treatment plans [3] Technological Advancements - The newly introduced AI organoid system can automate the entire biological process, significantly improving the efficiency of stem cell and organoid growth, and addressing challenges in clinical applications [4][5] - This system aims to overcome the "valley of death" in biomedicine by providing high-fidelity models that retain tumor microenvironments and generating predictive models for drug efficacy [4] Strategic Initiatives in Shanghai - Shanghai is positioning itself as a leader in the organoid innovation ecosystem, having supported various projects since 2021 focused on drug screening and personalized medicine [6] - The city has established a framework for integrating cutting-edge technologies like AI and organoids into clinical research, with policies that encourage innovation [6][7] - Shanghai's unique advantages include rich clinical resources, a robust AI infrastructure, and pioneering regulatory frameworks that facilitate clinical validation of organoid technologies [7]

Core Viewpoint - The FDA has initiated a significant project aimed at validating non-animal methods for predicting drug-induced liver injury, with completion expected in Q1 2026 [1][3]. Group 1: FDA's Initiative - The FDA is collaborating with multiple organizations, including YaoSu Technology, to implement a cross-platform drug validation project using organ-on-a-chip technology [3][4]. - The project aims to enhance the accuracy and efficiency of toxicity assessments, reducing reliance on animal testing [4][6]. - The FDA's recent policy updates encourage the use of organ chips and AI modeling in early drug development stages, signaling a shift in research funding priorities [3][10]. Group 2: Cost and Time Efficiency - Utilizing organ-on-a-chip technology can significantly reduce the time required for toxicity testing, with some tests potentially completed in two weeks compared to several months for traditional animal testing [5][6]. - The cost of animal testing is substantial, with a mouse costing around 100 yuan and a monkey potentially costing up to 100,000 yuan, making non-animal methods financially attractive [4][6]. Group 3: Accuracy of Testing Methods - Current animal models have a liver injury prediction accuracy of only 50% to 65%, which is marginally better than random chance [6][9]. - Organ-on-a-chip technology could improve prediction accuracy to between 80% and 90%, leading to significant cost savings in drug development [6][9]. Group 4: Challenges and Future Directions - There are still significant technical and regulatory hurdles to fully replace animal testing, with a complete transition unlikely within the next decade [8][10]. - The FDA's goal is not to eliminate animal testing entirely but to shift the focus towards in vitro models, using animals only when necessary [9][11]. - The development of multi-organ chips that can simulate human physiology remains a long-term objective, requiring further research and standardization [9][10].