Core Viewpoint - The collaboration between Qingdao Institute of Bioenergy and Process Research and Shandong Lukang Pharmaceutical has successfully developed a microbial green manufacturing technology for trans-aconitic acid, overcoming production challenges and achieving large-scale production, which has been recognized with a first-class award in Shandong Province for 2024 [1][3][12] Group 1: Production Challenges and Solutions - Trans-aconitic acid is a food additive with significant applications in agriculture, medicine, and chemicals, but traditional production methods face high costs and inefficiencies [3][9] - The research team developed an integrated technology system using industrial Aspergillus niger as a chassis cell, enabling the conversion of starch sugars into trans-aconitic acid through synthetic biology [3][5] - Key challenges addressed include the genetic modification of industrial strains, achieving high-efficiency synthesis, and optimizing fermentation processes for industrial application [5][7] Group 2: Industrial Application and Market Potential - The successful production of trans-aconitic acid opens up new avenues for its use as a biopesticide, particularly in combating root-knot nematodes in agriculture, aligning with national green agriculture initiatives [9][11] - In the chemical industry, trans-aconitic acid is being developed into a bio-based plasticizer, providing a safer alternative to petroleum-based phthalate plasticizers, which are facing regulatory restrictions due to health concerns [11][12] - The technology has garnered attention from various enterprises, leading to successful production demonstrations and positioning trans-aconitic acid as a key bio-based chemical in the upcoming 2024-2027 development plan for fine chemical industries [12]

Core Viewpoint - The company is advancing its "党建链" (Party Building Chain) to empower its "产业链" (Industrial Chain) by enhancing collaboration across innovation, industry, talent, and technology chains, aiming for high-quality development [2]. Group 1: Innovation Chain - The company is establishing a new model for collaborative innovation that includes "source innovation → technology development → achievement transformation → industrial application" through party building [2]. - Collaboration with the Chinese Academy of Sciences has led to the development of trans-aconitic acid, with significant contributions to innovation and talent exchange, culminating in a first-class award from Shandong Province for technological invention [2]. - The global first green bio-manufacturing project for trans-aconitic acid is set to commence production in June 2025 [2]. Group 2: R&D Chain - The company is creating a new collaborative model for R&D that focuses on "core technology breakthroughs → drug clinical applications → drug achievement transformation" [3]. - Joint efforts with China Pharmaceutical University and Peking University People's Hospital are enhancing the development of the innovative drug CIGB-814, which is expected to lead new directions in immunotherapy and cell therapy [3]. - The establishment of the "Innovative Drug Evaluation and Repositioning Laboratory" is a key initiative in advancing the research of CIGB-814 [3]. Group 3: Supply Chain - The company is enhancing upstream and downstream collaboration through party building, ensuring the stability and safety of its supply chain [5]. - Partnerships with companies like Sinopharm Holdings and Henan Renhua Biotech are driving sales growth through collaborative efforts [5]. Group 4: Professional Chain - The company is collaborating with various regulatory and research institutions to improve quality and compliance, thereby enhancing operational efficiency [6]. - Engagement with the Shandong Provincial Department of Ecology and Environment is facilitating the effective implementation of ecological policies and advanced technologies [6]. - The integration of party building with professional guidance is fostering a strong foundation for quality improvement and high-quality development [6].

Core Viewpoint - The successful launch of the world's first microbial green manufacturing project for trans-aconitic acid by Qingdao Energy Research Institute and Shandong Lukang Pharmaceutical Co., Ltd. marks a significant breakthrough in the accessibility of this important chemical raw material, which will effectively promote the rapid development of downstream applications such as bio-based materials and biopesticides [1][3]. Group 1: Project Overview - The project was officially launched on May 29, 2024, in Jining, Shandong, and is recognized for overcoming the challenges in microbial green manufacturing technology for trans-aconitic acid [1][3]. - The technology has been evaluated as internationally leading, with strong innovation and advanced indicators, suggesting further expansion of production and application scale [3][4]. Group 2: Technological Innovations - The project utilizes synthetic biology strategies to achieve microbial green manufacturing of trans-aconitic acid for the first time, employing high acid-resistant Aspergillus niger as the chassis cell [3][4]. - Key technological developments include enabling technology platforms, efficient cell factories, fermentation process demonstration, and separation and purification processes, leading to the establishment of the world's first demonstration line for microbial green manufacturing of trans-aconitic acid [3][4]. Group 3: Industry Impact - The collaboration between Qingdao Energy Research Institute and Lukang Pharmaceutical exemplifies interdisciplinary innovation in bio-chemical-materials integration, transforming disruptive technologies into new productive forces [4]. - The project has been recognized as a benchmark for green, low-carbon, and high-quality development, injecting new momentum into the bio-economy sector [5].

Core Viewpoint - The successful launch of the world's first microbial green manufacturing project for trans-aconitic acid by Qingdao Energy Institute and Shandong Lukang Pharmaceutical marks a significant breakthrough in the accessibility of this important chemical raw material, which will effectively promote the rapid development of downstream applications such as bio-based materials and biopesticides [1][3]. Group 1: Project Overview - The project was officially launched on May 29 in Jining, Shandong, and represents a major advancement in the microbial green manufacturing technology for trans-aconitic acid [1]. - The technology has been recognized as internationally leading, having overcome challenges in microbial green manufacturing, and has established the world's first demonstration line for this production method [3][4]. Group 2: Technological Innovations - The project utilized a high acid-resistant strain of Aspergillus niger as the chassis cell and developed key technologies including enabling technology platforms, efficient cell factories, fermentation process demonstration, and separation and purification processes [3]. - The successful scale-up of fermentation processes was achieved at a pilot level of ten tons, demonstrating the feasibility of large-scale production [3]. Group 3: Applications and Impact - The project has led to the development of environmentally friendly, safe, and economical new bio-based plasticizers derived from trans-aconitic acid, providing innovative solutions for sectors such as medical devices, electrical cables, and specialty rubber [4]. - The project has been awarded the highest prize at the first National Disruptive Technology Innovation Competition, showcasing its potential to lead industry innovation through technology [5].