长江商报消息 ●长江商报记者 黄聪 盈利转正后，百济神州（688235.SH、06160.HK、NASDAQ:BGNE）爆发出巨大的增长动力。 2月27日，百济神州发布业绩快报显示，公司2025年营业收入达382.05亿元，同比增长40.4%，其中产品收入达 377.7亿元，同比增长39.9%。同期，公司归母净利润达14.22亿元，上年同期亏损49.78亿元。 长江商报记者发现，百济神州研发费用已连续四年超过100亿元。近四年来，公司研发费用累计达492.64亿元，占 同期营业收入比例约60%。 进入2025年，百济神州业绩出现好转，除了一季度归母净利润亏损9450.3万元外，二季度和三季度归母净利润分 别为5.44亿元和6.89亿元。 百济神州介绍，2025年，公司产品收入的增长主要得益于百悦泽^?（泽布替尼），以及安进公司授权产品和百泽 安^?（替雷利珠单抗）的销售增长。 2025年，百悦泽^?全球销售额总计280.67亿元，同比增长48.8%，已在BTK抑制剂领域稳固确立全球领导者的地 位。其广泛的监管批准、持续深化的全球布局、临床医生的高度认可，以及在慢性淋巴细胞白血病（CLL）领域 卓越的长期疗效与 ...

核心产品表现亮眼 全球化布局加速推进 百济神州表示，2025年实现扭亏为盈，核心得益于产品收入的持续增长和费用管理推动的经营效率提 升。2025年，产品收入达377.70亿元，同比增长39.9%，主营业务优势凸显。从产品结构看，公司产品 收入增长主要得益于BTK抑制剂百悦泽（泽布替尼），以及安进公司授权产品和百泽安（替雷利珠单 抗）的销售增长。 其中，百悦泽2025年全球销售额总计280.67亿元，同比增长48.8%。按地区看，在美国市场，百悦泽销 售额总计202.06亿元，同比增长45.5%；在欧洲销售额总计42.65亿元，同比增长66.4%；在中国销售额 总计24.72亿元，同比增长33.1%。 公告显示，百悦泽是全球获批适应症最广泛的BTK抑制剂。目前，百悦泽已在全球超过75个市场获批。 在2025年美国血液学会（ASH）年会上，百济神州公布3期SEQUOIA试验六年随访数据以及ALPINE试 验的长期结果，进一步验证百悦泽在治疗初治及R/R CLL/SLL成人患者具有持续的获益。2026年上半 年，百济神州预计将对百悦泽联合利妥昔单抗对比苯达莫司汀联合利妥昔单抗用于套细胞淋巴瘤成人患 者一线治疗的3期 ...

Core Viewpoint - Despite achieving profitability in 2025, the stock price of BeiGene has experienced a significant decline, raising concerns among investors about future performance and market competition [1][3]. Financial Performance - In 2025, BeiGene reported total revenue of 38.205 billion yuan, a year-on-year increase of 40.4% - The net profit attributable to shareholders was 1.422 billion yuan, marking a turnaround from a loss of 5.379 billion yuan in the previous year - The adjusted net profit, excluding non-recurring items, was 1.381 billion yuan [1]. Stock Market Reaction - On February 26, 2025, BeiGene's Hong Kong stock price fell sharply, closing down 9.16% at 200 HKD, resulting in a market capitalization drop below 300 billion HKD - The stock continued to decline on February 27, closing at 192.3 HKD, a further decrease of 1.08%, with a market cap of 296.3 billion HKD - The A-share market also saw a decline, with a closing price of 263.44 CNY on February 26, down 5.65%, and a further drop to 257.7 CNY on February 27, down 2.18% [1]. Product Performance and Market Competition - BeiGene's core product, Zebrutinib (Brukinsa), is expected to face challenges in 2026, with sales projections falling short of expectations - In 2025, Zebrutinib generated revenue of 39.3 billion yuan, accounting for 73.5% of the company's total revenue, with a year-on-year growth rate of 48.8% - However, the quarterly growth rate for Zebrutinib in Q4 2025 was only 10.1%, significantly lower than the 20% growth in Q2 [3]. Competitive Landscape - Zebrutinib is facing increased competition, particularly from AstraZeneca's Acalabrutinib and Johnson & Johnson's Ibrutinib - AstraZeneca has recently launched a combination therapy involving Acalabrutinib, which has gained approval in key markets, posing a threat to Zebrutinib's market share [4]. Future Prospects - BeiGene's second major product, Tislelizumab (PD-1 inhibitor), is projected to have a global sales figure of 5.297 billion yuan in 2025, with an 18.6% year-on-year increase - The company plans to submit a new indication application for Tislelizumab in 2026, which could enhance its market position [6]. - Another product, Sotorasib (BCL-2 inhibitor), has received breakthrough therapy designation from the FDA and is expected to be a new growth driver in 2026, potentially offsetting the slowdown in Zebrutinib's growth [7].

Core Insights - BeiGene has become a focal point in China's innovative drug sector, achieving significant revenue and profit growth driven by its core products and strategic market positioning [1][11] - The company's total global revenue for 2025 reached $5.3 billion, marking a 40% year-on-year increase, primarily due to the strong performance of its flagship product, Brukinsa (Zebutinib) [1][11] - Brukinsa generated $3.9 billion in global sales, a 49% increase year-on-year, solidifying its role as the main driver of revenue growth [1][11] Revenue Growth - The two main self-developed products contributed over 90% of total revenue, with Brukinsa accounting for more than 70% [2][12] - The product matrix's synergy and the launch of new products, such as the BCL-2 inhibitor, have established a sustainable growth model for the company [2][12] Market Positioning - Brukinsa is recognized as the most widely approved BTK inhibitor globally, benefiting from its efficacy and safety, which has helped it secure a leading market position [3][13] - The BTK inhibitor market is experiencing a structural shift, with new-generation products gaining traction as first-generation products lose market share, providing a favorable environment for Brukinsa's growth [3][14] Product Development - The approval of the BCL-2 inhibitor, BeiGene's new product, in January 2026, fills a gap in the domestic treatment landscape and is expected to contribute to future revenue growth [5][15] - The steady growth of the other core product, Tislelizumab (Breztri), in the solid tumor space, further supports the company's dual-driven growth strategy [4][15] Industry Trends - The global demand for oncology drugs is expanding, driven by an aging population and increasing healthcare awareness, creating a broad market opportunity for innovative drug companies [6][16] - The competitive landscape in the innovative drug sector is intensifying, with both domestic and international companies vying for market share, leading to a phenomenon of "Matthew Effect" where established players gain more advantages [6][17] Future Outlook - The company projects total revenue for 2026 to be between $6.2 billion and $6.4 billion, indicating continued growth potential [9][20] - Future growth will rely on multiple product launches and expansions into new therapeutic areas, including autoimmune diseases, which could open new revenue streams [8][19]

Core Insights - BeiGene reported a total revenue of 38.205 billion RMB for the fiscal year 2025, marking a 40.4% year-on-year increase, driven by product revenue growth and improved operational efficiency [1] - The net profit attributable to the parent company reached 1.422 billion RMB, indicating a significant turnaround from previous losses [1] - The company's flagship product, Brukinsa (Zebutinib), achieved global sales of 28.067 billion RMB, a 48.8% increase, solidifying its position as a global leader in the BTK inhibitor market [1][2] Revenue Breakdown - Product revenue for BeiGene reached 37.770 billion RMB, up 39.9%, primarily due to the sales growth of Brukinsa, Amgen-licensed products, and Tislelizumab [1][2] - In the U.S. market, Brukinsa's annual sales were 20.206 billion RMB, a 45.5% increase; in Europe, sales reached 4.265 billion RMB, up 66.4%; and in China, sales were 2.472 billion RMB, a 33.1% increase [1] Product Approvals and Pipeline - Brukinsa is the most widely approved BTK inhibitor globally, with approvals in over 75 markets [2] - The company plans to conduct a mid-term analysis of the MANGROVE trial in the first half of 2026, comparing Brukinsa combined with Rituximab against Bendamustine plus Rituximab for adult patients with mantle cell lymphoma [2] - Tislelizumab's global sales reached 5.297 billion RMB, an 18.6% increase, with ongoing efforts to submit new indications for regulatory approval in the U.S. and China [2] Market Position and Future Outlook - Analysts noted that BeiGene's transition from a "cash-burning machine" to a "cash-generating machine" reflects a significant shift in the global strategy for Chinese innovative drugs [3] - The company is expected to generate revenue between 43.6 billion and 45 billion RMB in 2026, with a gross margin projected to remain high at around 80% [4] - Concerns remain regarding the pipeline for new products following Brukinsa and Tislelizumab, with several late-stage candidates nearing commercialization [4][5] Strategic Initiatives - BeiGene is exploring the introduction of BTK inhibitors and IRAK4 degraders into autoimmune diseases, which could expand its market reach beyond oncology [5] - The company has received priority review status from the FDA for its BCL2 inhibitor, which is aimed at treating adult patients with relapsed/refractory mantle cell lymphoma [4][5] - The market is keenly awaiting the potential of new innovative candidates to emerge from BeiGene's pipeline, which could further enhance its valuation in the long term [5]

2026.02.26 本文字数：1121，阅读时长大约2分钟 作者 |第一财经 林志吟 封图｜第一财经记者任玉明摄 2月26日下午临近收盘时，百济神州（ONC.NS、06160.HK、688235.SH）港股股价突然暴跌，最后以大 跌9.16%收盘。伴随着股价大跌，公司港股市场的市值也跌破3000亿港元，最后报2995亿港元，由此引 发市场对公司即将发布的业绩快报的担忧。 2月26日晚间，百济神州发布的2025年度业绩快报显示，2025年，公司营业总收入达382.05亿元，同比 增长40.4%。得益于产品收入增长和费用管理推动的经营效率提升，归属于母公司所有者的净利润达 14.22亿元，首次实现全年盈利。 不过，百济神州收入第一高产品，BTK抑制剂百悦泽（泽布替尼）收入虽然再创新高，2025年全球销售 额达280.67亿元，但同比增速为48.8%，较2023年、2024年的翻倍增长有所放缓。 百悦泽优势主要在血液瘤领域，销售放缓背后，其实跟美国市场表现有关，虽然美国仍是这款药物最大 的商业化市场，贡献的销售额达到202.06亿元，同比增长45.5%，但这样的销售增速低于2024年107.5% 的增速。 作为百 ...

Core Viewpoint - Despite achieving record revenue, the growth rate of Baiyueze is slowing down [1] Group 1: Financial Performance - On February 26, 2025, the company reported total revenue of 38.205 billion yuan, a year-on-year increase of 40.4% [1] - The net profit attributable to the parent company reached 1.422 billion yuan, marking the first annual profit for the company [1] - Baiyueze's global sales reached 28.067 billion yuan, with a year-on-year growth of 48.8%, which is a slowdown compared to the doubling growth rates in 2023 and 2024 [1] Group 2: Product Performance - Baiyueze is the most widely approved BTK inhibitor globally, with approvals in over 75 markets [3] - In the U.S., Baiyueze remains the largest commercial market, contributing sales of 20.206 billion yuan, with a year-on-year growth of 45.5%, which is lower than the 107.5% growth in 2024 [3] - The second-highest revenue product, PD-1 monoclonal antibody Baizean, achieved global sales of 5.297 billion yuan, with a year-on-year increase of 18.6% [3] Group 3: Future Outlook - The company forecasts 2026 revenue to be between 43.6 billion yuan and 45 billion yuan, representing a growth rate of 14.12% to 17.79% compared to 2025 [3] - The company is working to reduce its reliance on Baiyueze by advancing multiple cornerstone products in late-stage clinical trials [3][4] - Baiyue's new product, Baiyueda, has received the first global marketing approval application in China for treating R/R MCL and is expected to receive regulatory decisions from the FDA in the first half of 2026 [4]

Group 1 - The year 2025 marks a milestone for the company, celebrating its 15th anniversary and entering a clearer phase in its globalization process [2] - The company achieved significant global growth in the past year, reaching a critical profitability turning point, with its core self-developed BTK inhibitor, Baiyueze, establishing a leading position globally [2] - The company launched its second self-developed product in the hematology field, the BCL2 inhibitor Baiyueda (Sotukral), which is now commercially available [2] Group 2 - In Thailand, the approval process for Baizean took only 7 months, significantly reducing the time for patients to access innovative treatments [3] - In India, the company's two self-developed products have benefited over 1,500 patients, receiving positive clinical feedback [3] - The company is expanding its global footprint by supporting local commercialization efforts in Indonesia and providing PD-1 inhibitors for clinical trials in sub-Saharan Africa [3] Group 3 - The company's goals for 2026 remain clear: to continue pipeline expansion centered on science and to enhance drug accessibility for patients in more countries [4] - The commitment to making innovations accessible to more patients is seen as a long-term investment and a driving force for the company [4] - The company emphasizes the importance of collaboration with industry partners to gather diverse experiences and wisdom from different regions to improve patient outcomes globally [4]

Group 1 - The Hong Kong Innovation Drug ETF (159570) has seen a significant inflow of funds, with a recent trading volume exceeding 5 billion yuan and a net inflow of over 300 million yuan in the past five days [1] - As of January 20, the total size of the Hong Kong Innovation Drug ETF reached over 25.3 billion yuan, leading the market in terms of scale among innovation drug ETFs [1] - The index components of the ETF showed mixed performance, with notable gains from companies like Kingsoft Biotech and China Biologic Products, while companies like CanSino Biologics experienced declines [3][4] Group 2 - At the J.P. Morgan Healthcare Conference, several Chinese pharmaceutical companies showcased their advancements, including BeiGene's new drug approval in China and plans for accelerated approval in the U.S. [5] - Innovent Biologics and Pfizer are set to conduct five global Phase III trials for their drug SSGJ-707 by 2026, targeting various cancers [6] - The collaboration between NVIDIA and Eli Lilly aims to establish an AI innovation lab with a projected investment of up to 1 billion USD over five years, potentially transforming drug development processes [8] Group 3 - Tempus AI reported a revenue of approximately 1.27 billion USD for 2025, marking an 83% year-on-year increase, driven by significant growth in its diagnostic business [9] - The top ten components of the Hong Kong Innovation Drug ETF account for over 73% of its weight, highlighting the concentration of leading innovative drug companies within the ETF [10]