Core Viewpoint - The ongoing dispute over the exclusive agency rights for AestheFill products between Aimeike and Datou Medical has significant implications for Aimeike's future performance and market position [2][8]. Group 1: Arbitration and Legal Proceedings - Aimeike's subsidiary REGEN has sent a termination notice to Datou Medical, ending their exclusive distribution agreement for AestheFill products in mainland China [2]. - Datou Medical has filed for arbitration with the Shenzhen International Arbitration Court, seeking to confirm the validity of the exclusive agency agreement and demanding REGEN to continue fulfilling the contract [2][3]. - Datou Medical is claiming damages amounting to 1.6 billion yuan if their arbitration requests are not upheld [2]. Group 2: Financial Performance - Aimeike's revenue and net profit growth have significantly slowed, with 2024 showing a revenue increase of only 5.45% and a net profit increase of 5.33%, compared to much higher growth rates in 2023 [5]. - In the first half of 2025, Aimeike reported a revenue of 1.299 billion yuan, a decline of 21.59%, and a net profit of 789 million yuan, down 29.57% year-on-year [5]. - The revenue from solution and gel injection products, which are key income sources, has also seen a decline, with respective decreases of 23.79% and 23.99% in the first half of 2025 [5][6]. Group 3: Market Position and Strategy - Aimeike is focusing on diversifying its product offerings to mitigate competitive pressures in the increasingly crowded market for aesthetic products [6][7]. - The company is expanding its product pipeline in areas such as metabolic diseases and major surgeries, while also accelerating the development of products like botulinum toxin and collagen [6]. - Aimeike emphasizes that its product safety and efficacy have been validated globally, and it aims to provide a broader range of solutions to meet diverse consumer needs [7].

Core Insights - The article highlights that only 13 women globally have become billionaires by founding healthcare companies, with 7 of them from China, indicating a significant presence of Chinese female entrepreneurs in the healthcare sector [1][3]. Industry Overview - The Chinese biopharmaceutical industry is experiencing a transformative phase, referred to as the "DeepSeek moment," as it evolves from being a "generic drug powerhouse" to a competitive force against Western innovation in pharmaceuticals [2]. - In 2024, over 1,250 new drug candidates are expected to enter the research and development phase in China, surpassing the European Union and nearly matching the United States' 1,440 candidates [2]. - Nearly one-third of the drug candidates licensed by large pharmaceutical companies in 2024 are from Chinese firms, a significant increase from zero in 2019 [3]. Company Highlights - **Hansoh Pharmaceutical Group**: Founded by Zhong Huijuan, the company reported a total revenue of approximately 12.26 billion yuan in 2024, with a year-on-year growth of about 21.3% [7]. - **Aimeike**: Founded by Jian Jun, the company specializes in hyaluronic acid production and was listed on the A-share market in 2020, achieving a market value exceeding 170 billion yuan [10]. - **Qizheng Tibetan Medicine**: Founded by Lei Jufang, the company generated sales revenue of 1.655 billion yuan in 2024, with a year-on-year growth of 16.31% [14]. - **Haisco Pharmaceutical Group**: Co-founded by Fan Xiulian, the company reported a revenue of 3.721 billion yuan in 2024, with a year-on-year increase of 10.92% [17]. - **Teva Biopharmaceuticals**: Founded by Yang Ying, the company has shown rapid growth, with revenues increasing from 1.527 billion yuan in 2022 to 2.817 billion yuan in 2024 [18]. - **Kangfang Biopharmaceutical**: Founded by Xia Yu, the company has developed several innovative drugs and is recognized for its leading position in the biopharmaceutical sector [23]. - **Xinlitai**: Co-founded by Liao Qingqing, the company has shifted focus to self-research and development, achieving a revenue of 4.012 billion yuan in 2024, with a year-on-year growth of 19.22% [26].

Industry Overview - The medical beauty injection materials industry in China has a limited number of publicly listed companies, primarily including Huaxi Biological, Haohai Biological, Aimeike, and Juzhi Biological, with most companies involved in the supply of upstream raw materials [1][7]. Company Summaries - Huaxi Biological is a global leader in hyaluronic acid, with a projected revenue of 53.71 billion yuan in 2024, and has expanded into collagen products through acquisitions [2][9]. - Haohai Biological has secured exclusive rights for domestic and international botulinum toxin products and is focusing on a dual product line of hyaluronic acid and botulinum toxin [6][15]. - Aimeike is expected to generate approximately 29.60 billion yuan in sales for its medical beauty injection materials in 2024, emphasizing high-end products [9][15]. - Juzhi Biological is projected to achieve sales of around 55.20 billion yuan in 2024, focusing on collagen products and leading the industry in standard-setting [9][15]. Sales and Production Data - Huaxi Biological has sold over 10 million units of its products, while Haohai Biological and Aimeike have sales around 7 million units each [13]. - Juzhi Biological's collagen products have a sales volume of approximately 55.20 billion yuan, indicating a strong market presence [11][13]. Business Strategies - Huaxi Biological is focusing on core technologies in glyco-biology and cell biology, aiming to enhance its position in the extracellular matrix and anti-aging sectors [15]. - Haohai Biological is pursuing international collaborations and technology imports to strengthen its product offerings and market competitiveness [15]. - Aimeike is developing a high-end product matrix centered on regenerative materials, with significant investments in training and technology [15]. - Juzhi Biological is leading the development of industry standards and expanding its product offerings in the collagen segment [15]. Regional Distribution - The majority of medical beauty injection material companies are concentrated in Shandong Province, with key players in raw material production and equipment manufacturing [7].

Core Viewpoint - The article discusses the significant decline in the wealth of Jian Jun, the leader of Aimeike, a prominent player in the medical beauty industry, highlighting the challenges faced by the company amid increasing competition and changing market dynamics [2][3]. Group 1: Wealth Decline of Jian Jun - Jian Jun's wealth has decreased from 525 billion yuan in 2023 to 220 billion yuan in 2025, a loss of 305 billion yuan over two years [2][3]. - Aimeike, under Jian Jun's leadership, has become a leading company in the medical beauty sector, forming a competitive landscape with Huaxi Biological and Haohai Biological, known as the "three swordsmen of hyaluronic acid" [2][3]. - Despite previous high growth rates, Aimeike's revenue and net profit growth have slowed to single digits in 2024, with both metrics turning negative in Q1 2025 [2][10]. Group 2: Aimeike's Business Performance - Aimeike's revenue surged by 104.13% in 2021, reaching 1.448 billion yuan, with net profit increasing by 117.81% to 958 million yuan [10]. - In 2023, Aimeike's revenue reached 2.869 billion yuan, and net profit was 1.858 billion yuan, but growth rates fell to 5.45% and 5.33% respectively in 2024 [11]. - The company's gross margin has also declined, from 95.09% in 2023 to 93.85% in Q1 2025 [11]. Group 3: Strategic Moves and Acquisitions - In March 2025, Aimeike announced plans to acquire 85% of South Korean REGEN Biotech, Inc. for 1.9 billion USD, aiming to enhance its international presence and product offerings [12][13]. - The acquisition is seen as a strategic move to solidify Aimeike's leading position in the injectable product market and to drive future growth [13][14]. - Analysts believe that this overseas acquisition could provide new growth opportunities for Aimeike amid a challenging domestic market [12][13].