Group 1: Company Overview - He Yuan Bio is a pioneer in the "rice blood-making" industry, focusing on plant-derived recombinant protein expression technology[7] - The company's core product, recombinant human serum albumin injection (HY1001), was approved for market in July 2025, making it the first recombinant human albumin drug approved in China[12] - The market for human serum albumin in China is projected to grow from 25.8 billion RMB in 2020 to 57 billion RMB by 2030, with a compound annual growth rate (CAGR) of 8.25%[12] Group 2: Financial Metrics - As of September 23, 2025, comparable companies have a median market capitalization of 24.899 billion RMB, with a median price-to-earnings ratio of 26.60 times[20] - He Yuan Bio's revenue from 2022 to H1 2025 was 0.13 billion, 0.24 billion, 0.25 billion, and 0.13 billion RMB, respectively, which is below the average of comparable companies[24] - The company's R&D expenses from 2022 to H1 2025 were 1.10 billion, 1.59 billion, 1.17 billion, and 0.56 billion RMB, with a compound growth rate of 2.81%, slightly above the comparable average of 2.06%[29] Group 3: Market Position and Risks - He Yuan Bio has a unique first-mover advantage in the recombinant human albumin market, with no other similar products approved in China as of August 2025[12] - The company faces risks related to not yet being profitable, as most of its products are still in the R&D phase[43] - There is a risk that the supply of medicinal rice may not meet the demands of large-scale commercial production, which could impact operations[44]

Investment Rating - The report assigns a mid-to-low level investment rating to He Yuan Bio, with an AHP score of 2.59, placing it in the 42.6% percentile of the AHP model [7]. Core Insights - He Yuan Bio is a pioneer in the "rice blood production" industry, having launched the first recombinant human albumin product in China, which was approved in July 2025. This product addresses the market for liver cirrhosis with low albumin levels, which constitutes about 30% of the human serum albumin market [9][14]. - The company has developed two major technology platforms: the OryzHiExp for efficient recombinant protein expression and the OryzPur for protein purification, achieving high purity levels and cost reductions [17]. - He Yuan Bio has a robust pipeline with eight products in development or on the market, targeting various clinical needs across different age groups, thus reducing dependency on any single area [9][14]. Summary by Sections AHP Score and Expected Allocation Ratio - He Yuan Bio's AHP score is calculated to be 2.59, indicating a mid-to-low ranking within the AHP model [7]. - The offline issuance adopts a lock-up mechanism with varying lock-up ratios and periods for different classes of investors [7]. Company Highlights and Features - He Yuan Bio is recognized as the first company to utilize rice endosperm cell bioreactors for large-scale production of pharmaceutical proteins, with a focus on recombinant human albumin [9]. - The company has established a comprehensive sales network across over 30 provinces in China and is preparing for negotiations to enter the national medical insurance directory [21]. - The company has cultivated over 9,000 acres of medicinal rice to ensure a stable supply of raw materials for production [18]. Financial Comparison with Peers - He Yuan Bio has only one product on the market compared to an average of four for comparable companies, indicating a relatively slower development pipeline [25]. - The company's revenue and net profit figures are lower than those of comparable companies, primarily due to the lack of market-ready products [27]. - R&D expenses have shown a compound annual growth rate of 2.8%, slightly above the average of comparable firms [33]. Fundraising Projects and Development Vision - The company plans to use the funds raised from its IPO for the construction of a recombinant human albumin industrialization base, new drug development projects, and to supplement working capital [43]. - The industrialization base project aims to enhance production capacity and meet the growing market demand for human serum albumin [19].

Core Viewpoint - Wuhan Heyuan Biotechnology Co., Ltd. has successfully passed the review of the Shanghai Stock Exchange's Sci-Tech Innovation Board, marking a significant milestone in the integration of technology and industry in Wuhan's biopharmaceutical sector [1] Group 1: Industry Development - Wuhan is experiencing a transformation towards a complete new materials industry chain, providing vast market opportunities for startups [1] - The city is fostering a unique innovation ecosystem characterized by a "tolerance for failure" and "empowering dreams," attracting young talents to engage deeply in technology-industry integration [1][2] - The establishment of a "陪跑式" (accompanying) entrepreneurship mechanism supports startups at various stages, from incubation to scaling [3][4] Group 2: Innovation and Talent - Wuhan's innovation strategy is focused on creating a youth-friendly city, with policies that encourage entrepreneurship and innovation [3][4] - The city has implemented a government fund error tolerance mechanism, allowing for significant losses in early-stage investments, which encourages risk-taking in innovation [4] - The "武汉英才" (Wuhan Talent) program aims to attract over 300,000 university graduates annually, enhancing the talent pool for technology-industry integration [11] Group 3: Case Studies - NIO has received substantial investment and is expanding its battery swap stations in Wuhan, which is expected to generate significant revenue and attract related businesses [5] - Heyuan Biotechnology's innovative plant-based bioreactor technology has significantly increased the production efficiency of pharmaceutical proteins, addressing the reliance on imports [9][12] - The establishment of the "协和医院-衷华脑机院企联合实验室" aims to accelerate research and development in brain-machine interface technologies, showcasing the city's commitment to cutting-edge medical innovations [6][9] Group 4: Future Prospects - Wuhan's strategic focus on integrating AI and other emerging technologies is expected to drive substantial growth in various industries, with projected revenue increases of over 20% in strategic emerging sectors [10][14] - The city is actively promoting the commercialization of scientific research, exemplified by the success of local enterprises like Heyuan Biotechnology and Huazhong University of Science and Technology's spin-offs [12][14] - The ongoing development of a supportive ecosystem for innovation and entrepreneurship is anticipated to further enhance Wuhan's position as a leading hub for technology and industry integration [14][15]

Group 1 - The first company to be reviewed under the restarted fifth set of standards for the Sci-Tech Innovation Board is Wuhan Heyuan Biotechnology Co., Ltd. (Heyuan Bio) [1][3] - Heyuan Bio is an innovative biopharmaceutical company known for its "rice-derived blood" technology and has established a unique plant expression system and two technical platforms [3][4] - The company has adjusted its fundraising target down by approximately 1.1 billion yuan, from an initial 3.502 billion yuan to 2.4 billion yuan, due to steady progress in R&D and business operations [5][6] Group 2 - Heyuan Bio's asset-liability ratio is projected to increase significantly in 2024, with ratios of 18.81%, 23.96%, and 43.37% for the years 2022 to 2024 respectively [6][7] - The company has not yet achieved profitability, with reported revenues of approximately 13.4 million yuan, 24.3 million yuan, and 25.2 million yuan for the years 2022 to 2024, and net losses of approximately 144 million yuan, 187 million yuan, and 151 million yuan for the same period [7] - Heyuan Bio's core product, HY1001, is expected to be approved for market launch soon, having completed its Phase III clinical trials with promising results [7][8] Group 3 - The recent policy changes by the China Securities Regulatory Commission aim to enhance the inclusivity and adaptability of the Sci-Tech Innovation Board, facilitating the listing of unprofitable companies [4] - Other companies currently in the review process under the fifth set of standards include Beixin Life, Hengrun Da, Sizherui, and Bibete, with some making faster progress than others [8][9]

作为禾元生物的核心产品，HY1001获批上市将有效缓解我国人血清白蛋白长期依赖进口 的局面。 本文为IPO早知道原创 作者｜ Eric 微信公众号｜ipozaozhidao 在生物医药领域的激烈竞争中，武汉禾元生物科技股份有限公司（以下简称 "禾元生物"）正以其独 特的技术优势和深厚的研发实力，逐渐崭露头角。即将上会的禾元生物，不仅在稻米造血技术上取得 显著进展，其背后更蕴含着一系列值得关注的创新亮点，为行业发展带来新的思考与方向。 禾元生物自 2006 年成立以来，便专注于重组蛋白表达技术研究与产品开发。经过多年耕耘，公司 构建起了一套完整且先进的技术体系，其中水稻胚乳细胞生物反应器高效重组蛋白表达平台（ Oryz HiExp ）和重组蛋白纯化技术平台（ Oryz Pur ）是其核心竞争力所在。 Oryz HiExp 平台利用水稻胚乳细胞作为生物反应器，通过胚乳细胞特异性表达的启动子、人工定点突 变增强启动子转录水平、蛋白定向储存、内质网减负和密码子优化等综合技术，实现了重组蛋白在水 稻胚乳细胞中的特异性表达与高效储存。这一平台的优势在于，能够将重组蛋白产量从传统的 mg 级别大幅提升至 30g 级别，极大 ...