Aflac (NYSE:AFL) 2026 Conference February 11, 2026 09:40 AM ET Company ParticipantsDavid Young - SVP of Capital MarketsVirgil Miller - PresidentConference Call ParticipantsMichael Ward - North American Life Insurance AnalystMichael WardThank you, everyone, for joining us this morning. So, very pleased to have Aflac with us. So my name is Michael Ward. I'm the North American Life Insurance Analyst at UBS. So to my left, I have David, Virgil Miller, President of Aflac Inc., and David Young, SVP of Capital Mar ...

Financial Data and Key Metrics Changes - In 2025, the company reported approximately $14.3 billion in net sales, an increase of about $200 million year-over-year, supported by a 23% increase in light vehicle e-product sales [5][7] - The adjusted operating margin expanded by 60 basis points to 10.7%, with a 14% growth in EPS year-over-year and over $1.2 billion in free cash flow generated, marking a 66% increase from 2024 [7][28] - The fourth quarter adjusted operating income was $427 million, equating to a 12.0% adjusted operating margin, compared to 10.2% in the previous year [21][22] Business Line Data and Key Metrics Changes - Light vehicle e-product sales drove significant growth, with a 23% increase, while organic sales, excluding the battery and charging system segment, were up approximately 1.6% year-over-year [5][6] - The battery systems business faced a decline of 35%-40% year-over-year, contributing a 150 basis point headwind to overall growth [62] Market Data and Key Metrics Changes - The company expects total 2026 sales in the range of $14.0-$14.3 billion, with a projected organic sales decline of 3.5%-1.5% year-over-year, primarily due to a decrease in the battery business [23][24] - The China market, which constitutes about 20% of the company's overall business, has seen a slowdown in local vehicle sales, but exports from China reached over 7 million last year, indicating potential growth opportunities [94] Company Strategy and Development Direction - The company is focused on long-term profitable growth, with a new product aimed at the data center market expected to generate over $300 million in sales during its first year of production [11][14] - The strategy includes leveraging existing manufacturing capabilities and expanding into new markets, such as power generation, while maintaining a disciplined approach to capital allocation and M&A opportunities [19][70] Management's Comments on Operating Environment and Future Outlook - Management expressed optimism about future performance, citing a robust pipeline of new product awards and the potential for margin expansion and EPS growth in 2026 despite market challenges [7][19] - The company anticipates that the impact of EV program volume shortfalls will continue into 2026, but expects to see growth from new product launches starting in 2027 [75] Other Important Information - The company returned over 50% of its free cash flow to shareholders in 2025 through share repurchases and dividends, demonstrating a commitment to shareholder value [7][27] - The company has secured a record number of new product awards, indicating strong demand for its foundational and e-product portfolios [17][18] Q&A Session Summary Question: Can you elaborate on the data center opportunity and its margins? - Management indicated that the $300 million revenue target is for the ramp-up year, with a mid-teens incremental conversion expected, and immediate EPS accretion anticipated [33][34] Question: What is the outlook for the PowerDrive segment and the sustainability of growth? - Management noted a 100 basis point benefit in the fourth quarter and expects continued growth in light vehicle e-products in the low double digits for 2026 [36][37] Question: How does the company view the growth potential in the turbocharger market? - Management remains optimistic about growth in the turbo business, citing strong market leadership and ongoing technological advancements [58][59] Question: What is the future of the battery systems business given the current decline? - Management acknowledged the challenges but expressed confidence in the team's ability to minimize losses and adjust the cost structure for future growth opportunities [62][63] Question: How does the company approach M&A in the current market environment? - Management emphasized a disciplined approach to M&A, focusing on opportunities that leverage core competencies and provide near-term accretion [70][72]

Summary of Revolution Medicines Conference Call Company Overview - **Company**: Revolution Medicines (NasdaqGS: RVMD) - **Focus**: Development of targeted therapies for RAS-addicted cancers, particularly pancreatic cancer Key Points Clinical Trials and Data - **RASolute 302 Study**: - Phase 3 trial with dual primary endpoints: Progression-Free Survival (PFS) and Overall Survival (OS) [6][7] - Expected top-line data release in the first half of 2026 [6] - OS is prioritized as the main endpoint due to historical data showing PFS may not translate to survival benefits [7] - The trial is designed to be OS event-driven, with three possible outcomes: fail on both endpoints, succeed on both, or succeed on PFS but not OS [8] - **Control Arm Performance**: - Historical data indicates chemotherapy yields a PFS of 3-4 months and OS of 6-7 months in previously treated pancreatic cancer patients [11] - **Patient Population**: - The study includes both RAS mutation and wild-type patients, with a focus on G12 mutations, which represent about 85% of pancreatic cancer cases [12][14] - RAS is considered central to pancreatic cancer, with evidence suggesting that even wild-type patients may benefit from RAS-targeted therapies [12][13] Regulatory Considerations - The FDA will analyze data in various ways but will not seek statistical significance in small populations [19] - The company plans to share top-line results initially, with detailed data presented at a medical meeting [21] Future Studies - **RACELUTE 303 Study**: - A new three-arm trial for first-line metastatic pancreatic cancer patients is now open for enrollment [23] - High engagement and enthusiasm from investigators and patients are expected due to promising single-arm data from previous studies [23][25] - **Combination Therapies**: - The company is exploring multiple combination therapies, including zoldonrasib with chemotherapy, to provide more treatment options for patients [38][41] - Initial data shows that both monotherapy and combination regimens are well-tolerated and effective [35][41] Colorectal Cancer Research - The company is actively researching colorectal cancer, where 50% of patients have a RAS mutation [48] - Plans to share data on combination regimens targeting RAS and other pathways are expected later this year [49] New Developments - **RM055**: - A new class of pan-RAS inhibitors is in development, with a clinical trial expected to start by the end of the year [52] Strategic Decisions - The company opted for a global approach without partnerships, believing it to be the right decision given the complexities of managing pricing and market differentiation [55] Additional Insights - The company emphasizes the importance of providing multiple treatment options to cater to the diverse needs of patients [37] - There is a focus on the potential for post-progression use of therapies and the implications for overall survival data interpretation [30][31] This summary encapsulates the critical aspects of Revolution Medicines' conference call, highlighting their ongoing clinical trials, regulatory strategies, and future directions in cancer treatment development.

Summary of Celcuity Conference Call Company Overview - **Company**: Celcuity - **Product**: Gedatolisib - **Industry**: Healthcare, specifically oncology Key Points Product Development and Approval Timeline - Celcuity has received positive phase 3 data for gedatolisib in breast cancer and has an NDA accepted with a PDUFA date set for July 17, 2024, indicating a potential launch soon after approval [3][4] - Data for the mutant cohort of the VIKTORIA-1 study is expected to be available later this quarter or in Q2 2024 [4] Commercial Infrastructure - The Chief Commercial Officer was appointed in Q1 2024, with plans to prepare for a mid-2026 launch [7] - The commercial organization is being built out, with hiring in marketing, commercial operations, and medical affairs largely completed, leaving only field sales representatives to be hired [7][8] Clinical Data and Efficacy - Gedatolisib has shown a hazard ratio of 0.24, translating to a 76% reduction in the risk of progression or death compared to endocrine therapy, which is unprecedented [12] - The drug's efficacy is expected to be superior to existing options, with a nearly 5-fold improvement in progression-free survival (PFS) [12] Patient Experience and Side Effects - Stomatitis is a common side effect but tends to resolve within two weeks, with patients reporting a good sense of well-being while on the drug [16][17] - Gedatolisib's pharmacokinetics allow for dosing three times a month, maintaining effective drug levels while minimizing adverse effects [18][19] Market Opportunity - The overall market for gedatolisib is estimated to exceed $6 billion, with a potential of over $2 billion in the second-line indication alone at a 30% market penetration [35][36] - The drug could become a multi-billion dollar product, especially if successful in first-line settings [37] Ongoing Trials and Future Prospects - The ongoing trial for the treatment-naive population is focused on women who are endocrine resistant, with a safety run-in phase expected to conclude soon [40][41] - The company is optimistic about the results from the VIKTORIA-1 study, which showed significant benefits even in patients with prior CDK treatment [43][44] Financial Position - Celcuity reported $450 million in cash at the end of Q3 and has access to an additional $500 million through a term loan facility, providing flexibility for future operations [48] Additional Insights - The company is confident in its ability to execute the commercial launch of gedatolisib and is focused on building the necessary infrastructure [23][24] - The competitive landscape includes drugs like Truqap, which has a median PFS of 5.5 months, suggesting that gedatolisib could offer significant advantages in terms of efficacy [32][35]

Financial Data and Key Metrics Changes - In 2025, the company reported approximately $14.3 billion in net sales, an increase of about $200 million year-over-year, supported by a 23% increase in light vehicle e-product sales [4][5] - The adjusted operating margin expanded by 60 basis points to 10.7%, with a 14% year-over-year growth in EPS and over $1.2 billion in free cash flow generated, representing a 66% increase compared to 2024 [5][24] - The fourth quarter sales reached just under $3.6 billion, with an adjusted operating income of $427 million, equating to a 12.0% adjusted operating margin, up from 10.2% in the previous year [17][18] Business Line Data and Key Metrics Changes - Light vehicle e-product sales drove significant growth, with a 23% increase, while organic sales growth was approximately 1.6% year-over-year, excluding declines in the battery and charging system segment [4][5] - The PowerDrive Systems segment saw substantial e-product growth, contributing to the overall performance, with expectations for continued growth in the low double digits for 2026 [34][35] Market Data and Key Metrics Changes - The company anticipates a sales decline in the battery business due to reduced North American incentives and weaker European demand, representing a 150 basis point headwind to year-over-year sales growth [19][59] - The China market, which constitutes about 20% of overall business, is experiencing a slowdown in local vehicle sales, but exports from China have reached record highs, providing opportunities for growth [76] Company Strategy and Development Direction - The company is focused on long-term profitable growth, with a new product aimed at the data center market expected to generate over $300 million in sales during its first year of production, starting in 2027 [9][11] - The strategy includes leveraging core competencies in manufacturing and technology to secure new business awards and expand into new markets, such as power generation [14][26] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the company's ability to expand margins and grow adjusted EPS in 2026, despite anticipated declines in market volumes and battery sales [16][25] - The company is optimistic about future product launches and the potential for growth in both foundational and e-product segments, with expectations for improved performance starting in 2027 [66] Other Important Information - The company returned over 50% of its free cash flow to shareholders in 2025 through share repurchases and dividends, demonstrating a balanced capital allocation approach [5][22] - The company has repurchased over 31 million shares since 2021, representing a 13% reduction in outstanding shares [22] Q&A Session Summary Question: Can you elaborate on the data center opportunity and its margins? - The company expects a mid-teens incremental conversion on the $300 million in revenues from the data center business, which is anticipated to be EPS accretive immediately [30][31] Question: What is the size of the recovery in the PowerDrive segment? - The PowerDrive Systems segment saw about 100 basis points of benefit in Q4, with expectations for continued growth in the mid-teens for 2026 [34][35] Question: How does the company view the growth potential of the turbine generator system? - The data center market is expected to grow in the mid-teens annually for the next decade, with the turbine generator system positioned to capture significant market share [40][41] Question: What is the outlook for the battery systems business? - The battery systems business is expected to face a 150 basis point headwind in 2026, but management is optimistic about future growth opportunities and cost structure adjustments [59] Question: How does the company approach M&A opportunities? - The company remains disciplined in its M&A strategy, focusing on acquisitions that leverage core competencies and provide near-term accretion [63][64]

ProMIS Neurosciences (NasdaqCM:PMN) 2026 Conference February 11, 2026 09:30 AM ET Company ParticipantsNeil Warma - CEO and Member of the Board of DirectorsConference Call ParticipantsEddie Hickman - Biotechnology Equity Research AnalystYatin Suneja - Biotechnology Research AnalystYatin SunejaAll right, good morning everyone. Welcome to Guggenheim's Emerging Outlook, Biotech Summit 2026. My name is Yatin Suneja, one of the biotech analysts here at Guggenheim. I'm joined here with my colleague Eddie Hickman, ...

Investor Update Single Tenant Net Lease REIT with 36 consecutive annual dividend increases February 2026 Safe Harbor (All data as of December 31, 2025) This presentation contains certain statements that are the Company's and Management's hopes, intentions, beliefs, expectations, or projections of the future and might be considered to be forward-looking statements under Federal Securities laws. Prospective investors are cautioned that any such forward-looking statements are not guarantees of future performan ...

Financial Data and Key Metrics Changes - BorgWarner reported approximately $14.3 billion in net sales for 2025, an increase of about $200 million year-over-year, supported by a 23% increase in light vehicle e-product sales [4][5] - The adjusted operating margin expanded by 60 basis points to 10.7%, despite a 20 basis points net tariff headwind [5][15] - The company achieved a 14% year-over-year growth in EPS and generated over $1.2 billion in free cash flow, a 66% increase compared to 2024 [5][19] Business Line Data and Key Metrics Changes - Light vehicle e-product sales increased by 23%, contributing significantly to overall sales growth [4][5] - Organic sales growth was approximately 1.6% year-over-year when excluding the decline in the battery and charging system segment [4] - The battery systems business experienced a revenue decline of 35%-40% year-over-year, primarily due to challenges in North America and weaker demand in Europe [40][41] Market Data and Key Metrics Changes - The company expects its light vehicle business, which comprises over 80% of sales, to perform broadly in line with the weighted light vehicle market, which is projected to be flat to down 3% for 2026 [20][22] - The battery business is anticipated to represent a 150 basis point headwind to year-over-year sales growth due to a lack of North American incentives and weaker European demand [21][41] Company Strategy and Development Direction - BorgWarner is focusing on long-term profitable growth by investing in new product developments, including a Turbine Generator System for the data center market [6][10][16] - The company secured a record number of new product awards across its foundational and e-product portfolios, indicating a robust pipeline for future growth [5][16] - The strategic focus includes leveraging core competencies and exploring inorganic opportunities to enhance capabilities and shareholder value [44][45] Management's Comments on Operating Environment and Future Outlook - Management expressed confidence in the company's ability to expand margins, grow adjusted EPS, and generate strong free cash flow in 2026, despite anticipated declines in markets and battery sales [5][16][27] - The company expects to see top-line benefits from new product launches starting in 2027 and beyond, driven by recent business wins [34][47] - Management acknowledged the challenges in the EV market but remains optimistic about future growth opportunities from new product developments [34][46] Other Important Information - BorgWarner announced a Master Supply Agreement with TurboCell for the Turbine Generator System, expected to generate over $300 million in sales during the first year of production [10][12] - The company has repurchased over $400 million of its stock in the second half of 2025, returning approximately 52% of free cash flow to shareholders [24][25] Q&A Session Summary Question: Can you elaborate on the data center opportunity and its margins? - Management indicated that the $300 million in revenues from the data center business is expected to have a mid-teens incremental conversion margin, consistent with the automotive business [29] Question: What is the size of the recovery in the PowerDrive segment? - Management noted a 100 basis point benefit in the fourth quarter, with expectations for continued growth in light vehicle e-products in the low double digits for 2026 [30][31] Question: What is the outlook for the battery systems business? - The battery systems business is expected to face continued sales headwinds, with management taking actions to minimize losses and adjust the cost structure [40][41] Question: How does the company view its M&A strategy in light of current market conditions? - Management emphasized a disciplined approach to M&A, focusing on acquisitions that leverage core competencies and provide near-term accretion [44][45]

Summary of nLIGHT Conference Call Company Overview - nLIGHT is a founder-led defense laser technology company with a vertically integrated platform based in the U.S. [1] - The company specializes in high-power semiconductor lasers, with applications in both commercial and defense sectors [2][4]. - nLIGHT is headquartered in the Pacific Northwest, near major semiconductor fabs like Intel and TSMC, and has a site in Colorado [2]. Core Technologies and Applications - nLIGHT's technology stack includes semiconductor chips that produce tens of watts of power, which can be scaled to high-power laser systems [3][4]. - The company focuses on three core areas: directed energy, sensing, and advanced manufacturing [5][12]. Directed Energy - Directed energy applications utilize high-power lasers to damage or destroy various threats, including drones and missiles [5][6]. - nLIGHT claims to have the highest power laser in the world at over 300 kW, with plans to scale to 1 MW [9]. - The company emphasizes the importance of coherent beam combining for higher power applications, which offers advantages in brightness and atmospheric compensation [8][10]. Sensing - Sensing applications involve using pulse lasers for range finding and LiDAR, providing high-resolution data in a stealthy manner [11]. - nLIGHT has been involved in programs for over a decade and is currently deployed on various missiles [11]. Advanced Manufacturing - The company is engaged in laser additive manufacturing, which is crucial for producing complex parts for hypersonics and rocket engines [12][13]. - nLIGHT's technology is also applied in the automotive sector, with lasers used in the production of high-performance vehicles [28]. Market Dynamics - The defense sector is currently the core market driving nLIGHT's growth, with a strong alignment with the Department of Defense's priorities [5]. - The industrial market has seen significant growth, particularly in China, which is now the largest market for industrial lasers [29]. - However, the company has faced challenges due to excess capacity in the industrial market stemming from China [30]. Financial Position and Growth Strategy - nLIGHT recently raised $200 million to strengthen its balance sheet, which now exceeds $250 million [23][24]. - The capital will be used for product development, capital expenditures, and potential mergers and acquisitions [26][27]. - The company aims to invest ahead of program records to capitalize on known applications in directed energy [25]. Vertical Integration - nLIGHT's vertical integration strategy allows for rapid adaptation to technological changes and reduces transaction costs associated with external partnerships [34]. - The acquisition of Nutronics enhanced nLIGHT's capabilities in coherent beam combining and atmospheric correction, demonstrating the benefits of vertical integration [35][36]. Future Outlook - nLIGHT is optimistic about growth in the sensing and directed energy markets, which are expected to expand significantly [38]. - The company is also focused on addressing challenges in the U.S. Indo-Pacific Command, where both directed energy and sensing technologies are critical [39]. Additional Insights - The management highlighted the importance of thermal management in laser systems, which is critical for performance [18]. - nLIGHT is exploring partnerships with various government agencies and primes in both sensing and directed energy sectors [20].

Financial Data and Key Metrics Changes - Q4 2025 revenues were $80.6 million, up 11% year-over-year and 1% sequentially, marking solid execution across the portfolio [2][3] - Adjusted gross margin for Q4 was 37%, down from 40.5% in Q3, impacted by $3 million in headwinds [15][17] - GAAP net loss was $1.9 million, or $0.14 per diluted share, while adjusted diluted EPS was $0.07 [16][17] - Adjusted EBITDA was $6 million, or 7.5% of revenue, compared to $9.2 million or 11.5% of revenue in Q3 [17] Business Line Data and Key Metrics Changes - **Sensors Segment**: Q4 revenue declined 4% sequentially but was up 18% year-over-year; bookings rose 4% sequentially, resulting in a book-to-bill of 1.15 [4][5] - **Weighing Solutions Segment**: Q4 sales increased modestly from Q3 and grew 7.8% from the prior year; orders were up 14.9% sequentially, resulting in a book-to-bill of 1.02 [7][8] - **Measurement Systems Segment**: Q4 revenue was $22.4 million, up 9% sequentially and 6% year-over-year; however, orders declined 16% from Q3, resulting in a book-to-bill of 0.81 [9] Market Data and Key Metrics Changes - Total Sensors orders were up 18% in the second half of 2025 compared to the first half, with backlog at the highest level since Q3 2023 [5][6] - Weighing Solutions showed strength in precision agriculture, medical, construction, and e-bike applications, while transportation orders increased for onboard weighing systems [8] Company Strategy and Development Direction - The company is focusing on accelerating growth through the creation of two new senior executive positions: the Office of the Chief Business and Product Officer and the Office of Chief Operating Officer [10][11] - Aiming for a mid- to high-single-digit revenue growth in 2026, with a target of $45 million from business development initiatives, representing a 20% increase from 2025 [14][39] - Emphasis on Physical AI technologies and humanoid robotics as key growth areas, with expectations for continued momentum in 2026 [13][14] Management's Comments on Operating Environment and Future Outlook - Management expressed optimism regarding recovery in the marketplace, particularly in the Sensors and Weighing Solutions segments, despite softness in the steel market [21][22] - Anticipated improved gross margins in Q1 2026, with no lingering impacts from unusual headwinds identified in Q4 [23][27] - The company is prepared to support customer production demands in the humanoid robotics market, which is expected to see significant developments in 2026 [6][7] Other Important Information - The company generated adjusted free cash flow of $1.3 million in Q4, down from $7.4 million in Q3 [17] - As of the end of Q4, the cash position was $87.4 million, with long-term debt of $20.6 million, resulting in a net cash position of $66.8 million [18] Q&A Session Summary Question: Revenue guidance and its bias towards the sensor segment - Management is optimistic about recovery signs in the marketplace, particularly in Sensors, and expects higher revenues in the second half of the year [21][22] Question: Gross margin impact and lingering effects - Management identified a $3 million unusual effect in Q4, which is not expected to persist into Q1, leading to improved gross margins [23][27] Question: Organizational changes and financial targets - The new organizational structure aims to standardize processes and improve operational efficiency, with expected cost savings of $6 million in 2026 [36][39] Question: Details on new humanoid development customer - The new customer is smaller and still in the design stage, with no clear timeline for ramp-up, but the company is prepared to support them [40][41] Question: Discussions with other humanoid developers - The company is in dialogue with multiple humanoid manufacturers and hopes to report prototype orders from them in the future [42]