Zenas BioPharma (NasdaqGS:ZBIO) FY Conference September 10, 2025 07:45 AM ET Company ParticipantsLonnie Moulder - Founder and CEOConference Call ParticipantsJudah Frommer - AnalystJudah FrommerWelcome to this session of the Morgan Stanley Global Healthcare Conference. Let me read a quick disclosure before welcoming Zenas BioPharma to the stage. For important disclosures, please see the Morgan Stanley Research Disclosure website at www.morganstanley.com/researchdisclosures. If you have any questions, please ...

Summary of Altimmune Fireside Chat Company Overview - **Company**: Altimmune - **Focus**: Development of pemvidutide, a GLP-1/glucagon dual receptor agonist for treating serious liver diseases, particularly NASH (Non-Alcoholic Steatohepatitis) [3][4] Core Points and Arguments Pemvidutide and NASH - Pemvidutide is designed to have direct effects on the liver and provide metabolic benefits, primarily through weight loss [3][4] - Approximately 80% of NASH patients are overweight or obese, indicating that addressing both liver health and weight is crucial for treatment [4] - The drug shows significant reductions in liver fat, inflammation, and fibrosis, alongside weight loss [4] - Currently in a 48-week phase 2b trial for NASH, with 24-week data recently reported [5][6] Trial Design and Results - The phase 2b trial enrolled 212 patients with three treatment arms: placebo, 1.2 mg, and 1.8 mg of pemvidutide [6][7] - Class-leading NASH resolution was observed at the 24-week biopsy endpoint, exceeding results from other compounds [7][8] - Non-invasive tests showed robust anti-inflammatory and anti-fibrotic activity, with results indicating potential for FDA approval based on these tests [8][9] - The company plans to meet with the FDA to discuss transitioning from biopsy-based endpoints to non-invasive test-based endpoints for phase 3 trials [10][12] FDA Engagement and Future Plans - The company aims to align with the FDA on trial design, dose regimens, and endpoints during the end-of-phase 2 meeting [12][13] - Pemvidutide has shown excellent tolerability with no adverse event discontinuations, a significant advantage over other NASH treatments [15][17] - The company is preparing for phase 3 trials in NASH, expected to start in 2026 [5][10] Broader Implications and Market Position - The treatment landscape for NASH is evolving, with recent approvals for other drugs like semaglutide, which primarily focuses on metabolic components [23][24] - The combination of direct liver effects and weight loss in pemvidutide is positioned as a unique advantage over existing therapies [24][25] - The company is also exploring the use of pemvidutide in treating Alcohol Use Disorder (AUD) and Alcoholic Liver Disease (ALD), with ongoing trials [34][36] Additional Important Insights - The FDA has accepted applications for non-invasive tests, indicating a shift towards less invasive methods for evaluating liver health [9][10] - Pemvidutide's weight loss efficacy at the 2.4 mg dose was reported at 15.6% over 48 weeks, with potential for greater weight loss over longer periods [26][27] - The drug's ability to preserve lean mass during weight loss is highlighted as a critical factor, especially for older patients [28][29] - The company has received fast track status for AUD, emphasizing its commitment to addressing serious conditions related to obesity [39] Conclusion Altimmune is strategically positioned in the NASH treatment landscape with pemvidutide, focusing on both liver health and weight loss. The upcoming phase 3 trials and FDA meetings are critical milestones for the company's future in addressing serious liver diseases and related conditions.

Fifth Third Bancorp (NasdaqGS:FITB) FY Conference September 10, 2025 07:30 AM ET Company ParticipantsTim Spence - President and CEOBryan Preston - EVP and CFOConference Call ParticipantsJason Goldberg - AnalystJason GoldbergWelcome to day three of Barclays' 23rd Annual Global Financial Services Conference. Thank you. We appreciate all your attendance here. We had a jam-packed morning of banks. We have a great cross-section of companies all in this room: Fifth Third, Regions, Morgan Stanley, M&T, State Stree ...

Synchrony Financial (NYSE:SYF) FY Conference September 10, 2025 07:30 AM ET Company ParticipantsBrian Wenzel - EVP & CFOConference Call ParticipantsTerry Ma - Senior Equity Research AnalystTerry MaAlright. Good morning, everyone. Thank you for joining first presentation of the day. My name is Terry Muck. I'm a consumer finance here at Barclays.I'm very pleased to have on stage Brian Wenzel, c o CFO of Synchrony Financial. So welcome, Brian.Brian WenzelTerry, thank you. Glad to be here today.Terry MaGreat. L ...

Investor Day 2025 This presentation contains certain "forward-looking statements" based on management's current expectations. Forward-looking statements include, but are not limited to, the statements under "Financial Outlook," statements regarding long-term performance, statements regarding long-term brand growth ambitions beyond fiscal year 2028, statements regarding the Company's capital deployment plans, including anticipated annual dividend rates and share repurchase plans, and statements that can be i ...

Barclays Annual Financial Services Conference September 10 Internal Use Longstanding Strategic Priorities Committed to: • Diversified Revenue Streams • Appropriate Risk Adjusted Returns • Disciplined Expense Management Profitability Strategically Investing in: • Top quartile organic loan & deposit growth over the last 5 yrs vs. peers(1) • Opportunities to leverage superior growth of the core footprint: 3.5% projected population growth; Top 3 among peer group(2) • Non-bank M&A, expanding products and capabil ...

Summary of Adagene Inc. Conference Call Company Overview - **Company**: Adagene Inc. - **Industry**: Biotechnology, specifically focused on antibody generation and protein engineering Key Points and Arguments SAFEbody® Platform and ADG126 - Adagene utilizes AI for protein engineering and antibody generation, leading to the development of novel antibodies, including ADG126, a masked anti-CTLA-4 antibody [2][3] - ADG126 binds to a different epitope than first-generation anti-CTLA-4 antibodies (ipilimumab and tremelimumab), resulting in up to 10 times stronger antibody-dependent cellular cytotoxicity (ADCC) [2] - The proprietary masking technology of ADG126 allows for a significantly expanded therapeutic window, addressing the high dose-dependency and toxicity issues associated with anti-CTLA-4 therapies [3][4] Target Indication: Microsatellite Stable Colorectal Cancer (MSS-CRC) - MSS-CRC accounts for 95% of all colorectal cancer cases, presenting a significant unmet medical need as current immunotherapies have not been effective in this subgroup [5][6] - Adagene is focusing on patients without liver metastasis, which represent roughly one-third of MSS-CRC patients, equating to over 10,000 patients in the U.S. [26] - The combination of ADG126 with Keytruda (pembrolizumab) has shown a confirmed response rate of 29% in phase 1B trials, with a median overall survival of 19 months, outperforming standard care options [10][12][32] Clinical Development and Regulatory Path - A randomized phase 2 trial is set to begin before the end of 2023, testing two dose levels of ADG126 in combination with Keytruda [22][18] - The primary endpoint for the phase 2 trial will be the response rate, which will inform the pivotal phase 3 trial [18][19] - The FDA has indicated that a control arm may not be necessary for the phase 2 trial, recognizing the ineffectiveness of PD-1 and CTLA-4 monotherapies in the targeted setting [41][42] Financial Position and Collaborations - Adagene had approximately $63 million in cash at the end of June 2025, with a runway extending into 2027 due to a recent equity investment from SNOWPEA [27][28] - SNOWPEA has committed to invest up to $25 million, with the first tranche of $17 million already received, supporting the phase 2 trial [28] - The collaboration with SNOWPEA includes a phase 1/2 trial evaluating a novel combination involving ADG126, potentially expanding its addressable market [29] Competitive Landscape and Future Outlook - Adagene is well-positioned within the global biotech landscape, leveraging its Chinese heritage and global clinical trial capabilities [37][38] - The company is utilizing AI to enhance antibody design and decision-making processes, positioning itself as a disruptor in the biotech space [39] - Future data readouts and updates on clinical trials are anticipated, with a focus on durability and response rates from ongoing studies [30][32] Additional Important Points - The incidence of grade 3 adverse events in the high-dose cohort of ADG126 is less than 20%, with no grade 4 or 5 events reported, indicating a favorable safety profile [11][33] - The collaboration with SNOWPEA not only validates Adagene's technology but also enhances its clinical development capabilities [34]

Summary of Nurix Therapeutics FY Conference Call Company Overview - **Company**: Nurix Therapeutics (NasdaqGM:NRIX) - **Date**: September 10, 2025 - **Key Speaker**: Arthur T. Sands, President and CEO Core Industry and Company Insights Pipeline and Programs - Nurix is entering pivotal studies for its lead program, Bexobrutide (BexDeg), targeting chronic lymphocytic leukemia (CLL) [2] - The company is planning Phase 2 and 3 studies for BexDeg, with recent design considerations disclosed for the Phase 3 study [2][20] - Other programs include NX-2127 and NX-1607, focusing on aggressive lymphomas and immuno-oncology targets, respectively [2][3] - The company has a partnership with Sanofi for a STAT6 degrader and with Gilead for an IRAK4 degrader, both in IND-enabling studies [3][54] Platform and Technology - Nurix's platform is based on E3 ligases and has evolved to include a DEL-AI platform for ligand discovery, allowing for rapid development across oncology and inflammation [5][6] - The platform enables the development of degrader antibody conjugates (DACs), with a partnership with Pfizer [7] Safety and Efficacy of BexDeg - BexDeg has shown no drug-related atrial fibrillation above background levels, indicating a favorable cardiovascular profile compared to other BTK inhibitors [18] - The design of BexDeg aims for high selectivity and potency, which is expected to translate into better efficacy and safety [14] Pivotal Trial Design - The pivotal trial for BexDeg includes a single-arm study for accelerated approval in a third-line plus population, with a randomized control trial planned as a confirmatory study [20][21] - Key endpoints for the accelerated approval include overall response rate (ORR) and progression-free survival (PFS), with an observed ORR of about 80% in earlier trials [22][23] - The market opportunity for the third-line plus patient population is estimated to be between 8,000 to 10,000 patients in the U.S., with significant revenue potential [25] Future Aspirations - Nurix is considering combination therapies for earlier lines of treatment, with plans for a Phase 1B/2 study combining BexDeg with venetoclax and anti-CD20 antibodies [36] - The company is currently self-funding its studies but is open to partnerships for future combination studies [38] Financial Position - Nurix has a cash runway extending into the first half of 2027, with approximately $485 million in cash as of the last quarter [61] Additional Insights - The company is actively participating in upcoming medical conferences to present data on its various programs, including ESMO and ASH [42][45] - The STAT6 program with Sanofi is expected to enter healthy volunteer studies by 2026, pending Sanofi's timeline [56] This summary encapsulates the key points discussed during the conference call, highlighting Nurix Therapeutics' strategic priorities, pipeline developments, and market opportunities.

Outset Medical FY Conference Summary Company Overview - Outset Medical operates in the healthcare sector, focusing on dialysis technology with a highly differentiated product, Tablo, which has seen limited competition for decades [5][34] - Since its IPO in 2020, Outset Medical has expanded its installed base to approximately 6,000 consoles across over 900 hospitals and healthcare facilities [5][10] Financial Performance - The company reported a product revenue growth of 20% year-over-year and treatment utilization growth of 17% for Q2 [10] - Gross margin improved from a negative margin at IPO to approximately 38.4% in Q2 2025, with a product gross margin nearing 50% [6][17] - Operating expenses were reduced by about $80 million, positioning the company for near-term profitability [6][50] Business Model and Revenue Streams - Outset Medical's business model includes capital sales and recurring revenue, generating approximately $20,000 annually per console in acute settings and $15,000 in home settings [11][12] - The company expects to exit Q4 2025 with over $100 million in recurring revenue, which is characterized as high margin and predictable [11][12] - The recurring revenue model is driven by disposables and service, with a service reattach rate exceeding 95% [12] Market Dynamics - The acute and post-acute market is estimated at $2.5 billion, while the home market exceeds $9 billion [11] - The company is contracted with all major players in the critical care and long-term acute care markets, indicating strong market penetration potential [23] - The value proposition of insourcing dialysis with Tablo can lead to a 50% to 75% reduction in costs for hospitals [14][25] Competitive Landscape - Outset Medical faces competition from traditional behavior change rather than direct competitors, as many hospitals are accustomed to outsourcing dialysis [35] - The company positions itself as a change management partner, providing not just technology but also support in transitioning to insourced services [36] Utilization and Growth Strategy - Treatment utilization remains consistent, with approximately four to five treatments per week per console in acute settings and three to four in home settings [22] - The company aims to integrate home dialysis programs with acute care customers, addressing the growing need for home dialysis options [26] Sales Transformation - Outset Medical has undergone a sales transformation to better engage with larger health systems, focusing on enterprise-level sales processes [41][42] - The sales cycle remains stable at 9 to 12 months, with no observed elongation despite market conditions [46] Profitability and Future Outlook - The company is targeting profitability with a commitment to reducing cash burn from over $100 million in 2024 to under $50 million in 2025 [51] - Outset Medical anticipates continued growth in 2026 and beyond, aiming to maintain a high-growth trajectory within the medtech sector [54] Key Takeaways - The strength of the recurring revenue model, currently at approximately 65% of total revenue, is a significant asset for Outset Medical [60] - The potential for growth in the acute care space and the home dialysis market is substantial, with a focus on expanding market share and enhancing service delivery [61] Conclusion - Outset Medical is positioned as a leader in the dialysis market with a strong growth trajectory, innovative technology, and a robust business model that emphasizes recurring revenue and customer retention [61]

Investor & Analyst Event Redefining the Treatment of Duchenne Muscular Dystrophy (DMD) Del-zota EXPLORE44-OLE Topline and Functional Data September 10, 2025 NASDAQ: RNA | aviditybio.com 1 Forward-Looking Statements We caution the reader that this presentation contains forward-looking statements that involve substantial risks and uncertainties. All statements other than statements of historical fact contained in this presentation are forward-looking statements. Forward-looking statements include, but are not ...