Core Viewpoint - Heng Rui Medicine (01276) has received approval from the National Medical Products Administration for clinical trials of injectable acetic acid leuprolide microspheres, which will be conducted shortly [1] Group 1: Product Information - Acetic acid leuprolide is a GnRH analog used for the treatment of prostate cancer [1] - The original research product LEUPLIN®Pro was developed by Takeda Pharmaceutical Company and was approved for market in Japan in November 2015, but has not yet been launched domestically [1] - The dosage and administration of the injectable acetic acid leuprolide microspheres differ from the already marketed injectable leuprolide microspheres in China, making it a generic version of an overseas product that has not been launched domestically [1] Group 2: Financial Investment - The total research and development investment for the injectable acetic acid leuprolide microspheres project has reached approximately 24.68 million yuan [1]

Jiangsu Hengrui Pharmaceuticals Co., Ltd. 江蘇恒瑞醫藥股份有限公司 （於中華人民共和國註冊成立的股份有限公司） （股份代號：1276） 海外監管公告 本公告乃根據香港聯合交易所有限公司證券上市規則第13.10B條刊發。 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容所產生或因依賴 該等內容而引致的任何損失承擔任何責任。 证券代码：600276 证券简称：恒瑞医药 公告编号：临 2025-203 根據中華人民共和國的有關法例規定，江蘇恒瑞醫藥股份有限公司（「本公司」）在 上海證券交易所網站( www.sse.com.cn )刊發了以下公告。茲載列如下，僅供參閱。 承董事會命 江蘇恒瑞醫藥股份有限公司 董事長 孫飄揚先生 中國上海 2025年12月19日 於本公告日期，董事會成員包括(i)執行董事孫飄揚先生、戴洪斌先生、馮佶女 士、張連山先生、江寧軍先生及孫杰平先生；(ii)非執行董事郭叢照女士；及(iii) 獨立非執行董事董家鴻先生、曾慶生先生、孫金雲先生及周紀恩先 ...

Jiangsu Hengrui Pharmaceuticals Co., Ltd. 江蘇恒瑞醫藥股份有限公司 （於中華人民共和國註冊成立的股份有限公司） （股份代號：1276） 海外監管公告 香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容所產生或因依賴 該等內容而引致的任何損失承擔任何責任。 根據中華人民共和國的有關法例規定，江蘇恒瑞醫藥股份有限公司（「本公司」）在 上海證券交易所網站( www.sse.com.cn )刊發了以下公告。茲載列如下，僅供參閱。 承董事會命 江蘇恒瑞醫藥股份有限公司 董事長 孫飄揚先生 中國上海 2025年12月19日 於本公告日期，董事會成員包括(i)執行董事孫飄揚先生、戴洪斌先生、馮佶女 士、張連山先生、江寧軍先生及孫杰平先生；(ii)非執行董事郭叢照女士；及(iii) 獨立非執行董事董家鴻先生、曾慶生先生、孫金雲先生及周紀恩先生。 证券代码：600276 证券简称：恒瑞医药 公告编号：临 2025-202 江苏恒瑞医药股份有限公司 关于获得药物临床试验批准通知书的公告 ...

Group 1 - The top three companies with the highest short positions are Vanke Enterprises (02202), COSCO Shipping Holdings (01919), and Heng Rui Medicine (01276), with short ratios of 19.04%, 17.09%, and 15.18% respectively [1][2] - The companies with the largest absolute increase in short positions are Zhaoyan New Drug (06127), Lens Technology (06613), and China Everbright Holdings (00165), with increases of 2.08%, 1.68%, and 1.46% respectively [1][2] - The companies with the largest absolute decrease in short positions are ZTE Corporation (00763), Nuo Cheng Jian Hua (09969), and Yi Mai Tong (02192), with decreases of -3.12%, -2.21%, and -1.70% respectively [1][2] Group 2 - The top ten companies with the highest short ratios include Vanke Enterprises (02202) at 19.04%, COSCO Shipping Holdings (01919) at 17.09%, and Heng Rui Medicine (01276) at 15.18% [2] - The companies with the most significant increase in short ratios include Zhaoyan New Drug (06127) from 3.50% to 5.57%, Lens Technology (06613) from 3.07% to 4.75%, and China Everbright Holdings (00165) from 2.04% to 3.51% [2] - The companies with the most significant decrease in short ratios include ZTE Corporation (00763) from 17.63% to 14.51%, Nuo Cheng Jian Hua (09969) from 5.19% to 2.97%, and Yi Mai Tong (02192) from 3.06% to 1.36% [2][3]

Core Insights - The article highlights the top and bottom AH share premium rates as of December 19, with Northeast Electric (00042), Zhejiang Shibao (01057), and Hongye Futures (03678) leading in premium rates, while Ningde Times (03750), China Merchants Bank (03968), and Heng Rui Medicine (01276) are at the bottom [1][2]. Group 1: Top AH Share Premium Rates - Northeast Electric (00042) has a premium rate of 900.00% with a deviation value of 24.73% [2][3]. - Zhejiang Shibao (01057) follows with a premium rate of 311.98% and a deviation value of 45.26% [2][3]. - Hongye Futures (03678) ranks third with a premium rate of 272.19% and a deviation value of 0.86% [2]. Group 2: Bottom AH Share Premium Rates - Ningde Times (03750) has a negative premium rate of -11.29% with a deviation value of -3.35% [2][3]. - China Merchants Bank (03968) shows a premium rate of -1.47% with a deviation value of -0.68% [2]. - Heng Rui Medicine (01276) has a premium rate of 3.02% with a deviation value of 0.04% [2]. Group 3: Deviation Values - The highest deviation values are seen in Zhejiang Shibao (01057) at 45.26%, followed by Jun Da Co., Ltd. (02865) at 31.98%, and Northeast Electric (00042) at 24.73% [1][2]. - The lowest deviation values are recorded for GAC Group (02238) at -21.76%, First Tractor Company (00038) at -15.00%, and Changfei Optical Fiber Cable (06869) at -14.68% [1][3].

Core Viewpoint - The report highlights the current premium rates of AH shares, with Northeast Electric, Zhejiang Shibao, and Hongye Futures leading in premium rates, while CATL, China Merchants Bank, and Hansoh Pharmaceutical are at the bottom of the list [1][2][3]. Premium Rate Rankings - The top three AH shares by premium rate are: - Northeast Electric (00042) with a premium rate of 881.82% - Zhejiang Shibao (01057) with a premium rate of 313.67% - Hongye Futures (03678) with a premium rate of 275.08% [2] - The bottom three AH shares by premium rate are: - CATL (03750) with a premium rate of -9.90% - China Merchants Bank (03968) with a premium rate of 0.30% - Hansoh Pharmaceutical (01276) with a premium rate of 1.65% [3] Deviation Value Rankings - The top three AH shares by deviation value are: - Zhejiang Shibao (01057) with a deviation value of 49.12% - Junda Co. (02865) with a deviation value of 28.03% - Red Star Macalline (01528) with a deviation value of 27.57% [4] - The bottom three AH shares by deviation value are: - GAC Group (02238) with a deviation value of -18.06% - First Tractor Co. (00038) with a deviation value of -15.99% - Zhaoyan New Drug (06127) with a deviation value of -13.79% [5]

Group 1 - The article highlights the top three and bottom three AH premium rates for various companies, with Northeast Electric (00042) leading at 881.82% and Ningde Times (03750) at -10.13% [1] - The top three companies with the highest deviation values are Red Star Macalline (01528) at 23.82%, Fudan Zhangjiang (01349) at 18.61%, and China People's Insurance Group (01339) at 15.55% [1] - The bottom three companies with the lowest deviation values include Changfei Optical Fiber (06869) at -30.48%, GAC Group (02238) at -18.85%, and First Tractor Company (00038) at -17.07% [1] Group 2 - The top ten AH stocks by premium rate include companies like Zhejiang Shibao (01057) at 277.56% and Hongye Futures (03678) at 267.67% [1] - The bottom ten AH stocks by premium rate feature companies such as China Merchants Bank (03968) at 0.14% and Hengrui Medicine (01276) at 1.30% [1] - The article provides detailed tables showing the premium rates and deviation values for both top and bottom AH stocks, indicating significant variations in market performance [2]

Core Insights - The article highlights the top and bottom AH share premium rates, indicating significant discrepancies between H-shares and A-shares for various companies [1][2][3]. Group 1: Top AH Share Premium Rates - Northeast Electric (00042) leads with a premium rate of 900.00%, followed by Hongye Futures (03678) at 271.51% and Beijing Machinery (00187) at 270.90% [1][2]. - The top three companies with the highest deviation values are Beijing Machinery (29.68%), Guanghe Tong (28.56%), and Northeast Electric (27.53%) [1][4]. Group 2: Bottom AH Share Premium Rates - The companies with the lowest AH share premium rates include Heng Rui Medicine (01276) with an unspecified rate, Ningde Times (03750) at -10.42%, and China Merchants Bank (03968) at 0.30% [1][3]. - The bottom three companies with the lowest deviation values are First Tractor (00038) at -18.79%, Zhejiang Shibao (01057) at -17.76%, and GAC Group (02238) at -17.40% [1][5]. Group 3: Detailed Premium and Deviation Data - The detailed premium and deviation data for the top ten AH shares shows significant premiums for companies like Sinopec Oilfield Service (01033) at 265.22% and Fudan Zhangjiang (01349) at 254.87% [2]. - The bottom ten AH shares include companies like WuXi AppTec (02359) with a premium of 5.28% and Weichai Power (02338) at 6.70% [3].

Group 1 - Core viewpoint: JPMorgan has increased its stake in Heng Rui Medicine (01276) by acquiring 3.879413 million shares at a price of 72.5974 HKD per share, totaling approximately 282 million HKD [1] - After the acquisition, JPMorgan's total shareholding in Heng Rui Medicine is approximately 21.413 million shares, representing a holding percentage of 8.29% [1]

Core Insights - The article highlights the top and bottom AH share premium rates as of December 15, with Northeast Electric (00042) leading at a premium of 900.00% and CATL (03750) at the bottom with a premium of -11.03% [1][2][3] Premium Rate Rankings - The top three AH stocks by premium rate are: - Northeast Electric (00042) with a premium of 900.00% and a deviation value of 26.91% [1][2] - Beijing Capital Machinery (00187) with a premium of 266.67% and a deviation value of 27.25% [1][2] - Hongye Futures (03678) with a premium of 265.78% and a deviation value of -3.92% [1][2] - The bottom three AH stocks by premium rate are: - CATL (03750) with a premium of -11.03% and a deviation value of -2.28% [1][3] - China Merchants Bank (03968) with a premium of -0.77% and a deviation value of -0.05% [1][3] - Heng Rui Medicine (01276) with a premium of 1.62% and a deviation value of -1.73% [1][3] Deviation Value Rankings - The top three AH stocks by deviation value are: - Beijing Capital Machinery (00187) with a deviation value of 27.25% [1][4] - Northeast Electric (00042) with a deviation value of 26.91% [1][4] - Hongxing Meikailong (01528) with a deviation value of 18.57% [1][4] - The bottom three AH stocks by deviation value are: - GAC Group (02238) with a deviation value of -19.95% [1][5] - First Tractor Company (00038) with a deviation value of -16.78% [1][5] - Longyuan Power (00916) with a deviation value of -13.18% [1][5]