香港交易及結算所有限公司及香港聯合交易所有限公司對本公告之內容概不負責，對其準確 性或完整性亦不發表任何聲明，並明確表示，概不對因本公告全部或任何部分內容而產生或 因依賴該等內容而引致之任何損失承擔任何責任。 WUXI APPTEC CO., LTD. * 無錫藥明康德新藥開發股份有限公司 （於中華人民共和國註冊成立的股份有限公司） （股份代號：2359） 海外監管公告 本海外監管公告乃由本公司根據香港聯合交易所有限公司證券上市規則第 13.10B條作出。 茲載列本公司在上海證券交易所網站刊登的以下資料中文全文，僅供參閱。 承董事會命 無錫藥明康德新藥開發股份有限公司 董事長 李革博士 香港，2025年10月29日 截至本公告日期，本公司董事會包括執行董事李革博士、陳民章博士、楊青博士及張朝暉先生； 非執行董事童小幪先生及吳亦兵博士；以及獨立非執行董事盧韶華女士、俞衛博士、張新博士、 詹智玲女士及冷雪松先生。 * 僅供識別 证券代码：603259 证券简称：药明康德 公告编号：临 2025-070 无锡药明康德新药开发股份有限公司 股东减持股份计划公告 本公司董事会、全体董事及相关股东保证本公告内容不存在任何 ...

Core Insights - WuXi AppTec, a leading Chinese biopharmaceutical outsourcing (CXO) company, reported strong financial results for the first three quarters of 2025, with revenue of 32.857 billion yuan, a year-on-year increase of 18.61%, and a net profit of 12.076 billion yuan, up 84.84% [1][4] - The company announced a significant asset divestiture, selling its clinical research subsidiaries for 2.8 billion yuan, which is interpreted as a strategic move to focus on core business areas amid a challenging international environment [1][5] Financial Performance - For the first three quarters of 2025, the company achieved revenue of 32.857 billion yuan, a growth of 18.61% year-on-year, and a net profit of 12.076 billion yuan, reflecting an 84.84% increase [1][4] - The third quarter alone saw revenue of 12.057 billion yuan, up 15.26%, and a net profit of 3.515 billion yuan, which is a 53.27% increase [1] - The cash flow from operations reached 10.87 billion yuan, marking a 35% increase year-on-year [1] Business Segments - The chemical business segment emerged as the largest contributor to revenue, generating 25.978 billion yuan, a year-on-year increase of 29.28% [3] - The TIDES business (oligonucleotides and peptides) showed exceptional performance, with revenue reaching 7.84 billion yuan, a staggering growth of 121.1% [3] - The small molecule CRDMO business demonstrated a "funnel effect," successfully synthesizing and delivering over 430,000 new compounds in the past 12 months [4] Strategic Moves - The divestiture of the clinical research subsidiaries is seen as a strategic choice to optimize asset structure and focus on high-margin, high-growth areas like the chemical and TIDES businesses [5][7] - The sale of these subsidiaries, which contributed only about 3.5% of total revenue, allows the company to concentrate resources on its core CRDMO business [5][7] - The transaction includes a performance-based payment structure, allowing the company to benefit from future growth of the divested assets [7] Market Context - The backdrop of the company's performance includes ongoing geopolitical tensions and the looming threat of the U.S. Biodefense Act, which could significantly impact Chinese biotech firms [8][10] - Despite these challenges, revenue from U.S. clients grew by 31.9%, with North America accounting for 64% of total revenue [10][11] - The company is diversifying its market presence, with European client revenue increasing by 13.5% and stable growth in China and other markets [11][12] Market Reaction - Following the announcement of the asset divestiture, the company's stock prices rose, reflecting positive market sentiment towards its strong quarterly performance and strategic adjustments [12]

药明康德10月29日公告，公司实际控制人控制的股东G&C IV Hong Kong Limited、G&C V Limited、 G&C VI Limited、G&C VII Limited等17名股东计划自2025年11月20日起15个交易日后的3个月内，通过 集中竞价和大宗交易方式减持公司股份不超过5967.51万股，即不超过公司总股本的2%。其中，通过集 中竞价方式减持不超过2983.76万股，通过大宗交易方式减持不超过5967.51万股。减持原因为自身资金 需求。本次减持计划实施具有不确定性。 ...

药明康德公告，截至公告日，公司实际控制人控制的股东合计持有公司A股5.43亿股，占18.211%；因 自身资金需求，上述股东计划自2025年11月20日至2026年2月17日，通过集中竞价和/或大宗交易方式合 计减持不超过5967.51万股，减持比例不超过公司总股本的2%，其中集中竞价减持不超2983.76万股，大 宗交易减持不超5967.51万股。 ...

Core Insights - The top three companies with the highest AH premium rates are Northeast Electric (00042) at 900.00%, Sinopec Oilfield Service (01033) at 246.25%, and Hongye Futures (03678) at 245.50% [1][2] - The bottom three companies with the lowest AH premium rates are CATL (03750) at -14.52%, China Merchants Bank (03968) at -1.95%, and Heng Rui Medicine (01276) at 1.24% [1][2] - The companies with the highest deviation values are Northeast Electric (00042) at 73.25%, Shandong Molong (00568) at 39.97%, and Changfei Optical Fiber (06869) at 27.40% [1][3] - The companies with the lowest deviation values are Shanghai Electric (02727) at -16.60%, Tianjin Chuangye Environmental Protection (01065) at -16.50%, and First Tractor Company (00038) at -14.81% [1][3] Summary of Top AH Premium Rates - Northeast Electric (00042): H-share at 0.270, A-share at 2.25, premium rate at 900.00%, deviation at 73.25% [2] - Sinopec Oilfield Service (01033): H-share at 0.800, A-share at 2.31, premium rate at 246.25%, deviation at 17.04% [2] - Hongye Futures (03678): H-share at 4.000, A-share at 11.54, premium rate at 245.50%, deviation at 14.12% [2] Summary of Bottom AH Premium Rates - CATL (03750): H-share at 560.500, A-share at 400, premium rate at -14.52%, deviation at 1.38% [2] - China Merchants Bank (03968): H-share at 49.800, A-share at 40.77, premium rate at -1.95%, deviation at -5.47% [2] - Heng Rui Medicine (01276): H-share at 75.600, A-share at 63.9, premium rate at 1.24%, deviation at 3.98% [2] Summary of Top Deviation Values - Northeast Electric (00042): H-share at 0.270, A-share at 2.25, premium rate at 900.00%, deviation at 73.25% [3] - Shandong Molong (00568): H-share at 4.200, A-share at 7.92, premium rate at 125.95%, deviation at 39.97% [3] - Changfei Optical Fiber (06869): H-share at 40.040, A-share at 92.92, premium rate at 177.97%, deviation at 27.40% [3] Summary of Bottom Deviation Values - Shanghai Electric (02727): H-share at 4.780, A-share at 9.63, premium rate at 141.21%, deviation at -16.60% [3] - Tianjin Chuangye Environmental Protection (01065): H-share at 4.490, A-share at 6.32, premium rate at 68.60%, deviation at -16.50% [3] - First Tractor Company (00038): H-share at 7.940, A-share at 13.07, premium rate at 97.23%, deviation at -14.81% [3]

Core Insights - WuXi AppTec reported strong 3Q25 results, with revenue increasing by 15.3% YoY and adjusted non-IFRS net profit surging by 42.0% YoY [1] - Management raised its full-year guidance for 2025, expecting total revenue to be RMB43.5-44.0 billion, with revenue from continuing operations growing by 17-18% [1] - The backlog from continuing operations reached RMB59.88 billion, showing a strong YoY growth of 41.2% [1] Financial Performance - Revenue from continuing operations in 9M25 accounted for 73.8% of the full-year forecast, aligning with the historical average of 72% [1] - Adjusted non-IFRS net profit in 9M25 represented 85.7% of the full-year forecast, significantly higher than the historical average of 72% [1] - Revenue from drug discovery services declined by 2.0% YoY in 3Q25, but safety assessment services posted a 5.9% YoY growth [2] Growth Drivers - The small molecule D&M business is identified as a primary growth driver, accounting for 46% of total revenue in 2024 [1] - Management expects accelerated revenue growth for the small molecule D&M segment in 2026 [1] - Early-stage demand is showing signs of recovery, supported by a rebound in China's capital markets and robust global business development activity [2] Market Outlook - Management indicated that a broad-based industry recovery will take time, despite early signs of demand recovery [2] - The company is actively expanding manufacturing capacity in China, Singapore, the US, and Switzerland to meet rising customer demand [1] - The DCF-based target price has been raised from RMB118.79 to RMB123.35, reflecting an improved macro outlook [3]

Core Insights - The core viewpoint of the article emphasizes the strong financial performance and strategic focus of WuXi AppTec, particularly its integrated CRDMO model, which has driven significant revenue growth and established a solid competitive advantage in the biopharmaceutical industry [1][10]. Financial Performance - For the first three quarters of 2025, the company achieved a revenue of RMB 32.86 billion, representing a year-on-year growth of 18.6%. The revenue from its core operations grew by 22.5% [1]. - The company has raised its guidance for the full-year revenue growth of core operations to 17%-18%, with an overall revenue expectation adjusted to RMB 43.5 billion to RMB 44 billion [1]. - The gross margin exceeded 46%, and the adjusted profit margin surpassed 36%. The net cash flow from operating activities reached RMB 11.413 billion, a 36.21% increase year-on-year [4]. Strategic Focus - WuXi AppTec's strategic focus on the integrated CRDMO model is highlighted as a key driver of its long-term value creation, emphasizing the importance of making difficult yet correct strategic decisions [2][10]. - The company has divested non-core businesses, such as ATU (cell and gene therapy), to concentrate resources on its CRDMO mainstay, reinforcing its competitive position [4]. Operational Efficiency - The company has significantly improved its operational efficiency, reducing the time required for a new workshop to reach full production from 22.6 months in 2017 to just 2.4 months in 2024 [7]. - WuXi AppTec has implemented a self-developed digital system, the Pyxis intelligent scheduling system, which has increased equipment utilization from 60% to 72%, effectively enhancing production efficiency [8]. - The "Eagle Eye System" has minimized human error rates in drug production to 0.05 per 2000 batches, ensuring high-quality standards and reliability [9]. Growth Drivers - As of September 2025, the company had a backlog of RMB 59.88 billion in ongoing business orders, reflecting a robust growth foundation for the upcoming quarters [2]. - The TIDES business (oligonucleotides and peptides) generated revenue of RMB 7.84 billion, marking a year-on-year increase of 121.1%, indicating the successful establishment of a "second growth curve" [3]. Market Position and Future Outlook - The company’s unique integrated CRDMO model, proactive new business layouts, and strong global customer base are identified as the pillars of its fundamental growth [10]. - The ongoing global expansion, including capacity building in the U.S., Singapore, and Switzerland, positions the company to better meet global client demands and mitigate geopolitical risks [10][11].

在全球生物医药创新持续加速、研发需求日益多元化的背景下，药明康德（02359）发布其2025年第三 季度财务报告。 截至2025年前三季度，公司实现营业收入人民币328.6亿元，同比增长18.6%。尤其值得关注的是，代表 其核心竞争力的持续经营业务收入同比增长22.5%，增长势头强劲。公司将全年持续经营业务收入增速 指引上调至17%-18%，全年整体收入预期上调至人民币435亿—440亿元。 透过这些亮眼的数据，我们可以清晰地看到两条驱动药明康德穿越周期的核心主线：一是公司坚定聚焦 一体化CRDMO（合同研究、开发与生产）战略的正确性与前瞻性；二是在此战略指引下，其卓越的精 益运营能力如何构筑起一道坚实宽阔的"护城河"。 战略聚焦CRDMO：做难而正确的事，构筑长期价值壁垒 在战略聚焦上，近年来，公司果断出售ATU（细胞与基因治疗）等非核心业务，正是其为了集中资源、 聚焦CRDMO主航道所做的"难而正确"的战略决策。这种定力，让公司得以在核心领域构筑更深的壁 垒。 而药明康德的平台价值，恰恰在于通过提供一站式、高效率、规模化的服务，极大地降低了全球创新者 的研发门槛与资金压力，解决了这一核心痛点，真正践行"让 ...

Core Viewpoint - The article emphasizes the importance of efficiently identifying the true value of companies amidst the overwhelming influx of quarterly reports from A-share companies, with a focus on the innovative capabilities of the Alice Reader tool in enhancing research efficiency and depth [2][25]. Group 1: Quarterly Reports - A total of 851 A-share companies disclosed their third-quarter reports yesterday, with an additional 906 reports expected today, highlighting the busy reporting season for financial institutions [2]. - The article suggests that traditional document summaries only provide surface-level understanding, while Alice Reader aims to offer deeper insights into company announcements [8][9]. Group 2: Alice Reader Features - Alice Reader integrates professional research frameworks to summarize documents, moving beyond basic summaries to provide insights into the underlying logic of the information [10]. - The tool generates personalized analyses for each company, utilizing proprietary analytical models to decode the business logic and unique value behind the information [15]. - Users can obtain customized summaries in seconds, allowing for quick comprehension of a company's core highlights and potential risks [16]. Group 3: Performance Metrics - The article mentions that the pharmaceutical industry has seen a revenue increase of 9.50%, with a gross margin of 75.43%, despite a slight decline in margin percentage [21]. - For a specific company, total revenue reached 21.675 billion yuan, reflecting a year-on-year growth of 3.39%, while net profit increased by 7% [19]. - Another company reported a significant revenue growth of 18.6% year-on-year, with net profit soaring by 84.8%, indicating a strong improvement in profitability [22]. Group 4: Market Context - The article highlights the need for tools like Alice Reader in the context of information overload in the investment research world, where time is critical and deep understanding serves as a competitive advantage [25][26]. - Alice Reader is positioned as a reading assistant that not only speeds up reading but also enhances the depth of thought in company research [25].

Core Viewpoint - The company reported significantly better-than-expected performance in Q3 2025, with an upward revision of the full-year revenue guidance to a 17%-18% year-over-year growth rate [1][4]. Financial Performance - For the first nine months of 2025, the company achieved a revenue of RMB 32.86 billion (+18.6% YoY), with continuous operating revenue at RMB 32.45 billion (+22.5% YoY) and adjusted Non-IFRS net profit of RMB 10.54 billion (+43.4% YoY), all exceeding market expectations [2]. - In Q3 2025, revenue reached RMB 12.06 billion (+15.3% YoY, +8.2% QoQ), with continuous operating revenue at RMB 12.04 billion (+19.7% YoY, +9.4% QoQ) [2]. - The adjusted Non-IFRS net profit for Q3 2025 was RMB 4.22 billion (+42.0% YoY, +16.1% QoQ), with a net profit margin increasing to 35.0% (+6.6 percentage points YoY, +2.4 percentage points QoQ) [2]. Business Segments - The small molecule D&M revenue and TIDES business continued to drive revenue growth and improve gross margins in Q3 2025, with TIDES revenue growing by 92.1% YoY [3]. - The Wuxi Chemistry segment achieved a revenue growth of 22.7% YoY, supported by the strong performance of small molecule D&M and TIDES [3]. Order Backlog and Guidance - The order backlog reached a record high of RMB 59.88 billion (+41.2% YoY), with new order growth in Q3 2025 accelerating to around 18% [4]. - The company raised its 2025 continuous operating revenue guidance from RMB 42.5-43.5 billion to RMB 43.5-44 billion [4]. Strategic Developments - The company is divesting non-core businesses to enhance profit margins, having signed an agreement to sell its clinical CRO and SMO subsidiaries [5]. - Early-stage business recovery is noted, with positive signals from clients and a return to growth in laboratory testing services [5]. Market Position and Valuation - The company maintains a "Buy" rating and has raised its target prices for Hong Kong and A-shares to HKD 134.5 and RMB 124.4, respectively, based on updated financial information [6].