Financial Performance - The company's revenue for Q1 2025 reached ¥3,098,813,569.89, representing a 16.03% increase compared to ¥2,670,740,738.16 in the same period last year[4] - Net profit attributable to shareholders was ¥305,575,186.04, up 32.54% from ¥230,557,834.70 year-on-year[4] - The adjusted net profit under non-IFRS was ¥349,441,031.17, a 3.14% increase from ¥338,816,299.13 in the previous year[4] - The company's cash flow from operating activities was ¥852,829,144.27, reflecting a 14.38% increase compared to ¥745,630,586.78 in the same period last year[4] - Total operating revenue for the current period reached ¥3,098,813,569.89, an increase of 15.9% compared to ¥2,670,740,738.16 in the previous period[24] - Net profit for the current period was ¥279,654,565.09, compared to ¥215,919,833.12 in the previous period, representing an increase of 29.5%[25] - Basic earnings per share increased by 33.54% year-on-year to RMB 0.1736, reflecting the growth in net profit[12] - Basic earnings per share increased to 0.1736 from 0.1300, marking a growth of 33.1%[26] Revenue Breakdown - Revenue from laboratory services was ¥1,857,202,616.77, with a gross margin of 45.54%, up from 44.14% year-on-year[5] - Revenue from CMC (small molecule CDMO) services increased by 30.44% to ¥693,023,486.59, with a gross margin of 30.44%[5] - Revenue from clinical research services was ¥447,320,929.08, showing an 11.76% increase year-on-year[5] - Revenue from North American clients was ¥200,338.79 million, a 16.81% increase, accounting for 64.65% of total revenue[7] - The company signed new orders with a year-on-year growth of over 10%, particularly in laboratory services and CMC services[7] Assets and Liabilities - Total assets at the end of the reporting period were ¥24,332,822,720.98, a 1.69% increase from ¥23,927,398,321.23 at the end of the previous year[4] - Total current assets decreased to CNY 7,384,443,685.17 from CNY 7,608,179,522.72, representing a decrease of approximately 2.95%[21] - Long-term equity investments increased to CNY 727,361,422.75 from CNY 648,983,149.15, an increase of about 12.06%[21] - Total liabilities increased to CNY 7,206,443,000.00, reflecting a growth of approximately 3.5% compared to the previous period[21] - The total liabilities decreased slightly to ¥9,686,700,206.35 from ¥9,704,526,037.38, a reduction of 0.2%[23] Expenses and Taxation - Research and development expenses increased by 30.56% year-on-year to RMB 122,210,590.15, indicating a continued commitment to R&D investment[12] - Total income tax expenses rose by 59.27% year-on-year to RMB 83,932,205.84, corresponding to the increase in total profit[13] - The company paid $1,398,959,106.45 to employees, an increase from $1,313,660,048.35[29] - The company reported a total tax payment of $146,967,843.36, a decrease from $155,141,776.68[29] Comprehensive Income - Other comprehensive income surged by 1,370.30% year-on-year to RMB 98,545,941.98, mainly due to increases in foreign currency translation differences and cash flow hedging[12] - Other comprehensive income after tax for the current period was ¥110,016,172.44, compared to a loss of ¥53,277,635.07 in the previous period[26] - The company reported a total comprehensive income of ¥389,670,737.53, up from ¥162,642,198.05, indicating a significant increase of 139.5%[26] Cash Flow - Cash inflow from operating activities totaled ¥3,472,049,631.92, compared to ¥3,137,994,335.42 in the previous period, indicating a rise of 10.7%[28] - The net cash flow from operating activities was $852,829,144.27, an increase of 14.4% compared to $745,630,586.78 in the previous period[29] - The total cash outflow from investing activities was $2,181,721,151.04, up from $1,578,554,143.99, resulting in a net cash flow from investing activities of -$1,212,095,238.52[29] - Cash inflow from financing activities was $148,201,518.67, compared to $104,094,412.63 in the previous period, while cash outflow was $247,128,234.59, down from $1,616,695,006.87[29] - The ending balance of cash and cash equivalents was $1,173,579,263.69, down from $4,561,507,266.77[29] Future Plans and Investments - The company plans to invest in new product development and market expansion strategies in the upcoming fiscal year[18] - The company is collaborating with professional institutions for equity investments, indicating a strategic move towards enhancing its investment portfolio[18] - The company has announced a profit distribution plan for the fiscal year 2024, which is expected to be disclosed in detail soon[18] Miscellaneous - The company did not execute any new accounting standards adjustments for the first quarter report[30] - The first quarter report was not audited[30]

证券代码：300759 证券简称：康龙化成 康龙化成（北京）新药技术股份有限公司投资者关系活动记录表 编号：2025-03 问：请问目前中美关税情况对公司是否有影响？ 答：截至目前，美国加征关税对公司业务产生的影响有限。公司主要 是为客户提供研发服务，CMC 涉及的商业化货物出口的业务占比较 小，目前公司并未收到客户或其他合作伙伴向公司反馈关税问题对业 务合作造成影响。对于宏观的不确定性风险，公司会密切关注相关政 策动向。地缘政治背景下，也敬请投资者注意投资风险。 问：小分子 CDMO 产能利用率和毛利率趋势？ 答：从目前公司管线看，预计公司交付项目和收入规模会进一步提 高，产能利用率和毛利率也会同比提升。 | | □特定对象调研 □分析师会议 | | --- | --- | | | □媒体采访 □业绩说明会 | | 投资者关系 活动类别 | □新闻发布会 √路演活动 | | | □现场参观 | | | □其他 | | 参与单位名称及 | | | 人员姓名 | Manulife、TruMed、SinoPac、Library Group、华凯资产管理 | | 时 间 | 年 月 日 2025 4 24 | | ...

智通财经APP获悉，4月24日，国家卫健委等七部门联合印发《医药工业数智化转型实施方案(2025-2030 年)》。《方案》提出，到2030年，规上医药工业企业基本实现数智化转型全覆盖，数智技术融合创新 能力大幅提升，医药工业全链条数据体系进一步完善，医药工业数智化转型生态体系进一步健全。 《方案》重点布局了数智技术赋能行动、数智转型推广行动、数智服务体系建设行动、数智监管提升行 动四大专项行动，通过14项重点工作任务的顺利实施，整体提升我国医药工业数智化转型的能力水平， 构建完整的产业生态。 《方案》针对医药研发、医药生产、经营管理决策、医药质量安全保障、医药流通与追溯、医药合同研 发生产服务(CXO)等多个核心领域，落实数智转型推广行动，详尽地列出了数据要素、知识模型、工具 软件、人才技能等关键要素清单，为医药企业与信息技术服务企业之间的协同合作铺设了清晰的指引路 径，使双方能够有的放矢，携手共创数智化应用场景，从而系统性地推进医药企业的数智化转型进程。 中国医药工业信息中心主任郭文表示，《方案》的发布标志着我国医药产业正式进入以数据驱动、智能 赋能为核心的高质量发展新阶段。这一政策将深刻重塑行业格局：通 ...

Financial Performance - For the year ended December 31, 2024, total revenue reached RMB 12,275.8 million, an increase of approximately RMB 737.8 million or 6.4% compared to the previous year[3] - The profit attributable to equity holders of the parent company was approximately RMB 1,793.4 million, representing a growth of 12.0% from RMB 1,601.1 million in 2023[3] - The net cash flow from operating activities was approximately RMB 2,576.7 million, a decrease of about 6.4% compared to RMB 2,753.5 million in the prior year[3] - The gross profit for the year was RMB 4,149.3 million, reflecting a slight increase of 1.3% from RMB 4,094.8 million in 2023[5] - The group reported a pre-tax profit of RMB 2,091,263 thousand for the year ended December 31, 2024, compared to RMB 1,837,887 thousand in 2023, reflecting an increase of approximately 13.8%[17] - Total revenue for the year ended December 31, 2024, was RMB 12,275,775 thousand, an increase from RMB 11,537,996 thousand in 2023, representing a growth of approximately 6.4%[21] Dividends and Earnings - The board proposed a final dividend of RMB 2.0 per share, amounting to a total of approximately RMB 354.2 million[3] - The proposed final dividend for the year ending December 31, 2024, is RMB 2.0 per 10 shares, totaling approximately RMB 354,186,000 (tax included)[34] - The basic earnings per share for the year ending December 31, 2024, is RMB 1.014, compared to RMB 0.903 for 2023, reflecting an increase of approximately 12.3%[37] Assets and Liabilities - Total non-current assets increased to RMB 16,319.2 million from RMB 15,602.3 million in 2023[8] - Current assets decreased to RMB 7,608.2 million from RMB 10,874.4 million in the previous year[8] - Total liabilities decreased from RMB 9,584.2 million in 2023 to RMB 5,480.5 million in 2024[9] - The total equity attributable to equity holders of the parent company increased to RMB 13,619.3 million from RMB 12,556.8 million in the previous year[9] Revenue Breakdown - The revenue breakdown by region for 2024 shows North America at RMB 7,852,729 thousand, Europe at RMB 2,271,934 thousand, and mainland China at RMB 1,847,332 thousand[18] - The laboratory services segment generated revenue of RMB 7,046,875 thousand, while the CMC services segment contributed RMB 2,988,773 thousand, indicating strong performance across these divisions[17] - Total revenue from the European market increased significantly from RMB 1,844,397 thousand in 2023 to RMB 2,271,934 thousand in 2024, marking a growth of approximately 23.2%[18] - Laboratory services revenue grew to RMB 7,046,875 thousand in 2024, up 5.8% from RMB 6,660,117 thousand in 2023[21] Research and Development - Research and development costs amounted to RMB 469.3 million, up from RMB 448.3 million in the previous year[5] - The company operates 21 R&D centers and production bases across China, the UK, and the US, enhancing its global drug development services[44] - The company has established a bioanalytical platform in China and the US to support global clinical trials for small molecules and biologics[50] - The company is currently managing 1,062 ongoing clinical trial projects, including 94 Phase III trials and 407 Phase I/II trials[67] Operational Efficiency and Technology - The company emphasizes enhancing operational efficiency and service capabilities to meet market demands[44] - The company has begun applying artificial intelligence tools in laboratory chemistry and plans to continue expanding investments in AI and automation to enhance research efficiency[61] - The company is actively exploring the application of AI and machine learning in process chemistry research and production optimization to improve CDMO service efficiency[64] - The company achieved significant progress in digitalization and intelligence within its clinical sector, integrating multiple AI applications across various business areas[68] Market Outlook and Strategy - The company aims to become a global leader in multi-therapy drug development services, focusing on small molecules, large molecules, and cell and gene therapies[44] - The company plans to enhance its large molecule drug discovery and CDMO service capabilities in 2025, establishing a quality system that adheres to the highest international regulatory standards[144] - The company aims to strengthen its cell and gene therapy service platform by leveraging synergies between its U.S. and U.K. operations, gradually expanding its customer base and operational efficiency[145] - The company recognizes the risk of declining demand in the drug development service market due to fluctuations in investment and budget changes from multinational pharmaceutical companies[149] Employee and Talent Management - The company has a total of 21,370 employees as of December 31, 2024, compared to 20,295 employees as of December 31, 2023, indicating a growth of approximately 5.3% in workforce[159] - The company is committed to attracting and retaining top talent to maintain its competitive edge in providing high-quality services[149] - The company will optimize its human resources management system to enhance talent attraction, assessment, training, and motivation mechanisms[150] Compliance and Risk Management - The company has established an audit committee consisting of three independent non-executive directors, ensuring compliance with applicable accounting principles and standards[176] - The company is actively monitoring changes in pharmaceutical policies and is committed to meeting regulatory requirements to avoid operational disruptions[152] - The company faces risks from international policy changes and trade tensions, which could adversely affect its operations in overseas markets[153] Shareholder Actions - The company repurchased a total of 9,608,288 A-shares at a total cost of approximately RMB 200.1 million during the reporting period, with all shares canceled by December 25, 2024[160] - The company repurchased 7,263,300 H-shares at a total cost of approximately HKD 99.8 million from December 2024 to January 2025, which are held as treasury shares[162] - The company conducted a series of repurchases and redemptions of convertible bonds totaling approximately USD 573.1 million during the reporting period[166] Strategic Partnerships and Acquisitions - The company signed a strategic cooperation agreement with AstraZeneca Investment (China) for integrated services in drug discovery and development, increasing its investment in the AstraZeneca fund to RMB 191 million, representing 8.46% of the total subscription[120] - The company completed the acquisition of approximately 78.5% of Shanghai Jiying Intelligent Technology Co., Ltd. and a controlling transaction with Zhejiang Haixin Zhihui Technology Co., Ltd. in February 2025[68] - The company plans to acquire a 51.39% stake in Hai Xin Zhi Hui for approximately RMB 185.0 million, expected to complete by February 2025, enhancing its capabilities in digital tumor patient management[172]

Financial Performance - The company's operating revenue for Q3 2024 was CNY 3,212,811,697.13, representing a 10.02% increase compared to the same period last year[4]. - Net profit attributable to shareholders for Q3 2024 was CNY 308,396,080.13, a decrease of 12.62% year-on-year[4]. - The adjusted net profit attributable to shareholders under non-IFRS was CNY 417,128,142.56, down 13.20% compared to the previous year[4]. - Revenue from laboratory services for the first three quarters of 2024 was CNY 5,218,670,210.75, with a gross margin of 44.76%, up 2.95% year-on-year[5]. - Revenue from CMC (small molecule CDMO) services was CNY 1,976,627,679.48, with a gross margin of 30.82%, reflecting a 3.29% increase year-on-year[5]. - The company reported a significant increase in other comprehensive income by 1,170.63%, reaching 51,712,554.95 CNY compared to -4,830,087.99 CNY at the beginning of the year[10]. - The total income tax expense increased by 35.54%, amounting to 252,668,803.97 CNY compared to 186,420,334.57 CNY in the same period last year[11]. - The company reported a basic earnings per share of ¥0.8028, up from ¥0.6430 in the previous period, representing an increase of approximately 24.8%[34]. Assets and Liabilities - The total assets at the end of Q3 2024 were CNY 23,570,041,501.34, a decrease of 10.98% from the end of the previous year[4]. - The company's total current assets decreased from RMB 10.874 billion at the beginning of the period to RMB 7.098 billion at the end of the period[26]. - Non-current assets increased from RMB 15.602 billion at the beginning of the period to RMB 16.472 billion at the end of the period, indicating growth in long-term investments[27]. - Total liabilities at the end of the period amounted to ¥9,543,999,010.21, a decrease from ¥13,238,666,497.83 at the beginning of the period[30]. - The company’s total non-current liabilities were ¥5,387,955,744.22, compared to ¥9,584,190,645.48 at the beginning of the period, indicating a significant reduction[30]. - The total number of common shareholders at the end of the reporting period is 76,716[12]. Cash Flow - The company’s cash flow from operating activities for the year-to-date was CNY 1,770,502,528.88, down 12.76% year-on-year[4]. - Operating cash inflow for the current period reached CNY 8,940,386,810.41, an increase of 7.15% compared to CNY 8,345,874,274.78 in the previous period[35]. - Net cash flow from operating activities was CNY 1,770,502,528.88, down 12.73% from CNY 2,029,402,975.72 in the previous period[36]. - Cash inflow from investment activities totaled CNY 2,369,036,263.63, up from CNY 2,107,544,066.88 in the previous period[37]. - Net cash flow from investment activities was -CNY 897,439,031.21, an improvement from -CNY 1,807,866,341.75 in the previous period[37]. - Cash inflow from financing activities was CNY 793,674,688.64, down from CNY 1,445,088,087.27 in the previous period[38]. - Net cash flow from financing activities was -CNY 4,785,948,104.84, compared to a positive CNY 431,485,182.20 in the previous period[38]. Shareholder Information - The top 10 shareholders hold a combined 53.88% of the shares, with HKSCC NOMINEES LIMITED holding the largest share at 16.87%[12]. - The second-largest shareholder, Shenzhen Xinchongkang Investment Partnership, holds 14.59% of the shares[12]. - Pharmaron Holdings Limited, the third-largest shareholder, owns 10.10% of the shares[12]. - The total number of shares held by the top 10 unrestricted shareholders is 1,000,000,000[13]. - The largest unrestricted shareholder, HKSCC NOMINEES LIMITED, holds 301,501,968 shares[13]. - The total number of restricted shares at the beginning of the period was 64,260,000, with 6,986,213 shares released during the period[17]. - The number of shares held by the largest shareholder, Lou Xiaoqiang, decreased from 51,041,250 to 45,405,037 due to lock-up restrictions[17]. - The company has no preferred shareholders as of the reporting period[17]. - There are no known relationships or concerted actions among the top shareholders, except for specific connections mentioned[14]. Investments and Acquisitions - The company acquired approximately 78.5% of Shanghai Jiying Intelligent Technology Co., Ltd. for a total investment of RMB 43 million, enhancing its capabilities in AI technology[19]. - The company successfully repurchased and canceled all of its first batch of USD 300 million zero-coupon convertible bonds, with a net amount raised of approximately RMB 3.776 billion from the issuance[20]. - The company invested an additional USD 7 million in PharmaGend Global Medical Services Pte. Ltd., increasing its stake to 35%[21]. - The company signed a strategic cooperation agreement with AstraZeneca Investment (China) Co., Ltd., committing to a total investment of RMB 91 million in the AstraZeneca Fund, representing 8.46% of the total subscription amount[23]. Other Financial Metrics - The company recognized a one-time loss of RMB 44,016 thousand due to business closure during the reporting period[46]. - The company reported a foreign exchange-related loss of RMB 32,273 thousand and unrealized gains of RMB (468,170) thousand from equity investments[46]. - The company experienced a 41.74% increase in credit impairment losses, totaling -24,846,953.62 CNY compared to -17,530,101.09 CNY in the previous year[11]. - The company reported a decrease in operating income by 64.56%, amounting to 1,201,135.59 CNY compared to 3,389,121.43 CNY in the same period last year[11]. - Research and development expenses increased to ¥332,252,436.76 from ¥296,764,121.85, marking a rise of approximately 11.9%[32].

Financial Performance - For the six months ended June 30, 2024, the company reported total revenue of RMB 5,604.5 million, a decrease of approximately RMB 35.7 million or 0.6% compared to the same period in 2023[8]. - The gross profit for the same period was RMB 1,848.1 million, reflecting a decline of 9.3% from RMB 2,037.4 million in the previous year[8]. - Profit attributable to equity holders of the parent increased by approximately 41.6% to RMB 1,113.4 million, compared to RMB 786.1 million for the six months ended June 30, 2023[9]. - The net cash flow from operating activities was approximately RMB 1,099.7 million, down 14.1% from RMB 1,280.2 million in the same period last year[9]. - The company achieved a net profit attributable to shareholders of RMB 1,113.4 million, an increase of 41.6% year-on-year[12]. - The company’s adjusted net profit under IFRS was RMB 690.3 million, a decrease of 25.9% year-on-year[12]. - The company reported a total of RMB 50,026,000 in current liabilities related to derivative financial instruments as of June 30, 2024, compared to RMB 26,931,000 as of December 31, 2023, showing an increase of approximately 85.5%[164]. - The total comprehensive income for the period was RMB 1,050,416 thousand, compared to RMB 821,211 thousand in the previous year, indicating a growth of 28%[124]. Revenue Breakdown - In Q2 2024, the company achieved revenue of RMB 2,933.7 million, representing a 9.9% increase compared to Q1 2024, indicating a recovery in the global biopharmaceutical investment and financing environment[11]. - Revenue from European customers (including the UK) was RMB 945.6 million, a year-on-year increase of 10.0%, accounting for 16.9% of total revenue[12]. - Revenue from North American customers was RMB 3,668.2 million, accounting for 14.1% of total revenue[12]. - The laboratory services segment generated revenue of RMB 3,371.2 million, a slight decrease of 0.3% year-on-year, with a gross margin of 44.0%[13]. - CMC (small molecule CDMO) services generated revenue of RMB 1,175.7 million, a decrease of 6.0% year-over-year; Q2 2024 revenue was RMB 593.6 million, reflecting a 2.0% increase from Q1 2024[14]. - Clinical research services achieved revenue of RMB 843.3 million, a 4.7% increase year-over-year; Q2 2024 revenue was RMB 451.7 million, up 15.4% from Q1 2024[15]. - The company's revenue from macromolecule and cell gene therapy services reached RMB 211.2 million, representing a 5.5% increase compared to the same period last year[16]. Customer Base and Market Position - The company served over 2,200 global customers in the first half of 2024, with multi-segment customers contributing RMB 3,987.9 million, representing 71.2% of total revenue[12]. - The company added over 360 new customers, contributing RMB 161.2 million to total revenue[12]. - 97% of the company's revenue comes from a large, diverse, and loyal repeat customer base, enhancing sustainable growth[31]. - The global biopharmaceutical industry is showing signs of recovery, with financing amounts for biotech companies returning to growth, indicating a preliminary revival in customer demand[32]. Operational Efficiency and Strategy - The company is focused on building a multi-therapy, full-process integrated service platform, aiming to become a global leader in drug development services[10]. - The company continues to strengthen its international capabilities to provide cross-disciplinary, cross-regional, and cross-border collaborative service solutions[10]. - The company is committed to improving management efficiency and service capabilities to meet market and customer demands[10]. - The company emphasizes continuous investment in technology and innovation, particularly in AI, to support its research and development capabilities[22]. - The company has established a comprehensive drug research and development service platform, enhancing its competitive advantage in the pharmaceutical industry[26]. Sustainability and Corporate Governance - The company’s scientific carbon targets were officially verified by SBTi, indicating a commitment to sustainability and carbon reduction initiatives[12]. - The company is committed to environmental protection, health, safety, and intellectual property rights, ensuring client trust and recognition[31]. - The company has established a DEI (Diversity, Equity, and Inclusion) management structure to ensure effective implementation of DEI policies across governance and operational levels[50]. - The company has actively responded to national initiatives for renewable energy use, with domestic parks already implementing green electricity applications and overseas parks utilizing biomass energy and photovoltaic power generation[63]. Human Resources and Employee Engagement - The company has established a comprehensive training system, including the Kanglong Academy, to enhance employee skills and research capabilities[31]. - The company emphasizes talent acquisition and retention, aiming to attract top drug development talent and enhance its internal training platform[38]. - The company has implemented a systematic training program for all employees and contractors to ensure understanding of company policies and job responsibilities[51]. - The company provides 10 days of paid parental leave and flexible part-time work arrangements in the UK and US locations[54]. Financial Position and Investments - As of June 30, 2024, the total current assets amounted to approximately RMB 7,071.2 million, compared to RMB 10,874.4 million as of December 31, 2023[20]. - The total liabilities to total assets ratio (leverage ratio) improved to 40.5% as of June 30, 2024, down from 50.0% as of December 31, 2023[20]. - The company completed the sale of its stake in Proteologix, Inc. to Johnson & Johnson for approximately USD 102 million, receiving a net payment of USD 86.195 million after transaction costs[22]. - The company has outstanding bank loans totaling RMB 5,179,140,000, with RMB 852,040,000 due within one year, compared to RMB 727,412,000 in the previous year, indicating a year-over-year increase of 17.1%[171]. Risks and Challenges - The company faces regulatory risks related to drug development and production, which could impact its operations if it fails to meet compliance requirements[44]. - The company is exposed to foreign exchange risks primarily related to USD, GBP, and EUR, with a significant portion of its revenue coming from USD-denominated sales[45]. - The competitive landscape is expected to intensify as more competitors enter the market, impacting various factors such as service quality and pricing[47].

Financial Performance - Total revenue for the six months ended June 30, 2024, was approximately RMB 5,604.5 million, a decrease of about RMB 35.7 million or 0.6% compared to the same period in 2023[2] - Profit attributable to equity holders of the parent company was approximately RMB 1,113.4 million, an increase of about 41.6% compared to RMB 786.1 million in the same period of 2023[2] - Net cash flow from operating activities was approximately RMB 1,099.7 million, a decrease of about 14.1% compared to RMB 1,280.2 million in the same period of 2023[2] - Gross profit for the six months ended June 30, 2024, was approximately RMB 1,848.1 million, a decrease of 9.3% compared to RMB 2,037.4 million in the same period of 2023[2] - The company recorded other income and gains of RMB 776.3 million, significantly up from RMB 131.7 million in the same period of 2023[3] - The group reported a pre-tax profit of RMB 1,226,851,000, compared to RMB 908,525,000 for the same period in 2023, marking an increase of approximately 35%[16] - The company’s adjusted net profit under non-IFRS was RMB 690.3 million, down from RMB 931.9 million in the previous year[53] Revenue Breakdown - For the six months ended June 30, 2024, total revenue reached RMB 5,604,463,000, a slight decrease of 0.6% compared to RMB 5,640,118,000 for the same period in 2023[16] - The laboratory services segment generated revenue of RMB 3,371,177,000, accounting for approximately 60% of total revenue, while the CMC (small molecule CDMO) services segment contributed RMB 1,175,747,000[16] - The clinical research services segment achieved revenue of RMB 843,269,000, reflecting an increase of 4.7% from RMB 805,193,000 in the prior year[16] - Revenue from North America was RMB 3,668,223,000, a decrease of 0.2% from RMB 3,675,469,000 in the previous year[18] - Revenue from Europe increased by 10% to RMB 945,577,000 from RMB 859,776,000 in 2023[18] - Revenue from mainland China decreased by 13.2% to RMB 842,603,000 from RMB 970,977,000 in 2023[18] Expenses and Costs - The group incurred administrative expenses of RMB 841,221,000, which is consistent with the previous year's expenses of RMB 845,440,000[16] - Research and development costs amounted to RMB 207,798,000, up from RMB 182,179,000 in the same period last year, representing an increase of approximately 14.1%[16] - The company reported a total of RMB 2,137,594,000 in employee costs, an increase from RMB 2,029,553,000 in 2023[27] Assets and Liabilities - Total assets as of June 30, 2024, amounted to RMB 25,340.7 million, compared to RMB 25,186.5 million as of December 31, 2023[7] - Current assets decreased to RMB 7,071.2 million from RMB 10,874.4 million as of December 31, 2023, indicating a significant reduction in liquidity[7] - Non-current liabilities decreased to RMB 5,414.3 million from RMB 9,584.2 million as of December 31, 2023, reflecting a reduction in long-term debt obligations[8] - Trade receivables as of June 30, 2024, totaled RMB 2,179.3 million, down from RMB 2,242.2 million at the end of 2023[30] - Trade payables amounted to RMB 503.0 million, an increase from RMB 412.2 million at the end of 2023[32] Dividends and Shareholder Returns - The company decided not to declare any interim dividend for the six months ended June 30, 2024[2] - The company declared a final dividend of RMB 0.2 per share for the year ended December 31, 2023, totaling RMB 353,963,000[28] - The company plans to distribute a final dividend of RMB 0.2 per share to A-share and H-share shareholders, with the record date set for July 8, 2024[160] Employee and Workforce - The company employed a total of 20,342 staff, with 89.7% in R&D, production technology, and clinical services[38] - As of June 30, 2024, the company employed 20,342 staff, an increase from 20,295 employees on December 31, 2023, indicating a growth in workforce[149] - The company has a workforce of 18,241 R&D, production technology, and clinical service personnel across China, the UK, and the US, ensuring high-quality service delivery[121] Strategic Initiatives and Growth - The company continues to focus on expanding its integrated pharmaceutical R&D services platform globally, enhancing its capabilities in drug innovation[12] - The company has signed new contracts with a total value that increased by over 15% compared to 2023[34] - The company is collaborating with over 650 hospitals and clinical trial centers across more than 140 cities in China, with ongoing projects exceeding 1,500[47] - The company has established a leading integrated pharmaceutical R&D service platform, providing comprehensive services for drug discovery, preclinical, and clinical development[106] - The company aims to enhance its integrated drug development service platform, focusing on small molecule research and expanding into large molecule and gene therapy services[129] Risks and Challenges - The pharmaceutical research and development outsourcing industry may experience slower growth due to fluctuations in investment sentiment, which could negatively impact the company's performance[138] - The company is at risk of losing qualified research and development personnel due to competition from pharmaceutical and biotech firms, which could affect service quality[138] - The company faces risks related to intellectual property protection, as unauthorized disclosure of client information could lead to significant reputational damage[141] - Regulatory compliance is critical, as failure to meet standards could result in operational suspension or penalties[142] - The company is exposed to foreign exchange risks, particularly with the US dollar, British pound, and euro, and will continue to engage in hedging transactions to reduce this risk[144] Incentive Plans - Under the 2021 A-share incentive plan, the maximum number of restricted A-shares to be issued is 1,741,950, representing approximately 0.10% of the total issued shares as of June 30, 2024[64] - The 2022 A-share incentive plan allows for the issuance of a maximum of 3,304,800 restricted A-shares, accounting for approximately 0.18% of the total issued shares as of June 30, 2024[76] - The 2023 A-share incentive plan was approved by shareholders on June 21, 2023, aiming to enhance corporate governance and retain key personnel[85] Acquisitions and Investments - The company has completed the sale of its stake in PROTEOLOGIX, INC. to Johnson & Johnson for approximately USD 102 million, receiving a net payment of USD 86.195 million after transaction costs[102] - The company has acquired approximately 78.5% of Shanghai Jiying Intelligent Technology Co., Ltd. for a total investment of RMB 43.0 million, enhancing its capabilities in AI technology[102] - The company has signed a strategic cooperation agreement with AstraZeneca Investment (China) Co., Ltd. for a comprehensive investment in the AstraZeneca Fund, increasing its total investment in the fund to RMB 191 million, accounting for 8.46% of the total subscription[104]

Financial Performance - In 2023, the company achieved a revenue of RMB 11,538.0 million, representing a year-on-year growth of 12.4%[6] - The net profit attributable to shareholders was RMB 1,601.1 million, an increase of 16.5% compared to the previous year[6] - The net cash flow from operating activities reached RMB 2,753.5 million, up by 28.5% year-on-year[6] - Total revenue for the year ended December 31, 2023, was approximately RMB 11,538 million, an increase of about RMB 1,272 million or 12.4% compared to the previous year[10] - Gross profit for the same period was RMB 4,095 million, reflecting a growth of 9.2% from RMB 3,749 million in 2022[10] - Adjusted net profit under non-IFRS was RMB 1,903 million, a slight increase of 3.8% from RMB 1,834 million in 2022[10] - The profit attributable to the owners of the parent company was approximately RMB 1,601.1 million, an increase of about 16.5% compared to the year ended December 31, 2022[11] - The net cash flow from operating activities was approximately RMB 2,753.5 million, an increase of about 28.5% compared to the year ended December 31, 2022[11] Assets and Liabilities - By the end of 2023, total assets amounted to RMB 26,476.7 million, reflecting a growth of 29.2% from the beginning of the year[6] - The net assets attributable to shareholders were RMB 12,556.8 million, which is a 19.0% increase from the start of the year[6] - Total liabilities rose to RMB 13,238.667 million in 2023, compared to RMB 9,652.689 million in 2022[13] - The total current assets as of December 31, 2023, were approximately RMB 10,874.4 million, compared to RMB 6,536.0 million as of December 31, 2022[31] - The current ratio as of December 31, 2023, was approximately 3.0, compared to 1.7 as of December 31, 2022[31] Workforce and Operations - The workforce as of December 31, 2023, totaled 20,295 employees, with 89.87% engaged in R&D, production technology, and clinical services[8] - The total number of employees increased by 814 to 20,295, with R&D, production technology, and clinical service personnel making up 89.9% of the workforce[21] - The company operates 21 R&D service centers and production bases across China, the UK, and the US, providing innovative drug development solutions[6] - The company has a workforce of 9,466 employees in laboratory services, with over 6,000 laboratory chemists, positioning it as a leader in scale and experience globally[22] Research and Development - The company is diversifying its service offerings, expanding into new drug areas including small nucleic acids, peptides, antibodies, and ADC drugs[6] - The company continues to enhance its traditional small molecule drug development services while integrating new technologies[6] - The company participated in 764 small molecule drug discovery projects in 2023, maintaining growth in this segment[7] - The company’s integrated service platform has enhanced its competitive advantage in drug development, particularly in small molecule drug discovery and new drug modalities[7] - The company is focused on developing and producing gene and cell therapy products, meeting specific analytical requirements for clinical development[19] Client Base and Market Presence - The company expanded its customer base, adding over 800 new clients, with active clients exceeding 2,800[6] - Revenue from North American customers was RMB 7,400.8 million, an increase of 11.4%, accounting for 64.1% of total revenue[21] - The company served over 2,800 global customers, with those using multiple business segments contributing RMB 8,641.1 million, or 74.9% of total revenue[20] - New customers added during the reporting period exceeded 800, contributing RMB 858.7 million, which accounted for 7.4% of total revenue[20] Corporate Governance and Management - The board of directors was reduced from 11 to 9 members, with 3 executive directors, 2 non-executive directors, and 4 independent non-executive directors[36] - The company emphasizes a "people first, customer-centered" philosophy, focusing on employee development and improving mechanisms for personal career growth[54] - The board has established four specialized committees to oversee specific aspects of corporate governance[92] - The company has a strong management team, including Mr. Lou as COO and Ms. Zheng as Executive Vice President, both of whom have extensive backgrounds in their respective fields[72][73] Environmental, Social, and Governance (ESG) - The company is actively enhancing its ESG performance and has initiated ISO 14001 environmental management system certification[21] - The company has been recognized with multiple awards for its ESG efforts, including being rated as a "low-risk" company by Sustainalytics and included in the ESG Top 50 for Chinese listed companies[22] - The company is committed to environmental protection, health, safety, and intellectual property rights, ensuring the protection of clients' intellectual property[55] Future Outlook and Strategy - The company aims to enhance its service capabilities and management efficiency to meet market and customer demands through integrated drug research and development services[16] - The company plans to continue enhancing its R&D capabilities in large molecules and cell and gene therapy services[34] - The company aims to strengthen its CMC (small molecule CDMO) service competitiveness and expand into new drug areas such as oligonucleotides, peptides, antibodies, ADCs, and cell and gene therapies[58] - The company will continue to focus on "full-process, integrated, and international" development strategies to enhance service quality and gain market share in the pharmaceutical health industry[58] Financial Management and Investments - The company has implemented a series of financing and fiscal policies to manage its capital resources and mitigate related risks[33] - The company completed a capital increase agreement with Kanglong Biotech for a total consideration of approximately RMB 950 million on September 19, 2023[34] - The company has pledged deposits of approximately RMB 127.7 million for issuing letters of credit and environmental protection as of December 31, 2023, compared to RMB 49.3 million on December 31, 2022[33] - The company plans to utilize RMB 377.6 million for operational working capital and other general corporate purposes, with 100% of the funds expected to be utilized by December 31, 2023[144] Risk Management - The company has established a risk management system aimed at enhancing risk prevention capabilities and promoting sustainable development[114] - The internal audit system is designed to improve the quality and efficiency of internal audits, thereby enhancing the company's supervision and risk control mechanisms[114] - The company employs a combination of qualitative and quantitative methods for risk analysis, prioritizing risks based on their likelihood and impact[117] Shareholder Relations - The board of directors will continue to enhance investor relations management in 2024, focusing on proactive communication through various channels[129] - The company has adopted a shareholder communication policy, which was reviewed and deemed effective by the board on March 27, 2024[129] - The company reported a net amount of approximately RMB 4,522.7 million raised from the global offering, fully utilized as per the prospectus dated November 14, 2019[135]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告之內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或因依賴 該等內容而引致之任何損失承擔任何責任。 Pharmaron Beijing Co., Ltd. 康 龍 化 成（ 北 京 ）新 藥 技 術 股 份 有 限 公 司 （於中華人民共和國註冊成立的股份有限公司） （股份代號：3759） 2024年第一季度報告 本公告乃由康龍化成（北京）新藥技術股份有限公司（「本公司」，連同其附屬公司 「本集團」）根據香港聯合交易所有限公司證券上市規則第13.09條及第13.10B條以 及證券及期貨條例（香港法例第571章）第XIVA部項下的內幕消息條文（定義見上 市規則）而作出。 以下為本公司的2024年第一季度報告。除本報告第四節第四部分按照國際會計準 則理事會頒佈的國際財務報告準則（「國際財務報告準則」）編製或另有註釋外，本 2024年第一季度報告所載之財務數據根據中國企業會計準則編製且未經審計。 承董事會命 康龍化成（北京）新藥技術股份有限公司 主席 樓柏良博士 中華人民共和國，北京 2024年4月25日 於 ...

Financial Performance - For the year ended December 31, 2023, the total revenue was approximately RMB 11,538 million, an increase of about RMB 1,272 million or 12.4% compared to the previous year[4]. - The profit attributable to equity holders of the parent company was approximately RMB 1,601 million, representing an increase of 16.5% from RMB 1,375 million in 2022[4]. - The net cash flow from operating activities was approximately RMB 2,754 million, up 28.5% from RMB 2,143 million in the prior year[4]. - The basic earnings per share for the year was RMB 0.9033, compared to RMB 0.7750 in 2022, reflecting a significant increase[5]. - The gross profit margin reached 35.5%, a decrease of 1.0 percentage points compared to the previous year[59]. - The net profit attributable to the parent company was approximately RMB 1,601.1 million, an increase of 16.5% compared to RMB 1,374.6 million for the year ended December 31, 2022[84]. Revenue Breakdown - The laboratory services segment generated revenue of RMB 6,660,117 thousand, up from RMB 6,088,778 thousand in the previous year, reflecting a growth of about 9.4%[21]. - North America accounted for the largest share of revenue at RMB 7,400,776 thousand, an increase of 11.4% from RMB 6,644,016 thousand in 2022[22]. - The clinical research services segment reported a revenue of RMB 1,737,293 thousand, which is a significant increase from RMB 1,393,573 thousand in 2022, marking a growth of approximately 24.6%[21]. - Total revenue from Europe increased to RMB 1,844,397 thousand, up from RMB 1,483,241 thousand in 2022, representing a growth of approximately 24.4%[22]. - Revenue from the top 20 global pharmaceutical clients was RMB 1,722.7 million, a year-on-year increase of 14.9%, representing 14.9% of total revenue[61]. Asset and Equity Growth - Non-current assets totaled RMB 15,602 million as of December 31, 2023, compared to RMB 13,957 million in 2022, indicating growth in asset base[9]. - Current assets increased to RMB 10,874 million from RMB 6,536 million in the previous year, showing a strong liquidity position[9]. - The total equity attributable to equity holders of the parent company rose to RMB 12,557 million from RMB 10,549 million, indicating a solid capital structure[10]. Dividend and Shareholder Returns - The company proposed a final dividend of RMB 2.0 per share, amounting to a total of approximately RMB 358 million[4]. - The proposed final dividend for the year 2023 is RMB 0.20 per share, totaling approximately RMB 357,479,000, compared to RMB 0.30 per share in 2022, totaling RMB 357,367,000[38]. Research and Development - Research and development expenses increased to RMB 448 million from RMB 282 million, highlighting a commitment to innovation[5]. - The company operates a comprehensive integrated pharmaceutical R&D service platform with 21 R&D centers and production bases across China, the UK, and the US, focusing on accelerating drug innovation[49]. - The company is committed to becoming a global leader in multi-therapy drug development services, enhancing international collaboration and cross-disciplinary service offerings[49]. Employee and Operational Metrics - As of December 31, 2023, the company employed 9,466 laboratory service staff, including over 6,000 laboratory chemists, establishing a leading position in laboratory chemical services globally[68]. - The company participated in 764 drug discovery projects in 2023, an increase of approximately 17% compared to the previous year[66]. - The company has added over 800 new customers during the reporting period, contributing RMB 858.7 million to revenue, which is 7.4% of total revenue[60]. Financial Costs and Income - Total financial costs rose to RMB 213,502 thousand in 2023, compared to RMB 191,704 thousand in 2022, marking an increase of 11.3%[30]. - Interest income decreased slightly to RMB 33,543 thousand in 2023 from RMB 35,213 thousand in 2022[28]. - The total other income for 2023 was RMB 374,011 thousand, down from RMB 425,786 thousand in 2022, indicating a decline of 12.1%[28]. Market and Competitive Position - The global pharmaceutical market's R&D and production investment is projected to grow from approximately $625.1 billion in 2023 to $825.0 billion by 2028, with a CAGR of 5.7%[180]. - China's pharmaceutical market R&D and production investment is expected to increase from approximately ¥686.8 billion in 2023 to ¥1,035.6 billion by 2028, with a CAGR of 8.6%[180]. - The company aims to enhance its integrated drug development service platform while expanding into new drug areas such as oligonucleotides, peptides, and gene therapies[185]. Risk Management - The company acknowledges potential risks, including a decline in demand for drug development services and the loss of qualified research personnel, which could adversely affect operations[194]. - The company is closely monitoring environmental protection policies, as stricter regulations could increase compliance costs[197]. - The rise of international trade protectionism may negatively impact the company's operations, particularly as a significant portion of clients are overseas pharmaceutical and biotech companies[199]. Incentive Plans and Shareholder Alignment - The 2022 A-share incentive plan aims to attract and retain core management and technical personnel, with a total of 379 eligible participants[114]. - The incentive plans are designed to align the interests of shareholders, the company, and core employees, enhancing the company's competitiveness[114]. - The company recorded share-based compensation expenses of RMB 147,963,000 for the twelve months ending December 31, 2023, compared to RMB 127,248,000 for the same period in 2022, reflecting an increase of approximately 16%[145].