Core Insights - RemeGen Co., Ltd. has received clearance from the FDA for its IND application for phase II clinical trials of its bispecific antibody RC148 in the US [1][2] - RC148 targets PD-1 and VEGF and is developed using RemeGen's bispecific antibody technology platform [2] - The FDA clearance is a significant milestone that is expected to expedite the global development process of RC148 [2] Company Developments - RemeGen is currently conducting clinical trials of RC148 as both a monotherapy and in combination therapy for advanced solid tumors in China [2] - The successful IND application clearance marks an important step in RemeGen's strategy to expand its presence in the global oncology market [1][2]

Core Viewpoint - The domestic innovative drug sector has shifted from a previous upward trend to a phase of volatility, with market participants showing a tendency to buy more as prices drop, indicating a potential long-term investment interest despite short-term fluctuations [1][2]. Group 1: Market Trends - From June 16 to June 25, medical-themed ETFs saw a net inflow of over 6.4 billion yuan, with several leading innovative drug ETFs attracting more than 1.5 billion yuan [1][2]. - The Hong Kong innovative drug index experienced a significant drop of 8.51% from June 16 to June 20, yet funds continued to flow into innovative drug ETFs during this period [2]. - The recent performance of innovative drug stocks has been influenced by the high valuations already priced in, leading to increased sensitivity to any negative news [3][4]. Group 2: Business Development (BD) Impact - On June 26, the announcement from Rongchang Biopharmaceuticals regarding a licensing deal with Vor Bio led to a sharp decline in its stock price, with A-shares dropping over 18% and H-shares over 11% [3][4]. - The market's reaction to the BD announcement was notably negative, attributed to the lower-than-expected upfront payment and the nature of the partner company, which lacks commercialized products [4]. - Analysts suggest that the current market dynamics reflect a disconnect between actual BD outcomes and optimistic market expectations, contributing to volatility in the sector [4][5]. Group 3: Investment Considerations - The innovative drug sector's high volatility necessitates a longer-term investment perspective, as short-term trading strategies may not yield favorable returns [5][6]. - Companies with robust competitive positions and comprehensive business logic are viewed as more favorable investment targets amidst the current market conditions [5][6]. - The potential for significant market value remains in overseas markets, particularly in Europe and the U.S., despite short-term fluctuations in the domestic market [6].

Core Insights - The latest net value of Zhongyin Innovation Medical Mixed A (007718) is 2.1723 yuan, reflecting a decline of 3.54%. The fund has shown a one-month return of 12.66%, a six-month return of 78.76%, and a year-to-date return of 80.53% [1]. Fund Performance - The fund ranks 684 out of 4457 in the one-month category, 23 out of 4316 in the six-month category, and 29 out of 4287 in the year-to-date category [1]. Holdings Overview - The top ten stock holdings of Zhongyin Innovation Medical Mixed A account for a total of 62.83%, with significant positions in companies such as: - Innovent Biologics (8.33%) - Kelun-Biotech (8.15%) - Heng Rui Medicine (8.08%) - CanSino Biologics (8.07%) - New Horizon Health (6.13%) - Bai Li Tianheng (5.99%) - BeiGene (5.97%) - Hansoh Pharmaceutical (4.15%) - Rongchang Biologics (4.05%) - CanSino Biologics-B (3.91%) [1]. Fund Manager Background - Zheng Ning, the fund manager, has a master's degree and has previously held positions at Taikang Asset Management and Zhonggeng Fund Management. He joined Zhongyin Fund Management in 2022 and has been managing the Zhongyin Innovation Medical Mixed Fund since July 1, 2022 [2].

Core Viewpoint - The company Rongchang Biopharma has confirmed its ownership of warrants for 320 million shares of Vor Biopharma Inc., valued at $80 million, with an exercise price of $0.0001 per share, which have not yet been exercised [1] Group 1 - The company holds warrants for 320 million shares of Vor Biopharma Inc. valued at $80 million [1] - The exercise price for the warrants is set at $0.0001 per share [1] - The warrants have not yet been exercised, and further updates will be provided through official announcements [1]

致：香港交易及結算所有限公司 公司名稱: 榮昌生物製藥（煙台）股份有限公司 呈交日期: 2025年8月6日 股份發行人及根據《上市規則》第十九B章上市的香港預託證券發行人的證券變動月報表 I. 法定/註冊股本變動 截至月份: 2025年7月31日 狀態: 新提交 | 1. 股份分類 | 普通股 | 股份類別 | H | | 於香港聯交所上市 (註1) | | 是 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | | 證券代號 (如上市) | 09995 | 說明 | | | | | | | | | | 法定/註冊股份數目 | | | 面值 | | 法定/註冊股本 | | | 上月底結存 | | | 208,581,239 | RMB | | 1 RMB | | 208,581,239 | | 增加 / 減少 (-) | | | 0 | | | RMB | | 0 | | 本月底結存 | | | 208,581,239 | RMB | | 1 RMB | | 208,581,239 | | 2. 股份分類 | 普通股 | 股份類別 | A | ...

Market Overview - US stock indices rebounded, influenced positively by Trump's market support, leading to a 0.68% rise in Hong Kong stocks [1] - San Francisco Fed President Daly indicated that the timing for interest rate cuts is approaching, with expectations for two 25 basis point cuts this year [1] - Goldman Sachs predicts three consecutive 25 basis point cuts starting in September, with a potential 50 basis point cut if unemployment rises further [1] Domestic Market Sentiment - A-share new account openings in July reached 1.96 million, a 71% year-on-year increase, indicating rising domestic confidence [2] - The stock of Upwind New Materials surged 20% after resuming trading, reigniting market enthusiasm [2] - The steel sector saw a significant rise, with Maanshan Iron & Steel's stock increasing over 15% due to improved loss forecasts and supportive policies [2] Industry Trends - The paper industry is experiencing a price increase, with major companies like Nine Dragons Paper and Lee & Man Paper announcing price hikes [2] - The eleventh batch of centralized drug procurement in China saw a record 45 companies applying for the same drug, intensifying competition in the generic drug market [3] - Investment is shifting towards innovative drugs, with companies like Junshi Biosciences seeing stock increases of nearly 34% due to promising clinical trials [3] Financial Support for Key Industries - A joint guideline from the central bank and seven departments aims to support financing for key manufacturing sectors, including integrated circuits and medical equipment [4] - AI-related companies like Longi Green Energy and Lenovo's server business are seeing stock increases due to new orders and market interest [4] Gaming Industry Performance - The domestic gaming market is projected to reach RMB 168 billion in sales by the first half of 2025, a 14.08% year-on-year increase [4] - Heartbeat Games anticipates a revenue increase of approximately 37% for the first half of 2025, driven by strong performance from self-developed games [4] Individual Company Highlights - Tencent's mobile game "Valorant: Source Action" is set to launch on August 19, with projected annual revenue exceeding RMB 6 billion [5] - Oriental Selection's stock surged nearly 17% ahead of its upcoming financial report, reflecting strong market performance [6] - The Macau gaming sector is experiencing a positive trend, with Morgan Stanley raising its revenue growth forecast for the year from 5% to 10% [6] Technological Advancements - Apple's breakthrough in brain-computer interface (BCI) technology allows users to control devices through thought, indicating a significant market opportunity [7] - The Chinese BCI market is expected to exceed RMB 3.8 billion by 2025, with a CAGR of approximately 20% [7] Investment Opportunities - Kelun-Bio has become a top holding in a major fund, indicating strong market confidence in its innovative drug pipeline [8] - The company has established multiple technology platforms and is expected to accelerate commercialization in 2025 [8]

Core Insights - The report highlights that the total salary of A-share listed company secretaries in 2024 reached 4.086 billion yuan, with an average annual salary of 754,300 yuan [1] - A total of 1,144 company secretaries earn over 1 million yuan annually, accounting for more than 21% of the total [1] Salary Distribution - The average annual salary for company secretaries in the biopharmaceutical sector is 1.01 million yuan [5] - The distribution of salaries among company secretaries is as follows: below 500,000 yuan (15%), 500,000-1,000,000 yuan (41%), 1,000,000-2,000,000 yuan (38%), 2,000,000-3,000,000 yuan (4%), and above 3,000,000 yuan (2%) [5] Age and Education Distribution - The age distribution of company secretaries shows that those aged 40-50 make up 61%, while those over 50 account for 15%, and those aged 30-40 account for 18% [1] - In terms of education, 52% of company secretaries hold a bachelor's degree, while 44% have a master's degree, and only 2% have a doctoral degree [3] Investor Engagement - There is significant variation in the number of investor meetings held by companies, with 43% of companies hosting fewer than 10 meetings annually [7] - The top five companies with the highest number of investor meetings are: Bohui Innovation (1,500 meetings), Jindike (777 meetings), Nearshore Protein (681 meetings), Sailun Biotech (549 meetings), and Kanghua Biotech (504 meetings) [9]

Core Insights - The report highlights that the total salary of A-share listed company secretaries in 2024 reached 4.086 billion yuan, with an average annual salary of 754,300 yuan [1] - A total of 1,144 secretaries earned over 1 million yuan annually, accounting for more than 21% of the total [1] Salary Distribution - The average annual salary for secretaries in the A-share biopharmaceutical sector is 1.01 million yuan [5] - The distribution of salaries is as follows: below 500,000 yuan (15%), 500,000-1,000,000 yuan (41%), 1,000,000-2,000,000 yuan (38%), 2,000,000-3,000,000 yuan (4%), and above 3,000,000 yuan (2%) [5] Age and Education Distribution - The age distribution of secretaries shows that those aged 40-50 constitute 61%, while those over 50 account for 15%, and those aged 30-40 make up 18% [1] - In terms of education, 52% of secretaries hold a bachelor's degree, while 44% have a master's degree, and only 2% possess a doctoral degree [3] Investor Engagement - There is significant variation in the number of investor meetings held by companies, with 43% of companies hosting fewer than 10 meetings annually [7] - The top five companies with the highest number of investor meetings are: Bohui Innovation (1,500 meetings), Jindike (777 meetings), Nearshore Protein (681 meetings), Sailun Biotech (549 meetings), and Kanghua Biotech (504 meetings) [9]

Group 1 - The stock price of Rongchang Biopharma closed at 64.17 yuan on July 31, 2025, down by 2.53 yuan, a decline of 3.79% from the previous trading day [1] - The company operates in the biopharmaceutical industry, focusing on the research and commercialization of innovative drugs, with products covering oncology and autoimmune diseases [1] - Rongchang Biopharma has proprietary platforms for antibody fusion proteins, monoclonal antibodies, and bispecific antibodies, and is advancing multiple clinical studies in domestic and international markets [1] Group 2 - The innovative drug industry showed active performance in 2025, with the National Medical Products Administration approving over 20 Class 1 innovative drugs for market entry, marking the highest number in the past five years [1] - There has been frequent overseas licensing cooperation for domestic innovative drugs, with total transaction amounts exceeding 48.4 billion USD, indicating an accelerated trend of internationalization in the industry [1] - On July 31, 2025, the net outflow of main funds for Rongchang Biopharma was 76.38 million yuan, accounting for 0.73% of its circulating market value [2]

北京市金杜律师事务所 关于荣昌生物制药（烟台）股份有限公司 之法律意见书 致：荣昌生物制药（烟台）股份有限公司 北京市金杜律师事务所（以下简称本所）接受荣昌生物制药（烟台）股份有限 公司（以下简称公司）委托，根据《中华人民共和国证券法》 （以下简称《证券法》）、 《中华人民共和国公司法》（以下简称《公司法》）、中国证券监督管理委员会《上 市公司股东会规则》（以下简称《股东会规则》）等中华人民共和国境内（以下简 称中国境内，为本法律意见书之目的，不包括中国香港特别行政区、中国澳门特别 行政区和中国台湾省）现行有效的法律、行政法规、规章、规范性文件和现行有效 的公司章程的有关规定，指派律师出席了公司于 2025 年 7 月 31 日召开的 2025 年 第二次 H 股类别股东大会（以下简称"本次 H 股类别股东大会"），并就本次 H 股类别股东大会相关事项出具本法律意见书。 为出具本法律意见书，本所律师审查了公司提供的以下文件，包括但不限于： 公司章程》（以下简称《公司章程》）； （http://www.hkexnews.hk）、上海证券交易所网站（www.sse.com.cn）的《2025 年 第二次 H 股类 ...