Core Viewpoint - Jiangsu Sihuan Biological Co., Ltd. has completed the registration of changes in business operations and has obtained a new business license, along with a change in its office address [1] Group 1: Company Information - The company held its 13th meeting of the 10th Board of Directors on June 4, 2025, where it approved the proposal to change the registered address and amend the Articles of Association [1] - The new registered information includes: - Company Name: Jiangsu Sihuan Biological Co., Ltd. - Unified Social Credit Code: 913202001381477183 - Type: Joint-stock Company (Listed) - Legal Representative: Qiu Weibing - Registered Capital: 1,029.556222 million RMB - Establishment Date: May 18, 1992 - Address: 2 Binhai East Road, Building 41, Jiangyin City, Rooms 05 and 06 [1] Group 2: Business Scope - The company's business scope includes the manufacturing of large-volume injectables, small-volume injectables (including anti-tumor drugs), tablets (including anti-tumor drugs), hard capsules, syrups, oral solutions, alcoholic solutions, raw materials, traditional Chinese medicine extraction, and the manufacturing of Class II psychotropic drugs [1] - Additional activities include the packaging of specific health products, pharmaceutical consulting, technology transfer services, and the manufacturing of pharmaceutical intermediates (excluding chemical hazardous products) [1] - The company is also involved in the manufacturing and sales of textiles, chemical products (excluding hazardous products), electronic products, and telecommunications equipment, as well as investment activities and import/export operations related to its products and technologies [1]

Market Overview - The animal health sector experienced a decline of 0.53% on August 13, with Dayu Biological leading the drop [1] - The Shanghai Composite Index closed at 3683.46, up 0.48%, while the Shenzhen Component Index closed at 11551.36, up 1.76% [1] Individual Stock Performance - Key stocks in the animal health sector showed varied performance, with Xianfeng Holdings closing at 3.78, up 0.53%, and Dayu Biological closing at 9.84, down 3.15% [2][1] - Other notable stocks included Jinhe Biological at 7.45, down 3.12%, and Zhongmu Co. at 7.56, down 0.66% [2][1] Trading Volume and Value - The trading volume for Xianfeng Holdings was 268,700 shares with a transaction value of 102 million yuan, while Dayu Biological had a trading volume of 46,200 shares and a transaction value of 45.92 million yuan [2][1] Capital Flow Analysis - The animal health sector saw a net outflow of 175 million yuan from institutional investors, while retail investors contributed a net inflow of 143 million yuan [2][3] - The capital flow for specific stocks indicated that Hai Li Biological had a net inflow of 2.28 million yuan from institutional investors, while Xianfeng Holdings experienced a significant net outflow of 11.02 million yuan [3][2]

Core Viewpoint - Wuhan Keqian Biological Co., Ltd. plans to sign a cooperative research and development agreement with Huazhong Agricultural University, involving four vaccine projects, with a total payment of 4.9 million RMB [2][4][67]. Group 1: Overview of Related Transactions - The company has obtained cooperation for the development of four projects: "Canine Distemper, Canine Parainfluenza, Canine Adenovirus and Canine Parvovirus Quadrivalent Live Vaccine - Inactivated Canine Coronavirus Vaccine," "Porcine Gata Virus Inactivated Vaccine," "Porcine Proliferative Enteropathy Blocking ELISA Antibody Test Kit," and "NADC30-like Porcine Reproductive and Respiratory Syndrome Live Vaccine (GX2024 Strain)" [2][4][67]. - The total payment to Huazhong Agricultural University for these projects is 4.9 million RMB, with specific allocations of 1.5 million RMB, 2 million RMB, 400,000 RMB, and 1 million RMB for each project respectively [4][67]. - The transaction constitutes a related party transaction but does not qualify as a major asset restructuring under relevant regulations [2][4][67]. Group 2: Necessity and Impact of Related Transactions - The cooperative research aims to enhance the company's product portfolio and market competitiveness, although the success of the projects and their market introduction remain uncertain [67]. - The pricing and process of the transaction comply with legal regulations and do not harm the interests of the company or minority shareholders [67]. Group 3: Approval Procedures for Related Transactions - The board of directors and the supervisory board have approved the agreement, with related directors abstaining from voting [68][69]. - Independent directors have expressed that the agreement will enhance the company's core competitiveness in the biological products sector and that the transaction process is legal and fair [71][72]. Group 4: Research and Development Agreement Details - The agreement includes provisions for the rights and obligations of both parties, including the management of research funds and the ownership of intellectual property generated from the projects [8][37][52]. - The agreement is valid for 10 years, with provisions for extension and termination under certain conditions [20][36][66].

Core Viewpoint - The company has successfully developed a new veterinary drug, Mirtazapine Ointment, which has been approved as a Class V new veterinary drug by the Ministry of Agriculture and Rural Affairs, indicating a significant advancement in the company's product offerings and innovation capabilities [1][9]. Group 1: New Veterinary Drug Information - New veterinary drug name: Mirtazapine Ointment [2] - Developed by: A collaboration of multiple companies including Qingdao Weilan Pet Biotechnology Co., Ltd., Qingdao Kangdian Animal Pharmaceutical Co., Ltd., and others [2]. - Registration certificate number: (2025) New Veterinary Drug Certificate No. 82 [3]. - Monitoring period: 3 years [3]. - Main ingredient: Mirtazapine [3]. - Indication: Used to control weight loss in cats [3]. - Dosage: Apply a 3.8 cm strip of ointment (equivalent to 2 mg of Mirtazapine) to the inner side of the cat's ear once daily for 14 days, alternating between ears [3]. Group 2: Research and Development - The development of Mirtazapine Ointment involved significant investment, totaling 1.8622 million yuan in research and development costs [4]. - The product has undergone laboratory research, clinical trials, and new veterinary drug registration processes, culminating in the recent issuance of the registration certificate [4]. Group 3: Market Background - Weight loss and decreased appetite in cats are significant clinical signs of potential diseases, which can lead to malnutrition, organ dysfunction, and weakened immunity if not addressed [5]. - The new veterinary drug aims to meet the clinical needs of the pet market, characterized by controllable quality, safety, efficacy, ease of administration, and high compliance [5]. Group 4: Future Procedures - Before the product can be marketed, it must obtain the veterinary product approval number from the Ministry of Agriculture and Rural Affairs, as per relevant regulations [7]. Group 5: Impact on the Company - The acquisition of the new veterinary drug certificate reflects the company's commitment to technological innovation and increased R&D investment, enhancing its product portfolio and potentially providing new growth opportunities for the business [9].

Core Viewpoint - The rise of industrial and technological tourism in China reflects the country's manufacturing prowess and innovation, with listed companies leading the development of these tourism projects, which are increasingly focused on asset revitalization, flow conversion, ESG practices, and business model innovation [1][5][7]. Group 1: Industrial and Technological Tourism Trends - Industrial tourism has gained popularity, with factories and industrial parks becoming new attractions for tourists, especially among youth interested in robotics and technology [2][3]. - The tourism landscape now includes a third category of resources that showcases contemporary technological innovations alongside cultural and natural heritage [2]. - Listed companies are at the forefront of this trend, leveraging their advanced technologies and products to enhance industrial tourism experiences [2]. Group 2: Company Initiatives and Developments - Companies like 福瑞达 (Furida) have seen significant increases in visitor numbers, with their beauty technology museum receiving over 5000 visitors during the summer, indicating a strong interest in beauty industry innovations [3]. - 宝钢 (Baosteel) has established the Baosteel Industrial Creative Park, which features various attractions and educational tours, catering to different audience segments [4]. - 福瑞达 aims to attract 100,000 visitors annually to its beauty industrial tourism project, showcasing the high standards of China's beauty industry [3][6]. Group 3: Challenges and Considerations - The development of industrial tourism must balance production safety with visitor experience, ensuring that both operational integrity and tourist engagement are maintained [7][8]. - There is a need for improvement in the presentation of industrial tourism content, expanding the depth and breadth of exhibitions related to manufacturing achievements [7]. - Companies are encouraged to innovate their operational mechanisms to overcome existing limitations in integrating tourism with industrial production [7].

证券代码：688739 证券简称：成大生物 公告编号：2025-039 辽宁成大生物股份有限公司 第五届董事会第二十一次会议决议公告 本公司董事会及全体董事保证公告内容不存在任何虚假记载、误导性陈述或者 重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 一、董事会会议召开情况 辽宁成大生物股份有限公司（以下简称"公司"）第五届董事会第二十一次会议 通知已于 2025 年 8 月 8 日以电子邮件方式发出，会议于 2025 年 8 月 12 日以现场和 通讯相结合的方式召开并作出决议。公司应出席会议的董事 7 人，实际出席会议的董 事 7 人，会议由董事长李宁先生主持。本次会议的召集、召开和表决情况符合《中华 人民共和国公司法》（以下简称"《公司法》"）等法律法规及《公司章程》的规定， 形成的决议合法有效。 二、董事会会议审议情况 （一）审议通过《关于补选公司董事的议案》 公司董事会于近日收到董事董丙建先生与董事崔建伟先生的书面辞职报告。为完 善公司治理，保证公司董事会的规范运作，根据《公司法》《上海证券交易所科创板 上市公司自律监管指引第 1 号——规范运作》《公司章程》等相关规定，依据公司控 ...

Core Viewpoint - The company has successfully completed the non-trading transfer of shares related to its 2025 employee stock ownership plan, with a total of 221.1573 million shares transferred at a price of 8 yuan per share, representing 0.4745% of the company's total share capital [3]. Group 1: Employee Stock Ownership Plan - The company held meetings on March 24, 2025, and April 11, 2025, where the 2025 employee stock ownership plan was approved, allowing for the implementation of the plan [2]. - A total of 55 employees participated in the stock ownership plan, contributing a total of 17.692584 million yuan, with the corresponding shares to be allocated [2]. - The duration of the employee stock ownership plan is set for 48 months, starting from the date of the last stock transfer to the plan's account [3]. Group 2: Share Transfer Details - The company has transferred 221.1573 million shares to the employee stock ownership plan's securities account, with the transfer price set at 8 yuan per share [3]. - The shares held in the employee stock ownership plan account will be subject to a lock-up period, which will be released upon meeting specific performance criteria [3]. - The company will continue to monitor the implementation of the employee stock ownership plan and fulfill its information disclosure obligations as required [3].

Core Viewpoint - The company plans to utilize idle raised funds for cash management, not exceeding RMB 260 million, to enhance fund efficiency while ensuring the normal operation of fundraising projects and maintaining fund safety [1][2][8] Summary by Sections Investment Purpose - The company aims to improve fund efficiency and increase shareholder returns by managing temporarily idle raised funds, ensuring it does not affect the progress of fundraising projects [5][7] Fund Source and Limit - The company will use up to RMB 260 million of idle raised funds for cash management, which can be rolled over within the specified limit [2][5] Investment Duration - The investment period is valid for 12 months from the date of the board's approval [5][6] Investment Method - The company will invest in high-security, liquid products such as structured deposits, time deposits, and large certificates of deposit, ensuring compliance with relevant regulations [5][6] Impact on Daily Operations - The cash management of idle funds will not affect the normal operation of fundraising projects and is expected to enhance overall performance and shareholder returns [7][8] Approval Process - The proposal for cash management has been approved by the board and supervisory board, complying with legal and regulatory requirements [8]

证券代码：688739 证券简称：成大生物 公告编号：2025-041 辽宁成大生物股份有限公司 关于公司董事变更的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述 或者重大遗漏，并对其内容的真实性、准确性和完整性承担法律责任。 重要内容提示： 辽宁成大生物股份有限公司（以下简称"成大生物"或"公司"）董事会于 近日收到董事董丙建先生与崔建伟先生的书面辞职报告。因工作需要，董丙建先 生申请辞去公司董事及董事会战略委员会委员职务，辞职后将不再担任公司任何 职务；崔建伟先生申请辞去公司董事职务，辞职后仍将担任公司副总经理、财务 总监职务。根据公司控股股东辽宁成大股份有限公司推荐、经董事会提名委员会 资格审查通过，董事会同意提名徐飚先生、周岳先生为公司第五届董事会非独立 董事候选人，任期自公司股东会审议通过之日起至第五届董事会届满之日止。该 议案尚需提交公司股东会审议。 公司于 2025 年 8 月 12 日召开第五届董事会第二十一次会议，审议通过了 《关 于补选公司董事的议案》。根据公司控股股东辽宁成大股份有限公司推荐、经董 事会提名委员会资格审查通过，董事会提名徐飚先生、周岳先生为公司第 ...

辽宁成大生物股份有限公司 信息披露管理制度 辽宁成大生物股份有限公司 信息披露管理制度 第一章 总 则 第一条 为提高辽宁成大生物股份有限公司（以下简称"公司"）信息披露工作质 量和规范信息披露行为，确保公司对外信息披露工作的真实性、准确性、及时性，保 护公司、股东、债权人及其他利益相关者的合法权益，根据《中华人民共和国公司法》 （以下简称"《公司法》"）《中华人民共和国证券法》（以下简称"《证券法》"） 《上市公司信息披露管理办法》（以下简称"《管理办法》"）《上海证券交易所科 创板股票上市规则》（以下简称"《上市规则》"）及其他有关法律、法规、规范性 文件和《辽宁成大生物股份有限公司章程》（以下简称"《公司章程》"）的规定， 制定本制度。 第二条 本制度所称"信息披露"是指公司将对公司股票及其衍生品种交易价格可 能产生较大影响而投资者尚未得知的信息或影响投资者作出价值判断和投资决策的重 大信息，在规定的期限内，通过上海证券交易所网站和符合中国证监会规定条件的媒 体，以规定的方式向社会公众公布，并按照规定报送证券监管部门。 第三条 本制度适用于如下人员和机构： (一) 公司董事会秘书和信息披露事务管理部门； ...