Core Viewpoint - The management of Tibet Pharmaceutical held a performance briefing for the first half of 2025, highlighting the commercialization of the drug Zolbetuximab by its subsidiary, Chentai Pharmaceutical, which is specifically designed for advanced non-small cell lung cancer with CNS metastasis [1] Group 1: Product Overview - Zolbetuximab is the world's first drug targeting advanced non-small cell lung cancer (NSCLC) with CNS metastasis, achieving significant results in clinical trials [1] - It is the only EGFR tyrosine kinase inhibitor (EGFR-TKI) designed with a non-blood-brain barrier efflux protein substrate, demonstrating a 100% ability to penetrate the blood-brain barrier [1] Group 2: Commercialization and Financial Impact - Zolbetuximab was officially commercialized in the first half of this year, and preparations for medical insurance negotiations are underway [1] - The expected revenue from Zolbetuximab this year is not anticipated to have a significant impact on the company's overall financial performance [1]

Core Viewpoint - The innovative drug concept has seen a significant surge in the market, with several companies experiencing notable stock price increases [1] Group 1: Company Performance - Changchun High-tech has risen over 8% [1] - Xinghao Pharmaceutical and Wanbangde have both increased by over 5% [1] - Other companies such as Tibet Pharmaceutical, Rongchang Bio, Xinlitai, Guangsheng Tang, and Nuocheng Jianhua have also shown upward movement in their stock prices [1]

9月30日，锐正基因（苏州）有限公司宣布完成总额为7500万美元的A轮融资，并与A轮融资投资方西藏 药业（600211.SH）与康哲药业（867.HK）启动全面战略合作。 ...

Core Viewpoint - Tibet Pharmaceutical is focusing on transformation and innovation, aligning with national policies and aiming for high-quality growth through increased R&D investment and strategic partnerships [1][2]. Group 1: Company Strategy and Growth - The company plans to invest $60 million in Accuredit Therapeutics Limited, acquiring a 40.82% stake, which is seen as a strategic move to enhance its innovation capabilities [1]. - Tibet Pharmaceutical has achieved significant growth over the past decade, with revenue increasing from 521 million to 2.807 billion yuan, representing a compound annual growth rate (CAGR) of 18.34%, and net profit rising from 92 million to 1.051 billion yuan, with a CAGR of 27.63% [2]. - The company aims to stabilize its core product "Xinhua Su" while exploring new growth opportunities through product rebranding and enhanced marketing strategies [3]. Group 2: Market Challenges and Opportunities - In 2024, the company experienced a revenue decline of 10.45%, raising concerns about its ability to maintain high growth rates, despite a 9.45% increase in net profit [3]. - The company is addressing its reliance on single products and insufficient R&D investment by pursuing mergers and acquisitions, particularly in the gene editing sector [3][4]. Group 3: Acquisition and Innovation - The acquisition of Accuredit Therapeutics is part of Tibet Pharmaceutical's strategy to enter the gene editing market, which is expected to drive innovation and growth [4][5]. - Accuredit Therapeutics focuses on developing gene editing drugs and has a strong team with experience in biopharmaceuticals, which aligns with Tibet Pharmaceutical's goals [5]. - The CEO of Accuredit, Wang Yongzhong, has a robust background in the biopharmaceutical industry, which could enhance the company's international expansion efforts [5]. Group 4: Safety and Regulatory Considerations - Gene editing technology is characterized by irreversible effects, making safety a primary concern, with clinical data required to validate its safety over 2 to 5 years [6]. - The company is working on improving safety through reversible gene editing techniques and off-target detection methods [6].

西藏药业办公楼 本报记者 吴科任 摄 ...

Core Viewpoint - Tibet Pharmaceutical is focusing on transformation and innovation, aligning with national policies, particularly in the field of innovative drugs and gene editing technology [1][3]. Group 1: Investment and Strategic Direction - Tibet Pharmaceutical plans to invest $60 million in Accuredit Therapeutics Limited, acquiring a 40.82% stake, which has been approved by the company's shareholders [1]. - The company aims to enhance its growth through both internal and external strategies, emphasizing R&D investment and project acquisition to drive sustainable development [1][2]. Group 2: Financial Performance - Over the past decade, Tibet Pharmaceutical's revenue increased from 521 million to 2.807 billion, with a compound annual growth rate (CAGR) of 18.34%, while net profit rose from 92 million to 1.051 billion, with a CAGR of 27.63% [2]. - However, in 2024, the company experienced a revenue decline of 10.45%, raising concerns about its growth sustainability, despite a 9.45% increase in net profit [2]. Group 3: Growth Strategy - To achieve sustained growth, the company must establish a second growth curve focusing on internal growth through product enhancement and external growth via R&D and acquisitions [3]. - The acquisition of Accuredit Therapeutics is seen as a critical step in the company's innovation journey, aligning with its transformation strategy [3][4]. Group 4: Gene Editing Focus - Accuredit Therapeutics, established in 2021, specializes in developing non-viral vector-based gene editing drugs and has a comprehensive technology platform [4]. - The company is currently conducting clinical trials for its lead product, ART001, which has received IND approval in both China and the U.S. [4][5]. Group 5: Safety and Market Considerations - Gene editing technology is characterized by irreversible effects, making safety a primary concern, with a typical waiting period of 2 to 5 years for clinical data to confirm safety [5]. - The company is enhancing safety through reversible gene technology and off-target detection methods [5].

证券代码：600211 证券简称：西藏药业 公告编号：2025-036 西藏诺迪康药业股份有限公司 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述或者重大遗 漏，并对其内容的真实性、准确性和完整性承担法律责任。 二、说明会召开的时间、地点、方式 重要内容提示： ●会议召开时间：2025 年 10 月 10 日 15:00-16:00 召开时间：2025 年 10 月 10 日（星期五）15:00-16:00 ●会议召开方式：本次业绩说明会将采用网络方式举行 ●投资者可于 2025 年 10 月 9 日（星期四）前将相关问题通过电子邮件的形式发送至邮 箱：chenxu@xzyy.cn，本公司将在 2025 年半年度业绩说明会上对投资者普遍关注的问题进行 回答。 本公司已于 2025 年 8 月 16 日在《中国证券报》《上海证券报》《证券时报》及上海证券 交易所网站（www.sse.com.cn）披露公司 2025 年半年度报告，为便于广大投资者更全面深入 了解公司 2025 年半年度的经营成果、财务状况，公司计划于 2025 年 10 月 10 日 15:00-16:00 召开 2025 ...

Core Viewpoint - The innovative pharmaceutical concept stocks continue to decline, with significant drops observed in several companies [1] Company Summary - Borui Pharmaceutical has seen a decline of over 8% [1] - Tibet Pharmaceutical has dropped by more than 7% [1] - Fuyuan Pharmaceutical, Zhendong Pharmaceutical, and Maiwei Biotechnology have also experienced declines [1]

Investment Rating - The report maintains a "Recommended" investment rating for the pharmaceutical industry as of September 21, 2025 [1] Core Insights - The trend of Chinese innovative drugs going global is a significant industry trend, with a notable increase in License-out transactions in the first half of 2025, surpassing the total number for 2024 by over half and increasing transaction amounts by 16% [2] - The report highlights the importance of structural opportunities within the industry, emphasizing the need to select high-quality companies amidst the competitive landscape [2] - The report notes that while the trend of innovative drugs going abroad continues, concerns have arisen due to fewer major transactions and proposed U.S. regulations affecting Chinese drug licensing [2] - The report identifies significant breakthroughs in small nucleic acid drugs, particularly in chronic disease areas such as hypertension, with notable partnerships and potential milestone payments [3] - The report discusses promising clinical data from Chinese ADCs presented at the World Lung Cancer Conference, showcasing competitive advantages in efficacy and safety [4] - The report mentions the advancements in GLP-1 analogs for weight loss, with ongoing developments from both multinational corporations and domestic companies [5] - The CXO sector is expected to gradually recover, driven by an increase in orders and favorable policy changes [6] - The report outlines the completion of expert reviews for the 2025 medical insurance negotiation and commercial insurance innovative drug directories, indicating potential impacts on participating companies [7] Summary by Sections 1. Pharmaceutical Market Tracking - The pharmaceutical industry index has underperformed compared to the CSI 300 index, with a recent weekly decline of 2.07% [22] - Over the past month, the industry has lagged behind the CSI 300 index by 7.79 percentage points [23] 2. Pharmaceutical Sector Trends and Valuation - The current PE (TTM) for the pharmaceutical industry index is 39.77, above the five-year historical average of 31.50 [48] 3. Recent Research Achievements - The report includes various recent research outputs, highlighting the ongoing focus on innovative drug development and market opportunities [50] 4. Recent Industry Policies and News - The report details recent policy updates from the National Medical Insurance Administration regarding drug directory adjustments and the implications for the industry [52][54]

Company Overview - Tibet Pharmaceutical Co., Ltd. is located in Lhasa Economic and Technological Development Zone, Tibet, and was established on July 14, 1999, with its listing date on July 21, 1999. The company primarily engages in pharmaceutical manufacturing, with 99.80% of its revenue coming from drug sales and 0.20% from other sources [1]. Stock Performance - As of September 19, the stock price of Tibet Pharmaceutical fell by 2.00% to 51.34 CNY per share, with a trading volume of 272 million CNY and a turnover rate of 1.62%. The total market capitalization is 16.548 billion CNY [1]. - Year-to-date, the stock has increased by 46.40%, but it has decreased by 9.02% over the last five trading days. In the last 20 days, the stock rose by 13.69%, and over the past 60 days, it increased by 43.49% [1]. Financial Performance - For the first half of 2025, Tibet Pharmaceutical reported a revenue of 1.651 billion CNY, representing a year-on-year growth of 2.23%. However, the net profit attributable to shareholders decreased by 8.96% to 567 million CNY [2]. Shareholder Information - As of June 30, 2025, the number of shareholders for Tibet Pharmaceutical was 45,200, a decrease of 8.08% from the previous period. The average number of circulating shares per person increased by 8.79% to 7,132 shares [2]. - The company has distributed a total of 2.258 billion CNY in dividends since its A-share listing, with 1.580 billion CNY distributed over the last three years [3]. Institutional Holdings - As of June 30, 2025, Hong Kong Central Clearing Limited was the seventh-largest circulating shareholder, holding 2.5902 million shares, a decrease of 1.6084 million shares from the previous period. Huaxia Industry Prosperity Mixed Fund (003567) was the tenth-largest circulating shareholder, maintaining its holding of 1.9036 million shares [3].