上海君實生物醫藥科技股份有限公司 Shanghai Junshi Biosciences Co., Ltd.* ( 於中華人民共和國註冊成立的股份有限公司 ) 股份代號 : 1877 2025 中期報告 * 僅供識別 目錄 2 公司資料 4 摘要 8 管理層討論及分析 42 其他資料 58 簡明綜合財務報表審閱報告 59 簡明綜合損益及其他全面收益表 61 簡明綜合財務狀況表 63 簡明綜合權益變動表 64 簡明綜合現金流量表 66 簡明綜合財務報表附註 90 釋義 2 上海君實生物醫藥科技股份有限公司 公司資料 執行董事 熊俊先生 （主席兼法定代表） 李寧博士 （副主席） 鄒建軍博士 （首席執行官兼總經理） 李聰先生 （聯席首席執行官） 張卓兵先生 姚盛博士 王剛博士 李鑫博士 非執行董事 湯毅先生 獨立非執行董事 張淳先生 馮曉源博士 楊悅博士1 酈仲賢先生 魯琨女士 監事4 匡洪燕女士 （監事會主席） 王萍萍女士 霍依蓮女士 審計委員會 張淳先生 （主席） 湯毅先生 酈仲賢先生 薪酬與考核委員會 張淳先生 （主席） 熊俊先生 鄒建軍博士 馮曉源博士 楊悅博士1 戰略委員會 熊俊先生 （主席） 鄒建軍博士 ...

Market Overview - On September 26, the biopharmaceutical sector declined by 0.95%, with Junshi Bioscience leading the drop [1] - The Shanghai Composite Index closed at 3828.11, down 0.65%, while the Shenzhen Component Index closed at 13209.0, down 1.76% [1] Stock Performance - Notable gainers in the biopharmaceutical sector included: - Aopumai (688293) with a closing price of 66.17, up 5.28% [1] - Kanghua Biological (300841) at 77.28, up 5.26% [1] - Changchun High-tech (000661) at 126.89, up 3.53% [1] - Significant decliners included: - Junshi Bioscience (688180) at 41.00, down 4.16% [2] - Olin Bio (688319) at 25.50, down 3.66% [2] - Baipusais (301080) at 59.90, down 3.64% [2] Capital Flow - The biopharmaceutical sector experienced a net outflow of 412 million yuan from institutional investors, while retail investors saw a net inflow of 205 million yuan [2] - The capital flow for specific stocks showed: - Aopumai had a net inflow of 26.26 million yuan from institutional investors [3] - Kanghua Biological had a net outflow of 1.11 million yuan from retail investors [3] - Tonghua Dongbao (600867) saw a net inflow of 15.15 million yuan from institutional investors [3]

Market Overview - The biopharmaceutical sector experienced a decline of 0.21% on September 25, with Nossland leading the drop [1] - The Shanghai Composite Index closed at 3853.3, down 0.01%, while the Shenzhen Component Index closed at 13445.9, up 0.67% [1] Stock Performance - Notable gainers in the biopharmaceutical sector included: - Aopu Mai (688293) with a closing price of 62.85, up 7.42% and a trading volume of 30,600 [1] - Rongchang Biotech (688331) closed at 108.50, up 3.43% with a trading volume of 89,200 [1] - Baipusais (301080) closed at 62.16, up 3.43% with a trading volume of 43,500 [1] - Major decliners included: - Nossland (430047) closed at 22.99, down 3.69% with a trading volume of 57,000 [2] - Wufan Biotech (301393) closed at 53.12, down 3.42% with a trading volume of 24,600 [2] - Kexing Pharmaceutical (688136) closed at 38.75, down 3.34% with a trading volume of 53,500 [2] Capital Flow - The biopharmaceutical sector saw a net outflow of 207 million yuan from institutional investors, while retail investors contributed a net inflow of 45.07 million yuan [2] - Notable capital flows included: - Rongchang Biotech (688331) with a net inflow of 1.021 billion yuan from institutional investors [3] - Junshi Biosciences (688180) with a net inflow of 35.36 million yuan from institutional investors [3] - Aopu Mai (688293) with a net inflow of 9.41 million yuan from institutional investors [3]

来源：新浪证券-红岸工作室 9月24日，君实生物涨0.22%，成交额6.21亿元。两融数据显示，当日君实生物获融资买入额6709.54万 元，融资偿还4696.78万元，融资净买入2012.75万元。截至9月24日，君实生物融资融券余额合计14.29 亿元。 融资方面，君实生物当日融资买入6709.54万元。当前融资余额14.23亿元，占流通市值的4.46%，融资 余额超过近一年90%分位水平，处于高位。 融券方面，君实生物9月24日融券偿还2.09万股，融券卖出0.00股，按当日收盘价计算，卖出金额0.00 元；融券余量13.60万股，融券余额566.81万元，超过近一年50%分位水平，处于较高位。 资料显示，上海君实生物医药科技股份有限公司位于上海市浦东新区平家桥路100弄6号7幢16层,香港铜 锣湾希慎道33号利园1期19楼1918室，成立日期2012年12月27日，上市日期2020年7月15日，公司主营业 务涉及单克隆抗体药物和其他治疗型蛋白药物的研发与产业化,单克隆抗体药物研发的技术服务与技术 转让等。主营业务收入构成为：药品销售90.67%，技术许可及特许权使用收入8.74%，技术服务及其他 0. ...

每经AI快讯，9月25日，港股君实生物(01877.HK)涨超6%，截至发稿，涨6.34%，报31.54港元，成交额 1.82亿港元。 ...

Core Viewpoint - Junshi Biosciences (01877) shares rose over 6%, currently up 6.34% at HKD 31.54, with a trading volume of HKD 182 million [1] Group 1: Upcoming Conference - The European Society for Medical Oncology (ESMO) annual meeting will be held in Berlin, Germany from October 17 to October 21, 2025 [1] - Junshi Biosciences will present over 20 studies on its innovative products, including anti-PD-1 monoclonal antibody Toripalimab, anti-BTLA monoclonal antibody Tifcemalimab, and selective PI3K-α inhibitor JS105 at the conference [1] Group 2: Research Highlights - The conference's latest breakthrough abstracts (Late-Breaking Abstracts, LBA) have been announced, with two studies on Toripalimab selected for oral presentations [1] - One of the studies on Toripalimab has been chosen for the prestigious Proffered Paper session, showcasing cutting-edge advancements in combination therapy [1]

Core Viewpoint - Junshi Biosciences (01877) shares rose over 6%, currently up 6.34% at HKD 31.54, with a trading volume of HKD 1.82 billion [1] Group 1: Upcoming Conference - The European Society for Medical Oncology (ESMO) annual meeting will take place from October 17 to October 21, 2025, in Berlin, Germany [1] - Junshi Biosciences will present over 20 studies on its innovative products, including anti-PD-1 monoclonal antibody Toripalimab, anti-BTLA monoclonal antibody Tifcemalimab, and selective PI3K-α inhibitor JS105 at the conference [1] Group 2: Research Highlights - The conference's latest breakthrough abstracts (Late-Breaking Abstracts, LBA) have been announced, with two studies on Toripalimab selected for oral presentations [1] - One of the studies has been honored with a spot in the prestigious Proffered Paper session, showcasing advancements in Toripalimab combination therapy [1]

Core Viewpoint - Junshi Bioscience's stock price has shown significant volatility, with a year-to-date increase of 55.80% but a recent decline over the past five days of 6.89% [2] Company Overview - Junshi Bioscience, established on December 27, 2012, and listed on July 15, 2020, is located in Shanghai and focuses on the research and commercialization of monoclonal antibody drugs and other therapeutic protein drugs [2] - The company's main revenue sources are drug sales (90.67%), technology licensing and royalties (8.74%), and technical services and others (0.59%) [2] Financial Performance - For the first half of 2025, Junshi Bioscience reported revenue of 1.168 billion yuan, representing a year-on-year growth of 48.64%, while the net profit attributable to shareholders was -413 million yuan, an increase of 36.01% year-on-year [2] Stock Performance - As of September 25, Junshi Bioscience's stock price was 42.58 yuan per share, with a market capitalization of 43.716 billion yuan [1] - The stock has experienced a trading volume of 56.48 million yuan and a turnover rate of 0.17% [1] Institutional Holdings - As of June 30, 2025, the top ten circulating shareholders include Huaxia SSE Sci-Tech Innovation Board 50 ETF, holding 29.7167 million shares (a decrease of 536,700 shares), and E Fund SSE Sci-Tech Innovation Board 50 ETF, holding 22.2132 million shares (an increase of 630,000 shares) [3]

Core Viewpoint - Junshi Biosciences aims to establish itself as a global innovative pharmaceutical company with a complete industry chain capability from drug discovery to commercialization, focusing on quality and innovation [2][3]. Company Overview - Junshi Biosciences, founded on December 27, 2012, and listed on July 15, 2020, specializes in the research and commercialization of monoclonal antibody drugs and other therapeutic proteins [7]. - The company's main revenue sources include drug sales (90.67%), technology licensing (8.74%), and other services (0.59%) [7]. Product Development - The company has developed a promising drug portfolio, including its core product, Toripalimab, which is the first domestically approved PD-1 monoclonal antibody in China, with 11 approved indications and one supplemental NDA under review [2]. - Toripalimab is also the first innovative biopharmaceutical developed and produced in China to receive FDA approval, with approvals in multiple regions including the U.S., EU, and Australia [2]. - Junshi's self-developed Tifcemalimab is the first anti-tumor anti-BTLA monoclonal antibody to enter clinical development, currently undergoing two Phase III trials [2]. Vaccine Development - Junshi's subsidiary, JunTuo Biotech, is developing vaccine-related products, including monkeypox and Zika vaccines, which are currently in preclinical development [3]. - The company has partnered with several institutions, including Peking University and the Chinese Academy of Sciences, to jointly develop a recombinant protein vaccine for monkeypox [3]. Financial Performance - For the first half of 2025, Junshi Biosciences reported revenue of 1.168 billion yuan, a year-on-year increase of 48.64%, while the net profit attributable to shareholders was -413 million yuan, a 36.01% increase [8]. - As of June 30, 2025, the number of shareholders increased by 5.88% to 31,200, with a decrease in average circulating shares per person by 5.56% [8]. Market Activity - On September 24, Junshi Biosciences' stock rose by 0.22%, with a trading volume of 621 million yuan and a turnover rate of 1.95%, bringing the total market capitalization to 42.782 billion yuan [1]. - The stock has seen a net outflow of 27.407 million yuan from major funds, indicating a lack of strong buying interest [4][5].

Core Viewpoint - The A-share market is experiencing a significant rebound, particularly in the Sci-Tech Innovation Board, with the ETF Huatai-PineBridge (589120) showing a notable increase of 1.59% as of 13:54 on September 24, and attracting over 20 million yuan in net subscriptions within three trading days [1][3]. Group 1: ETF Performance - The Huatai-PineBridge Sci-Tech Innovation Drug ETF (589120) has seen strong performance, with most of its constituent stocks rising, including Teva Biopharma up over 3%, and several others like Zai Lab and Eucure Biopharma rising over 2% [3]. - The top ten constituent stocks of the ETF include notable companies such as RYSE Pharmaceuticals (688235) with a weight of 9.92% and a rise of 1.93%, and Eucure Biopharma (688578) with a weight of 8.03% and a rise of 2.27% [4]. Group 2: Market Dynamics - The National Healthcare Security Administration is set to hold a communication meeting in Beijing to discuss negotiations and pricing with companies, marking a significant innovation in this year's healthcare directory adjustments [5]. - The current innovation drug market is driven by the trend of "local innovation - global monetization," which is seen as a key support for the industry's growth [6]. - Analysts from Xinda Securities believe that the trend of innovation in the drug sector is not over, with expectations for continued growth in innovative drugs, medical devices, and AI healthcare [7]. Group 3: Industry Outlook - Tianfeng Securities highlights that the Chinese innovative drug industry has achieved significant results and is now globally competitive, entering a phase of self-sustainability through commercialization [8]. - The industry is supported by favorable policies, a well-structured talent pool, and a collaborative approach between academia and industry, which enhances the efficiency of drug development [9]. - The future outlook suggests that increasing innovation will further unlock commercial value, with China becoming one of the most efficient countries in the drug development process [10].