从消息人士处确认，武田中国事业部总裁单国洪决定离开武田，寻求外部发展机会，最后工作日是6月 30日。消化事业部负责人刘燕被任命为武田中国事业部代理总裁。对于单国洪的去向，有媒体报道称将 加入百济神州。对此消息，截至发稿，百济神州方面未予回应。（智通财经） ...

Core Viewpoint - The Chinese innovative pharmaceutical industry is experiencing a significant transformation, marked by increased research breakthroughs, active business development (BD) transactions, and a shift in market perception, moving away from the "me too" label associated with Chinese drugs [1][5][10] Market Performance - The innovative pharmaceutical sector has seen a strong resurgence in the secondary market, with A-share and Hong Kong stock indices rising significantly; A-share innovative drug stocks increased by 34.27% and Hong Kong's innovative drug index surged over 70% from April 8 to June 16 [3] - The sector had previously undergone a four-year adjustment period, with the Hang Seng Innovative Drug Index hitting a historical low in July 2023, down over 70% from July 2021 [3] - The recovery is driven by active BD transactions and the commercialization of innovative drugs, with a notable shift in market sentiment towards the sector [3][4] Business Development Trends - Numerous Chinese innovative drug companies have announced significant BD projects in cutting-edge fields, with notable transactions including a $12.5 billion upfront payment from Pfizer to 3SBio for a PD-1/VEGF dual antibody [5] - The License-out model has become a primary funding source for unprofitable innovative drug companies, with Q1 2025 seeing a record 41 transactions totaling $369.29 billion, surpassing the total for the first half of 2024 [6] - The ability of Chinese companies to leverage their research platforms and enhance capital efficiency is reshaping the traditional high-risk, high-investment model of the industry [6] Commercialization and Profitability - The commercialization of innovative drugs is gaining momentum, with 20 new class 1 innovative drugs approved in the first five months of 2023, marking a five-year high [7] - Companies like BeiGene are expected to achieve positive operating profits by 2025, indicating a shift from the traditional "burning cash" phase to profitability [7][8] - The improved financial health of innovative drug companies enhances their negotiating power in BD transactions, allowing them to demand better terms [8] Competitive Landscape - The competition in the innovative drug sector is intensifying, with a focus on efficiency across the entire drug development chain, from target discovery to commercialization [9] - The majority of BD transactions are concentrated in the oncology sector, particularly in ADC and dual antibody technologies, leading to increased competition and market saturation [9] - Companies are encouraged to innovate and differentiate their products to avoid the pitfalls of homogeneity and to enhance their global competitiveness [9] Challenges Ahead - Despite the progress, the high failure rate in new drug development remains a significant challenge, particularly for early-stage research [10] - There is a growing expectation among investors for innovative drug companies to not only achieve profitability but also to provide stable dividends in the future [10]

Core Insights - The 2025 European Hematology Association (EHA) annual meeting showcased nearly 60 clinical research results from four Chinese innovative drug companies, highlighting China's scientific strength in developing innovative therapies for hematological cancers [1] - The collective breakthroughs of these companies at international platforms like ASCO and EHA signify a strategic shift in China's innovative drug industry from "fast following" to "independent innovation" [1] - The EHA annual meeting is a significant academic event in the global hematology field, attracting over 10,000 professionals from more than 100 countries [1] Company Highlights - BeiGene presented four major oral reports at the EHA meeting, demonstrating key breakthroughs in its pipeline for hematological cancer treatments [1] - The next-generation BCL2 inhibitor, Sotorasib, combined with Baiyueze®, achieved total response rates of 96% and 79% for patients with relapsed/refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma, respectively [2] - The potential first-in-class BTK degrader BGB-16673 showed promising early data for treating CLL and Waldenström's macroglobulinemia [2] - Innovent Biologics had 25 studies presented as posters at the EHA meeting, focusing on new BTK inhibitors and BCL2 inhibitors for various lymphomas [2] Research Developments - The combination of Mesutoclax and Obinutuzumab for first-line treatment of CLL/SLL showed a total response rate of 97.6% in a cohort of 42 newly diagnosed patients, with a registration phase III clinical trial now underway [3] - Dizhizhi Pharmaceuticals showcased multiple research advancements covering T-cell and B-cell lymphomas, including the JAK1 inhibitor, Gyrizhe®, which demonstrated effective maintenance treatment in peripheral T-cell lymphoma [3] - Micu Biotech presented 19 new research results on its selective HDAC inhibitor, Sitarabin, across various hematological malignancies, indicating significant tumor response and broad application prospects [4]

华福证券认为，港股创新药（含Pharma）为医药板块中最强势的板块，其次为创新药产业链CRO板 块，创新药已成为市场认可的主线之一，个股方面从主流一二线标的，行情亦在向有创新药布局或BD 预期的中药或仿制药标的扩展。短期创新药建议积极拥抱龙头和一线标的。 （本文机构观点来自持牌证券机构，不构成任何投资建议，亦不代表平台观点，请投资人独立判断和决 策。） 消息面上，据央视新闻，6月13日国务院常务会议召开研究优化药品和耗材集采有关举措。会议指出， 要加强药品和耗材集采政策评估，总结经验、补齐短板，推动集采工作规范化制度化常态化开展。要更 好促进"三医"协同发展和治理，完善公立医院补偿机制，支持医药企业提高创新能力，更好满足群众多 元化就医用药需求。要加强对药品和耗材生产、流通、使用全链条质量监管，扎实推进仿制药质量和疗 效一致性评价，让人民群众用药放心安心。 东吴证券指出，创新药BD推动及优秀临床数据下，看好的医药子行业排序分别为：创新药>CXO>中药 >医疗器械>药店>医药商业等。具体标的选择思路：从成长性角度选股，主要集中创新药领域；从左侧 角度选股，主要集中在CXO、医疗器械。 6月16日，创新药概念小幅 ...

Core Viewpoint - The A-share market has undergone a series of index adjustments effective from June 16, impacting various indices including the Shanghai Composite and Shenzhen Composite indices, with a total of 187 sample changes across six cross-market indices [1][3][4]. Group 1: Index Adjustments - The Shanghai and Shenzhen indices have collectively replaced 61 samples, with the Shanghai 50 index changing 4 samples, the Shanghai 180 index changing 18 samples, the Shanghai 380 index changing 38 samples, and the Sci-Tech 50 index changing 1 sample [21][30]. - The six cross-market indices have replaced a total of 187 samples, with the CSI 300 index changing 7 samples, the CSI 500 index changing 50 samples, and the CSI 1000 index changing 100 samples [4][19]. Group 2: New Index Launch - The Shanghai 580 index has been officially launched, focusing on smaller market capitalization stocks within the Shanghai market, reflecting the overall performance of smaller listed companies [2][31]. - Approximately 30% to 60% of the sample weight in the Shanghai 580 index is attributed to sectors such as the Sci-Tech board, specialized and innovative companies, private enterprises, and emerging industries, highlighting its innovative small-cap characteristics [33]. Group 3: Industry Representation - The adjustments have led to an increase in the representation of information technology, communication services, and industrial sectors within the indices, enhancing market representation [18][19]. - The manufacturing sector's weight in the Shenzhen Component Index remains high at 73%, with 211 companies projected to achieve revenue and profit growth in 2024 [30].

Core Insights - The pharmaceutical-themed funds are dominating the performance rankings for the first half of the year, with nine out of the top ten funds being pharmaceutical-focused, led by Huatai-PineBridge Hong Kong Advantage Select A, which achieved a 103.67% return [1][2] - The strong performance of these funds is driven by multiple factors, including breakthroughs in innovative drug development, recovery of liquidity in the Hong Kong stock market, and restructuring of valuation systems through cross-border business development transactions [1][2] Fund Performance - The average return of the top ten actively managed equity funds exceeds 69%, with notable performances from Changcheng Pharmaceutical Industry Select A and Yongying Pharmaceutical Innovation Smart Select A, achieving returns of 87.73% and 79.79% respectively [2] - Huatai-PineBridge Hong Kong Advantage Select A is highlighted as a "doubling fund" for the year, marking a significant achievement in the market [2] Market Dynamics - The pharmaceutical sector is experiencing a "double hit" in profitability and valuation in 2025, with the Hang Seng Hong Kong Stock Connect Innovative Drug Index showing a year-to-date increase of 70.09% [3] - The performance of pharmaceutical funds is significantly influenced by their exposure to Hong Kong stocks, with the Hang Seng Healthcare Index rising by 54.59%, outperforming the A-share innovative drug index, which increased by 24.15% [3] Investment Strategy - Huatai-PineBridge Hong Kong Advantage Select A has benefited from investments in leading companies in the Hong Kong innovative drug and medical device sectors, capitalizing on improved overseas liquidity and favorable industry policies [4] - The introduction of financing channels for unprofitable biotech companies in Hong Kong has allowed competitive biotech firms to enter the market, with many now in advanced stages of research and commercialization [4] Future Outlook - The pharmaceutical industry is expected to maintain long-term investment value driven by demographic aging, consumption upgrades, and technological innovation, although caution is advised regarding potential overvaluation of certain stocks [6] - The current market for innovative drugs is characterized by high valuations and volatility, with expectations for a rebalancing between these factors in the near future [6][7] - The valuation of leading companies and key stocks is anticipated to be reassessed, with a focus on the long-term potential of authorized products and revenue realization from commercial partnerships [7]

Summary of Key Points from the Conference Call Industry Overview - The Chinese innovative drug industry is experiencing a systematic valuation increase, primarily benefiting from the realization of business development (BD) opportunities abroad, with multinational corporations (MNCs) beginning to pay for early pipeline products, reshaping the valuation system and reversing the previous reliance on domestic market payments [1][5][6]. Core Insights and Arguments - The industry has reached an operational turning point, with large biotech companies like BeiGene demonstrating profitability trends, entering a profit window, validating the market acceptance of the innovative drug commercialization model [1][5][6]. - MNCs are facing a patent cliff and urgently need to introduce innovative drugs through BD to fill sales gaps, while Chinese innovative drug research has made significant progress over the past decade, providing high-quality alternative products for BD collaborations [1][7]. - BD activities in the Chinese innovative drug sector are concentrated in the areas of antibody-drug conjugates (ADC) and second-generation immuno-oncology (IO), with companies like Kelun-Biotech and Innovent Biologics leading globally by enhancing product efficacy and reducing toxicity through innovative designs [1][9][10]. - The Harmony Two study data from CanSino Biologics has sparked MNC interest in the second-generation IO track, accelerating related layouts and facilitating several large BD transactions, such as BMS's collaboration with a biotech firm totaling over $9 billion [1][12]. Market Trends - The current innovative drug market is performing strongly, with minor adjustments observed primarily in second- and third-tier stocks, while core assets remain largely unaffected, indicating a good entry opportunity [2]. - The valuation levels of innovative drugs are not yet at a bubble stage, and the current market cycle is believed to be far from over, with a shift in valuation dynamics due to MNCs beginning to pay for early-stage products [3][5]. Future Prospects - The Chinese innovative drug industry is optimistic about future development, with more biotech companies entering profitability windows, further driving industry growth [6]. - The second-generation IO track is still in the expansion phase, with significant potential and investment prospects, particularly for companies like 3SBio, Innovent Biologics, and Abogen Biosciences [4][13]. Noteworthy Developments - The increase in BD activities is attributed to both supply and demand factors, with MNCs needing to fill sales gaps due to expiring patents on major drugs, while Chinese companies have made substantial advancements in drug development [7][8]. - The ADC and second-generation IO fields are highlighted as key areas of focus, with Chinese companies showing strong competitive advantages and technological capabilities [9][10]. Investment Logic and Company Classification - Investment logic varies among innovative drug companies based on their R&D direction, technology platform, and market demand, necessitating a comprehensive evaluation of specific fields and company strengths [16]. - Companies can be classified into four categories: early-stage biotech, pre-balance biotech, platform biopharma, and generic innovators, each with distinct characteristics and development stages [17][18]. Conclusion - The innovative drug sector in China is poised for growth, driven by advancements in BD activities, strong company performances, and a favorable market environment, making it a critical area for investment and research [1][6][19].

Core Insights - The Chinese innovative pharmaceutical industry is experiencing a significant surge, with the Hang Seng Biotechnology Index rising over 60% this year, surpassing the 17% increase in the AI sector [1][3] - The surge is driven by a series of billion-dollar licensing deals, successful IPOs, and strong R&D pipelines, igniting investor enthusiasm [1][3] Licensing and IPO Trends - In Q1 2025, the total value of mergers and licensing transactions involving Chinese pharmaceutical companies doubled to $36.9 billion, accounting for over half of the global total of $67.5 billion [3] - Notable licensing deals include Pfizer's $1.25 billion upfront payment to 3SBio Inc. for an experimental cancer drug and Bristol-Myers Squibb's announcement of a licensing deal with BioNTech SE worth up to $11.5 billion [3][4] - The IPO market is also thriving, with companies like Duality Biotherapeutics Inc. and Jiangsu Hengrui Medicine seeing significant stock price increases post-IPO [4][5] Market Confidence and Financial Performance - The series of licensing deals and IPOs has boosted market confidence in the innovative drug sector, making the Hang Seng Biotechnology Index a standout performer in Asia [5] - Chinese innovative pharmaceutical companies are moving towards profitability, breaking the stereotype of continuous cash burn. For instance, BeiGene achieved profitability in Q1 2025, with revenue guidance of $4.9 to $5.3 billion [7][9] BD (Business Development) Growth - The increase in profitability is attributed to the normalization of BD licensing income, with Chinese companies seeing substantial upfront payments from licensing deals [9][11] - As of June 8, 2025, Chinese companies' upfront payments for licensing transactions exceeded $2.5 billion, reflecting a fundamental shift in the global value chain for Chinese innovative drugs [11] Technological Innovations and Market Dynamics - Technological innovations, particularly in areas like ADC (Antibody-Drug Conjugates) and dual antibodies, are driving the growth of the Chinese innovative drug sector [15][17] - The global demand for innovative drugs is increasing, with significant opportunities arising from the expiration of patents for blockbuster drugs, creating a strong need for new products from Chinese companies [11][23] Talent and Policy Support - The return of overseas talent and favorable policies are providing long-term momentum for the industry, enhancing domestic R&D capabilities [23] - Collaborations between Chinese pharmaceutical companies and U.S. firms are becoming more common, positioning these companies as service providers rather than mere exporters [23]

随着上半年公募基金业绩收官战进入倒计时，医药主题基金以碾压性优势席卷收益榜单。 Wind数据显示，截至6月14日，公募主动权益类基金前十名中竟有9只医药主题产品，汇添富香港优势精选A更 以103.67%的收益率率先撞线"翻倍基"，暂居收益率榜首，2025年半程 悬念花落谁家 ，值得期待。 多位公募业内人士对券商中国记者表示，这场由创新药研发突破、港股流动性复苏、跨境BD交易重构估值体 系等多重动能驱动的医药盛宴，不仅改写了年度基金排名格局，更折射出资本市场对"中国创新"力量的重估与 期待。 医药基金霸屏公募半年业绩榜 随着6月过半，半年度公募主动权益基金的业绩排名即将出炉。年初至今，医药板块延续强势表现，多只医药 主题基金凭借精准布局和行业红利实现业绩爆发，市场无重大变化之下，医药基金将成为半年度收益最大的赢 家。 以汇添富香港优势精选A为例，此前披露的一季报显示，一季度末前十大重仓股分别是荣昌生物、科伦博泰生 物-B、信达生物、和黄医药、康诺亚-B、翰森制药、康方生物、诺诚健华、来凯医药-B、百济神州，创新药概 念股占据绝大多数。 唐晨对记者表示，香港联交所于2018年推出18A上市规则，较科创板更早地为未 ...

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或因依賴 該等內容而引致的任何損失承擔任何責任。 BeOne Medicines Ltd. 百濟神州有限公司 （根據瑞士法律註冊成立的公司） （股份代號：06160） 授出購股權、受限制股份單位及業績股份單位 本公告乃根據上市規則第17.06A、17.06B以及17.06C條作出。於2025年6月10 日，董事會及薪酬委員會根據2016期權及激勵計劃的條款向三十一名承授人（包 括兩名董事）授出可認購合共147,355股美國存託股份的購股權，向九千零一十二 名承授人（包括兩名董事）授出涉及合共1,720,092股美國存託股份的受限制股份單 位，並向三十名承授人（包括一名董事）授出涉及合共141,377股美國存託股份的 業績股份單位。 2016期權及激勵計劃項下的購股權 於2025年6月10日，董事會及薪酬委員會根據2016期權及激勵計劃的條款授予三 十一名承授人（包括兩名董事）可認購合共147,355股美國存託股份的購股權。 授出購股權詳情 購股權詳情如下 ...