Core Viewpoint - The company Beigene has completed its name change, and its stock trading name on the Hong Kong Stock Exchange will change from "BEIGENE" to "BEONE MEDICINES" effective from October 22, 2025 [1] Company Summary - The English stock trading name change will take effect at 9:00 AM Hong Kong time on October 22, 2025 [1] - The Chinese stock trading name will remain unchanged as "百济神州" [1]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或因依賴 該等內容而引致的任何損失承擔任何責任。 BeOne Medicines Ltd. 百濟神州有限公司 （前稱BeiGene, Ltd. 百濟神州有限公司） （先前於開曼群島註冊成立的有限公司，並已在瑞士存續註冊） （股份代號：06160） 變更英文公司名稱及英文股份簡稱 茲提述BeOne Medicines Ltd.百濟神州有限公司（「本公司」）日期為2025年5月27日 的公告，內容有關（其中包括）完成遷址及存續及公司英文名稱變更（「該公告」）。 本公司欣然宣佈，香港公司註冊處處長已於2025年10月2日發出註冊非香港公司 變更名稱註冊證明書，證明BeOne Medicines Ltd.已根據香港法例第622章《公司 條例》第16部在香港註冊為本公司英文名稱。 變更英文股份簡稱 公司英文名稱變更完成後，於香港聯交所進行股份交易的英文股份簡稱將由 「BEIGENE」變更為「BEONE MEDICINES」，自2025年10月22日星期三上午九時 ...

● 本报记者 张勤峰 杨洁 王婧涵 郑萃颖 五千余家A股上市公司，以超百万亿元市值、逾1.8万亿元的研发投入，不断夯实中国经济高质量发展 的"基本盘"。 五年来，上市公司勇立创新潮头，从规模最大的5G网络，到刷新时速的CR450动车组，再到全球领先 的创新药，上市公司以一批具有全球影响力的创新成果标注了中国创新的新高度。 五年来，高端化、智能化、绿色化转型纵深推进，上市公司以创新为帆、以实干为桨，不仅重塑自身发 展轨迹，更为中国经济驶向"深海航程"注入强劲动力。 中国上市公司协会学术顾问委员会委员程凤朝精准概括：这五年，上市公司实现了从做大到做强、从数 量扩张到质量跃迁的关键跨越。 这些闪耀的创新成果，离不开一支活跃在创新前沿的中坚力量——上市公司。五年来，创新驱动已成为 上市公司高质量发展最鲜明的底色。 ——上市公司持续加大研发投入，扮演创新引领者。 2024年，我国全社会研发投入超3.6万亿元，较2020年增长48%；研发投入强度达到2.68%，超过欧盟国 家平均水平。其中，上市公司贡献突出：2024年A股上市公司研发投入总额达1.88万亿元，占全国研发 经费总量的51.96%；研发强度提升至2.61%， ...

Core Insights - A-share listed companies have significantly contributed to China's high-quality economic development, with over 1.8 trillion yuan in R&D investment and a market capitalization exceeding 100 trillion yuan [1] - The past five years have seen a transition from quantity expansion to quality improvement among listed companies, marking a critical leap in their development [1][2] R&D Investment - In 2024, China's total R&D investment is expected to exceed 3.6 trillion yuan, a 48% increase from 2020, with listed companies contributing 1.88 trillion yuan, accounting for 51.96% of the national total [3] - The R&D intensity of listed companies has risen to 2.61%, up by 0.1 percentage points from the previous year, with 26 companies entering the "billion R&D club" [3] Innovation and Technology - Major technological achievements during the "14th Five-Year Plan" include advancements in space exploration, high-speed rail, and renewable energy, with listed companies playing a pivotal role in these innovations [2] - Companies like BeiGene have invested heavily in R&D, with over 47 billion yuan from 2021 to 2024, showcasing the potential of Chinese original research drugs on the global stage [3] Industry Transformation - Listed companies are integrating technological innovation with industrial innovation, exemplified by successful case studies in tire manufacturing and battery recycling [4] - The shift towards smart manufacturing has led to significant efficiency improvements, with over 230 exemplary smart factories reporting an average production efficiency increase of 22.3% [6][7] Green Development - The "14th Five-Year Plan" has seen the establishment of the world's largest renewable energy industry chain, with listed companies investing 1.3 trillion yuan in renewable projects [8] - Companies like Yanjing Beer are implementing green practices throughout their production lifecycle, contributing to a 16.9% reduction in carbon emissions per unit of revenue since 2020 [9] Global Expansion - A-share listed companies achieved 9.52 trillion yuan in overseas revenue in 2024, a 56.58% increase from 2020, indicating a qualitative shift in their global presence [10] - The export of innovative drugs has surged, with nearly 66 billion USD in foreign licensing agreements in the first half of 2025, reflecting the global recognition of China's R&D capabilities [10] Conclusion - The trajectory of A-share listed companies reflects the microcosm of China's economic high-quality development, transitioning from innovation-driven breakthroughs to global value elevation [11]

Core Insights - The 2025 Sustainable Global Leaders Conference is being held in Shanghai from October 16 to 18, highlighting the importance of sustainable development and innovation in the financial sector [1] - Guo Chuan Zhou, Chairman of Yuekai Securities, emphasized the need for "patient capital" to support transformation and long-term development in technology finance [2] Company Focus - Yuekai Securities is strategically positioned in the Guangzhou Economic and Technological Development Zone, a key area in the Guangdong-Hong Kong-Macao Greater Bay Area known for its economic scale and technological innovation [2] - The company is focusing on three main levels of service in technology finance, with "transformation" being the primary task [2] Investment Strategy - The core approach of Yuekai Securities in serving the technology industry is "investment-led," aiming to drive growth through strategic investments [2] - The investment segment has been concentrating on "high-end" fields, with notable projects including investments in leading biopharmaceutical companies listed on the Sci-Tech Innovation Board [2]

专题：2025可持续全球领导者大会&首届绿色产业与可持续消费博览会 炒股就看金麒麟分析师研报，权威，专业，及时，全面，助您挖掘潜力主题机会！ 10月16日至18日，2025可持续全球领导者大会在上海世博园区召开。粤开证券董事长郭川舟受邀出席大 会，并做主旨演讲。 他介绍，粤开证券背靠广州经开区——这一粤港澳大湾区内经济总量与科技创新水平均位居前列的核心 区域。基于此，公司在服务科技金融方面主要从三个层面展开，其中"转型"是首要任务。自2017年起， 集团及粤开证券在战略与主营业务上实现了全面转型。八年来，通过持续收购与整合，包括完成对粤开 证券的并购，公司构建了新的主营业务生态，目前旗下拥有三家上市公司，覆盖能源发电、生物医疗器 械及新能源板块，并成功发行了广东省首单产业园区REIT。集团亦是中国服务业企业500强及全国唯一 一家"双百企业"区属国企。 在服务科技产业的具体模式上，郭川舟指出是以"投资引领"为核心。他举例称，自并购粤开证券后，投 资板块持续聚焦"高精尖"领域，代表性项目包括投资了科创板生物医药市值领军企业百济神州，以及小 鹏汽车、文远知行等知名公司。持续的收并购不仅是资产提升、实现产业投资退出 ...

Core Insights - The GLP-1 weight loss market is experiencing significant investment and growth, with a notable $600 million Series B funding for NewCo, a subsidiary of Heng Rui Pharmaceutical, highlighting the industry's potential [1] - The focus has shifted from merely developing GLP-1 drugs to effectively commercializing them, as evidenced by the increasing number of IPO filings and soaring stock prices of companies in this sector [1] Investment Trends - Major investments are flowing into the GLP-1 market, with companies like NewCo receiving substantial funding [1] - Several companies, including Senwa Biotech and Chengyi Biotech, have filed for IPOs, indicating strong investor interest [1] Product Landscape - As of 2025, five GLP-1 injection products have been approved in China, with more in the pipeline, including those from Senwa Biotech and Heng Rui Pharmaceutical [2][6] - The approved products vary in administration frequency and weight loss efficacy, with some showing significant results over extended periods [2] Market Challenges - New GLP-1 products face hurdles in hospital sales due to strict prescription regulations and procurement limitations [3][6] - The market is transitioning towards e-commerce as a viable sales channel to overcome these challenges, with companies looking to leverage online platforms for broader consumer access [3][4] E-commerce Strategy - E-commerce is becoming a critical sales channel for GLP-1 products, with companies like Novo Nordisk and Eli Lilly beginning to embrace this shift [4][5] - By 2030, the GLP-1 market in the weight loss sector is projected to exceed 30 billion, with e-commerce expected to capture over 50% of this market [5] Consumer Engagement - The marketing approach has evolved from focusing on clinical data to enhancing consumer awareness and engagement, emphasizing the importance of user-friendly communication [5][6] - Companies are increasingly investing in promotional activities and partnerships with e-commerce platforms to drive consumer interest and sales [10][12] Competitive Landscape - The competition among e-commerce platforms is intensifying, with each platform leveraging its unique strengths to capture market share [13][14] - Cold chain logistics are becoming a crucial factor in the distribution of GLP-1 products, with companies like JD Health and Meituan Buy Medicine enhancing their capabilities to ensure product integrity [14] Future Outlook - The GLP-1 market is expected to grow rapidly, but the industry is cautious about maintaining healthy competition rather than descending into chaos [15][16]

Core Viewpoint - The innovation drug sector in China is experiencing significant growth, driven by increased investment, favorable policies, and a strong pipeline of new drugs entering clinical trials, positioning it for a robust future in both domestic and international markets [6][8][10]. Group 1: Market Performance - As of October 16, the Science and Technology Innovation Drug ETF (Huitianfu, 589120) saw a notable increase of 3.31%, maintaining a rise of over 2% despite a slight pullback [1]. - The ETF has attracted over 40 million yuan in net inflows over the past five days, indicating strong investor interest [1]. - Key constituent stocks such as Sangfor Technology and Yifang Bio have shown significant gains, with Sangfor hitting the daily limit up and Yifang Bio rising by 8.61% [2][3]. Group 2: Industry Trends - The number of License-out transactions in China reached 72 in the first half of 2025, surpassing half of the total for 2024, with a total transaction value 16% higher than the previous year [5]. - The innovation drug sector is primarily driven by business development (BD) expectations, with a significant portion of annual BD activity occurring in the fourth quarter [6]. - The Chinese innovation drug market is expected to see a recovery in confidence as more BD deals materialize, particularly as companies prepare for the upcoming European Society for Medical Oncology (ESMO) conference [6][7]. Group 3: R&D and Financial Outlook - Since 2015, Chinese innovation drug companies have significantly increased R&D investments, leading to a rise in the number of original innovative drugs entering clinical trials, with 704 drugs expected to enter Phase I trials in 2024 [8]. - The revenue of innovation drug companies has been steadily increasing, with projections indicating that one-third of these companies will achieve profitability by 2025, and 70% will reach breakeven by 2026 [8]. - The Chinese government's support for innovation drugs through favorable policies and increased funding is expected to enhance the sector's growth, with healthcare spending on innovation drugs projected to rise from 50 billion yuan in 2022 to 120 billion yuan in 2024 [9]. Group 4: Competitive Landscape - The impending patent cliff for multinational corporations (MNCs) is expected to create a demand for new products, with 190 drugs losing patent protection by 2030, including 69 with annual sales exceeding 1 billion dollars [10]. - Chinese innovation drug companies are well-positioned to fill this gap due to their high R&D efficiency and rich technological outcomes, making them attractive partners for MNCs [10].

Core Insights - The Shanghai Stock Exchange Sci-Tech Innovation Board 100 Index has shown a slight increase of 0.21%, with notable gains from companies such as Sangfor Technologies and Dige Medical [3] - The ETF tracking the Sci-Tech 100 Index has also risen by 0.22%, with a cumulative increase of 1.81% for the month as of October 15, 2025 [3] - The liquidity of the Sci-Tech 100 Index ETF is strong, with a turnover rate of 1.93% and a transaction volume of 1.26 billion yuan [3] - Recent partnerships in the AI sector, such as the collaboration between Yuke and Haiguang Information, highlight the growing demand for AI computing power [4] - OpenAI's significant cloud computing contract with Oracle, valued at 300 billion USD, indicates a surge in global AI computing needs [4] Market Performance - The Sci-Tech 100 Index ETF has experienced a scale increase of 4.64 million yuan over the past month, ranking second among comparable funds [4] - The ETF's share count has grown by 2.76 million shares in the same period, also placing it second among comparable funds [4] - Despite recent net outflows of 1.56 million yuan, the ETF has attracted a total of 4.61 billion yuan over the last 16 trading days [4] Index Composition - The Sci-Tech 100 Index is composed of 100 medium-sized, liquid stocks selected from the Sci-Tech Innovation Board, reflecting the overall performance of different market capitalizations [5] - As of September 30, 2025, the top ten weighted stocks in the index account for 24.32% of the total index, including companies like Hua Hong Semiconductor and BeiGene [5]

Core Viewpoint - BeiGene's stock has shown significant volatility, with a year-to-date increase of 78.46%, but a recent decline over the past five and twenty trading days [1] Group 1: Stock Performance - As of October 16, BeiGene's stock price was 287.36 CNY per share, with a market capitalization of 442.73 billion CNY [1] - The stock experienced a 2.03% increase during the trading session on October 16, with a trading volume of 2.47 billion CNY and a turnover rate of 0.76% [1] - Year-to-date, the stock has risen by 78.46%, but it has decreased by 5.62% over the last five trading days and 9.35% over the last twenty trading days [1] Group 2: Financial Performance - For the first half of 2025, BeiGene reported a revenue of 17.518 billion CNY, representing a year-on-year growth of 46.03% [2] - The net profit attributable to shareholders for the same period was 450 million CNY, showing a significant increase of 115.63% year-on-year [2] Group 3: Shareholder Information - As of June 30, 2025, the number of BeiGene's shareholders was 23,300, a decrease of 3.90% from the previous period [2] - The average number of circulating shares per shareholder increased by 4.11% to 4,976 shares [2] - Among the top ten circulating shareholders, notable changes included an increase in holdings by China Europe Medical Health Mixed A and a decrease by Wan Jia You Xuan [2]