香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性 或完整性亦不發表任何聲明，並明確表示概不就因本公告全部或任何部分內容而產生或因依賴 該等內容而引致的任何損失承擔任何責任。 BeOne Medicines Ltd. 百濟神州有限公司 （根據瑞士法律註冊成立的公司） （股份代號：06160） 授出購股權、受限制股份單位及業績股份單位 本公告乃根據上市規則第17.06A、17.06B以及17.06C條作出。於2025年6月10 日，董事會及薪酬委員會根據2016期權及激勵計劃的條款向三十一名承授人（包 括兩名董事）授出可認購合共147,355股美國存託股份的購股權，向九千零一十二 名承授人（包括兩名董事）授出涉及合共1,720,092股美國存託股份的受限制股份單 位，並向三十名承授人（包括一名董事）授出涉及合共141,377股美國存託股份的 業績股份單位。 2016期權及激勵計劃項下的購股權 於2025年6月10日，董事會及薪酬委員會根據2016期權及激勵計劃的條款授予三 十一名承授人（包括兩名董事）可認購合共147,355股美國存託股份的購股權。 授出購股權詳情 購股權詳情如下 ...

Investment Rating - The report maintains an "Accumulate" rating for the pharmaceutical and biotechnology sector [8] Core Insights - The report highlights that the pharmaceutical sector, particularly the innovative drug segment, is experiencing a significant bull market, with the innovation drug index outperforming other indices [2][13] - The report emphasizes the strong liquidity in the market, which has led to increased investment in innovative drugs, particularly those related to PD1 and weight loss drugs [2][15] - Future outlook remains optimistic for 2025, focusing on innovative drugs, new technologies, and restructuring of the supply chain [3][16] Summary by Sections 1. Pharmaceutical Core Insights - The pharmaceutical index increased by 1.40% during the week of June 9-13, outperforming both the ChiNext and CSI 300 indices [13] - The innovative drug index rose by 3.07%, indicating strong market performance [50] 2. MNC Cash and Potential Layouts - MNCs have substantial cash reserves, with major companies like Johnson & Johnson and Merck holding over $10 billion in cash, indicating strong purchasing power for potential business development (BD) opportunities [27][25] - The report analyzes MNC revenue sources, highlighting a focus on oncology, metabolism, and mental health, which are areas of high market potential [25][27] 3. Investment Strategies and Thoughts 3.1 Broad Pharmaceuticals - Innovative drugs are a key focus, with a recommendation to explore opportunities in core stocks and those with BD expectations [3][16] - The report identifies specific companies for investment, including major players in the innovative drug space and smaller market cap stocks with promising pipelines [17][18] 3.2 Generic Drugs - The generic drug sector showed a weekly increase of 5.24%, outperforming the broader pharmaceutical index [59] - Top-performing stocks in the generic sector include Yiming Pharmaceutical and Sai Sheng Pharmaceutical, indicating strong market activity [62] 4. Market Review and Hotspot Tracking - The report notes that innovative drugs are becoming the most attractive sector, with significant price increases observed in several companies due to market catalysts [2][15] - Key events, such as the NMPA's inclusion of a new treatment for cardiovascular disease, are highlighted as important developments in the sector [57]

Core Viewpoint - The A-share pharmaceutical sector, particularly the innovative drug segment, has shown strong performance, with R&D investment becoming a critical variable for company success in a competitive environment [1] Group 1: R&D Investment Overview - The total R&D expenditure of A-share pharmaceutical companies has steadily increased over the past three years, reaching 111.11 billion yuan in 2022, 118.50 billion yuan in 2023, and projected to be 121.01 billion yuan in 2024 [2][3] - The chemical pharmaceutical sector leads in R&D spending, with an expected 2024 expenditure close to 60 billion yuan, followed by the medical device sector at over 23 billion yuan and the biological products sector at 16.87 billion yuan [2][3] Group 2: R&D Intensity - The R&D intensity, measured as the ratio of R&D expenditure to revenue, ranks the biological products sector highest at 13.01%, followed by chemical pharmaceuticals at 10.87% and medical devices at 9.68% for 2024 [4][5] Group 3: Performance of Key Sectors - Despite overall pressure on performance, the chemical pharmaceutical sector has shown consistent growth, with net profits increasing from 21.68 billion yuan in 2022 to 34.44 billion yuan in 2024 [3][14] - The medical device sector has faced significant declines, with net profits dropping from 80.28 billion yuan in 2022 to 33.18 billion yuan in 2024, a nearly 59% decrease [3][14] Group 4: Leading Companies in R&D Investment - Among biological products companies, Changchun High-tech leads with an average R&D investment of 2.26 billion yuan over the past three years, showing a growth of over 60% from 1.66 billion yuan in 2022 to 2.69 billion yuan in 2024 [10][11] - In the chemical pharmaceutical sector, BeiGene has the highest average R&D investment at 12.70 billion yuan, with a significant reduction in losses from 13.64 billion yuan in 2022 to 4.98 billion yuan in 2024 [12][14] - In the medical device sector, Mindray Medical tops the list with an average R&D investment of 3.66 billion yuan, maintaining stable profit growth despite overall sector challenges [16][17]

A股千亿级研发投入行业系列三：医药生物行业连续三年研发投入超千亿元，化学制药研发费用居首业 绩亮眼，龙头百济神州股价最高涨超200%（附表） 每经资本眼记者根据同花顺iFinD数据统计发现，2022年至2024年，A股医药生物行业上市公司合计研 发费用稳步上升，分别为1111.09亿元、1185.02亿元和1210.07亿元。从细分二级行业来看，化学制药板 块的研发总费用目前仍然排在医药生物行业第一位，2024年接近600亿元。最近三年医药生物行业的业 绩增长整体承压，但研发投入最高的化学制药板块实现逆势增长。2022年至2024年，医药生物行业的营 业收入分别为2.47万亿元、2.49万亿元和2.47万亿元，净利润分别为1992.25亿元、1619.33亿元和1411亿 元。从细分二级行业来看，仅化学制药板块业绩的呈现持续增长态势，净利润由2022年的216.84亿元增 长到2024年的344.41亿元。 统计的158家A股化学制药上市公司中，入围最近三年平均研发投入总额TOP10的门槛接近10亿元。其 中，最近三年平均研发投入总额最高的为百济神州，达到127.02亿元。入围最近三年平均研发投入总额 TOP ...

Group 1 - Shengxiang Biology plans to acquire 10% equity of Hunan Shengweisi Rui Biotechnology Co., Ltd. for 5 million RMB, focusing on sepsis diagnostic products for emergency and critical care [1] - This acquisition is expected to expand Shengxiang's business in the in vitro diagnostic field and enhance its competitiveness in severe infection diagnostics, signaling a proactive approach to seeking new growth points [1] Group 2 - Changfeng Pharmaceutical has submitted an IPO application to the Hong Kong Stock Exchange, with CITIC Securities and CMB International as joint sponsors [2] - Established in 2007, Changfeng focuses on inhalation technology and drugs for respiratory diseases, with its first approved product CF017 for bronchial asthma [2] - The IPO aims to leverage capital markets to expand R&D and production scale, enhancing market competitiveness in the respiratory disease treatment sector [2] Group 3 - BeiGene announced that the FDA approved its "Baiyueze" tablet for all approved indications, based on studies showing bioequivalence with the capsule form [3] - The tablet form is smaller and easier to swallow, which may improve patient compliance and expand market applications [3] - This approval strengthens BeiGene's competitiveness in the global hematologic oncology market and boosts investor confidence in future growth [3] Group 4 - Rongchang Biopharmaceutical's stock surged over 20% following news of international cooperation discussions at the European Renal Association Congress [4] - The company highlighted its research capabilities and international potential, with expectations for product collaboration to maximize commercial value [4] - This reflects the capital market's recognition of the overseas prospects for domestic innovative pharmaceutical companies [4] Group 5 - Hecolin Pharmaceuticals' subsidiary, Nona Bio, entered into a licensing agreement with Visterra, Inc. to utilize its HCAb technology platform for advancing next-generation immunotherapy and autoimmune disease treatments [5][6] - This collaboration showcases the competitive and commercial value of the HCAb technology platform, potentially enhancing Hecolin's influence in the biotherapy field [6] - The partnership is expected to attract investor interest and drive stock price and valuation increases [6]

Market Overview - The A-share market experienced slight fluctuations with the Shanghai Composite Index up by 0.01%, the Shenzhen Component down by 0.11%, and the ChiNext Index up by 0.26% [1] - The total market turnover reached 1,303.5 billion yuan, an increase of 16.9 billion yuan compared to the previous day [1] Innovation Drug Sector Performance - The Guotai Innovation Drug ETF (517110) saw a daily increase of 4.39% [2] Driving Factors for Growth - On June 12, China Biopharmaceutical announced potential landmark licensing deals at the 46th Goldman Sachs Global Healthcare Conference, following similar announcements from other companies [4] - The National Healthcare Security Administration released a draft for the 2024 National Medical Insurance Drug List, indicating a more favorable review process for innovative drugs, which is expected to ease pricing pressure [4] - Local governments, including Shanghai and Beijing, have introduced supportive policies for the biopharmaceutical industry, enhancing confidence in the sector [4] Clinical Progress and Data - The ASCO conference showcased a record 73 studies from Chinese innovative drug companies, with nearly 50% focused on ADC and bispecific antibody fields [5] - Notable clinical results include: - Heng Rui Medicine's PD-1 inhibitor showing a median progression-free survival (mPFS) of 10.2 months, a 35% improvement over existing therapies [5] - BeiGene's BTK inhibitor achieving a total response rate (ORR) of 78% in lymphoma indications [5] - Rongchang Biopharmaceutical's ADC drug receiving FDA breakthrough therapy designation for gastric cancer [5] - Kangfang Biopharmaceutical's bispecific antibody AK112 meeting primary endpoints in Phase III trials [5] Future Outlook - The FDA is expected to make a decision on Innovent Biologics' PD-1 inhibitor for lung cancer on June 15, which could mark a significant milestone for Chinese innovative drugs in the U.S. market [6] - The upcoming ESMO conference is anticipated to reveal more clinical data from Chinese innovative drugs, particularly in high-incidence cancers [6] - The total value of License-out transactions for Chinese innovative drugs has surpassed 50 billion USD, reflecting a 30% increase year-on-year [6] Financial Performance Expectations - Approximately 60% of companies in the CSI Hong Kong-Shenzhen Innovation Drug Index are expected to achieve positive operating cash flow by 2025, driven by the commercialization of key products and improved R&D efficiency [7] Investment Opportunities - The Guotai Innovation Drug ETF (517110) closely tracks the CSI Hong Kong-Shenzhen Innovation Drug Industry Index, capturing beta opportunities in the sector [10]

百济神州美股涨近7%，FDA官网显示，百济神州的泽布替尼片剂获批上市。 ...

科创板股中，收盘价最高的是寒武纪，今日报收604.80元，上涨0.77%，其次是惠泰医疗、恒玄科技 等，最新收盘价分别为407.60元、367.36元。 科创板百元股中，今日平均上涨0.36%，具体来看，今日上涨的有16只，涨幅居前的有浩欧博、百济神 州、达梦数据等。下跌的有24只，跌幅居前的有恒玄科技、C影石、纳芯微等。 向前追溯发现，科创板百元股最新收盘价相对发行价平均溢价311.47%，溢价幅度居前的有百利天恒、 安集科技、寒武纪等，溢价幅度分别为1266.40%、1011.48%、839.28%。 以申万一级行业分类，科创板百元股较为集中的行业有电子、医药生物、计算机等，分别有18只、9 只、6只股票上榜。 以最新收盘价计算，科创板平均股价为30.21元，其中股价超100元的有40只，股价最高的是寒武纪。 证券时报·数据宝统计显示，科创板股今日上涨的有261只，下跌的有316只，以收盘价为基准测算，科 创板平均股价为30.21元，其中，收盘价超过100元的有40只，股价在50元至100元之间的有103只，股价 在30元至50元的有149只。 资金流向方面，科创板百元股今日主力资金合计净流出5.09亿元 ...

以下文章来源于动脉网 ，作者Melody 动脉网 . 动脉网（www.vbdata.cn）聚焦于技术驱动下生命健康领域产业创新和变革的报道与研究。 报告措辞强硬，明确指出："中国在过去20年将生物技术作为国家战略重点，大规模投入资源，使其在多个生物技术核心领域实现显著赶超，并由此 构成对美国主导地位的直接挑战。" 作者 | Melody 来源 | 动脉网 导语： 在美国管控、打压、警告的三重围堵下，中国生物医药却反手主导交易议价，坐上了全球创新药的"卖方席"。 今年4月，美国国家新兴生物技术安全委员会（NSCEB）发布了一份极具分量的报告。 这份题为《Charting the Future of Biotechnology》的报 告，首次从国家安全高度全面审视美国生物技术面临的全球竞争格局，将中国生物医药产业视作最具战略挑战性的对手。 NSCEB援引多项行业数据指出，中国已经通过20年的政策倾斜、产业集群发展与资本驱动，从研发到制造构建起完整的生物科技体系。 一些数据包括： ● 中国生物科技公司市值增长：2016-2021年，中国生物科技企业的市值增长了100倍，达到约3000亿美元，成为全球仅次于美国的生物 ...

Core Viewpoint - The innovation drug sector is a prominent investment theme this year, showing strong performance driven by policy support, global competitiveness, and commercial profitability [1][3][31]. Group 1: Market Performance - The Hang Seng Pharmaceutical ETF (159892) increased by 60% this year, while the STAR Pharmaceutical ETF (588130) rose by 10.9% in the last ten trading days [3][27]. - Despite a recent pullback, the innovation drug sector continues to dominate the ETF performance rankings [2][3]. Group 2: Driving Factors - Two main reasons for the strong performance of innovation drugs: improvement in the macroeconomic environment and favorable policy developments [4][5]. - The U.S. CPI in May was lower than expected, leading to increased market expectations for a potential interest rate cut by the Federal Reserve, which would benefit the valuation of innovation drug stocks [4]. Group 3: Market Dynamics - The innovation drug sector is experiencing a turning point characterized by macroeconomic recovery, industry fundamentals, and valuation adjustments [9][10]. - The latest PE ratio of the Hang Seng Biotechnology Index is 27.64, indicating room for further valuation recovery as it remains below the historical range of the past decade [11]. Group 4: Industry Developments - Recent approvals of 11 innovative drugs by the National Medical Products Administration signify a growing pipeline for domestic innovation drug companies [11][12]. - Successful international collaborations and participation in global events like the ASCO conference highlight the competitive strength of Chinese innovation drug firms [11][12]. Group 5: Liquidity and Investment Trends - The influx of foreign capital into the Hong Kong market is evident, with 27 companies listed this year, 15 of which attracted foreign cornerstone investors [19][20]. - The average daily trading volume in Hong Kong has significantly increased, reflecting heightened liquidity that benefits the innovation drug sector [25][27]. Group 6: Future Outlook - The innovation drug sector is expected to continue benefiting from a favorable macroeconomic environment, policy support, and increasing global competitiveness [31][34]. - The current growth cycle for innovation drugs is distinct due to the backdrop of macroeconomic recovery and industry value reassessment [33][34].