1月22日，由中欧基金葛兰与赵磊共同管理的中欧医疗健康混合披露2025年四季报。截至2025年12月末，葛兰旗下 在管基金总规模由去年三季度末的435.44亿元降至353.89亿元。目前，葛兰在管3只公募基金，分别是中欧医疗健 康、中欧医疗创新、中欧明睿新起点混合，其中规模最大的产品是中欧医疗健康。报告期内，中欧医疗健康混合 基金A类份额净值增长率为-14.81%，同期业绩比较基准收益率为-8.21%；基金C 类份额净值增长率为-14.98%，同 期业绩比较基准收益率为-8.21%。 持仓方面，中欧医疗健康的前十大重仓股依次为：药明康德(603259.SH)、恒瑞医药(600276.SH)、康龙化成 (300759.SZ)、泰格医药(300347.SZ)、百利天恒(688506.SH)、凯莱英(002821.SZ)、信立泰(002294.SZ)、海思科 (002653.SZ)、科伦药业(002422.SZ)、百济神州-U(688235.SH)。其中，海思科、泰格医药获增持，科伦药业、信立 泰等多只个股遭减仓。 | | | ○ 中欧医疗健康混合A 2025年4季度股票投资明细 | | | | | 来源:天天基金 ...

数据显示，截至2025年12月31日，上证科创板生物医药指数前十大权重股分别为联影医疗、百济神州、 艾力斯、百利天恒、惠泰医疗、君实生物、泽璟制药、华大智造、博瑞医药、荣昌生物，前十大权重股 合计占比48.85%。 科创医药ETF嘉实(588700)紧密跟踪上证科创板生物医药指数，一键布局生物医药产业。 没有股票账户的投资者可以通过科创医药ETF嘉实联接基金(021061)一键布局科创板生物医药板块机 遇。 2026年1月23日早盘，医药商业、医疗服务等板块涨幅居前，截至11:05，上证科创板生物医药指数强势 上涨1.52%，成分股成都先导上涨5.48%，华大智造上涨4.25%，欧林生物上涨3.69%，荣昌生物，奕瑞 科技等个股跟涨。 消息上，商务部等九部门发布关于促进药品零售行业高质量发展的意见提出，推动药品零售企业参加药 品集中采购。鼓励行业协会或区域医药流通龙头企业牵头，引导药品零售企业参与药品集中带量采购。 针对其他药品，鼓励零售药店整合采购需求，开展联合采购，实现量价挂钩，提升议价能力。支持药品 零售企业按规定通过省级医药采购平台采购，生产企业需做好供应保障。 近期，中国医药产业正站在全球化价值重估 ...

今日（1.23），港药强势反攻，创新药纯度100%的港股通创新药ETF(159570)涨近2%，成交额快速突破7亿元！资金面上，近5日累计净流入超4.3亿 元！最新规模超251亿元，同类规模领先！ 2026 JPM召开，中国创新药再次成为亮点。恒瑞医药目标26年创新药收入增长25%+，未来两年多款重磅药/适应症获批，管线厚度孕育未来持续 BD；百济神州26年预计实体瘤领域多个已经POC资产将推至注册临床；中国生物制药披露TYK2数据，治疗UC数据亮眼，并且大会期间收购赫吉亚 布局小核酸；迪哲医药披露四代EGFR TKI治疗3代EGFR TKI治疗失败NSCLC的数据，疗效方面，ORR达60%，mPFS＞10m，并且安全性优异。（东 吴证券20260118《JPM 2026最前线观察：中国创新药再次成为全球焦点！》） 本届JPM大会中国药企凭借ADC、IO双抗、GLP-1等领域的技术突破，通过Licenseut及合作开发等方式走向全球。百济神州等龙头已实现组织出海， 部分Biotech实现细分领域突破。整体看，中国医药产业正站在全球化价值重估的起点，2026年将成为验证转型成效的关键节点。 国内药企技术快速突破 ...

Group 1 - In the fourth quarter of last year, 464 Sci-Tech Innovation Board stocks appeared in the fund's heavy holdings list, with 60 new additions, 193 increased holdings, and 207 reduced holdings compared to the previous quarter [1] - The total shareholding amount for these stocks reached 4.801 billion shares, with a total market value of 536.151 billion yuan at the end of the period [1] - Major stocks held by funds include SMIC, Hu Silicon Industry, and Lanke Technology, with respective holdings of 377 million shares, 295 million shares, and 268 million shares [1] Group 2 - The stocks with the highest fund holdings include Baijie Shenzhou, Baili Tianheng, and Zhongke Feicai, with fund ownership ratios of 26.20%, 25.07%, and 24.51% respectively [2] - A total of 184 stocks were held by more than 10 funds, while 80 stocks saw collective new investments from 5 to 9 funds [1][2] - The stock with the most fund holders is Cambricon, with 1,067 funds collectively holding 5.935 million shares, accounting for 14.19% of its circulating shares [1][2] Group 3 - In terms of new investments, 60 stocks were newly added, with Frontier Biotech, Baio Saitu, and New Xiangwei having the largest new holdings of 11.3733 million shares, 7.7342 million shares, and 7.1080 million shares respectively [2] - The stocks with the highest increase in holdings include Shenkong Co., Fangyuan Co., and Longda Co., with Shenkong Co. seeing a staggering increase of 59,020.96% in holdings [2] - Significant reductions were noted in stocks such as Tiejian Heavy Industry, Sikan Technology, and Electric Wind Power, with reductions of 100.00%, 99.91%, and 99.63% respectively [2]

1月22日，百济神州跌1.77%，成交额5.83亿元。两融数据显示，当日百济神州获融资买入额5186.56万 元，融资偿还4397.53万元，融资净买入789.03万元。截至1月22日，百济神州融资融券余额合计8.71亿 元。 机构持仓方面，截止2025年9月30日，百济神州十大流通股东中，中欧医疗健康混合A（003095）位居 第四大流通股东，持股467.88万股，相比上期减少14.66万股。香港中央结算有限公司位居第五大流通股 东，持股315.65万股，为新进股东。万家优选（161903）位居第六大流通股东，持股250.00万股，相比 上期减少50.00万股。永赢医药创新智选混合发起A（015915）位居第八大流通股东，持股213.36万股， 为新进股东。工银前沿医疗股票A（001717）位居第九大流通股东，持股200.00万股，相比上期减少 70.00万股。南方中证500ETF（510500）位居第十大流通股东，持股166.44万股，相比上期减少6.16万 股。 融资方面，百济神州当日融资买入5186.56万元。当前融资余额8.64亿元，占流通市值的2.61%，融资余 额低于近一年40%分位水平，处于较 ...

Group 1 - The core viewpoint of the article highlights that BeiGene has received approval for certain indications of its products, Baiyueze® and Baizean®, from the European Commission, enabling sales through distributors or direct hospital distribution [2] - In 2024, the revenue from the European region is projected to be 2.64 billion yuan, accounting for 9.7% of the company's total revenue for that year [2] - For the first half of 2025, the European region is expected to generate revenue of 1.939 billion yuan, representing 11.1% of the company's revenue for that period [2]

Core Viewpoint - The company is focusing on accelerating the development of innovative drugs through its strong oncology research team and strategic global clinical development capabilities, aiming to become a leading innovator in cancer treatment [1]. Group 1: Company Strategy and Development - The company has one of the largest oncology clinical research teams in the industry and is leveraging this to enhance its innovative drug offerings [1]. - In the past 18 months, the company has advanced 15 new molecular entities into clinical development, covering various treatment modalities [1]. - From 2026 onwards, the company expects to introduce 8 to 10 new molecular entities into clinical development each year, signaling a new wave of innovation [1]. Group 2: Pipeline and Future Prospects - Several products in the company's pipeline, including CDK4 inhibitors, B7-H4 ADC, PRMT5 inhibitors, GPC3x41BB bispecific antibodies, and CEA ADC, are expected to enter late-stage clinical development by 2026 [1]. - The company is committed to building a sustainable competitive advantage and will continue to invest in a rich and innovative R&D pipeline [1]. - The company aims to actively seek and execute business expansion opportunities that create long-term value [1].

Investment Rating - The report indicates a significant acceleration in BD (Business Development) overseas for Chinese innovative drugs, suggesting a positive investment outlook for the industry [3]. Core Insights - The number of BD projects, upfront payments, and total amounts for Chinese pharmaceutical companies significantly increased in 2025, with 165 projects, over $7.03 billion in upfront payments (up 226.8% year-on-year), and a total amount of $136.68 billion (up 192.2% year-on-year) [2][7]. - The report highlights a focus on dual antibodies (双抗), antibody-drug conjugates (ADC), GLP-1 receptor agonists (GLP1RA), and small nucleic acids as key areas for BD overseas [2][3]. Summary by Sections BD Project Growth - In 2025, the quarterly breakdown of BD projects shows 41, 43, 30, and 51 projects in Q1, Q2, Q3, and Q4 respectively, with significant year-on-year increases [2][7]. - Upfront payments for each quarter were $0.9 billion, $2.0 billion, $1.86 billion, and $2.27 billion, reflecting substantial growth rates [2][7]. Outbound BD Models - The predominant model for BD remains license in/out, while the NewCo/Co-CoJV model is gaining attention, with limited successful cases of independent commercialization [2][12][13]. - In 2025, MNCs (Multinational Corporations) accounted for $4.71 billion in upfront payments, representing 67% of total BD upfront payments [12]. Key Drug Categories - Dual antibodies saw a remarkable increase, with $3.5 billion in upfront payments (up 414.7%) and a total amount of $21.85 billion (up 361.5%) in 2025 [2][18]. - ADCs emerged as a significant focus, with $1.63 billion in upfront payments (up 676.2%) and a total amount of $21.13 billion (up 390.6%) [2][26]. - GLP-1RA projects achieved $470 million in upfront payments, marking a 109.8% increase, with a total amount of $9.6 billion [2]. NewCo Model - The NewCo model has facilitated overseas BD, with a total of $350 million in upfront payments and $13.74 billion in potential total amounts from 2023 to 2025 [17]. - In 2025, NewCo projects secured $110 million in upfront payments and $4.76 billion in potential total amounts [17]. Clinical Development Stages - Approximately 62% of molecules were in early clinical stages (pre-clinical to before Phase II) at the time of BD, indicating a trend towards early-stage licensing [8][9].

Core Viewpoint - The A-share market is experiencing fluctuations, particularly affecting the innovative drug sector, with the ETF Huatai Innovation Drug (589120) declining by 2.05% and facing a five-day losing streak, despite attracting over 7.9 million yuan in funds [1][3]. Group 1: Market Performance - The Huatai Innovation Drug ETF (589120) has seen a decline in its constituent stocks, with major players like I-Mab and Junshi Biosciences dropping over 3%, and others like BeiGene and Zai Lab falling more than 2% [3]. - The top ten constituent stocks of the ETF show a negative trend, with BeiGene-U down by 2.38% and Junshi Biosciences-U down by 3.42%, indicating a general downturn in the sector [3]. Group 2: Long-term Outlook - Despite the short-term market pressure, the long-term outlook for the innovative drug sector remains positive, with expectations of a clear beta market driven by liquidity recovery at the beginning of the year [4]. - The JPM conference highlighted the achievements of over 20 Chinese pharmaceutical companies, with projections for significant revenue growth in innovative drugs, such as a 25% increase for Heng Rui in 2026 [4]. Group 3: Business Development (BD) Trends - The BD activities in the sector are at a peak, with 17 transactions occurring since January, totaling approximately 10.15 billion USD in upfront payments, significantly exceeding market expectations [5]. - The ongoing trend of foreign companies expanding in China and the increasing flow of funds into the innovative drug sector suggest a favorable environment for growth and investment [5]. Group 4: Investment Strategy - The innovative drug sector is recommended for increased allocation, particularly in Hong Kong stocks, as the market is currently at a relative bottom, with potential for new historical highs [5]. - The ETF focuses on leading innovative drug companies, providing a high degree of exposure to the opportunities presented by the rise of Chinese innovative drugs [5].

Core Viewpoint - The Chinese innovative drug business development (BD) for overseas licensing reached a record high of $135.655 billion in total transaction value for 2025, with a significant increase in upfront payments and transaction numbers compared to previous years [1][2]. Group 1: Market Performance - The China Securities Hong Kong Stock Connect Pharmaceutical and Health Comprehensive Index (930965) showed mixed performance among its constituent stocks, with Times Angel leading at a 4.83% increase [1]. - The Hong Kong pharmaceutical ETF (159718) was quoted at 0.96 yuan [1]. Group 2: Industry Developments - The innovative drug BD overseas licensing transactions in China for 2025 totaled $135.655 billion, with upfront payments of $7 billion and 157 transactions, all marking historical highs [2]. - Notable collaborations include Rongchang Biopharma's PD-1/VEGF dual antibody RC148 receiving a $650 million upfront payment from AbbVie, and Yilian Biopharma's partnership with Roche on B7H3-targeted ADC [2]. - GSK's Bepirovirsen for chronic hepatitis B showed positive results in Phase III trials, and Arrowhead announced advancements in RNAi therapies for weight loss, validating the clinical value of small nucleic acid drugs [2]. Group 3: Investment Outlook - The 44th Annual J.P. Morgan Healthcare Conference revealed positive updates from leading global pharmaceutical companies, with significant BD transactions and improved forecasts from CXO companies like WuXi AppTec [2]. - The global pharmaceutical industry remains robust, with innovation in drugs and medical devices continuing to be the main investment theme [2].