海创药业股份有限公司 简式权益变动报告书 上市公司名称：海创药业股份有限公司 股票上市地点：上海证券交易所 股票简称：海创药业 股票代码：688302 信息披露义务人：成都盈创动力创业投资有限公司 注册地址：中国（四川）自由贸易试验区成都高新区天府大道北段 1480 号高新孵化园 12 号楼 A 座 103 号 通讯地址：中国（四川）自由贸易试验区成都高新区天府大道北段 1480 号高新孵化园 12 号楼 A 座 103 号 权益变动性质： 股份减少（持股比例下降至 5%） 签署日期：2025 年 7 月 31 日 信息披露义务人声明 一、本报告书系信息披露义务人依据《中华人民共和国公司法》《中 华人民共和国证券法》《上市公司收购管理办法》《公开发行证券的公 司信息披露内容与格式准则第 15 号——权益变动报告书》及其他相 关法律、法规和部门规章的有关规定编写。 二、信息披露义务人签署本报告书已获得必要的授权和批准，其履行 亦不违反信息披露义务人公司章程或内部规则中的任何条款，或与之 相冲突。 三、依据《中华人民共和国证券法》《上市公司收购管理办法》和《公 开发行证券的公司信息披露内容与格式准则第 15 号— ...

Core Insights - The Chinese pharmaceutical industry is experiencing a resurgence after three years of stagnation, driven by high-value licensing deals from multinational pharmaceutical companies [1][2] - There is a significant interest from overseas investors in Chinese biopharmaceutical companies, with a notable increase in licensing agreements and IPO activities [2][8] - The trend of "licensing out" Chinese drug candidates to foreign companies is becoming more common, providing Chinese firms with milestone payments and a share of sales revenue [4][6] Group 1: Market Dynamics - As of mid-July, approximately 288 companies are waiting for IPOs in Hong Kong, many of which are biopharmaceutical firms seeking to list under the 18A rule [1][8] - The Hong Kong medical sector has seen a 54% increase this year, significantly outperforming the MSCI China Index, which rose by 17% [8] - The average price-to-earnings (PE) ratio for the sector is around 30 times, placing it in the 15th percentile of its valuation range over the past five years [8] Group 2: Investment Trends - U.S. investment banks are playing a crucial role in facilitating these licensing deals and IPOs, with cornerstone investors contributing 42% of IPO financing this year, two-thirds of which comes from overseas [1][12] - The trend of U.S. pharmaceutical companies seeking to lower costs through partnerships with Chinese firms is expected to continue, especially in light of U.S. drug pricing policies [2][6] Group 3: Licensing Agreements - The number of licensing transactions from China has increased significantly, with 35 deals in 2023 and projected to reach 43 in 2024, alongside a total upfront payment of $2.957 billion in 2023 [3][6] - Notable licensing agreements include Akeso's ivonescimab, which was licensed to Summit Therapeutics for a total value of $5 billion, marking one of the largest overseas licensing deals in Chinese biopharmaceutical history [7][6] Group 4: Future Outlook - Chinese biopharmaceutical companies are increasingly able to produce globally recognized clinical data, particularly in competitive fields like oncology and immunology [2][6] - The shift from merely selling drug pipelines to achieving global commercialization is essential for the future growth of Chinese pharmaceutical companies [13][15] - There is a need for Chinese firms to enhance their innovation capabilities and international execution to compete effectively on a global scale [14][15]

Group 1 - The financing balance of the Sci-Tech Innovation Board increased by 115 million yuan compared to the previous day, marking an increase for eight consecutive trading days [1] - As of July 23, the total margin financing balance on the Sci-Tech Innovation Board reached 165.993 billion yuan, with a financing balance of 165.389 billion yuan [1] - There are 435 stocks on the Sci-Tech Innovation Board with a financing balance exceeding 100 million yuan, and 17 stocks have a financing balance over 1 billion yuan [1] Group 2 - The stock with the highest net financing purchase is Shangwei New Materials, with a latest financing balance of 26.818 million yuan, increasing by 94.9546 million yuan, and the stock rose by 19.73% on that day [2] - Other stocks with significant net purchases include Electric Wind Power and Haichuang Pharmaceutical, with net purchases of 66.8525 million yuan and 54.0988 million yuan, respectively [2] - The average increase for stocks with net purchases exceeding 10 million yuan was 0.84%, with Electric Wind Power and Shangwei New Materials leading the gains [2] Group 3 - The industry sectors favored by financing customers include pharmaceuticals, electronics, and machinery, with 13, 12, and 11 stocks respectively [2] - The average ratio of financing balance to circulating market value for stocks with significant net purchases is 4.49%, with Xinyu Ren having the highest ratio at 9.53% [2] - Other stocks with high financing balance ratios include Huahai Chengke, Yangguang Nuohuo, and Yinuosi, with ratios of 8.49%, 8.31%, and 8.00% respectively [2]

Summary of Key Points Core Viewpoint - On July 18, a total of 16 stocks on the Sci-Tech Innovation Board (STAR Market) experienced block trading, with a cumulative transaction amount of 171 million yuan, indicating active trading activity in this sector [1]. Group 1: Trading Activity - A total of 31 block trades were recorded, with a cumulative trading volume of 4.8367 million shares [1]. - The stock with the highest transaction amount was Haitan Ruisheng, which had 9 block trades totaling 38.30 million shares and a transaction amount of 38.30 million yuan [1]. - Other notable stocks in terms of transaction amounts included Guangyun Technology and Fuchuang Precision, with transaction amounts of 24.9162 million yuan and 20.9360 million yuan, respectively [1]. Group 2: Price and Discount Analysis - The stocks that experienced the highest discount rates relative to their closing prices included Qingyun Technology, Weixin Bio, and Guangyun Technology, with discount rates of 19.48%, 17.25%, and 14.95%, respectively [1]. - The average increase for the stocks involved in block trading was 2.55%, with the top gainers being Dema Technology, Qingyun Technology, and Huasheng Lithium, which saw increases of 14.74%, 7.90%, and 7.22% respectively [1]. Group 3: Institutional Participation - Among the block trades, 12 transactions involved institutional buyers or sellers, with the highest buying amounts for Haitan Ruisheng, Guangyun Technology, and Qingyun Technology, at 27.70 million yuan, 11.2276 million yuan, and 7.579 million yuan, respectively [2]. - In terms of net capital flow, six stocks saw net inflows, with Dema Technology, Huasheng Lithium, and Qingyun Technology leading with net inflows of 51.1035 million yuan, 33.284 million yuan, and 32.1246 million yuan, respectively [2].

Group 1 - The Shanghai Stock Exchange has released the "Self-Regulatory Supervision Guidelines for Companies Listed on the Sci-Tech Innovation Board No. 5 - Sci-Tech Growth Tier" [1] - The reform does not impose additional listing thresholds for unprofitable companies entering the Sci-Tech Growth Tier, allowing 32 existing unprofitable companies to enter immediately upon the guideline's implementation [1] - Newly registered unprofitable companies will enter the Sci-Tech Growth Tier from the date of their listing [1] Group 2 - Investors participating in the subscription and trading of newly registered stocks in the Sci-Tech Growth Tier must sign a "Risk Disclosure Statement for the Sci-Tech Growth Tier" [2] - The 32 existing companies that have not yet removed the "U" designation include: Zejing Pharmaceutical, Junshi Biosciences, Frontier Biotech, Qingyun Technology, Hehui Optoelectronics, Jingjin Electric, BeiGene, Dize Pharmaceutical, Maiwei Biotech, Aojie Technology, Yuhong Pharmaceutical, Shouyao Holdings, Haichuang Pharmaceutical, CloudWalk Technology, Yifang Biotech, Obsidian Optics, Mengke Pharmaceutical, Nuo Cheng Jianhua, Xinke Mobile, Xinghuan Technology, Yutai Micro, Yuntian Lifa, Tianzhihang, Qi Anxin, Hanwujin, Yihua Tong, Aifute, Huizhiwei, Xinlian Integrated, Zhixiang Jintai, Shengke Communication, and Zhongjuxin [2]

Core Viewpoint - Haichuang Pharmaceutical Co., Ltd. has launched its self-developed innovative anti-cancer drug, Dihydro-Enzalutamide soft capsule, marking a significant milestone in its development journey [2][3] Group 1: Product Launch and Clinical Significance - Dihydro-Enzalutamide soft capsule is recognized as a new type of androgen receptor antagonist (ARi) and has shown significant clinical value, particularly in treating metastatic castration-resistant prostate cancer (mCRPC) [2] - Clinical studies indicate that Dihydro-Enzalutamide significantly improves disease progression and survival rates while demonstrating excellent safety profiles, with no adverse events such as falls or seizures reported [2] - Experts suggest that Dihydro-Enzalutamide has the potential to be moved forward in treatment protocols for metastatic hormone-sensitive prostate cancer (mHSPC) [2][3] Group 2: Company Development and Future Plans - The inauguration of Haichuang Pharmaceutical's headquarters and the rapid nationwide supply of Dihydro-Enzalutamide signify a critical leap from research innovation to industrial empowerment [3] - The company focuses on developing innovative drugs for cancer and metabolic diseases and plans to accelerate the global rollout of multiple anti-cancer and metabolic disease drugs [3] - Haichuang Pharmaceutical's chairman emphasized the importance of patient-centered research and the collective effort of employees and partners in achieving this milestone [3]

Group 1 - The announcement indicates that Chengdu Yingchuang Power Venture Capital Co., Ltd. has reduced its shareholding in Haichuang Pharmaceutical Co., Ltd. from 6.28% to 6.00%, a decrease of 0.28% [1][2] - The reduction in shareholding was executed through centralized bidding transactions, with a total of 276,133 shares sold [1] - The reduction has triggered a change in equity that touches the 1% threshold, but the overall reduction plan has not yet been fully implemented [1][2] Group 2 - The announcement confirms that the equity change does not violate any prior commitments or plans made by the shareholder [1] - The company has disclosed that there are no other shareholders acting in concert with Chengdu Yingchuang Power Venture Capital Co., Ltd. [1] - The specific details of the share reduction plan were previously disclosed on May 14, 2025, in a separate announcement [1]

证券代码：688302 证券简称：海创药业 公告编号：2025-031 海创药业股份有限公司 关于持股5%以上股东权益变动触及1%刻度的提示性公告 信息披露义务人成都盈创动力创业投资有限公司保证向本公司提供的信息真实、 准确、完整，没有虚假记载、误导性陈述或重大遗漏。 本公司董事会及全体董事保证公告内容与信息披露义务人提供的信息一致。 重要内容提示： | 权益变动方向 | 比例增加□ | | 比例减少 | | --- | --- | --- | --- | | 权益变动前合计比例 | 6.28% | | | | 权益变动后合计比例 | 6.00% | | | | 本次变动是否违反已作出的承 诺、意向、计划 | 是□ | 否 | | | 是否触发强制要约收购义务 | 是□ | 否 | | 一、 信息披露义务人及其一致行动人的基本信息 1.身份类别 | | □控股股东/实际控制人及其一致行动人 | | --- | --- | | | 其他 5%以上大股东及其一致行动人 | | 投资者的身份 | □合并口径第一大股东及其一致行动人（仅适用于无控股股东、 | | | 实际控制人） | | | □其他_/_ | ...

Core Viewpoint - The successful launch of the self-developed Class 1 anti-cancer drug, Deuteroenzalutamide, by Haichuang Pharmaceutical marks a significant milestone for the company and its mission to create effective medicines for the benefit of society [1][2]. Company Overview - Haichuang Pharmaceutical is a global innovative drug company focused on cancer and metabolic diseases, with four core technology platforms: PROTAC targeted protein degradation, deuterated drug development, targeted drug discovery and validation, and translational medicine [2]. - The company has been recognized in two national "Major New Drug Creation" science and technology projects and several provincial and municipal research projects, with eight products in development and one product already launched [2]. Product Details - Deuteroenzalutamide soft capsules are designed for adult patients with metastatic castration-resistant prostate cancer who have experienced disease progression after treatment with abiraterone acetate and chemotherapy, and who have not previously received new androgen receptor inhibitors [1]. - Prostate cancer is the second most common cancer among men globally, with 1.467 million new cases reported in 2022, and the incidence in China has been rising, with 134,000 new cases in the same year [1]. Market Launch - The product received approval from the National Medical Products Administration at the end of May and began national distribution in late June, with the first prescription issued shortly after [2]. - Patients can purchase the product at major provincial capital DTP pharmacies with a doctor's prescription, indicating its significant clinical value and urgent demand [2].

Group 1 - The core point of the news is that Haichuang Pharmaceutical has launched its self-developed Class I anti-cancer drug, Deuteroenzalutamide soft capsules, which are now available nationwide for patients with metastatic castration-resistant prostate cancer [1][2] - The drug is specifically designed for adult patients who have progressed after treatment with Abiraterone acetate and chemotherapy, and who have not previously received new androgen receptor inhibitors [1] - Prostate cancer is the second most common cancer among men globally, with 1.467 million new cases reported in 2022, and China saw 134,000 new cases in the same year, indicating a rising trend in incidence [1] Group 2 - Deuteroenzalutamide soft capsules are the first innovative drug approved in China for patients with metastatic castration-resistant prostate cancer, highlighting its clinical significance and urgent demand [1][2] - The company emphasizes its commitment to ensuring the quality and stable supply of the drug while accelerating the development of its rich pipeline of innovative therapies for global patients [2] - The drug reportedly shows superior safety compared to other endocrine therapies, significantly reducing the incidence of central nervous system adverse events and common complications in elderly patients [1]