Group 1 - The recombinant protein sector experienced a decline of 1.53%, ranking among the top declines in concept sectors as of the market close on May 26 [1][2] - Within the recombinant protein sector, notable declines were observed in companies such as Sanofi (三生国健) and Yipin Pharmaceutical (一品红), while a few companies like ST Wanfang (*ST万方) and Xilong Science (西陇科学) saw increases of 3.19% and 2.76% respectively [1][2] Group 2 - The recombinant protein sector faced a net outflow of 276 million yuan, with 33 stocks experiencing net outflows, and 17 stocks seeing outflows exceeding 10 million yuan [2] - The stock with the highest net outflow was Sanofi (三生国健), which had a net outflow of approximately 46.36 million yuan, followed by companies like Betta Pharmaceuticals (贝达药业) and Xilong Science (西陇科学) with net outflows of 32.77 million yuan and 29.11 million yuan respectively [2][3] Group 3 - The top gainers in the recombinant protein sector included ST Wanfang (*ST万方) and Kaiyin Technology (凯因科技), which saw net inflows of 9.82 million yuan and 11.86 million yuan respectively [3] - Other companies with significant net inflows included Guoyao Modern (国药现代) with 14.46 million yuan and Rejing Biological (热景生物) with 35.44 million yuan [3]

Summary of Key Points Core Viewpoint - The financing balance of the Sci-Tech Innovation Board (STAR Market) has decreased, indicating a potential shift in investor sentiment and market dynamics [1]. Financing Balance - As of May 23, the total margin financing balance on the STAR Market is 1520.11 billion yuan, a decrease of 4.30 billion yuan from the previous trading day [1]. - The highest financing balance is held by SMIC at 73.74 billion yuan, followed by Cambrian and Haiguang Information with balances of 44.94 billion yuan and 32.70 billion yuan, respectively [1]. - A total of 237 stocks saw an increase in financing balance, while 346 stocks experienced a decrease [1]. - Notable increases in financing balance include Sangfor Technologies (49.76%), Hengxuan Technology (22.29%), and Zhixiang Jintai (14.98%) [1][2]. - Significant decreases were observed in Maide Medical (-14.67%), Kejie Intelligent (-12.68%), and Zhongyou Technology (-12.22%) [1]. Securities Lending Balance - The total securities lending balance on the STAR Market is 5.42 billion yuan, down by 366.74 million yuan from the previous trading day [1]. - The highest securities lending balance is held by Haiguang Information at 0.20 billion yuan, followed by Cambrian and SMIC at 0.18 billion yuan and 0.17 billion yuan, respectively [2]. - A total of 91 stocks saw an increase in securities lending balance, while 173 stocks experienced a decrease [2]. - The largest increases in securities lending balance were seen in Meidisi (2712.57%), Aladdin (797.05%), and Liyuanheng (282.84%) [2]. - The most significant decreases were in Tianzhihang (-59.93%), Sifang Optoelectronics (-50.95%), and Yihuatong (-50.71%) [2].

Market Overview - During the week of May 19 to May 23, the A-share market saw a collective decline in the three major indices, with the Shanghai Composite Index closing at 3348.37 points, down 0.57% for the week, the Shenzhen Component Index at 10132.41 points, down 0.46%, and the ChiNext Index at 2021.50 points, down 0.88% [2] - Approximately 31% of stocks experienced gains during the week, with 93 stocks rising over 15% and 18 stocks falling over 15%. The pharmaceutical, non-ferrous metals, automotive, home appliances, and coal sectors showed the highest gains, while the computer, machinery, communication, electronics, and non-bank financial sectors saw declines [2] Top Gainers - The top-performing stock was Sanofi Biotech (三生国健), which surged by 99.96% during the week, followed by Huibo Yuntong (慧博云通) with a 69.00% increase. Other notable gainers included Binhai Energy (滨海能源), Liren Lizhuang (丽人丽妆), and Haichen Pharmaceutical (海辰药业), all of which saw gains exceeding 50% [4][5] Sanofi Biotech's Performance - Sanofi Biotech operates in the biotechnology sector, focusing on innovative antibody drug research and has a mature integrated platform for research, production, and sales. The company specializes in monoclonal, bispecific, and multifunctional recombinant proteins [5] - Following the announcement of a collaboration with Pfizer for a dual-target antibody product, Sanofi Biotech's stock hit the daily limit up on May 20 and 21, with significant trading volumes. However, on May 23, the stock experienced a sharp decline, dropping over 10% during intraday trading and closing down more than 3% [6][7] Collaboration with Pfizer - On May 20, Sanofi Biotech announced a collaboration with Pfizer, granting exclusive global development, production, and commercialization rights for the dual-target antibody SSGJ-707, excluding mainland China. Pfizer will pay a non-refundable upfront fee of $1.25 billion, with potential milestone payments reaching up to $4.8 billion, plus a percentage of sales based on the product's performance in authorized regions [7] Market Trends in Innovative Drugs - The Chinese innovative drug sector is witnessing an increase in outbound licensing transactions, with 126 events recorded in 2024, involving upfront payments totaling $4.099 billion and a total deal value of $52.577 billion. The first quarter of 2025 also showed active outbound transactions, with 33 deals disclosed, exceeding $36.2 billion [8] Top Losers - The worst-performing stock for the week was Yuzhong Sanxia A (渝三峡A), which fell by 25.91%. Other significant decliners included Jitai Co. (集泰股份), Qifeng Precision (七丰精工), and Ningbo Ocean (宁波远洋), all of which experienced declines exceeding 18% [10][11]

Market Performance - On May 23, major market indices experienced fluctuations and closed lower, with A-shares trading volume reaching 1.18 trillion yuan, and over 1,100 stocks closing higher, including 52 stocks hitting the daily limit [1] - For the week, the Shanghai Composite Index fell by 0.57%, the ChiNext Index dropped by 0.88%, and the STAR Market 50 Index decreased by 1.47% [1] Individual Stock Performance - Over 1,600 stocks rose this week, with 22 stocks gaining over 30%. Notably, six stocks surged over 50%, with the largest increase being 99.96% for Sanofi [1][2] - Other significant gainers included Huibo Yuntong (301316) and Binhai Energy (000695), both of which saw weekly increases exceeding 60% [1][2] Sector Analysis - Among the stocks that rose over 30%, the pharmaceutical and biological sector had six representatives, followed by light industry manufacturing with three stocks [1] Historical Highs - On May 23, 17 stocks reached historical closing highs, with the pharmaceutical and biological, mechanical equipment, and automotive sectors showing a concentration of high performers [3][4] - The average increase for stocks reaching historical highs was 8.20%, with notable gainers including Xintiandi (301277) and Zhongzhou Special Materials (300963) [3] Institutional Activity - On May 23, ten stocks saw net purchases from institutions, with Yixin Tang (002727) leading at a net buy of 102 million yuan [5][6] - Conversely, institutions sold off stocks such as Hongchuang Holdings (002379) and Tianqimo (002510), each experiencing net sales exceeding 50 million yuan [5][6] Northbound Capital Flow - Northbound capital was present in nine stocks on the trading board, with net purchases in three stocks: Xue Ren Shares (002639), Huibo Yuntong, and Jinlongyu (002882) [7] - Yixin Tang faced the highest net sell-off from northbound capital, totaling 68.98 million yuan [7] Company Announcements - Zhongjin Gold (600489) plans to inject four companies, including Inner Mongolia Jintao, into the company to resolve competition issues [8] - Huakang Clean (301235) won a bid for a healthcare project with a contract value of 60.24 million yuan and a duration of 120 days [8] - Weier Shares (603501) intends to issue H-shares and list on the Hong Kong Stock Exchange [9] - Yunchongma (603130) plans to raise no more than 640 million yuan for a project to produce DTY silk and high-performance leather base fabric [9]

Investment Rating - The investment rating for the company is "Buy" (maintained) [3][8] Core Views - The company has strong revenue growth and is on the verge of breakthroughs in its clinical pipeline [4][5] - The recent licensing agreement with Pfizer for the PD1×VEGF dual antibody SSGJ707 is a significant milestone, with an upfront payment of $1.25 billion and potential milestone payments of up to $4.8 billion, along with double-digit royalties on net sales [4][5] - The company is expected to achieve substantial revenue growth from its main business, with key products in late-stage clinical development [5] Financial Summary - Projected revenue for 2023A is 1,014 million, with a growth rate of 23% year-over-year; expected revenue for 2025E is 1,370 million, with a growth rate of 15% [3] - Projected net profit for 2023A is 295 million, with a staggering growth rate of 498% year-over-year; expected net profit for 2025E is 300 million, reflecting a decline of 57% [3] - Earnings per share (EPS) is projected to be 0.48 for 2023A and 0.49 for 2025E [3] Clinical Pipeline and Market Potential - The company has four mid-to-late stage clinical assets, each expected to generate over 1 billion in revenue, with the IL17 monoclonal antibody anticipated to be commercialized in 2025 [5] - The IL1β monoclonal antibody is expected to submit its NDA in 2025, targeting a large patient population with limited treatment options [5] Valuation Metrics - The company is projected to have a P/E ratio of 116.5 for 2025E and a P/B ratio of 6.1 for the same year [3] - The net asset return rate (ROE) is expected to be 5% for 2025E, with a net profit margin of 21.5% [7]

Core Insights - The company has signed a licensing agreement with Pfizer for the PD1×VEGF dual antibody SSGJ707, granting Pfizer global rights (excluding mainland China) for development, production, and commercialization, with an upfront payment of $1.25 billion and potential milestone payments of up to $4.8 billion [1] - The PD1×VEGF dual antibody market is validated, with significant clinical results from competitors enhancing expectations for IO dual antibodies as alternatives to PD1 [2] - The company is expected to achieve substantial revenue growth from its main business, with several late-stage clinical assets projected to generate significant sales [2] Company Developments - The upfront payment of $1.25 billion is the largest for a Chinese innovative drug license out, setting a new record [1] - The company retains a 30% stake in the SSGJ707 project, indicating a strong interest in its future success [1] - The company is positioned as a leader in the domestic autoimmune field, with robust R&D capabilities and a pipeline of clinical assets nearing commercialization [3] Financial Projections - Revenue forecasts for 2025-2027 are projected at 1.37 billion, 1.57 billion, and 1.94 billion yuan, respectively, with net profits expected to be 300 million, 333 million, and 416 million yuan [3] - The company is anticipated to commercialize its IL17 monoclonal antibody by 2025 and submit an NDA for its IL1β monoclonal antibody in the same year, targeting a market with limited competition [2][3]

Group 1 - The stock of Sanofi Guojian (688336) experienced a significant drop of over 10% during trading on the 23rd, following a continuous rise of 100% over the previous four trading days [1] - The company issued a risk warning on May 22, indicating the potential for irrational speculation and a market correction due to the substantial increase in stock price [1] - The trading volume exceeded 530 million yuan, reflecting heightened market activity [1] Group 2 - The company, along with its affiliates, granted Pfizer Inc. exclusive rights for the development, production, and commercialization of a dual-targeting antibody product (Project 707) outside of mainland China [2] - The revenue sharing from this licensing agreement is set at 30% for Sanofi Guojian and 70% for Shenyang Sanofi, based on prior R&D investments and asset ownership [2] - The agreement requires approval from the company's shareholders and antitrust regulatory bodies in the U.S. and other jurisdictions, introducing uncertainty regarding its effectiveness [2] Group 3 - The development, registration, and sale of the licensed product in the designated regions are subject to regulatory approvals, which are inherently uncertain due to the lengthy nature of new drug development [3] - Milestone payments tied to clinical and regulatory events are contingent upon the successful completion of specified conditions, adding another layer of uncertainty [3] - Sales milestone payments and royalties are dependent on market factors such as demand, competition, and sales channels, which may affect the actual revenue received by the licensing parties [3]

上述融资客大手笔净买入的科创板股中，从最新融资余额占流通市值比例看，算术平均值为4.39%，融 资余额占比最高的是容百科技，该股最新融资余额为11.71亿元，占流通市值的比例为13.26%，融资余 额占比较高的还有汇成股份、国科军工、臻镭科技，占比分别为11.45%、8.00%、7.74%。（数据宝） | 代码 | 简称 | 最新融资余额（万 | 环比增减金额（万 | 环比增减 | 当日涨跌幅 | | --- | --- | --- | --- | --- | --- | | | | 元） | 元） | （%） | （%） | | 688336 | 三生国 健 | 15511.65 | 8774.89 | 130.25 | 20.00 | | 688400 | 凌云光 | 41292.90 | 5406.04 | 15.06 | 5.74 | | 688018 | 乐鑫科 技 | 57644.28 | 3593.83 | 6.65 | 0.45 | | 688049 | 炬芯科 技 | 31230.41 | 2237.08 | 7.72 | 2.70 | | 688331 | 荣昌生 物 | 20367.14 ...

Group 1: Stock Performance - Yibin Paper (600793.SH) has experienced a significant short-term stock price increase and a substantial rise in trading volume [1] - Sanofi Health (688336.SH) has seen a cumulative stock price increase of over 100% since May 19, 2025, indicating potential irrational speculation and a possible correction [1] - Laisun Tongling (603900.SH) has shown a notable short-term increase in stock price and turnover rate, exceeding most companies in the industry [1] Group 2: Project Investments - Youyan Powder Materials (688456.SH) plans to establish a subsidiary to invest in an additive manufacturing metal powder materials industrial base [1] - Suqian Agricultural Development (601952.SH) intends to initiate a project for the construction of a 14,000-ton grain storage facility [1] Group 3: Contract Awards - Zhongnan Media (601098.SH) has signed a procurement contract through its wholly-owned subsidiary [1] Group 4: Operating Data - China Power Construction (601669.SH) reported a total new contract amount of 386.49 billion yuan from January to April, a year-on-year decrease of 4.9% [1] - China Chemical (601117.SH) recorded a total contract amount of 123.017 billion yuan from January to April [1] Group 5: Equity Acquisitions - Health元 (600380.SH) announced that its controlling subsidiary, Lizhu Group, plans to acquire equity in Vietnam's IMP company [1] Group 6: Share Buybacks - Geling Deep Vision (688207.SH) has completed a buyback of 1.29% of its shares [1] Group 7: Shareholding Changes - Yiwan Yichuang (300792.SZ) shareholders Zhang Fan and director Lu Hualiang plan to reduce their holdings by up to 3.02% [1] - Daqian Ecology (603955.SH) has announced that Xinhua Publishing Group intends to reduce its holdings by up to 3% [1] - Hongli Zhihui (300219.SZ) controlling shareholder plans to increase holdings by 25 million to 50 million yuan [1] - Sanfeng Environment (601827.SH) controlling shareholder intends to increase holdings by 150 million to 300 million yuan [1] - Chengdu Xian Dao (688222.SH) plans to increase holdings by 25 million to 50 million yuan [1] Group 8: Strategic Partnerships - Tiantie Technology (300587.SZ) has signed a strategic cooperation framework agreement with Xinjie Energy [2]

Market Overview - On May 22, major market indices collectively retreated, with a total trading volume of 1.14 trillion yuan, a decrease of 74.7 billion yuan compared to the previous day [1] - The number of stocks that rose was less than 900, while nearly 4,500 stocks declined, with 51 stocks hitting the daily limit up and 18 stocks hitting the daily limit down [1] - Industry sectors experienced widespread declines, with beauty care, social services, and basic chemicals dropping over 1.5%, while only banking, media, and household appliances saw gains [1] Stockholder Changes - A total of 365 stocks reported changes in shareholder numbers as of May 20, with 170 stocks seeing a decrease in shareholder accounts compared to May 10 [2] - The stock with the largest decline in shareholder accounts was Shanshui Bide, which saw a 33.18% drop to 4,909 accounts [2] - Ji Qi Co., Ltd. also reported a significant decrease of 15.50% in shareholder accounts, totaling 17,413 [2] Institutional Trading - On May 22, 10 stocks saw net purchases from institutions, with Tianqi Mould and Aerospace Nanhu receiving over 50 million yuan in net buying [3] - The stock San Sheng Guo Jian faced the largest net selling from institutions, amounting to 151 million yuan, following a 100% increase in price over four consecutive days of hitting the daily limit up [3][4] - The institutional trading data indicates a trend of increasing net selling for San Sheng Guo Jian over three consecutive days [3] Northbound Capital Flow - On May 22, seven stocks experienced net buying from northbound funds, with San Sheng Guo Jian leading at 35.03 million yuan [5] - The stock Lianyun Port saw the highest net selling from northbound funds, totaling 51.66 million yuan [5] Important Announcements - Chao Da Equipment was selected for the 2025 Jiangsu Province Advanced Intelligent Factory list for its smart collaborative manufacturing project [6] - Bo Rui Pharmaceutical received a drug registration certificate for Iopamidol injection from the National Medical Products Administration [6] - Chengdu Xian Dao's shareholder plans to increase its stake in the company by 25 to 50 million yuan without a set price range [6] - Xinhua Insurance signed a contract to establish a private equity fund with a total scale of 20 billion yuan, contributing 10 billion yuan [6] - Zhongnan Media's subsidiary signed a government procurement contract worth 1.009 billion yuan, positively impacting the company's operations in 2025 [6]