Summary of the Conference Call for Aidi Pharmaceutical Company and Industry Overview - Aidi Pharmaceutical is actively engaged in the research and development of new generation non-nucleoside reverse transcriptase inhibitors, Anovelin, and other innovative products in the field of HIV treatment [2][3] - The company is also developing a domestic innovative lipase inhibitor, SC07, and is focusing on long-acting risk prevention products in the anti-infection field to enrich its product line [2][3] Key Points and Arguments Challenges in HIV Treatment - HIV treatment faces two main challenges: the virus reservoir and high mutation rates, complicating vaccine development [4][5] - The cocktail therapy introduced by Chinese scientist He Dayi in 1996 significantly reduced drug resistance, transforming AIDS from a terminal illness to a manageable disease [6] Drug Development and Efficacy - Aidi Pharmaceutical's Anovelin and similar products demonstrate high efficacy, good immune reconstitution ability, safety, low resistance risk, and good adherence, achieving a 95% efficacy rate after 144 weeks of continuous use [4][23] - The HARVIA drug development has seen a significant increase in drug activity levels, with concentrations decreasing from micromolar to picomolar levels, enhancing efficacy and reducing patient dosage [9] Treatment Guidelines and Recommendations - Current international and domestic HIV treatment guidelines recommend a combination therapy of backbone drugs (NRTIs) and core drugs (NNRTIs or integrase inhibitors), with Anovelin maintaining an efficacy rate of 95% [17][31] Long-term Treatment Considerations - Long-term HIV treatment is recommended to be taken once daily, closely related to the drug's half-life, with the ideal half-life being around 24 hours [11][12] - The relationship between drug concentration and therapeutic effect is crucial, with the goal of maintaining drug levels between the minimum effective concentration and toxic reaction concentration [10] New Product Development - Multiple new HIV products are under development, including non-nucleoside reverse transcriptase inhibitors IC00 and integrase inhibitors 017, with ongoing clinical trials for various patient populations [18][39] - Aidi Pharmaceutical is also advancing two candidate vaccines, SC085 and SC077, currently in preclinical stages, with SC085 expected to enter clinical trials soon [19][42] Market Position and Challenges - Aidi Pharmaceutical faces challenges in brand recognition compared to international brands, particularly in market promotion [53] - The company is focusing on enhancing hospital output and leveraging long-term data to build confidence among healthcare providers and patients [54][56] Future Directions - The company plans to focus on the development of reverse transcriptase inhibitors and integrase inhibitors over the next 3 to 5 years, with an emphasis on long-acting preventive HRV control drugs [46][57] - Aidi Pharmaceutical aims to expand its international presence, particularly in high-prevalence regions like Africa, while navigating the complexities of local market dynamics [48][50] Additional Important Insights - The importance of long-term data for Anovelin is highlighted, showing sustained efficacy and safety, which is crucial for gaining physician and patient confidence [54][56] - The development of generic drugs is not only aimed at providing affordable alternatives but also at filling market gaps, with significant resources allocated to ensure better treatment options for Chinese patients [21]

民生证券股份有限公司 关于江苏艾迪药业股份有限公司 重大资产购买 之 2024 年度持续督导核查意见 独立财务顾问 二〇二五年五月 1 释 义 在本核查意见中，除非文义载明，以下简称具有如下含义： | 艾迪药业、公司、本公 | | 江苏艾迪药业股份有限公司 | | --- | --- | --- | | 司、股份公司、上市公 | 指 | | | 司、受让方 | | | | 标的公司、南大药业 | 指 | 南京南大药业有限责任公司 | | 华西银峰 | 指 | 华西银峰投资有限责任公司，南大药业原股东 | | 湖南可成 | 指 | 湖南可成创新投资合伙企业（有限合伙），南大药业 | | | | 原股东 | | 本次交易 | 指 | 上市公司通过支付现金购买华西银峰、湖南可成、 许志怀、陈雷、姚繁狄合计持有的南大药业31.161% | | | | 的股权 | | 《证券法》 | 指 | 《中华人民共和国证券法》 | | 《公司法》 | 指 | 《中华人民共和国公司法》 | | 《重组管理办法》 | 指 | 《上市公司重大资产重组管理办法》 | | 本协议 | 指 | 《关于南京南大药业有限责任公司之股权转让协 | ...

江苏艾迪药业股份有限公司 2024 年年度股东会会议资料 二○二五年五月 1 江苏艾迪药业股份有限公司 2024 年年度股东会会议资料目录 二、出席会议的股东及股东代理人须在会议召开前 30 分钟到会议现场办 理签到手续，并按规定出示证券账户卡、身份证明文件或企业营业执照复印 件（加盖公章）、授权委托书等，经验证后领取会议资料，方可出席会议。会 议开始后，由会议主持人宣布现场出席会议的股东人数及其所持有表决权的 股份总数，在此之后进入的股东无权参与现场投票表决。 三、为保证股东会的严肃性和正常秩序，切实维护与会股东的合法权益， 除出席会议的股东及股东代理人、公司董事、监事、高级管理人员、公司聘 任律师及董事会邀请的人员外，公司有权依法拒绝其他人员进入会场。 四、为保证会场秩序，进入会场后，请关闭手机或调至振动状态。谢绝 个人录音、拍照及录像。场内请勿大声喧哗。对干扰会议正常秩序、侵犯其 他股东合法权益的行为，工作人员有权予以制止，并及时报告有关部门查处。 五、股东参加股东会依法享有发言权、质询权、表决权等权利。股东要 求在股东会上发言或就相关问题提出质询的，应事先在股东会签到处进行登 记。股东不得无故中断会议 ...

Group 1 - Mingyu Asset recently conducted research on a listed company, Aidi Pharmaceutical, focusing on its commercialization strategy for a new class of HIV drugs [1] - Aidi Pharmaceutical has established a marketing approach centered on "medical leadership, market pull, and sales implementation," marking the beginning of its new commercialization journey [1] - The company is developing long-acting series drugs for HIV treatment and has completed pre-toxicology trials for a new molecule [1] Group 2 - Aidi Pharmaceutical has integrated its strategy in the field of human-derived proteins, covering the supply of raw materials, production of active pharmaceutical ingredients, and the manufacturing of urokinase preparations [1] - The company has launched two phases of a restricted stock incentive plan, which will include specific performance assessment indicators based on job contributions and value [1] Group 3 - Mingyu Asset Management, established in September 2009, focuses on secondary market stock investments and has a registered capital of 20 million yuan [2] - The founder of Mingyu Asset, Wang Yicong, has 27 years of experience in the securities industry and is known for strong market timing abilities [2] - The firm has won multiple industry awards, including seven Golden Bull trophies over five consecutive years, highlighting its reputation in the investment community [2]

Investment Rating - The report maintains a "Buy" rating for the company, indicating an expected relative return of over 20% within the next six months [5][16]. Core Insights - The company reported a steady growth in HIV revenue, with a first-quarter revenue of 198 million yuan in 2025, representing a 113% year-on-year increase, and a net profit of 16 million yuan, marking a turnaround from losses [1][4]. - The company's product, AINOMITE tablets, has advantages in convenience and is expected to continue gaining market share, with first-quarter revenue of 62.72 million yuan in 2025, a 76% increase year-on-year [2][4]. - The company is deeply engaged in the HIV treatment sector, with two key products in development, including the integrase inhibitor ACC017, which is expected to enter Phase III clinical trials this year [3][4]. Financial Performance - The company achieved a revenue of 418 million yuan in 2024, a 1.57% increase year-on-year, but reported a net loss of 141 million yuan, an increase in losses by 85.63% [1][4]. - The projected revenue for 2025 has been revised down from 808 million yuan to 732 million yuan, with expected revenues of 1.022 billion yuan and 1.235 billion yuan for 2026 and 2027, respectively [4][9]. - The forecasted net profit for 2025 and 2026 has been adjusted to -10 million yuan and 37 million yuan, respectively, with an anticipated net profit of 79 million yuan in 2027 [4][9]. Market Position - The company is positioned as a significant player in the HIV treatment market, with its AINOMITE tablets being the first domestic three-in-one single tablet formulation with independent intellectual property rights [2][3]. - The competitive landscape is noted to be intense, which may impact the company's market performance [4].

Investment Rating - The investment rating for the company is "Buy" and it is maintained [5][16]. Core Views - The company reported a steady growth in HIV revenue, with a first-quarter revenue of 198 million yuan in 2025, representing a year-on-year increase of 113% [1]. - The company’s HIV product, AINOMITE tablets, has advantages in convenience and is expected to continue to grow in sales in 2025, with first-quarter revenue of 62.72 million yuan, a 76% increase year-on-year [2]. - The company has a deep layout in the HIV drug field, with two key products under development, including the integrase inhibitor ACC017, which is expected to enter Phase III clinical trials this year [3]. Financial Performance - In 2024, the company achieved an operating income of 418 million yuan, a year-on-year increase of 1.57%, while the net profit attributable to the parent company was -141 million yuan, a year-on-year increase in loss of 85.63% [1]. - The expected operating income for 2025 has been revised down from 808 million yuan to 732 million yuan, with projected revenues of 1.022 billion yuan and 1.235 billion yuan for 2026 and 2027, respectively [4]. - The net profit attributable to the parent company for 2025-2026 has been adjusted from 16 million yuan and 84 million yuan to -10 million yuan and 37 million yuan, respectively, with an expected net profit of 79 million yuan in 2027 [4]. Market Position - The company’s AINOMITE tablets are the first domestic three-in-one single-tablet combination with independent intellectual property rights, showing better cardiovascular safety compared to competitors [2]. - The company is positioned in a competitive market for HIV treatments, with ongoing research and development efforts aimed at innovative long-acting drugs [3].

Group 1 - Eddie Pharmaceuticals (688488.SH) reported its Q1 2025 results on April 30, 2025, with 15 institutional investors holding a total of 226 million shares, representing 53.78% of the company's total equity [1] - The top ten institutional investors collectively hold 52.67% of the shares, with a decrease of 1.14 percentage points compared to the previous quarter [1] Group 2 - In the public fund sector, four funds reduced their holdings compared to the previous quarter, with a total decrease of 0.91% [2] - One new public fund disclosed its holdings during this period, namely Hongtu Innovation Healthcare Stock [2] - A total of 93 public funds did not disclose their holdings this quarter, including several notable funds such as GF Healthcare Stock A and Bank of China Healthcare Mixed A [2]

医药生物/生物制品 艾迪药业（688488.SH） 2025Q1 业绩扭亏为盈，抗艾新药有望快速放量 2025 年 04 月 30 日 投资评级：买入（维持） 相关研究报告 《2024 年公司收入稳健增长，抗艾新 药持续放量—公司信息更新报告》 -2025.3.3 《抗艾新药持续放量，收购南大药业 打造第二曲线—公司信息更新报告》 -2024.11.3 《新患数量稳健提升，抗艾新药持续 放量—公司信息更新报告》-2024.8.26 | 余汝意（分析师） | 刘艺（联系人） | | --- | --- | | yuruyi@kysec.cn | liuyi1@kysec.cn | | 证书编号：S0790523070002 | 证书编号：S0790124070022 | | 日期 | 2025/4/29 | | --- | --- | | 当前股价(元) | 11.36 | | 一年最高最低(元) | 17.33/6.58 | | 总市值(亿元) | 47.80 | | 流通市值(亿元) | 47.80 | | 总股本(亿股) | 4.21 | | 流通股本(亿股) | 4.21 | | 近 3 个月换手率(% ...

证券代码：688488 证券简称：艾迪药业 公告编号：2025-018 江苏艾迪药业股份有限公司 关于公司 2024 年度利润分配预案的公告 本公司董事会及全体董事保证本公告内容不存在任何虚假记载、误导性陈述或 者重大遗漏，并对其内容的真实性、准确性和完整性依法承担法律责任。 重要内容提示： 2024 年度利润分配预案为：拟不实施利润分配。 二、2024 年度拟不进行利润分配的情况说明 根据《公司章程》第一百六十条第（三）项的规定，公司拟实施现金分红时应 满足的条件为"公司每个会计年度以现金方式分配的利润不少于当年度实现的可分 配利润（指公司弥补亏损、扣除法定公积金后所余税后利润）的百分之十，最近三 年以现金方式累计分配的利润不少于最近三年实现的年均可分配利润的百分之三 十。"因 2024 年度可分配利润为负值，因此 2024 年度拟不实施现金分红。 根据《上海证券交易所科创板上市公司自律监管指引第 1 号——规范运作》《公 司章程》等有关规定，鉴于 2024 年度公司实现归属于母公司所有者的净利润为负， 母公司累计未分配利润及合并报表累计未分配利润为负，同时考虑到公司日常经营、 研发投入及创新药商业化等需要 ...

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