Core Insights - The cell immunotherapy sector saw a 2.42% increase, ranking 6th among concept sectors, with 42 stocks rising, led by Ruizhi Pharmaceutical with a 20% limit-up [1] - Major inflows were observed in the cell immunotherapy sector, with a net outflow of 239 million yuan, while 31 stocks experienced net inflows, with Ruizhi Pharmaceutical leading at 235 million yuan [1][2] Group 1: Sector Performance - The cell immunotherapy concept had a 2.42% increase, with notable performers including Ruizhi Pharmaceutical (20.02%), Sanyuan Gene (20.76%), and Haitai Biological (15.28%) [1] - The sector's performance was contrasted by declines in stocks like Saili Medical (-4.62%), Zexin Pharmaceutical (-3.47%), and Xue Rong Biological (-2.39%) [1] Group 2: Fund Flow Analysis - Ruizhi Pharmaceutical, Jinyu Medical, and Chengda Pharmaceutical had the highest net inflow ratios at 15.31%, 10.34%, and 9.67% respectively [2] - The top stocks by net inflow included Ruizhi Pharmaceutical (234.82 million yuan), Hanyu Pharmaceutical (73.39 million yuan), and Jiu Zhitang (49.52 million yuan) [2][3] Group 3: Stock Performance - Stocks like Haitai Biological and Yuedong Pharmaceutical showed significant gains, with Haitai Biological rising by 15.28% and Yuedong Pharmaceutical by 9.96% [1][4] - Conversely, stocks such as Saili Medical and Zexin Pharmaceutical faced notable declines, with Saili Medical down by 4.62% and Zexin Pharmaceutical by 3.47% [5]

证券代码：000597 证券简称：东北制药 公告编号：2025-056 东北制药集团股份有限公司 关于聘任董事会秘书的公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假记载、 误导性陈述或重大遗漏。 东北制药集团股份有限公司（以下简称"公司"）于2025年7月28日召开第十届 董事会第四次会议，审议通过了《关于聘任董事会秘书的议案》。具体情况如下： 传真：024-25806400 经公司董事长周凯先生提名，公司董事会提名委员会审核，公司董事会同意聘 任宋立志先生为董事会秘书（简历详见附件），任期自本次董事会审议通过之日起 至第十届董事会届满之日止。同时，公司董事长周凯先生不再代行董事会秘书职责。 宋立志先生已取得深圳证券交易所颁发的《董事会秘书资格证书》，熟悉董事 会秘书履职相关的法律法规，具备与岗位相应的专业能力，符合《中华人民共和国 公司法》《深圳证券交易所股票上市规则》等法律法规及《公司章程》的规定。 联系电话：024-25806963 电子邮箱：dshbgs@nepharm.com.cn 联系地址：沈阳经济技术开发区昆明湖街8号 宋立志先生的联系方式如下： 1 附件： 董事会秘书 ...

证券代码：000597 证券简称：东北制药 公告编号：2025-055 第十届董事会第四次会议决议公告 东北制药集团股份有限公司 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假记载、 误导性陈述或重大遗漏。 一、董事会会议召开情况 1.东北制药集团股份有限公司（以下简称"公司"）第十届董事会第四次会 议于 2025 年 7 月 21 日发出会议通知，于 2025 年 7 月 28 日以通讯表决的方式召 开。 2.会议应参加董事 11 人，实际参加董事 11 人。 3.本次会议的召集、召开和表决程序符合有关法律、行政法规、部门规章、 规范性文件和《东北制药集团股份有限公司章程》的规定，会议形成的决议合法 有效。 二、董事会会议审议情况 会议审议并以记名投票表决方式通过以下议案： 议案：关于聘任董事会秘书的议案 具体内容详见公司于同日披露于巨潮资讯网的《东北制药集团股份有限公司 关于聘任董事会秘书的公告》（公告编号：2025-056） 表决结果：同意 11 票，反对 0 票，弃权 0 票。 本议案在提交董事会审议前，已通过董事会提名委员会审核。 三、备查文件 东北制药集团股份有限公司第十届董事 ...

Core Viewpoint - Northeast Pharmaceutical has significantly improved its operational quality and company value since its mixed-ownership reform in 2018, driven by market-oriented strategies and innovation in the pharmaceutical industry [1][2]. Group 1: Mixed-Ownership Reform - The introduction of Liaoning Fangda Group as a strategic investor in 2018 has led to a clearer market position and a more scientific corporate governance structure, effectively addressing the issues of market-oriented operation [2]. - The company has increased its R&D investment and adopted a three-pronged approach to its R&D strategy, focusing on independent development, joint development, and project introduction [2][3]. - Northeast Pharmaceutical has established a biological research base in Shanghai and successfully acquired Dingcheng Peptide Source, enhancing its capabilities in cancer cell therapy [2]. Group 2: Talent and Management Innovation - The company has initiated a large-scale recruitment of master's and doctoral talents to strengthen its research capabilities, aiming to create a competitive edge in the biopharmaceutical sector [3]. - A new management model has been implemented, allowing for efficient communication of employee suggestions to decision-makers, resulting in numerous improvements and economic benefits [3][4]. - The company has established a robust incentive mechanism, rewarding employees for cost-saving and innovative suggestions, which has fostered a culture of engagement and productivity [3][4]. Group 3: Quality Control and Production Efficiency - Northeast Pharmaceutical has maintained a strong commitment to product quality, successfully passing a rigorous FDA inspection with zero defects, which enhances its reputation in international markets [5]. - The company has implemented advanced information technology to innovate its production processes and management models, improving efficiency and product quality [6]. - The focus on quality control and the introduction of smart production lines have led to higher production efficiency and lower costs, increasing the competitiveness of the company's products [6].

Core Viewpoint - The company, Northeast Pharmaceutical Group Co., Ltd., has received notification from its controlling shareholder, Liaoning Fangda Group Industrial Co., Ltd., regarding the pledge of a portion of its shares [2]. Summary by Relevant Sections Share Pledge Details - Liaoning Fangda Group pledged 48,740,000 shares, which accounts for 14.81% of its total holdings and 3.42% of the company's total share capital [2]. - The pledge is not part of a controlling shareholder's actions and does not affect the company's overall shareholding structure [2]. Cumulative Pledge Situation - Before this pledge, the total number of shares pledged by Liaoning Fangda Group was 329,068,713, representing 23.06% of its holdings [5]. - After the current pledge, the total pledged shares will increase to 285,062,211, which is 42.42% of the total shares held by the group [5]. - The company will continue to monitor the share pledge situation and will disclose relevant information in accordance with regulations [5].

东北制药集团股份有限公司 证券代码：000597 证券简称：东北制药 公告编号：2025-054 一、股东本次质押基本情况 1.本次方大集团股份质押与公司生产经营相关需求无关。 2.本次质押股份不涉及重大资产重组等业绩补偿义务。 | | | | | | | | 已质押股份情况 | | 未质押股份情况 | | | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | --- | | | | 持股 | 本次质押前 | 本次质押后质 | 占其所 | 占公司 | 已质押 | | | | | 股东 | 持股数量 | | | | 持股份 | 总股本 | | 占已 | 未质押 | 占未 | | | | 比例 | 质押股份数 | 押股份数量 | | | 股份限 | 质押 | 股份限 | 质押 | | 名称 | （股） | （%） | 量（股） | （股） | 比例 | 比例 | 售和冻 | | | | | | | | | | （%） | （%） | | 股份 | 售和冻 | 股份 | | | | | | | | | 结、标 | | | | | | | | | ...

Group 1 - The cell immunotherapy concept index rose by 0.56%, ranking fourth among concept sectors, with 25 stocks increasing in value [1] - Notable gainers included Nanjing Xinbai, Saily Medical, and *ST Biology, which reached their daily limit up, with increases of 8.61%, 7.86%, and 7.18% respectively [1] - The largest declines were seen in Chengda Pharmaceutical, Hainan Haiyao, and Jiuzhitang, with decreases of 13.12%, 6.31%, and 5.07% respectively [1] Group 2 - The cell immunotherapy sector experienced a net outflow of 213 million yuan in main funds, with 27 stocks seeing net inflows [2] - Saily Medical led the net inflow with 336 million yuan, followed by Zhaoyan New Drug, Nanjing Xinbai, and Northeast Pharmaceutical with net inflows of 203 million yuan, 111 million yuan, and 77.41 million yuan respectively [2] - The net inflow ratios for Nanjing Xinbai, Saily Medical, and Zhaoyan New Drug were 43.57%, 21.82%, and 12.72% respectively [3] Group 3 - The cell immunotherapy sector's performance was highlighted by the significant trading volumes and turnover rates of leading stocks, indicating strong investor interest [3][4] - Stocks like Saily Medical and Nanjing Xinbai showed high turnover rates of 28.92% and 2.96% respectively, reflecting active trading [3] - The overall market sentiment in the cell immunotherapy sector remains positive despite some individual stock declines [2][6]

Policy Developments - The National Health Commission issued a work plan for the integration of medical and elderly care services, promoting the establishment of national demonstration counties and institutions [2] - The criteria for creating demonstration institutions include operating for over 5 years, a bed occupancy rate of at least 65% in the last 2 years, and over 65% of residents being elderly individuals with disabilities or dementia [2] - The plan emphasizes comprehensive health assessments for the elderly, early intervention for age-related diseases, and the use of traditional Chinese medicine and information technology to enhance service quality [2] Drug and Device Approvals - Humanwell Healthcare announced that its subsidiary received a drug registration certificate for the transdermal patch for treating mild to moderate Alzheimer's disease, with a total R&D investment of approximately RMB 19 million [4] - Kehua Bio received medical device registration certificates for two nucleic acid testing kits, valid until July 16, 2030 [5] Financial Reports - Wohua Pharmaceutical reported a 303.16% year-on-year increase in net profit for the first half of the year, with revenue of RMB 425 million, a 7.64% increase [7] Capital Market Activities - Xiangsheng Medical signed an agreement with the Gates Foundation for the joint development and promotion of innovative obstetric and breast ultrasound screening devices, receiving project funding of USD 2.1 million [9] - Sanofi announced a deal to acquire Vicebio for up to USD 1.6 billion, including an upfront payment of USD 1.15 billion and milestone payments of USD 450 million [11] Industry Developments - The National Medical Insurance Administration reported that from January to June 2025, there were 200 million instances of personal account pooling in employee medical insurance, amounting to RMB 26.177 billion [13]

Core Viewpoint - Northeast Pharmaceutical has transformed from a state-owned enterprise into a modern pharmaceutical company under the mixed-ownership reform led by the Liaoning Fangda Group, focusing on both public welfare and global pharmaceutical innovation [1][2]. Group 1: Commitment to Public Welfare - Northeast Pharmaceutical produces affordable medications, such as paracetamol tablets priced at 2 yuan per pack and vitamin C tablets at 1.60 yuan per bottle, ensuring consistent supply and earning consumer trust [1]. - The company has invested nearly 300 million yuan in social donations over the past seven years for industrial poverty alleviation, rural revitalization, and pandemic relief [1]. Group 2: Quality Assurance and International Standards - The company successfully passed a stringent FDA inspection with a "zero defect" rating, demonstrating its commitment to high-quality production and gaining access to international markets [1]. Group 3: Management and Operational Efficiency - Northeast Pharmaceutical has implemented a suggestion system that encourages employees to propose solutions, resulting in over 1,345 suggestions received in the past year, with more than 900 being adopted [3]. - The company has streamlined its operations, with daily production and sales meetings completed efficiently in 30 minutes, reflecting the effective management practices of the Fangda Group [3]. Group 4: Innovation and R&D Strategy - Following the mixed-ownership reform, the company has increased its R&D investment and established a biological research base in Shanghai, acquiring Beijing Dingcheng Peptide Source Biotechnology Co., Ltd. to enhance its capabilities [4]. - Northeast Pharmaceutical has developed a robust R&D system focusing on cutting-edge technologies like TCR-T and CAR-T, with over ten cell immunotherapy products targeting various cancers [4].

证券代码：000597 证券简称：东北制药 公告编号：2025-053 东北制药集团股份有限公司 关于公司董事会秘书辞职的公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假记载、 误导性陈述或重大遗漏。 特此公告。 东北制药集团股份有限公司董事会 传真：024-25806400 电子邮箱：dshbgs@nepharm.com.cn 联系地址：沈阳经济技术开发区昆明湖街8号 东北制药集团股份有限公司（以下简称"公司"）董事会于近日收到公司董事 会秘书阎小佳先生的书面辞职报告。由于个人原因，阎小佳先生申请辞去公司董事 会秘书职务，其辞职后将不在公司及公司下属企业任职。根据《深圳证券交易所股 票上市规则》等有关规定，该辞职报告自送达董事会时生效。 截至本公告披露日，阎小佳先生未持有公司股份，不存在应当履行而未履行或 仍在履行中的承诺事项。阎小佳先生在担任公司董事会秘书期间，勤勉尽责，恪尽 职守，公司及董事会对阎小佳先生在任职期间所做出的贡献表示衷心感谢！ 根据《深圳证券交易所股票上市规则》等相关规定，公司将尽快聘任董事会秘 书，新任董事会秘书履职前，暂由公司董事长周凯先生代行董事会秘书职责。 ...