Market Overview - On September 12, the Chinese medicine sector declined by 0.56%, with Qianjin Pharmaceutical leading the drop [1] - The Shanghai Composite Index closed at 3883.69, up 0.22%, while the Shenzhen Component Index closed at 12996.38, up 0.13% [1] Stock Performance - Notable gainers in the Chinese medicine sector included: - Wanbangde (002082) with a closing price of 10.25, up 3.64% on a trading volume of 228,400 shares and a turnover of 230 million yuan [1] - Jiuzhitang (000989) closed at 10.91, up 2.83% with a trading volume of 212,800 shares and a turnover of 233 million yuan [1] - Kangmei Pharmaceutical (600518) closed at 2.07, up 2.48% with a trading volume of 4,321,600 shares and a turnover of 891 million yuan [1] - Conversely, significant decliners included: - Qianjin Pharmaceutical (600479) closed at 11.05, down 1.60% with a trading volume of 115,400 shares and a turnover of 128 million yuan [2] - Jianmin Group (600976) closed at 42.45, down 1.12% with a trading volume of 18,100 shares and a turnover of 77 million yuan [2] - Hansen Pharmaceutical (002412) closed at 6.74, down 1.03% with a trading volume of 133,300 shares and a turnover of 89 million yuan [2] Capital Flow - The Chinese medicine sector experienced a net outflow of 642 million yuan from institutional investors, while retail investors saw a net inflow of 448 million yuan [2] - The following stocks had notable capital flows: - Kangmei Pharmaceutical had a net inflow of 65.97 million yuan from institutional investors, but a net outflow of 14.99 million yuan from retail investors [3] - Jiuzhitang saw a net inflow of 33.21 million yuan from institutional investors, with a net outflow of 16.66 million yuan from retail investors [3] - Wanbangde had a net inflow of 30.43 million yuan from institutional investors, but also faced a net outflow of 19.37 million yuan from retail investors [3]

章程附件 九芝堂股份有限公司 股东会议事规则 （2025 年修订） (2001 年 4 月 27 日 2000 年年度股东大会通过； 2001 年 12 月 27 日 2000 年第 2 次临时股东大会修正； 2002 年 5 月 9 日 2002 年年度股东大会修正； 2003 年 5 月 9 日 2002 年年度股东大会修正； 2005 年 6 月 28 日 2005 年第 1 次临时股东大会修正； 2006 年 9 月 2 日 2006 年第 3 次临时股东大会修订； 2007 年 11 月 7 日 2007 年第 5 次临时股东大会修正； 2014 年 2 月 28 日 2014 年第 1 次临时股东大会修正； 2016 年 1 月 15 日 2016 年第 1 次临时股东大会修正； 2016 年 5 月 12 日 2015 年年度股东大会修正； 2017 年 5 月 11 日 2016 年年度股东大会修正； 2017 年 11 月 2 日 2017 年第 1 次临时股东大会修正； 2018 年 1 月 18 日 2018 年第 1 次临时股东大会修正； 2019 年 5 月 29 日 2018 年年 ...

公司章程 九芝堂股份有限公司章程 （2025 年修订） （1999 年 11 月 8 日第 1 次临时股东大会会议通过； 2000 年 6 月 5 日第 1 次临时股东大会修正； 2001 年 12 月 27 日第 2 次临时股东大会修正； 2003 年 5 月 9 日 2002 年年度股东大会修正； 2003 年 6 月 25 日 2003 年第 1 次临时股东大会修正； 2004 年 4 月 22 日 2003 年度股东大会修正； 2005 年 4 月 4 日 2004 年股东大会修正； 2005 年 6 月 28 日 2005 年第 1 次临时股东大会修正； 2006 年 4 月 19 日 2005 年年度股东大会修正； 2006 年 9 月 2 日 2006 年第 3 次临时股东大会修订； 2007 年 8 月 16 日 2007 年第 3 次临时股东大会修正； 2007 年 11 月 7 日 2007 年第 5 次临时股东大会修正； 2008 年 9 月 19 日 2008 年第 1 次临时股东大会修正； 2009 年 4 月 22 日 2008 年年度股东大会修正； 2010 年 1 月 15 日 ...

公告资料 证券代码：000989 证券简称：九芝堂 公告编号：2025-065 九芝堂股份有限公司 2025年第二次临时股东大会决议公告 本公司及董事会全体成员保证信息披露内容的真实、准确和完整，没有虚假记载、误导 性陈述或者重大遗漏。 特别提示： 1、本次股东大会未出现否决议案的情形。 2、本次股东大会未涉及变更以往股东大会已通过的决议。 一、会议召开和出席情况 1、会议召开情况 （1）现场会议召开时间：2025 年 9 月 10 日（星期三）下午 14:30 （2）网络投票时间： 通过深圳证券交易所（以下简称"深交所"）交易系统进行网络投票的具体时 间为 2025 年 9 月 10 日上午 9:15—9:25，9:30—11:30，下午 13:00—15:00； 通过深交所互联网投票系统投票的具体时间为：2025 年 9 月 10 日上午 9:15 至下午 15:00 的任意时间。 （3）召开方式：本次股东大会采用现场表决与网络投票相结合的方式召开。 （4）现场会议召开地点：九芝堂股份有限公司管理中心第一会议室（北京 市朝阳区朝阳体育中心东侧路甲 518 号 A 座） （5）召集人：公司董事会 （6）主持 ...

湖南启元律师事务所 关于九芝堂股份有限公司 2025年第二次临时股东大会的 法律意见书 1 致：九芝堂股份有限公司 湖南启元律师事务所（以下简称"本所"）接受九芝堂股份有限公司（以下简 称"公司"）的委托，指派本所律师出席了公司 2025 年第二次临时股东大会（以 下简称"本次股东大会"），对本次股东大会的召集和召开程序、出席会议人员及 召集人的资格、表决程序和表决结果的合法有效性进行律师见证，并发表法律意 见。 本所律师根据《中华人民共和国公司法》（以下简称"《公司法》"）、《中 华人民共和国证券法》（以下简称"《证券法》"）等我国现行法律法规、规范性 文件以及《九芝堂股份有限公司章程》（以下简称"《公司章程》"）等有关规定 出具本法律意见书。 本所及本所律师声明如下： （一）本所律师根据本法律意见书出具日以前已经发生或者存在的事实，严 格履行了法定职责，遵循了勤勉尽责和诚实信用原则，进行了充分的核查验证， 保证本法律意见书所认定的事实真实、准确、完整，所发表的结论性意见合法、 准确，不存在虚假记载、误导性陈述或者重大遗漏，并承担相应法律责任。 （二）本所律师出具本法律意见书是基于公司已承诺所有提供给本所律 ...

Core Viewpoint - The stock price of Jiuzhitang has shown significant fluctuations in 2023, with a year-to-date increase of 38.85% but a recent decline in the last five and twenty trading days [2] Group 1: Stock Performance - As of September 10, Jiuzhitang's stock price rose by 2.21% to 10.64 CNY per share, with a trading volume of 1.22 billion CNY and a turnover rate of 1.67% [1] - The stock has experienced a 2.65% decline over the last five trading days and a 4.40% decline over the last twenty trading days, while it has increased by 19.69% over the last sixty days [2] Group 2: Financial Performance - For the first half of 2025, Jiuzhitang reported a revenue of 1.265 billion CNY, a year-on-year decrease of 24.71%, and a net profit attributable to shareholders of 144 million CNY, down 29.71% year-on-year [3] - The company has distributed a total of 4.364 billion CNY in dividends since its A-share listing, with 935 million CNY distributed in the last three years [4] Group 3: Shareholder Information - As of June 30, 2025, Jiuzhitang had 50,500 shareholders, an increase of 25.14% from the previous period, with an average of 13,739 circulating shares per shareholder, a decrease of 20.09% [3] - The top ten circulating shareholders include a new entrant, Qianhai Kaiyuan Steady Growth Mixed Fund, holding 1.996 million shares [4] Group 4: Business Overview - Jiuzhitang, established on May 12, 1999, and listed on June 28, 2000, is primarily engaged in the research, production, and sales of traditional Chinese medicine and biopharmaceuticals, with a revenue composition of 50.27% from prescription drugs and 46.11% from OTC products [2]

Investment Rating - The investment rating for the company is "Buy-A" with a 12-month target price of 13.66 CNY [4][12]. Core Views - The company's performance in the first half of 2025 was under pressure, with a revenue of 1.265 billion CNY, a year-on-year decrease of 24.71%, and a net profit of 144 million CNY, down 29.71% [1][2]. - The pharmaceutical industrial sector is facing short-term challenges, but marketing reforms and new product development are expected to support long-term growth [2][3]. - The company is advancing its research projects, particularly in the stem cell drug market, which shows significant potential [3]. Summary by Sections Financial Performance - In H1 2025, the company reported a revenue of 1.265 billion CNY, a decrease of 24.71% year-on-year, and a net profit of 144 million CNY, down 29.71% [1]. - The second quarter of 2025 saw a revenue of 459 million CNY, a decline of 23.52%, and a net profit of 27 million CNY, down 54.58% [1]. Business Segments - The pharmaceutical industrial segment generated 1.229 billion CNY in revenue, down 25.06%, while the pharmaceutical commercial segment brought in 33 million CNY, down 3.12% [2]. - The OTC series revenue was 583 million CNY, a decrease of 36.05%, and the prescription drug series revenue was 636 million CNY, down 10.67% [2]. Marketing and R&D Initiatives - The company is implementing marketing reforms, including optimizing pricing policies and enhancing online and offline collaboration [2]. - Several R&D projects are progressing, including clinical trials for stem cell treatments, which are expected to contribute to long-term growth [3]. Future Projections - Revenue projections for 2025-2027 are estimated at 2.417 billion CNY, 2.629 billion CNY, and 2.887 billion CNY, respectively, with corresponding net profits of 224 million CNY, 292 million CNY, and 366 million CNY [8][10]. - The company anticipates a gradual recovery starting in 2026, with expected growth rates of 1.9%, 8.8%, and 9.8% for revenue [10][12].

Core Viewpoint - The company Jiuzhitang is advancing its research in stem cell therapy, particularly focusing on a new drug for treating Autism Spectrum Disorder (ASD) using human bone marrow mesenchymal stem cells, marking a significant milestone in clinical trials in China [1][2]. Group 1: Clinical Trial Developments - Jiuzhitang's subsidiary, Beijing Meike, has received ethical approval to initiate clinical trials for its human bone marrow mesenchymal stem cell injection project, specifically targeting ASD [1][2]. - The clinical trial for the stem cell injection has been approved by the National Medical Products Administration, making it the first of its kind in China for treating ASD [2]. Group 2: Product and Market Potential - The human bone marrow mesenchymal stem cell injection is classified as a Class 1 new drug and is aimed at treating Autism Spectrum Disorder, a complex neurodevelopmental disorder with no approved medications in China [2]. - Jiuzhitang is also making progress in other projects, including YB209, an innovative anticoagulant drug, and YB211, a new antibiotic targeting drug-resistant bacterial infections, both of which show promising market potential [3]. Group 3: Infrastructure and Recognition - Beijing Meike has established a large-scale stem cell drug research and production facility that meets GMP standards in China, the US, and the EU, positioning itself as a leading enterprise in the stem cell field in China [4].

Company Overview - JiuZhiTang Co., Ltd. is located in Beijing and Changsha, established on May 12, 1999, and listed on June 28, 2000. The company specializes in the research, production, and sales of traditional Chinese medicine, biological pharmaceuticals, and cardiovascular drugs [2][3] - The revenue composition includes prescription drugs (50.27%), OTC products (46.11%), other products (2.50%), health products (0.92%), and other supplementary products (0.20%) [2] Financial Performance - For the first half of 2025, JiuZhiTang reported revenue of 1.265 billion yuan, a year-on-year decrease of 24.71%, and a net profit attributable to shareholders of 144 million yuan, down 29.71% year-on-year [2] - The company has distributed a total of 4.364 billion yuan in dividends since its A-share listing, with 935 million yuan distributed over the past three years [3] Stock Performance - As of August 27, JiuZhiTang's stock price was 12.00 yuan per share, with a market capitalization of 10.271 billion yuan. The stock has increased by 56.60% year-to-date [1] - The stock has seen a net outflow of 22.5743 million yuan in major funds, with significant trading activity reflected in the recent five-day (1.44% increase), twenty-day (5.36% increase), and sixty-day (16.62% increase) performance [1] Shareholder Information - As of June 30, 2025, the number of shareholders increased by 25.14% to 50,500, with an average of 13,739 circulating shares per shareholder, a decrease of 20.09% [2][3] - The top ten circulating shareholders include a new entrant, Qianhai Kaiyuan Stable Growth Mixed Fund, holding 1.996 million shares [3]

Investment Rating - The report maintains a "Positive" investment rating for the stem cell therapy industry [12]. Core Insights - Stem cell therapy is accelerating from theory to clinical application, with mesenchymal stem cells (MSC) becoming the mainstream due to their application advantages. Over ten products have been approved globally, covering various fields such as cardiovascular, metabolic, and neurological diseases. The approval of the first "off-the-shelf" MSC therapy by the FDA in late 2024 and the first MSC drug in China in early 2025 marks a significant milestone in the industry [3][7][8]. Summary by Sections Industry Overview - Stem cells, known for their self-renewal and multi-directional differentiation capabilities, have evolved since their concept was introduced in the 19th century. MSCs have become the primary focus in clinical research and application due to their broad application advantages. The global stem cell therapy market is rapidly advancing, with numerous products approved for various indications [7][20]. Regulatory Milestones - The FDA's approval of the first "off-the-shelf" MSC therapy in late 2024, which demonstrated a 70.4% objective response rate by day 28 and a 68.5% overall survival rate by day 180, sets a precedent for the industry. Concurrently, the approval of "Aimi Maitosai" in China in early 2025 signifies the recognition of stem cell therapy in regulatory and clinical practices [8][45]. Company Spotlight: Jiuzhitang - Jiuzhitang has established a comprehensive stem cell research and industrialization platform, leading in clinical trials in China. Its core product, itMSC, has shown promising results in I/II phase clinical trials for ischemic stroke in the U.S., with significant improvements in patient outcomes. The company is also exploring other indications such as aPAP and AD, indicating a broad potential market [9][67]. Market Potential and Applications - The MSC therapy market is expanding into various fields, including cardiovascular, immune, and metabolic diseases. Companies are actively exploring applications in these areas, with early research showing potential benefits in diabetes and IBD, although further validation is needed [10][30][47]. Clinical Development - The report highlights the ongoing clinical trials for various MSC products targeting conditions like ischemic stroke and aPAP. Jiuzhitang's itMSC is in advanced clinical stages, with promising safety and efficacy data, suggesting a strong potential for long-term patient benefits [64][66].