Summary of Yiling Pharmaceutical Conference Call Company Overview - **Company**: Yiling Pharmaceutical - **Industry**: Pharmaceutical Key Financial Metrics - **Q1 2025 Revenue**: 2.358 billion CNY, a decrease of 6.5% year-on-year [2][4] - **Q1 2025 Net Profit**: 326 million CNY, an increase of 7.25% year-on-year [2][4] - **Operating Cash Flow**: 340 million CNY, an increase of 190% year-on-year [2][4] - **Accounts Receivable Turnover Days**: Decreased by 35 days year-on-year, indicating improved operational quality [2][4] Product Performance - **Lianhua Qingwen Sales**: Increased by nearly 30% year-on-year in Q1 2025 [2][6] - **Cardiovascular Prescription Drugs**: Experienced a decline due to policy impacts but expected to recover in Q2 2025 [2][6] - **Secondary Products**: Steady progress in products like Jing Shen Capsules and Compound Danshen Tablets, with OTC product Ba Zi Bu Shen Capsules seeing a 260% increase in shipments [2][7][5] Health Technology Sector - **Health Technology Products**: Focus on promoting blue hat health foods and functional plant beverages, with sales of Yi Meng beverage exceeding 120 million CNY and blood sugar regulation beverage sales exceeding 50 million CNY [2][8] Research and Development Achievements - **New Drug Approvals**: Mingmu Capsules for diabetic retinopathy entered medical insurance; Qi Fang Bi Tong Tablets for allergic rhinitis approved for market [2][9] - **Clinical Trials**: Six products in clinical stages, including pediatric Lianhua Qingwen granules in Phase III [2][9] - **Publications**: Five evidence-based medical research results published in top international journals [2][9] Chemical Biology Innovations - **Innovative Drugs**: Four innovative drugs in clinical stages, with multiple first-class innovative drugs in preclinical verification [2][10] Future Outlook - **2025 Goals**: Aim for gradual recovery across all business lines, enhance management efficiency, and optimize marketing strategies [2][11] Cost and Margin Analysis - **Gross Margin Trends**: Decline in gross margins for cardiovascular and respiratory products in 2024, but significant improvement noted in Q1 2025 [2][12] - **Inventory Levels**: Lianhua Qingwen inventory at historical lows, with expectations for respiratory product sales to return to normal levels in 2025 [2][12] Strategic Adjustments - **Market Strategy**: Adjustments in marketing strategies for cardiovascular products due to external policy impacts, with expectations for recovery starting Q2 2025 [2][21] - **Sales Team Optimization**: Continuous optimization of the sales team structure to enhance efficiency and reduce costs [2][24] Regulatory and Policy Impact - **Industry Policies**: Long-term policies expected to drive industry optimization and innovation, with stable pricing systems mitigating short-term impacts [2][16] International Expansion - **Overseas Strategy**: Plans to enhance the influence of traditional Chinese medicine abroad, with over 50 patented products approved in various countries [2][23] Conclusion - **Overall Performance**: After overcoming recent challenges, the company aims for improved performance in 2025, focusing on operational efficiency and market recovery [2][27]

Core Viewpoint - In 2024, Yiling Pharmaceutical (002603) faced competitive pressure in the pharmaceutical industry and adhered to a strategy focused on "standardization, professionalism, health, sustainability, and leapfrogging," aiming for brand success, scale formation, goal achievement, and profit creation [1] Financial Performance - In 2024, Yiling Pharmaceutical reported revenue of 6.513 billion yuan, a year-on-year decrease of 36.88%, and a net profit attributable to shareholders of -0.725 billion yuan, down 153.57% [2] - The decline in performance was attributed to the expiration of certain respiratory products, leading to reduced sales and inventory impairment losses, alongside rising raw material costs and sustained high R&D investments [2] - Despite the net loss, operating cash flow significantly improved, reaching 0.611 billion yuan, a year-on-year increase of 293%, with Q4 cash flow alone at 0.288 billion yuan, up over 26 times [2] - Accounts receivable decreased significantly, with a reduction of 1.176 billion yuan, a drop of 50%, and total liabilities decreased to 3.117 billion yuan, down 24.24 billion yuan or 43.75%, resulting in a debt-to-asset ratio decline of nearly 10 percentage points to 23.4% [2] R&D Investment - Yiling Pharmaceutical maintained a strong focus on R&D, with expenses reaching 0.908 billion yuan in 2024, accounting for 13.94% of revenue, reinforcing its leadership in traditional Chinese medicine innovation [3] - The company developed 17 innovative traditional Chinese medicines targeting eight major clinical disease systems, achieving industry leadership in cardiovascular and respiratory disease treatments [3] - New drug approvals included a treatment for allergic rhinitis and a new drug for gallbladder inflammation, with several patented traditional medicines included in the new medical insurance directory [3] Market Expansion and Strategic Initiatives - Yiling Pharmaceutical has registered products in over 50 countries and regions, actively entering the biopharmaceutical and health sectors, with recent approval for a breast cancer treatment [4] - Continuous R&D investment is expected to enhance product offerings and market share, while the transformation of technological innovations will improve product structure and competitiveness [4] - The company’s strategic focus on R&D and market trends positions it for greater growth in the pharmaceutical market [4] 2025 Outlook - In Q1 2025, Yiling Pharmaceutical reported revenue of 2.358 billion yuan and a net profit of 0.326 billion yuan, reflecting a year-on-year increase of 7.25% [5] - The company’s operating cash flow reached 0.34 billion yuan, nearly doubling year-on-year, with gross margin increasing by 2.34 percentage points to 53.82% [5] - The company aims to enhance its innovation capabilities, accelerate drug development, and implement a brand strategy while optimizing operational management and cost control [6]

Group 1 - The company announced a change in accounting policies based on new regulations issued by the Ministry of Finance, which will take effect on January 1, 2024, and December 31, 2024, respectively [2][3][4] - The change in accounting policies is deemed reasonable and will not have a significant impact on the company's financial status, operating results, or cash flow [5][6] Group 2 - The company appointed Zhongqin Wanxin Certified Public Accountants as the financial and internal control audit institution for the year 2025, with an audit fee of 2.9 million yuan [6][13] - Zhongqin Wanxin has been providing audit services to the company for 22 consecutive years and possesses the necessary qualifications for auditing listed companies [8][9] Group 3 - The company expects a total of 69.62 million yuan in daily related transactions for the year 2025 with its affiliated companies [21] - The related transactions are considered routine and do not pose significant risks to the company's operations or financial health [28][35] Group 4 - The company plans to conclude the "Lianhua Qingwen series product capacity enhancement project" and terminate the "Lianhua Qingwen capsule international registration project," reallocating the surplus funds to supplement working capital permanently [41][42] - The total surplus funds from these projects amount to 21.46 million yuan, which will be used to support the company's daily operations [52][53] Group 5 - The company will hold its 2024 annual general meeting on May 26, 2025, allowing shareholders to participate both in person and via online voting [56][58] - The meeting will address various resolutions that have been approved by the board and supervisory committee [65][66]

Core Viewpoint - The company reported a net profit loss of approximately 724.52 million yuan for the year 2024, with no cash dividends or stock bonuses proposed for shareholders [33][87]. Company Overview - The company specializes in the research, production, and sales of patented innovative traditional Chinese medicine, while also expanding into biopharmaceuticals and the health industry [4][5]. - The company has developed a unique research model for innovative traditional Chinese medicine, focusing on major diseases and leveraging its strong scientific research capabilities [5][6]. Business Segments Traditional Chinese Medicine - The company holds 17 patented traditional Chinese medicines, covering eight major clinical disease systems, with leading positions in cardiovascular and respiratory disease treatments [5][19]. - Key products include Tongxinluo capsules, which treat coronary heart disease and cerebral infarction, and have received multiple national science and technology awards [8]. Biopharmaceuticals - The company has established a comprehensive development strategy for biopharmaceuticals, including international registration and global sales [6]. - It has received approvals for 13 ANDA products in the U.S. market and has submitted registration applications in 53 countries [6][20]. Health Industry - The company is actively developing health products based on traditional Chinese health theories, integrating modern technology [7]. - It has launched a series of health products aimed at various health needs, including heart health and anti-aging [7]. Financial Performance - The company achieved a total revenue of approximately 6.51 billion yuan in 2024, with a significant net loss [33]. - The proposed profit distribution plan for 2024 includes no cash dividends or stock bonuses, reflecting the company's current financial situation [87]. Market Position - The company ranks 7th among traditional Chinese medicine companies in China and 30th in the broader pharmaceutical industry [17]. - Despite a declining trend in the market for traditional Chinese medicine for cardiovascular diseases, the company has maintained a growing market share in oral formulations [19]. Product Performance - The market share of key products such as Tongxinluo capsules has increased from 13.64% in 2015 to 17.69% in the first half of 2024 [19]. - The company’s diabetes medication, Jinlida granules, saw its market share rise from 4.42% in 2015 to 16.20% in the first half of 2024 [20].

石家庄以岭药业股份有限公司 证券代码：002603 证券简称：以岭药业 公告编号：2025-020 关于化药创新药"G201-Na 胶囊"药物临床试验申请获 得受理的公告 本公司及董事会全体成员保证信息披露内容的真实、准确和完整，没有虚 假记载、误导性陈述或重大遗漏。 石家庄以岭药业股份有限公司（以下简称"公司"）于 2025 年 4 月 29 日收到 国家药品监督管理局核准签发的《受理通知书》，现将相关情况公告如下： 一、临床试验申请主要内容 药物名称：G201-Na 胶囊 受 理 号：CXHL2500424，CXHL2500425 受理日期：2025 年 04 月 29 日 剂 型：胶囊剂 适 应 症：辅助生殖，用于控制性超促排卵治疗的患者，防止提前排卵。 申请事项：境内生产药品注册临床试验 申 请 人：石家庄以岭药业股份有限公司 通知书意见：自受理之日起 60 日内，未收到药审中心否定或质疑意见的， 申请人可以按照提交的方案开展临床试验。 二、G201-Na 胶囊相关情况 G201-Na胶囊项目是公司自主研发、具有独立知识产权的1类化学新药。本 品为小分子促性腺激素释放激素（GnRH）受体拮抗剂。可以阻 ...

Group 1: Product Development and Clinical Trials - The company plans to submit 1-2 new products for approval each year, with recent submissions including products for chronic cholecystitis and rheumatoid arthritis [2] - Currently, there are 6 products in clinical stages, with one in Phase III for treating children's colds and five in Phase II for various conditions [2][3] - The company has completed the registration of 536 products and has a 90% average registration rate across 14 provinces for formula granules [5] Group 2: Health Industry Progress - The company has developed a comprehensive health product system integrating traditional Chinese medicine with modern technology, focusing on health management and product development [4] - Key promoted products include health foods and functional beverages, with significant revenue growth expected in 2024 [4] Group 3: Sales Strategies and Market Expansion - The company is enhancing sales of its BaZi products through retail, e-commerce, and partnerships, aiming to build brand recognition and customer loyalty [6][7] - The company has seen rapid growth in BaZi product sales in Q1 2025, with strategies to improve customer adherence and long-term management [6][7] Group 4: International Market Development - The company aims to enhance the international influence of traditional Chinese medicine by promoting its unique theories and establishing academic collaborations globally [11][12] - It has established over 130 professional committees abroad and has received approvals for its patented traditional medicines in over 50 countries [12] Group 5: OTC Product Strategy - The company’s Lianhua Qingke product transitioned to OTC status in November 2023, which is expected to create new marketing opportunities and enhance sales through flexible promotion strategies [13]

Core Viewpoint - Yiling Pharmaceutical reported a net loss for 2024 due to revenue reduction from expiring respiratory products and increased inventory impairment, but maintains high R&D investment levels, with over 900 million yuan allocated, representing 13.94% of revenue, which is leading in the industry [1][5]. R&D Investment - Yiling Pharmaceutical has a strong R&D capability based on its unique theory of network disease, which has led to a nearly 25-fold increase in R&D investment since 2008 [2]. - The company continues to maintain high R&D investment levels, with 900 million yuan in 2024, ranking among the top in the industry [5]. Product Development and Pipeline - The company has 17 patented new drugs, with 11 included in the national medical insurance directory and 5 in the national essential drug list [5]. - Yiling Pharmaceutical has ongoing registration applications for two innovative traditional Chinese medicine products and three chemical drug products, enhancing its product pipeline [6]. Market Performance - Yiling Pharmaceutical's respiratory and cardiovascular products lead their respective markets, with Lianhua Qingwen capturing 24.36% of the cold medicine market in public healthcare [7]. - The company’s core cardiovascular products hold a combined market share of 17.69% in the public healthcare sector [7]. New Growth Areas - The company is expanding into the health and wellness sector, with products targeting blood lipid regulation, sleep improvement, and blood sugar control [8]. - Yiling Pharmaceutical's OTC product Baizi Bujin Capsule is highlighted as a potential new pillar product, supported by extensive evidence from clinical studies [8].

石家庄以岭药业股份有限公司董事会 2025 年 4 月 29 日 关于独立董事独立性自查情况的专项意见 根据《上市公司独立董事管理办法》《深圳证券交易所股票上市规则》 《深圳证券交易所上市公司自律监管指引第 1 号——主板上市公司规范运作》 等要求，就石家庄以岭药业股份有限公司（以下简称"公司"）第八届董事会在 任独立董事刘骁悍先生、陈刚先生、柴振国先生的独立性情况进行评估并出具 如下专项意见： 经核查独立董事刘骁悍先生、陈刚先生、柴振国先生的任职经历及其签署 的独立性自查文件，上述人员未在公司担任除独立董事以外的任何职务，也未 在公司主要股东公司担任任何职务，与公司以及主要股东之间不存在利害关系 或其他可能妨碍其进行独立客观判断的关系，不存在影响独立董事独立性的情 况，符合《上市公司独立董事管理办法》《深圳证券交易所上市公司自律监管 指引第 1 号——主板上市公司规范运作》及公司《独立董事制度》中对独立董 事独立性的相关要求。 石家庄以岭药业股份有限公司 董事会 ...

石家庄以岭药业股份有限公司 2024 年度独立董事述职报告 董事会专门委员会任职情况：第八届董事会提名委员会召集人、薪酬与考核 委员会委员、战略与规划委员会委员、审计委员会委员。 （二）关于独立性自查情况 根据《上市公司独立董事管理办法》《深圳证券交易所上市公司自律监管指 引第 1 号—主板上市公司规范运作》等相关规定，本人作为公司独立董事，对自 身独立性情况进行了自查。2024 年度，本人未在公司担任除独立董事以外的任 何职务，也未在公司控股股东、实际控制人及其附属企业担任任何职务，与公司 以及公司控股股东、实际控制人及其附属企业之间不存在利害关系或其他可能妨 碍本人进行独立客观判断的关系，本人任职符合《上市公司独立董事管理办法》 等规定的独立性要求，不存在影响独立性的情形。 二、2024 年度履职情况 （刘骁悍） 本人作为石家庄以岭药业股份有限公司（以下简称"公司"）的独立董事，严 格按照《公司法》《上市公司治理准则》《上市公司自律监管指引第 1 号——主板 上市公司规范运作》等法律法规以及《公司章程》、《公司独立董事制度》的规定， 本着客观、公正、独立的原则，勤勉尽责，积极发挥独立董事作用，维护公司整 ...