乐普（北京）医疗器械股份有限公司 证券代码：300003 证券简称：乐普医疗 公告编号：2025-042 第六届董事会第十五次会议决议公告 本公司及董事会全体成员保证信息披露的内容真实、准确、完整，没有虚假 记载、误导性陈述或重大遗漏。 乐普（北京）医疗器械股份有限公司（以下简称：公司）第六届董事会第十 五次会议于 2025 年 5 月 19 日在北京市昌平区超前路 37 号公司会议室以现场 及通讯相结合的方式召开，会议通知于 2025 年 5 月 16 日以邮件、电话方式通 知全体董事。会议应出席董事 7 名，实际出席董事 7 名，其中以通讯表决方式出 席会议董事 6 名。本次会议召开符合《公司法》及《公司章程》的相关规定。会 议由董事长蒲忠杰先生主持。出席会议的董事审议并以记名方式投票表决通过了 如下决议： 特此公告。 乐普（北京）医疗器械股份有限公司 董事会 二〇二五年五月十九日 2 鉴于公司已新增可转换公司债券募集资金投资项目"电生理植介入研发"、 "生物类似物司美格鲁肽研发"，项目实施主体分别为乐普医学电子仪器股份有 限公司和乐普药业股份有限公司。为满足公司募投项目发展需要，提升募集资金 使用效率， ...

Group 1 - BYD reported August sales of 174,915 new energy vehicles, a year-on-year increase of 184.84% [1] - Cumulative sales from January to August reached 978,795 units, representing a year-on-year growth of 267.31% [1] - The company sold 5,092 new energy passenger vehicles overseas in August [1] Group 2 - Zhongke Electric's subsidiary plans to establish a joint venture with Chongqing Fudi for the production of anode materials, with a registered capital of 1 billion RMB [2] - Zhongke Electric's subsidiary will contribute 650 million RMB, while Chongqing Fudi will contribute 350 million RMB [2] Group 3 - Yuyuan Group intends to transfer 13% of its shares in Jinhuijiu for approximately 1.937 billion RMB, reducing its stake to 25% [3] - The company plans to further reduce its holdings by more than 5% within the next six months [3] Group 4 - Lizhu Group's recombinant COVID-19 fusion protein vaccine has been included in the emergency use for sequential booster immunization [4] Group 5 - Guanghui Energy plans to repurchase shares worth between 800 million and 1 billion RMB to support employee stock ownership plans [5] Group 6 - Cambrian has launched four cloud-based intelligent chips, although mass sales will require a longer time frame and initial technical service investments [7] Group 7 - LePu Medical has received approval from the China Securities Regulatory Commission for the issuance of Global Depositary Receipts (GDRs) and listing on the Swiss Stock Exchange [9] - The GDR issuance will correspond to no more than 180,458,875 new A-shares [9] Group 8 - Fushi Holdings' subsidiary has entered into an exclusive advertising agency cooperation with the Central Radio and Television Station's automotive channel for three years [10] Group 9 - Guangzhou Port's container throughput in August was 1.981 million TEUs, a year-on-year increase of 2.4% [11] - The total cargo throughput for August was 44.788 million tons, a decrease of 0.6% [11] Group 10 - Ningbo Port expects to complete a container throughput of 3.58 million TEUs in August, a year-on-year increase of 10.2% [12] - The total cargo throughput is projected to decline by 3.0% [12] Group 11 - Ming Tai Aluminum reported a 7% year-on-year decrease in aluminum plate and strip sales in August, while aluminum profile sales increased by 47% [13] Group 12 - Electric Power Investment plans to invest in multiple wind and solar projects, with total static investments of 1.585 billion RMB for wind and 538 million RMB for solar [14] Group 13 - Northeast Pharmaceutical has signed a cooperation agreement with MedAbome for the development of the MAb11-22.1 antibody project [19] Group 14 - New Five Feng plans to acquire equity in Tianxin Seed Industry and several other companies for a total price of approximately 2.208 billion RMB [26] Group 15 - Sumeida's subsidiary plans to transfer 100% equity of eight photovoltaic power station project companies, with an estimated transaction value of 657 million RMB [27] Group 16 - *ST Tongzhou intends to acquire 51% equity in Tongtaiwei, fulfilling the capital contribution obligation of 10.2 million RMB [29] Group 17 - Tianyin Holdings' subsidiary plans to invest 120 million RMB in Xundong Xintong to acquire 40% equity [30] Group 18 - Hainan Haiyao plans to publicly transfer 43% equity in Shanghai Lishengte to attract new investors [31] Group 19 - New Asia Process plans to transfer 7.76% of its shares to Xiangcai New Materials at a price of 5.274 RMB per share [32] Group 20 - Lanwei Medical plans to raise no more than 664 million RMB through a private placement for provincial laboratory construction projects [34] Group 21 - Lida New Materials plans to issue convertible bonds to raise no more than 300 million RMB for a new aluminum material project [35] Group 22 - Gekewei has successfully launched its 12-inch CIS integrated circuit project, achieving over 95% yield [51] Group 23 - Baijin Medical's tricuspid valve ring product has received registration approval [52] Group 24 - Shanghai Pharmaceuticals has received approval to initiate Phase I clinical trials for a recombinant anti-CD20 humanized monoclonal antibody [53] Group 25 - Junda Co. has increased the production capacity of its solar cell production base project from 8GW to 10GW [54]

Core Viewpoint - The electrophysiology device market in China is experiencing rapid growth due to an aging population, increasing prevalence of arrhythmias, improved early screening rates, and advancements in electrophysiological procedures, with the market expected to reach over 40 billion yuan by 2032 [1][10][21]. Industry Overview - Electrophysiology devices are used to monitor and study electrical activities in biological systems, widely applied in medical, research, and clinical diagnosis fields. Common products include ECG machines, EEG machines, EMG machines, and electrophysiological navigation systems [2][4]. Industry Environment - The number of patients with rapid arrhythmias in China is projected to reach 28.2 million by 2024, driving demand for treatment. Electrophysiological surgeries have become a primary treatment method due to their advantages such as minimal invasiveness and high safety [6][8]. Industry Status - The market size for electrophysiology devices in China has grown from 2.42 billion yuan in 2017 to 12.55 billion yuan in 2024. The surgical volume for electrophysiology has increased from 138,000 cases in 2017 to 456,000 cases in 2024, indicating significant growth potential [10][8]. Competitive Landscape - The market is dominated by foreign companies such as Johnson & Johnson, Abbott, and Medtronic, which hold a combined market share of over 64%. Domestic companies like Huatai Medical and MicroPort EP have a much smaller share, indicating a high concentration in the industry [12][14]. Key Enterprises - MicroPort EP focuses on innovative medical devices for electrophysiology and has achieved significant revenue growth, with a projected income of 413 million yuan in 2024, up 25.51% [17]. Huatai Medical, specializing in electrophysiology and interventional medical devices, expects a revenue of 440 million yuan in 2024, reflecting a 19.73% increase [19]. Development Trends 1. **Accelerated Domestic Substitution**: Domestic brands are gaining market share due to supportive policies and technological advancements, with MicroPort EP and Huatai Medical leading in key areas [21]. 2. **Technological Innovation**: The industry is moving towards smart and precise technologies, enhancing the performance of electrophysiology devices and expanding clinical applications [22]. 3. **Growing Market Demand**: The demand for electrophysiology devices is surging, particularly in grassroots healthcare and international markets, with significant growth in overseas revenues for domestic companies [23].

Core Viewpoint - The high-end medical device industry in Shenzhen is a significant indicator of national manufacturing capability and technological development, with a projected revenue of 200 billion yuan by 2025, highlighting its importance in the global medical device market [1]. Group 1: Industry Overview - Shenzhen's medical device output reached 99 billion yuan in 2023, accounting for approximately 10% of the national total, with exports also around 10% [1]. - The city is home to leading companies like Mindray Medical and BGI, which are recognized among the top 100 global medical device firms [1]. Group 2: Technological Advancements - The brain-computer interface technology developed by Shenzhen Ruihan Medical has shown significant promise in rehabilitation, with patients experiencing better recovery outcomes compared to traditional methods [2][3]. - Ruihan Medical's brain-computer interface rehabilitation robot system is the first commercialized product of its kind globally, with over 100 patents and a focus on practical application [3]. Group 3: Collaborative Innovation - The National High-Performance Medical Device Innovation Center in Shenzhen is addressing core technological challenges in the medical device sector through collaborative projects with key enterprises [6][7]. - The center has successfully developed a 5.0T whole-body MRI system, marking a significant breakthrough in high-field MRI technology [6]. Group 4: Market Dynamics - The medical device industry in Shenzhen is characterized by a "chain development" model, where breakthroughs in technology stimulate growth across the entire supply chain [8]. - Companies like Mindray Medical and Libang Instruments have successfully disrupted international monopolies in their respective fields, leading to increased domestic production capabilities [9][10]. Group 5: Spatial and Policy Support - Shenzhen's medical device industry faces challenges such as limited industrial space, prompting local governments to create favorable conditions for business growth [11][12]. - The city has introduced comprehensive support measures for the medical and pharmaceutical sectors, aiming to solidify its position as a leading hub for medical device innovation [13].

Core Viewpoint - The company announced a temporary suspension of the conversion of its convertible bonds "乐普转2" during the repurchase period, which is set to last from May 19, 2025, to May 23, 2025, due to specific conditions being met for the bondholders to exercise their repurchase rights [1][2]. Group 1 - The company issued 16.38 billion yuan worth of convertible bonds on March 30, 2021, with a face value of 100 yuan per bond, totaling 16.38 million bonds [1]. - The conversion period for "乐普转2" is from October 8, 2021, until the stock price falls below 70% of the conversion price of 27.92 yuan per share for thirty consecutive trading days [1]. - The company held a bondholders' meeting on May 15, 2025, to approve changes to the use of raised funds, activating the additional repurchase clause for "乐普转2" [2]. Group 2 - The suspension of the conversion of "乐普转2" will last for five trading days, starting from May 19, 2025, and will resume on May 26, 2025 [2]. - During the suspension period, the convertible bonds will continue to trade normally [2].

北京市中伦律师事务所（以下简称"本所"）作为乐普（北京）医疗器械股 份有限公司（以下简称"公司"）的常年法律顾问，受公司委托，指派律师出席 公司2024年年度股东大会（以下简称"本次股东大会"）。本所律师根据《中华 人民共和国公司法》（以下简称"《公司法》"）、《中华人民共和国证券法》 （以下简称"《证券法》"）《上市公司股东会规则》等相关法律、法规、规范 性文件及《乐普（北京）医疗器械股份有限公司章程》（以下简称"《公司章程》"） 的规定，对本次股东大会进行见证并出具法律意见。 法律意见书 北京市中伦律师事务所 关于乐普（北京）医疗器械股份有限公司 2024 年年度股东大会的 法律意见书 致：乐普（北京）医疗器械股份有限公司 本所及经办律师依据《证券法》《律师事务所从事证券法律业务管理办法》 和《律师事务所证券法律业务执业规则》等规定及本法律意见书出具日以前已经 发生或者存在的事实，严格履行了法定职责，遵循了勤勉尽责和诚实信用原则， 进行了充分的核查验证，保证本法律意见所认定的事实真实、准确、完整，所发 表的结论性意见合法、准确，不存在虚假记载、误导性陈述或者重大遗漏，并承 担相应法律责任。 为出具本法律意 ...

国泰海通证券股份有限公司 关于乐普（北京）医疗器械股份有限公司 可转换公司债券回售有关事项的核查意见 国泰海通证券股份有限公司（以下简称"保荐机构"）作为乐普（北京）医疗 器械股份有限公司（以下简称"乐普医疗"、"公司"）创业板向不特定对象发行可 转换公司债券的保荐机构，根据《证券发行上市保荐业务管理办法》《深圳证券 交易所创业板股票上市规则》《深圳证券交易所上市公司自律监管指引第 2 号— —创业板上市公司规范运作》等相关法律、法规和规范性文件的要求，对乐普医 疗可转换公司债券（以下简称"乐普转 2"，债券代码：123108）回售有关事项进 行了审慎核查，并出具本核查意见。核查情况如下： （一）回售条款 1、有条件回售条款 根据《募集说明书》，有条件回售条款的约定如下： 在本次可转债最后两个计息年度内，如果公司股票收盘价在任何连续三十个 交易日低于当期转股价格的 70%时，本次可转债持有人有权将其持有的本次可 转债全部或部分以面值加上当期应计利息回售给公司。 若在上述交易日内发生过转股价格因发生送红股、转增股本、增发新股、配 股或派发现金股利等情况（不包括因本次发行的可转债转股而增加的股本）而调 整的情形， ...

乐普（北京）医疗器械股份有限公司 "乐普转2"2025年第一次债券持有人会议决议公告 | 证券代码：300003 | 证券简称：乐普医疗 | 公告编号：2025-037 | | --- | --- | --- | | 债券代码：123108 | 债券简称：乐普转 2 | | 本公司及董事会全体成员保证信息披露内容的真实、准确、完整，没有虚 假记载、误导性陈述或重大遗漏。 乐普（北京）医疗器械股份有限公司于2025年5月15日召开可转换公司债券 "乐普转2"2025年第一次债券持有人会议（以下简称：本次会议），本次会议相 关情况具体如下： 一、会议召开和出席情况 1、会议召集人：董事会 2、会议召开及投票表决方式：本次会议采取现场方式召开，投票采取记名 方式表决。 审议《关于变更募投项目部分募集资金用途及相关事项》的议案 1 表决情况：同意 701,504 张，占出席会议所有债券持有人所持债券的 100％； 反对 0 张，占出席会议所有债券持有人所持债券的 0％；弃权 0 张，占出席会议 所有债券持有人所持债券的 0％；获得通过。 3、会议召开时间：2025 年 5 月 15 日上午 10:00。 4、会议召开 ...

法律意见书 北京市朝阳区金和东路 20 号院正大中心 3 号南塔 22-31 层 邮编：100020 22-31/F, South Tower of CP Center, 20 Jin He East Avenue, Chaoyang District, Beijing l00020, P.R. China 电话/Tel : +86 10 5957 2288 传真/Fax : +86 10 6568 1022/1838 www.zhonglun.com 北京市中伦律师事务所 关于乐普（北京）医疗器械股份有限公司 可转换公司债券回售的 法律意见书 致：乐普（北京）医疗器械股份有限公司 北京市中伦律师事务所（以下简称"本所"）是在中华人民共和国境内执业 的专业法律服务机构。本所接受乐普（北京）医疗器械股份有限公司（以下简称 "公司"或"发行人"）的委托，根据《中华人民共和国公司法》（以下简称"《公 司法》"）、《中华人民共和国证券法》（以下简称"《证券法》"）、《可转 换公司债券管理办法》（以下简称"《管理办法》"）、《深圳证券交易所上市 公司自律监管指引第15号--可转换公司债券》（以下简称"《监管指引》"）等 ...

北京市中伦律师事务所 关于乐普（北京）医疗器械股份有限公司 "乐普转 2"2025 年第一次债券持有人会议的 法律意见书 二〇二五年五月 1 北京市中伦律师事务所 关于乐普（北京）医疗器械股份有限公司 "乐普转2"2025年第一次债券持有人会议的 法律意见书 法律意见书 致：乐普（北京）医疗器械股份有限公司 北京市中伦律师事务所（以下简称"本所"）受乐普（北京）医疗器械股份 有限公司（以下简称"公司"）委托，指派律师出席公司"乐普转2"2025年第 一次债券持有人会议（以下简称"本次持有人会议"）。本所律师根据《中华人 民共和国公司法》（以下简称"《公司法》"）、《中华人民共和国证券法》《公 司债券发行与交易管理办法》等相关法律、法规、规范性文件及上述债券的《乐 普（北京）医疗器械股份有限公司创业板向不特定对象发行可转换公司债券募集 说明书》（以下简称"《募集说明书》"）、《乐普（北京）医疗器械股份有限 公司可转换公司债券持有人会议规则》（以下简称"《债券持有人会议规则》"） 等相关规定，对本次持有人会议进行见证并出具法律意见。 本所及经办律师依据《证券法》《律师事务所从事证券法律业务管理办法》 和《律师事务 ...