国泰海通证券股份有限公司 关于沈阳兴齐眼药股份有限公司 （中国（上海）自由贸易试验区商城路 618 号） 上市保荐书 保荐机构（主承销商） 向特定对象发行股票并在创业板上市 之 二〇二五年八月 沈阳兴齐眼药股份有限公司 上市保荐书 声 明 本保荐机构及其保荐代表人已根据《中华人民共和国公司法》（以下简称 "《公司法》"）、《中华人民共和国证券法》（以下简称"《证券法》"）等法 律法规和中国证券监督管理委员会（以下简称"中国证监会"）及深圳证券交易 所的有关规定，诚实守信，勤勉尽责，严格按照依法制定的业务规则和行业自律 规范出具上市保荐书，并保证所出具文件真实、准确、完整。 如无特殊说明，本上市保荐书中的简称或名词释义与《沈阳兴齐眼药股份有 限公司向特定对象股票并在创业板上市募集说明书》一致。 3-3-1 | 声 | 明 1 | | --- | --- | | 目 | 录 2 | | | 一、发行人基本情况 3 | | | 二、发行人本次发行情况 10 | | | 三、本次证券发行上市的项目保荐代表人、协办人及项目组其他成员情况 | | | 13 | | | 四、保荐机构是否存在可能影响公正履行保荐职责情形的说 ...

沈阳兴齐眼药股份有限公司 审计报告及财务报表 二四年度 此码闸 证明该审 告是青由具有执业许可的会ìl 务所出具， 您时使用 ·扫 J' 量入"注册会计师行业统 管乎台 叩/ cc of.gov 时. 进行查验. 告份码·沪2SQ90YHYF8 6-1-1 lm 特殊自 」丘 沈阳兴齐眼药股份有限公司 审计报告及财务报表 (2 日至 024 日止〉 | | 目录 | 页次 | | --- | --- | --- | | | 审计报告 | 1-5 | | -、 | 财务报表 | | | | 合并资产负债表和母公司资产负债表 | 1-4 | | | 合并利润表和母公司利润表 | 5-6 | | | 合并现金流量表和母公司现金流量表 | 7-8 | | | 合并所有者权益变动表和母公司所有者权益变动表 | 9-12 | | | 财务报表附注 | 1-92 | 6-1-2 审计报告 信会师报字[2025] ZAI0684 沈阳兴齐眼药股份有限公司 体股东 审计意见 我们审计了沈阳兴齐眼药股份有限公司(以下简称"兴齐眼药") 财务报表，包括 24 日的合并及母公司资产负债表 2024 年度的合并及母公司利润表、合并及母 ...

证券代码：300573 证券简称：兴齐眼药 公告编号：2025-033 沈阳兴齐眼药股份有限公司 关于向特定对象发行股票申请获得深圳证券交易所受理的 沈阳兴齐眼药股份有限公司（以下简称"公司"）于2025年8月26日收到深 圳证券交易所（以下简称"深交所"）出具的《关于受理沈阳兴齐眼药股份有限 公司向特定对象发行股票申请文件的通知》（深证上审〔2025〕159号）。深交 所对公司报送的向特定对象发行股票的申请文件进行了核对，认为申请文件齐备， 决定予以受理。 公司本次向特定对象发行股票的事宜尚需通过深交所审核，并获得中国证券 监督管理委员会（以下简称"中国证监会"）同意注册后方可实施，最终能否通 过深交所审核并获得中国证监会同意注册的决定及时间仍存在不确定性。公司将 根据该事项进展情况及时履行信息披露义务，敬请广大投资者谨慎决策，注意投 资风险。 特此公告。 沈阳兴齐眼药股份有限公司 董事会 2025 年 8 月 26 日 1 公告 本公司及董事会全体成员保证信息披露内容的真实、准确、完整，没有 虚假记载、误导性陈述或重大遗漏。 ...

国泰海通证券股份有限公司 关于沈阳兴齐眼药股份有限公司 向特定对象发行股票并在创业板上市 之 发行保荐书 保荐机构（主承销商） （中国（上海）自由贸易试验区商城路 618 号） 二〇二五年八月 沈阳兴齐眼药股份有限公司 发行保荐书 声 明 本保荐机构及保荐代表人根据《中华人民共和国公司法》（以下简称"《公 司法》"）、《中华人民共和国证券法》（以下简称"《证券法》"）、《证券发行 上市保荐业务管理办法》（以下简称"《保荐管理办法》"）、《上市公司证券发 行注册管理办法》（以下简称"《注册管理办法》"）、《深圳证券交易所创业板 股票上市规则》（以下简称"《上市规则》"）等有关法律、行政法规和中国证 券监督管理委员会（以下简称"中国证监会"）、深圳证券交易所的规定，诚实 守信，勤勉尽责，严格按照依法制订的业务规则、行业执业规范和道德准则出具 本发行保荐书，并保证所出具文件的真实性、准确性和完整性。 如无特殊说明，本发行保荐书中的简称或名词释义与《沈阳兴齐眼药股份有 限公司向特定对象发行股票并在创业板上市募集说明书》一致。 | 目 | 录 2 | | --- | --- | | 第一节 | 本次证券发行基本情况 3 ...

证券之星消息，8月21日化学制药板块较上一交易日上涨0.09%，*ST苏吴领涨。当日上证指数报收于 3771.1，上涨0.13%。深证成指报收于11919.76，下跌0.06%。化学制药板块个股涨跌见下表： | 代码 | 名称 | 收盘价 | 涨跌幅 | 成交量(手) | 成交额(元) | | | --- | --- | --- | --- | --- | --- | --- | | 600200 | *ST苏吴 | 0.96 | 5.49% | 43.67万 | | 4141.60万 | | 300705 | 九典制药 | 19.87 | 4.97% | 52.35万 | | 10.35 Z | | 300573 | 兴齐眼药 | 67.48 | 4.69% | 22.77万 | | 15.19 Z | | 688506 | 百利天恒 | 324.96 | 4.21% | 1.62万 | | 5.23亿 | | 002940 | 昂利康 | 51.36 | 3.86% | 15.16万 | | 7.69亿 | | 002020 | 京新药业 | 19.52 | 2.90% | 32.05万 | | 6.16 ...

格隆汇8月21日｜昂利康、九典制药、康泰生物涨超6%，兴齐眼药涨超5%，君实生物、阳光诺和、荣 昌生物涨超3%。 | 代码 | 名称 | 涨幅% ↓ | 总市值 | 年初至今涨幅%。 | | --- | --- | --- | --- | --- | | 002940 | 昂利康 | 6.59 | 106亿 | 301.09 | | 300705 | 九典制药 | 6.39 | 101亿 | 14.43 | | 300601 | 康泰生物 | 6.14 | 210亿 | 10.48 | | 300573 | 兴齐眼药 | 5.71 | 167亿 | 38.45 | | 600200 | *ST苏吴 | 5.49 | 6.82亿 | -89.70 | | 002424 | 贵州百灵 | 4.79 | 88.75亿 | 64.94 | | 430047 | 诺思兰德 | 3.94 | 80.25亿 | 153.77 | | 300147 | ST香雪 | 3.81 | 75.65亿 | 17.09 | | 688180 | 君实生物-し | 3.44 | 476亿 | 69.67 | | 688621 | 阳光诺 ...

Group 1: Dongcheng Pharmaceutical - Dongcheng Pharmaceutical reported a 2.6% decline in revenue to 1.384 billion yuan for the first half of 2025, with net profit attributable to shareholders decreasing by 20.70% to 88.6525 million yuan [1] - The nuclear medicine segment generated sales of 503 million yuan, a year-on-year increase of 0.78%, with key product F-FDG achieving revenue of 212 million yuan, up 8.72% due to increased sales volume [1] - The raw material drug segment saw sales of 611 million yuan, down 7.02%, with heparin raw material revenue falling by 8.90% to 440 million yuan due to price declines, while chondroitin sulfate product revenue rose by 4.26% to 165 million yuan [1] Group 2: Haosen Pharmaceutical - Haosen Pharmaceutical experienced a 14.93% increase in revenue to 242 million yuan for the first half of 2025, with net profit rising by 4.74% to 60.7942 million yuan [2] - The raw material drug and intermediate business segments reported sales growth of 13.94% and 29.24% respectively, driving overall performance improvement [2] - The company achieved a significant 53.04% increase in overseas sales, supported by a strong focus on product quality and service, leading to an expanded market share [2] Group 3: Fuhong Hanlin - Fuhong Hanlin's application for the market registration of HLX04-O, a recombinant humanized monoclonal antibody injection for wet age-related macular degeneration, has been accepted by the National Medical Products Administration [3] - Currently, there are no approved products for this indication in China, highlighting a potential market opportunity [3] Group 4: Huazhong Medicine - Huazhong Medicine announced plans to invest up to 87 million yuan to establish a biopharmaceutical industry fund, targeting a total fundraising goal of 500 million yuan [5] - The fund aims to optimize the company's strategic layout in synthetic biology and enhance innovation incubation and product commercialization [6] Group 5: Xingqi Eye Medicine - Xingqi Eye Medicine has initiated the Phase II clinical trial for voriconazole eye drops, targeting fungal keratitis, a common cause of blindness in China [7] - Voriconazole is noted for its broad antimicrobial spectrum and low toxicity, with the trial designed to explore its efficacy and safety in patients [7] Group 6: East China Pharmaceutical - East China Pharmaceutical has signed an exclusive commercialization agreement for VC005 with Jiangsu Weikail, committing to an initial payment of 50 million yuan and potential milestone payments up to 180 million yuan [8] - The agreement grants East China exclusive rights for the oral formulation of VC005 in mainland China, indicating a strategic move to expand its product portfolio [8]

Group 1 - The company has completed the enrollment of the first subject in the Phase II clinical trial for the innovative drug SQ-22031 on June 27, 2025 [2] - The trial is a randomized, double-blind, placebo-controlled study aimed at evaluating the efficacy of SQ-22031 eye drops in treating neurotrophic keratitis (NK) patients [2]

Core Viewpoint - The company has initiated the Phase II clinical trial for Voriconazole eye drops, targeting fungal keratitis, a common and severe eye disease in China [1] Group 1: Company Developments - On August 12, the company announced the enrollment of the first subject in the Phase II clinical trial for Voriconazole eye drops [1] - Voriconazole is a new generation triazole antifungal with a broad antibacterial spectrum, low toxicity, and strong antibacterial efficacy [1] - The Phase II clinical trial is a randomized, positive-controlled, multi-center exploratory study aimed at assessing the efficacy and safety of Voriconazole eye drops in subjects with fungal keratitis [1] Group 2: Industry Context - Fungal keratitis is a common cause of blindness in China, characterized by high incidence, difficult clinical diagnosis, long treatment cycles, and a tendency to recur, causing significant patient suffering [1] - As of the announcement date, there are no approved Voriconazole eye drops listed on the National Medical Products Administration website [1]

Group 1 - The company has initiated Phase II clinical trials for its Voriconazole eye drops, with the first subject enrolled, targeting fungal keratitis, a common cause of blindness in China [1] - Voriconazole is a new generation triazole antifungal with a broad antibacterial spectrum, low toxicity, and strong antibacterial efficacy [1] - The Phase II trial aims to explore the efficacy and safety of Voriconazole eye drops in subjects with fungal keratitis, paving the way for a Phase III trial [1] Group 2 - The company previously announced the enrollment of the first subject in Phase III clinical trials for Lidocaine Hydrochloride eye gel, which is used for surface anesthesia [2] - Lidocaine Hydrochloride eye gel enhances the contact time with the eye surface, improving anesthesia effectiveness [2] - The company also completed the first subject enrollment for the Phase II clinical trial of SQ-22031 eye drops for treating neurotrophic keratitis [2] Group 3 - As of the 2024 annual report, the company holds 60 approved ophthalmic drug licenses, with 38 products included in the medical insurance catalog and 6 in the national essential drug list [3] - The company's R&D investments over the past three years were 190 million, 181 million, and 235 million yuan, representing 15.22%, 12.38%, and 12.11% of revenue, respectively [3] - The company plans to continue increasing R&D investments to expand its product line in the ophthalmic sector and strengthen its biopharmaceutical presence in treating retinal diseases [3]