Fundraising Overview - The company raised a total of RMB 200,000.00 million through a share placement, with actual funds raised amounting to RMB 171,599.38 million after deducting issuance costs of RMB 4,625.36 million, resulting in a net amount of RMB 166,974.02 million [1][5] - As of June 30, 2025, the company has utilized RMB 171,655.28 million of the raised funds, with RMB 4,865.02 million used in the first half of 2025 [1][5] - The balance of the fundraising account as of June 30, 2025, is RMB 947.31 million, primarily held in dedicated fundraising accounts [1][5] GDR Issuance - The company issued Global Depository Receipts (GDR) corresponding to 63,825,000 shares, raising approximately USD 9,204 million, with a net amount of about USD 8,930 million after deducting underwriting and bank fees [1][5] - As of June 30, 2025, the GDR fundraising account balance is USD 9,766.53 million, including interest income of USD 1,087.17 million [1][5] Fund Management - The company has established a fundraising management system to ensure that the funds are used specifically for their intended purposes, with strict approval processes in place [1][5] - Funds are stored in dedicated accounts approved by the board, and a tripartite supervision agreement has been signed with the sponsoring institution and banks [1][5] Fund Utilization - In the first half of 2025, the company used RMB 4,865.02 million of the raised funds, with approximately 70% allocated for global R&D and industrialization plans, 10% for global sales and service network development, and 20% for working capital and other general corporate purposes [1][5] - The company has replaced RMB 21,532.82 million of self-raised funds with the raised funds for investment projects, complying with legal requirements [1][5] Project Changes - The company has changed the use of funds from the Zhuhai Health Industry Base project to new product R&D, expansion of the Haibin Pharmaceutical Pingshan base, and information technology platform projects due to changes in project feasibility and market conditions [1][5] - The company plans to return RMB 3,386.29 million from the sale of land use rights related to the Zhuhai project to the fundraising account for new product R&D [1][5] Compliance and Disclosure - The company has complied with relevant regulations regarding the disclosure of fundraising storage and utilization, with no violations reported [1][5]

Core Insights - The article highlights the ongoing development and innovation in the synthetic biology and biomanufacturing sectors in China, with a focus on Guangdong province, particularly Guangzhou and Shenzhen, which are leading in policy support and innovation outcomes [2][3]. Summary by Sections Industry Overview - Guangdong province's biomanufacturing industry is valued at approximately 1.3 trillion yuan, ranking third nationally, with plans to elevate the industry to a trillion-yuan scale through the "Action Plan for Accelerating the Construction of Biomanufacturing Industry Innovation High Ground" [2]. - Shenzhen has positioned synthetic biology as one of its "20+8" future industries, establishing a comprehensive support system for biomanufacturing, including a major synthetic biology infrastructure and a national innovation center [2]. Company Rankings - SynBioCon has released the "Top 500 Representative Enterprises in Biomanufacturing (Guangdong Edition)," featuring 76 companies recognized for their competitiveness based on team, core products, and diverse possibilities [3]. Upcoming Events - The "China Biomanufacturing Industry Map (2025)" will be published in August 2025, with a focus on 500 representative enterprises in biomanufacturing [1]. - The Fourth Synthetic Biology and Green Biomanufacturing Conference will be held from August 20-22, 2025, in Ningbo, Zhejiang, focusing on AI and biomanufacturing, green chemicals, new materials, future food, and agriculture [12][14].

Core Viewpoint - The continuous implementation of centralized drug procurement in China is reshaping the pharmaceutical industry, pushing traditional companies towards efficiency, innovation, and international expansion to ensure sustainable development [1][2]. Group 1: Centralized Drug Procurement - The National Healthcare Security Administration has conducted the tenth batch of centralized drug procurement, involving 62 types of drugs, bringing the total to 435 since 2018 [1]. - Experts indicate that the normalization of centralized procurement is forcing traditional pharmaceutical companies to abandon simple expansion strategies and adapt to a more efficient and innovative operational model [1][2]. Group 2: Cost Control and Efficiency - Centralized procurement has significantly reduced drug prices by compressing the price margins in the distribution chain, compelling traditional companies to optimize costs and build a lean management system across the entire industry chain [2]. - Companies like Jiangsu Jibeier Pharmaceutical have implemented strict procurement management systems to control costs, while Health元药业 has integrated AI technology to enhance production efficiency and reduce risks [2]. Group 3: Research and Development - 博瑞医药 has increased its R&D investment in innovative drugs and inhalation formulations to 62.78% of total R&D spending, a year-on-year increase of 77.37% [3]. - The shift from scale expansion to lean survival is seen as a long-term strategic choice for traditional pharmaceutical companies, emphasizing the importance of genuine innovation for sustainable growth [3][4]. Group 4: Innovation and Market Position - Traditional pharmaceutical companies are increasingly focusing on developing innovative drugs and high-barrier generic drugs to transition from reliance on low-cost generics [4]. - 恒瑞医药 has invested 46 billion yuan in R&D since 2011, achieving significant milestones in innovative drug approvals and clinical trials [5]. Group 5: International Expansion - Chinese pharmaceutical companies are becoming key players in the global market, with over 90 licensing transactions completed in 2024, totaling over 50 billion USD [7]. - The trend of "going global" is driven by enhanced R&D capabilities and favorable external conditions, allowing companies to compete effectively on the international stage [7][8].

调研纪要：博瑞医药在mylin靶点研发上取得进展，BGM1812具备减脂少减肌潜力，计划中美IND申 请。公司认为mylin及mylin加双靶点组合具国际竞争力，计划在美国推进临床，口服多肽有望超越小分 子单靶点GLP-1。公司重点开发吸入制剂和注射用补铁剂，多个产品已报产或完成BE试验，未来继续开 发难仿产品和技术壁垒高的管线。外销占45%，直接发货美国业务规模较小，影响有限。发酵半合成板 块稳定，传统全合成小分子仿制药易受竞争影响，注射用铁剂等新药获批可弥补影响。超一半研发投入 用于代谢方向，其余投向有门槛的仿制药和创新药，以呼吸制剂、吸入制剂为主。 机构简介： 上海健顺投资管理公司成立于2006年4月，是由北京大学校友合作发起的，致力于资本市场投资管理及 咨询服务的专业投资管理公司，公司资产管理投资范围覆盖国内A股和香港股票市场，并专注于为机构 客户和高端私人客户提供专业的财富管理服务。 以上内容为证券之星据公开信息整理，由智能算法生成（网信算备310104345710301240019号），不构成投资建议。 2）沃顿科技 （健顺投资参与公司特定对象调研&现场参观） 调研纪要：沃顿科技业务涵盖核心膜业务 ...