2025年，恒生医疗保健指数在经历下半年大回撤后依旧保住了50%以上的年度涨幅。相较之下，作为一家手握3款商业化创新药并拥有首创抗体靶向偶联药 物的创新药企，和黄医药(00013)却最终以8.56%的年度跌幅收场，显著跑输指数。 该公司股价在2025年最高涨幅仅36.36%，并且"跟跌不跟涨"。2025年下半年，其股价从30.75港元年内高点，一路跌至19.95港元区间低点，4个半月内最大跌 幅达到35.12%。 不过就在市场以为和黄医药股价会一路低迷下去时，其在2026年开年却走出了一波量价齐升的行情。 智通财经APP观察到，和黄医药在2026年前5个交易日持续发力，走出一段"五连阳"，区间内单日成交量最大达到1545.16万股，刷新自去年10月以来的单日 成交量记录。 港股通更趋向"右侧交易" 据智通财经APP观察，和黄医药股价自去年4月初因外部环境震荡影响跌破BOLL线下轨后，其后续股价大部分时间都在BOLL线的中轨至上轨之间浮动，这 一股价表现也契合了2025年港股创新药拉升行情。但25中报的披露成为了其二级市场反转的一个转折点。 去年8月7日美股盘前，和黄医药公布了其2025年中报业绩。财报显示，公 ...

科伦博泰生物-B(06990)核心产品TROP2 ADC芦康沙妥珠单抗(SAC-TMT)联合免疫疗法帕博利珠单抗一 线治疗PD-L1阳性局部晚期或转移性非小细胞肺癌获NMPA突破性疗法认定 英硅智能(03696)与施维雅达成价值8.88亿美元的多年期抗肿瘤药物研发合作 和黄医药(00013)启动现正进行中的索凡替尼联合卡瑞利珠单抗用于治疗初治胰腺导管腺癌研究的III期 阶段 重大事项： "山海‧知医大模型"赋能 云知声 (09678) 拿下超 2000 万区域医疗合作大单 海天国际(01882)附属拟3.42亿元出售国华机械的100%股权 越秀地产(00123)附属拟出售杭州越运合共73.74%实际权益 歌礼制药-B(01672)宣布ASC30在糖尿病受试者中的 13周II期研究IND获美国FDA批准 复锐医疗科技(01696)旗下获再授权注射用A型肉毒毒素已通过中国食品药品检定研究院质量标准检验 康希诺生物(06185)：24价肺炎球菌多糖结合疫苗(CRM197╱破伤风类毒素)在中国获临床试验批准 石四药集团(02005)：取得培哚普利氨氯地平片(Ⅲ)(精氨酸培哚普利10mg、苯磺酸氨氯地平5mg)的药品 ...

Core Viewpoint - The company, Hutchison China MediTech Limited (和黄医药), has initiated the Phase III portion of a clinical trial for surufatinib in combination with camrelizumab, nab-paclitaxel, and gemcitabine for the first-line treatment of metastatic pancreatic ductal adenocarcinoma (PDAC) patients in China, with the first patient receiving treatment on December 30, 2025 [1]. Group 1 - The study is a multicenter, randomized, open-label, positive-controlled Phase II/III clinical trial aimed at evaluating the efficacy and safety of the S+C+AG regimen compared to the AG regimen in adult patients with metastatic pancreatic cancer who have not previously received systemic anti-tumor therapy [2]. - The Phase II portion of the study included 62 patients, with plans to enroll approximately 400 additional patients in the Phase III portion [2]. - The primary endpoint of the Phase III portion is overall survival (OS), while secondary endpoints include progression-free survival (PFS), objective response rate (ORR), duration of response (DoR), disease control rate (DCR), quality of life, and safety [2]. Group 2 - Results from the Phase II portion were recently presented at the 2025 European Society for Medical Oncology (ESMO) Asia Congress, showing a median PFS of 8.15 months as of the data cutoff on July 24, 2025 [3]. - The S+C+AG group had a median PFS of 7.20 months compared to 5.52 months for the AG group, indicating a 50.1% reduction in the risk of disease progression or death (HR 0.499, p=0.0407) [3]. - Other key efficacy endpoints showed similar benefits, with an ORR of 67.7% versus 41.9% (p=0.0430) and a DCR of 93.5% versus 71.0% (p=0.0149) [3]. - Although overall survival data is not yet mature, a positive trend has been observed, with 9 events in the S+C+AG group and 15 events in the AG group [3]. - The treatment demonstrated manageable safety characteristics, with 80.6% of patients in the S+C+AG group experiencing grade 3 or higher treatment-emergent adverse events (TEAEs), compared to 61.3% in the AG group [3].

该研究II期部分的结果近期已于2025年欧洲肿瘤内科学会(ESMO)亚洲大会上公布。至数据截止日2025 年7月24日，中位PFS随访时间为8.15个月。S+C+AG方案组的中位PFS为7.20个月，而AG组则为5.52个 月(分层风险比[HR]0.499，log-rank检验p=0.0407)，意味着疾病进展或死亡风险降低了50.1%。其他关键 疗效终点也观察到了类似的获益，包括ORR(67.7%对比41.9%，p=0.0430)和DCR(93.5%对比71.0%， p=0.0149)。尽管在分析时总生存期数据尚未成熟，但已观察到积极趋势(未达到对比8.48个月，未分层 HR0.555)，S+C+AG组发生了9例事件(N=31)，AG组则发生了15例事件(N=31)。治疗展示出可控的安全 性特徵，S+C+AG组中80.6%的患者发生3级或以上治疗期间不良事件(TEAE)，而AG组则为61.3%。 和黄医药(00013)公布，公司今日宣布启动索凡替尼(surufatinib)联合卡瑞利珠单抗(camrelizumab)、白蛋 白结合型紫杉醇(nab-paclitaxel)和吉西他滨(gemcitabine)用 ...

格隆汇1月5日丨和黄医药(00013.HK)宣布启动索凡替尼(surufatinib)联合卡瑞利珠单抗(camrelizumab)、 白蛋白结合型紫杉醇(nab-paclitaxel)和吉西他滨(gemcitabine)用于一线治疗转移性胰腺导管腺癌(PDAC) 患者的中国II/III期研究的III期部分。首名患者已于2025年12月30日接受首次给药治疗。 ...

Group 1 - The core viewpoint of the articles highlights the rapid development of Shanghai's Pudong New Area as a leading zone for socialist modernization, driven by technological innovation and a robust innovation ecosystem [1][2]. - Pudong's three leading industries—integrated circuits, biomedicine, and artificial intelligence—are projected to reach a scale of 832.3 billion RMB in 2024, accounting for 46% of Shanghai's total, with an average annual compound growth rate of 11.7% over the past three years [2]. - The Zhangjiang Fudan International Innovation Center exemplifies the transformation of traditional campuses into technology innovation parks, focusing on key industries and establishing a top-tier research hub [1][3]. Group 2 - Hutchison Whampoa Pharmaceutical (Shanghai) Co., as a benchmark enterprise in Pudong's biomedicine sector, has established a global innovation drug production base, which is expected to increase production capacity by over five times [2]. - Pudong has attracted over 4,000 enterprises in the biomedicine field, including nine of the world's top ten pharmaceutical companies, with nearly 2,000 research pipelines currently under development [2]. - The rapid growth of Zhiyuan Robotics, a humanoid robot mass production company, is attributed to Pudong's supportive industrial environment, talent policies, and the clustering of related industries [3][4]. Group 3 - The establishment of the Moli Community in Zhangjiang has led to the rapid gathering of over 150 large model enterprises, showcasing the area's commitment to fostering innovation in various high-tech sectors [4]. - Pudong has initiated the first batch of autonomous taxi operation licenses and has opened over 1,000 kilometers of advanced autonomous driving testing roads, further enhancing its technological landscape [4]. - The region is making strides in multiple emerging fields, including synthetic biology, satellite internet, new energy storage, and nuclear fusion, positioning itself at the forefront of industrial development [4].

形势越复杂，浦东的战略地位越凸显。 在经历一段压力期后，上海浦东重拾引领性增长。 2025年前三季度，浦东新区地区生产总值达到13536亿元，现价同比增长6%，分别高出上海、全国0.5个、0.8个百分点。 自2020年11月，浦东被赋予打造社会主义现代化建设引领区的这5年，恰逢纷繁复杂的国际国内环境和大国竞争博弈交织，以及新一轮科技革命和产业变革 的加速演进。"形势越复杂，浦东的战略地位越凸显。"上海浦发新区发改委主任肖林表示。 目前，《中共中央 国务院关于支持浦东新区高水平改革开放打造社会主义现代化建设引领区的意见》（下称中央《引领区意见》）明确的121项任务基本完 成。2024年浦东生产总值达1.78万亿元，比2020年现价增长34%，2025年前三季度人均生产总值达4.3万美元，超过意大利水平；全员劳动生产率达60.6万元/ 人；城乡居民人均收入达9.5万元。 在打造国内大循环的中心节点和国内国际双循环的战略链接的过程中，基于引领区建设而持续增强的科技创新策源功能、高端产业引领、高水平改革开放、 全球资源配置能力等，正在为浦东积蓄更多动能，也成为上海为全国发展大局挑大梁的一张重要"王牌"。 更多"从0到 ...

Group 1: Company Highlights - The new generation industrial-grade interactive humanoid robot "Spirit G2" is undergoing final factory testing, with a procurement contract exceeding 100 million yuan for delivery to Yujin Electronics' automotive parts factory [1] - ZhiYuan Robotics, founded in Pudong two years ago, has emerged as a leader in humanoid robot commercialization, reflecting the development of the Pudong New Area over the past five years [1][3] - As of September 2025, ZhiYuan Robotics has achieved significant growth in delivery volume, with thousands of units delivered across various sectors including research, education, interactive services, and industrial operations [4] Group 2: Industry Growth - The Pudong New Area has seen a remarkable economic performance, with a projected GDP of 1.78 trillion yuan in 2024, a nearly 35% increase from 2020, and a per capita GDP of $43,000, surpassing Italy [1][4] - The high-end industrial clusters in Pudong are thriving, with the integrated circuit, biomedicine, and artificial intelligence sectors reaching a combined scale of 832.3 billion yuan in 2024, growing at an average annual rate of 11.7% over the past three years [8] - The biopharmaceutical sector is also flourishing, with the innovative anti-tumor drug Fuzhuotini, developed by Huaneng Pharmaceutical, successfully entering over 30 countries and expected to reach a billion-dollar market [4][5] Group 3: Policy and Ecosystem Support - The supportive policies and innovation ecosystem in Pudong, including the "Qingchuang 15 Articles" talent policy, have fostered a conducive environment for startups and innovation [4][15] - The establishment of the Pudong New Area's "Going Global" service center has facilitated over 270 global service points, providing comprehensive support for enterprises looking to expand internationally [13] - The continuous improvement of the business environment in Pudong has led to a more than 40% increase in the number of market entities over five years, with over 200 new companies established daily [15][17]

Core Viewpoint - Hutchison China MediTech Limited (HCM) announced the latest updates on several research studies of its self-developed compounds, which will be presented at major upcoming oncology conferences in 2025 [1] Group 1: Upcoming Presentations - Results from the first human clinical trial of the anti-CD47 monoclonal antibody HMPL-A83 for the treatment of advanced solid tumors will be presented at the ESMO Asia Congress in Singapore from December 5 to 7, 2025 [1] - The results of the FRUSICA-2 registration study's Phase II portion, which examines fruquintinib in combination with sintilimab for second-line treatment of locally advanced or metastatic renal cell carcinoma, will also be shared at the same ESMO Asia Congress [1] - Additionally, results from a Phase II/III study of surufatinib combined with camrelizumab and chemotherapy for first-line treatment of metastatic pancreatic cancer will be presented at the conference [1]

Core Viewpoint - Hutchison China MediTech Limited (HCM) announced the latest and updated data from several studies of its self-developed compounds, which will be presented at the European Society for Medical Oncology (ESMO) Asia Congress in Singapore and the American Society of Hematology (ASH) Annual Meeting in Orlando in December 2025 [1] Group 1: Clinical Trials and Presentations - The first human clinical trial results of the anti-CD47 monoclonal antibody HMPL-A83 for the treatment of advanced solid tumors will be presented at the 2025 ESMO Asia Congress [1] - Results from the FRUSICA-2 registration study's Phase II portion, which examines fruquintinib in combination with sintilimab for second-line treatment of locally advanced or metastatic renal cell carcinoma, will also be disclosed at the 2025 ESMO Asia Congress [1] - The Phase II portion results of a study combining surufatinib with camrelizumab and chemotherapy for first-line treatment of metastatic pancreatic cancer will be presented at the same congress [1]