Shares of Eli Liy are now down over 14 plus%. That is uh well more than where uh the stock opened this morning. This follows what is being seen as disappointing data for its upcoming pill to treat obesity.Let's get to Angelica Peebles for more. Angelica, this is uh this is getting pretty serious in terms of a market cap loss now. Yeah, David, quite a big reaction today and that's because of the data like you talked about.So, let's get into the numbers. people lost about 12% of their body weight after a litt ...

Group 1 - Novo Nordisk (NVO.US) shares rose nearly 6%, reaching $47.99 as of the report [1] - Eli Lilly (LLY.US) competitor's first small molecule oral GLP-1 drug, Orforglipron, achieved an average weight loss of 11.2%, which is below the expected range of 13% to 15% or more [1]

Summary of Eli Lilly's Q2 2025 Earnings Call Company Overview - **Company**: Eli Lilly - **Date**: Q2 2025 Earnings Call Key Financial Performance - Gross margin reached **85%**, up **3%** year-over-year, driven by lower production costs and optimized product mix, partially offset by price declines [2][3] - Non-GAAP operating margin at **40.5%**, an increase of over **6 percentage points** year-over-year [4] - Earnings per share (EPS) increased by **61%** to **$6.31**, including a negative impact of **$0.14** from the acquisition of IPR and depreciation [4] - Revenue growth of **38%** in the U.S., primarily due to strong sales of **Mounjaro**, despite an **8%** price decline [3][5] - European revenue grew by **77%**, reflecting strong performance from the Montana business [5] - Revenue in China increased by **19%**, mainly due to increased sales from the Montana business [5] - Total revenue expected to be between **$60 billion** and **$62 billion** for 2025, with non-GAAP operating margin projected between **43%** and **45.5%** [3][13] Market Performance - U.S. market revenue growth driven by **Mounjaro**, **Bydureon**, and **Trulicity** sales [3] - International sales growth of **12%** in oncology, with U.S. prescriptions up **454%** [3][10] - Montana product line achieved **$5.2 billion** in global sales, becoming a leader in the type 2 diabetes prescription market [12] Research and Development Highlights - Multiple new clinical projects initiated, with increased R&D investment [6] - Acquisition of **Site One Therapeutics** and **Verb Therapeutics** to expand non-opioid pain and cardiovascular gene therapy portfolios [6] - FDA approval for new dosing schedule of **Casirol** and positive results from **Surpass CDOT** and **Brewing CLL 314** Phase III trials [7] - **Atern** Phase I trial showed significant weight loss in obese patients, with safety comparable to injectable GLP-1 drugs [8] Addressing Global Health Challenges - Eli Lilly is actively addressing the global obesity challenge with new drug submissions planned [8] - The company supports government reforms to share the costs of medical research more equitably and reduce consumer costs in the U.S. pharmaceutical market [9] Pricing and Cost Management - Eli Lilly's **Lily Direct** model offers affordable medications, with weight loss drugs priced over **50%** lower than previous prices and insulin prices reduced by **70%** [9] - The company emphasizes the need for urgent reforms in the U.S. pharmaceutical market to lower consumer costs [9] Future Expectations - Anticipated production capacity in the second half of 2025 expected to be at least **1.8 times** that of the second half of 2024 [14] - Continued focus on expanding market share in the obesity and diabetes sectors, with new product launches planned [12][20] Conclusion Eli Lilly's Q2 2025 performance reflects strong revenue growth across multiple markets, significant advancements in R&D, and a commitment to addressing global health challenges while managing costs effectively. The company is well-positioned for future growth with a robust pipeline and strategic acquisitions.

【#礼来口服减重药数据公布# ，#礼来口服减重药72周平均减重12.4%#】 当地时间8月7日，礼来公布了一项口服减重药的重磅三期临床数据，患者用药72周后平均实现减重 12.4%。同日，礼来公布第二季度业绩，上调全年利润预期。 礼来公布的最新临床数据显示，在超过3000名肥胖或至少伴有一种体重相关合并症的超重但无糖尿病的 成人中，每日服用一次的GLP-1口服减重药Orforglipron，在72周用药时，最高剂量组平均减重12.4kg， 减重幅度达12.4%。 不过，由于此前市场对于这款口服减重药数据预期更高，礼来股价在盘前交易中下跌了约10%。 ...

Group 1: 401K Retirement Savings Plan Changes - The U.S. President Trump is set to sign an executive order allowing alternative assets such as private equity, real estate, and cryptocurrencies to be included in 401K retirement savings plans, potentially opening up approximately $12.5 trillion in retirement account funds to these sectors [3][4] - The executive order will instruct the Department of Labor to reassess guidelines regarding alternative asset investments in retirement plans and clarify the government's fiduciary responsibilities when offering funds that include alternative investments [3][4] Group 2: Eli Lilly's Weight Loss Drug Performance - Eli Lilly reported second-quarter earnings that exceeded market expectations, with revenue of $15.557 billion, a 38% year-over-year increase, and net income of $5.661 billion, a 91% increase [8] - Despite strong earnings, the company's stock plummeted by 13% due to disappointing results from its experimental weight loss drug orforglipron, which helped patients lose about 11% of their weight, falling short of market expectations [8] Group 3: Unemployment Claims and Federal Reserve - The U.S. Department of Labor reported an increase of 38,000 in continuing unemployment claims, reaching 1.97 million, indicating growing difficulty for unemployed individuals to find new jobs [6] - Following a significant downward revision of employment data, there are heightened concerns among investors and economists regarding further deterioration in the labor market, which may influence expectations for a potential interest rate cut by the Federal Reserve in September [6] Group 4: Intel CEO Controversy - President Trump called for Intel CEO Pat Gelsinger to resign, citing serious conflicts of interest, which led to a more than 2% drop in Intel's stock price following the announcement [10] - Intel stated that it values national security and the integrity of its role in the U.S. defense ecosystem, indicating ongoing communication regarding the issues raised by Trump [10]

周四美股开盘后整体表现平稳，三大股票指数小幅上涨，但涨幅均不超过1%。 当天最重磅的消息是美国总统特朗普即将签署行政命令，允许私募股权、房地产、加密货币等另类资产进入401K退休储蓄计划。此外，礼来公司因为减肥药效果不 达预期股价暴跌。 401K可投资加密货币 据媒体最新报道，美国总统特朗普将于当地时间周四签署行政令，允许私募股权、房地产、加密货币等另类资产进入401K退休储蓄计划，为这些行业打开约12.5万 亿美元退休账户资金的大门。 所谓的401K计划是指美国1978年《国内税收法》新增的第401条K项条款的规定，是一种由雇员、雇主共同缴费建立起来的完全基金式的养老保险制度。按该计 划，企业为员工设立专门的401K账户，员工每月从其工资中拿出一定比例的资金存入养老金账户，而企业一般也按一定的比例（不能超过员工存入的数额）往这一 账户存入相应资金。与此同时，企业向员工提供3到4种不同的证券组合投资计划。员工可任选一种进行投资。员工退休时，可以选择一次性领取、分期领取和转为 存款等方式使用。 据透露，新签署的行政令将指示劳工部重新评估《1974年雇员退休收入保障法》规定的退休计划中另类资产投资的相关指导意见。 ...

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礼来大幅低开后持续走低， 股价跌近14%。 ...

智通财经APP获悉，周四，诺和诺德(NVO.US)股价走高，截至发稿，该股涨近6%，报47.99美元。消息 面上，该公司竞争对手礼来(LLY.US)的首个小分子口服GLP - 1药物Orforglipron实现平均减重11.2%，低 于预期的13%至15%或更多。 ...

Core Viewpoint - Novo Nordisk's stock price increased by nearly 6% to $47.99 following news about a competitor's drug performance [1] Group 1: Company Performance - Novo Nordisk's stock price rose significantly, indicating positive market sentiment towards the company [1] - The competitor Eli Lilly's first oral GLP-1 drug, Orforglipron, achieved an average weight loss of 11.2%, which was below the expected range of 13% to 15% or more [1] Group 2: Market Reaction - The market reacted positively to Novo Nordisk's stock, reflecting investor confidence in its products compared to competitors [1] - The underperformance of Eli Lilly's drug may create a competitive advantage for Novo Nordisk in the GLP-1 market [1]