浦安谛同样认为，在中国，专家的科研能力，政府的支持和监管推动创新，企业家敢于且善于将优秀的 科研成果转化为产品，三者形成合力。未来中国新的研发成果，可能会在相关靶点既有机制上做出有创 新性的改良。 王璘指出，中国在AI等科技领域越来越强大，可以为全球研发带来加速度，我们希望进一步深化在华 研发战略。(完) "过去几年，中国已经出现了很多同类最佳(best-in-class)、同类首创(first-in-class)的创新成果。在与上海 知名医院的合作中，我们也看到一些具有首创潜力的靶点。"王璘表示，中国的创新不仅能帮助本地患 者，还能惠及全球患者。 （文章来源：中国新闻网） 中新社上海9月18日电 (记者陈静)"中国在生命科学领域飞速发展，我认为并不是一蹴而就的，而是经历 了数十年的积累。"武田全球研发总裁浦安谛(Andy Plump)博士17日接受中新社记者采访时指出。 "用于治疗1型发作性睡病的药物TAK-861就是一个非常好的例子。中国不仅参与了Ⅲ期研究，还参与了 Ⅰ期研究。"王璘举例说，中国患者基数大，研究人员和临床中心专业能力强，都在助力武田的全球研 发，关键在于让中国尽早参与全球研发和讨论。 武田 ...

"生物学本身充满不确定性。"浦安谛客观地说，在生物医药行业，开发新药是极其困难的事情。从0到1 的创新确实很难，但从1到10、从10到100，每一步都很难。 "让我印象深刻的是中国专家卓越的学术能力、样本可及性、对前沿成果的关注以及成果转化的决 心。"这位跨国企业全球研发总裁表示，"中国还需要一些时间来证明自己。但我有信心，中国不仅能够 实现从0到1的原创创新，还能达到全球领先水平。" 跨国药企高层：中国可为全球研发带来"加速度" 会成全球研发典范 中新网上海9月17日电 (记者 陈静)"中国在生命科学领域的发展飞速，令人瞩目。我认为中国的成功并 不是一蹴而就的，而是经历了数十年的积累。"武田全球研发总裁浦安谛(Andy Plump)博士17日接受中 新网记者采访时指出，"我相信未来五年，中国会成为全球研发的一个典范"。 "中国具备卓越的人才和完善的基础设施，能够低成本、高质量完成研发，这是世界罕见的。"浦安谛直 言。 在武田全球研发高级副总裁、全球研发区域负责人兼武田研发中国及亚太中心负责人王璘博士看来，来 自中国药监部门的推动力、政策带来的加速度以及来自专家的驱动力都是创新生态体系中的重要组成部 分。浦安 ...

Hosted by the TAK Product Center, alongside the C5ISR Center and TAK Configuration Steering Board, the TAK Offsite brought together government agencies, federal contractors, and technology providers to share insights, lessons, and solutions within the growing TAK ecosystem. As part of the event, John Dames, a recognized expert in C4ISR systems, demonstrated how VASTâ"¢Â enhances TAK capabilities by enabling multiple simultaneous HD streams over MANET as well as real-time video streaming over constrain ...

PresentationShinichiro MuraokaEquity Analyst Okay. So let's start the session with Takeda. My name is Shinichiro Muraoka, covering Japanese pharma. And before starting this, for important disclosures, please see the Morgan Stanley Research disclosure website at www.morganstanley.com/researchdisclosures. If you have any questions, please reach out to your Morgan Stanley sales representative. So yes, let's get started with Takeda. The speaker is CFO, Mr. Milano Furuta. Thank you for joining us. ...

PresentationChristopher David O'ReillyGlobal Head of Investor Relations & Global Finance Hello, everyone, and welcome to this investor call to discuss oveporexton Phase III data and commercial readiness. My name is Christopher O'Reilly, Head of Investor Relations at Takeda. Today's presentation will take place in English with simultaneous Japanese translation. During the Q&A, we may take questions in either English or Japanese. [Operator Instructions] I'd like to remind everyone that in this call, we will b ...

Takeda Pharmaceutical Company (NYSE:TAK) Investor Call Summary Company Overview - **Company**: Takeda Pharmaceutical Company Limited - **Focus**: Development and commercialization of Oveporexton, an orexin 2 receptor agonist for narcolepsy type 1 (NT1) Key Points and Arguments Oveporexton Development - Oveporexton is positioned to be the first orexin therapy addressing the underlying pathophysiology of NT1, with phase three results showing statistically significant improvements across all primary and secondary endpoints [3][8][35] - The drug has the potential to normalize how NT1 patients feel and function, setting a new standard of care [8][35] - The anticipated global commercial potential for Oveporexton is estimated between $2 billion to $3 billion [8][35][53] Clinical Trial Results - Phase three trials demonstrated high statistical significance across all 14 primary and secondary endpoints, with the majority of patients achieving normative ranges for excessive daytime sleepiness and cataplexy [4][18][35] - The mean sleep latencies for untreated NT1 patients were around 4-5 minutes, while patients on Oveporexton achieved results comparable to healthy individuals (20 minutes or more) [19][20] - Approximately 85% of patients on the two-milligram dose of Oveporexton achieved normal levels of daytime sleepiness as measured by the Epworth Sleepiness Scale [22][35] Patient Impact and Unmet Needs - NT1 significantly impacts patients' daily lives, leading to social isolation, cognitive impairment, and depression [9][10][42][44] - Current treatments do not address the underlying orexin deficiency, resulting in high rates of treatment switching and residual symptoms [40][41][58] - Oveporexton aims to provide a holistic approach to treatment, addressing both core symptoms and overall quality of life [47][55] Commercial Strategy - Takeda is preparing for the launch of Oveporexton by investing in education for healthcare providers and patients about orexin deficiency and the burden of NT1 [48][49] - The company plans to improve diagnosis rates from 50% to 60-70% through targeted initiatives [52] - Takeda's strategy includes developing innovative solutions for early and accurate diagnosis of NT1, leveraging partnerships and technology [50] Safety and Tolerability - Oveporexton has shown a consistent safety profile with no serious treatment-related adverse events reported [33][35] - Most adverse events were mild to moderate and self-limiting, with insomnia being a common but transient effect [33][66] Future Directions - Takeda is committed to expanding its orexin franchise with additional programs like TAC360 for other sleep disorders [36][53] - The company aims to lead in orexin science, exploring potential treatments for conditions beyond narcolepsy [54] Additional Important Content - The call highlighted the long and challenging journey patients face in obtaining an accurate NT1 diagnosis, often taking 10-15 years [39] - The emotional and social consequences of NT1 were emphasized, with patients feeling isolated and struggling with relationships [42][44] - Anecdotal evidence from patients indicated that Oveporexton could significantly improve their quality of life, allowing them to re-engage in activities they had previously given up [46] This summary encapsulates the critical insights from the investor call regarding Takeda's Oveporexton, its clinical efficacy, patient impact, and commercial strategy, while also addressing the unmet needs in the treatment of narcolepsy type 1.

Oveporexton Clinical Trial Results - Oveporexton U S and global filings are on track to start in FY25, with a global peak revenue potential of $2-3B+[11] - Phase 3 results demonstrated oveporexton's potential to achieve outcomes that matter most to patients[99] - Oveporexton is designed to treat the root cause of NT1 and has the potential to be a transformative Orexin therapy[99] - Ph3 results demonstrated oveporexton's potential to achieve outcomes that matter most to patients[99] Efficacy and Safety - In The First Light study, 95% of participants who completed the study continued into the long-term extension study[121] - In The Radiant Light study, 99% of participants who completed the study drug continued into the long-term extension study[157] - Oveporexton significantly improved mean sleep latency at 12 weeks compared with placebo, with 69% of participants in The Radiant Light study achieving mean sleep latency ≥20 min[163] - Oveporexton significantly reduced WCR over 12 weeks versus placebo and increased the number of cataplexy-free days for both doses[132] - Across both studies, >70% of participants treated with oveporexton had mild symptoms at week 12 versus <25% with placebo[204] Market Opportunity - Takeda estimates Oveporexton's NT1 global peak revenue potential at $2-3B+[93]

Sep 8, 2025 3:00 AM Eastern Daylight Time Takeda Presents Orexin Data from Landmark Oveporexton (TAK-861) Phase 3 Program in Narcolepsy Type 1 at World Sleep 2025 Share – Takeda is the Leader in Orexin Science and is on Track to Submit Global Regulatory Applications Starting in Fiscal Year 2025 – Four Orexin Oral Presentations from Phase 3 Pivotal Studies Highlight Statistically Significant and Clinically Meaningful Improvement in Narcolepsy Type 1 Symptoms Demonstrating the Potential for a New Era of Care ...

Group 1 - The Hebei Financial Regulatory Bureau approved the request from Taikang Life Insurance Co., Ltd. Hebei Branch regarding the change of business location for its Shijiazhuang Jingxing Sub-branch [1] - The new business location is specified as Room 0007 and Room 0008, 7th Floor, Building 3, Binhai World, No. 3514, Hebei Province, Shijiazhuang City, Jingxing County [1] - Taikang Life Insurance Co., Ltd. is required to handle the change and license renewal in accordance with relevant regulations [1]

三、请泰康人寿保险有限责任公司持此批复和泰康人寿保险有限责任公司河北张家口阳原支公司的保险 许可证到国家金融监督管理总局张家口监管分局办理有关换证手续，并按照《银行保险机构许可证管理 办法》的规定办理有关公告事宜。 此复。 2025年8月20日，国家金融监督管理总局张家口监管分局发布批复称，《泰康人寿保险有限责任公司河 北分公司关于泰康人寿保险有限责任公司河北张家口阳原支公司变更营业场所的请示》（泰康人寿冀发 〔2025〕136号）收悉。经审查，批复如下： 一、同意泰康人寿保险有限责任公司河北张家口阳原支公司营业场所由"河北省张家口市阳原县西城镇 光华路东河湾御景5幢5号"变更为"河北省张家口市阳原县西城镇光华路西侧紫昱嘉苑小区S3幢三层309 室"。 二、变更营业场所后，泰康人寿保险有限责任公司河北张家口阳原支公司不得在原营业场所办理业务。 ...