摩比发展(00947)发布公告，于2025年10月17日，该公司斥资1686港元回购1.1万股。 ...

据悉，博度曲妥珠单抗是一款用于治疗晚期HER2+实体瘤的差异化HER2ADC。作为一款由本公司开发 的创新HER2ADC，其通过稳定的酶可裂解连接子将新型单甲基奥瑞他汀F(MMAF)衍生物(高细胞毒性 微管蛋白抑制剂Duo-5)与HER2单克隆抗体偶联，药物抗体比(DAR)为2。博度曲妥珠单抗特异性地结合 肿瘤细胞表面的HER2，并被肿瘤细胞内吞，在胞内释放毒素分子Duo-5。Duo-5诱导肿瘤细胞週期阻滞 在G2/M期，引起肿瘤细胞凋亡。博度曲妥珠单抗靶向结合HER2后也可抑制HER2介导的信号通路;其具 有抗体依赖细胞介导细胞毒作用(ADCC)活性。 本次批准是基于一项多中心、随机、开放标签、对照3期KL166-III-06研究，旨在评估博度曲妥珠单抗对 比恩美曲妥珠单抗(T-DM1)用于治疗既往接受过曲妥珠单抗和紫杉类治疗的HER2阳性不可切除或转移 性BC患者中的疗效和安全性结果。在预设的期中分析中，与T-DM1相比，博度曲妥珠单抗单一疗法在 主要研究终点盲态独立中心评估(BICR)评估的无进展生存期(PFS)具有显著统计学意义和临床意义的改 善;亦观察到博度曲妥珠单抗总生存期(OS)的获益趋势。该研 ...

中石化炼化工程(02386)发布公告，截至2025年9月30日止九个月期间，集团新签订合同总值为人民币 913.47亿元，较截至2024年9月30日止九个月期间的人民币734.57亿元增加24.4%;于2025年9月30日，集 团未完成合同量为人民币2154.70亿元，较2024年12月31日的人民币1726.77亿元增加24.8%。 ...

Core Viewpoint - Hang Seng Bank has announced the appointment of Ms. Lin Huihong as the Executive Director and Chief Executive Officer, effective from October 20, 2025, marking a significant leadership change within the bank [1] Group 1: Leadership Changes - Ms. Lin Huihong will take over as Executive Director and Chief Executive Officer of Hang Seng Bank, also serving as the Chairman of the Operations Committee and a member of the Nomination Committee [1] - Ms. Shi Yingyin will step down from her roles as Executive Director and Chief Executive Officer, as well as from the positions of Chairman of the Operations Committee and member of the Nomination Committee, transitioning to a role as Vice Chairman of HSBC Hong Kong [1]

（原标题：汇丰控股(00005)10月16日斥资2.14亿港元回购209.48万股） 智通财经APP讯，汇丰控股(00005)发布公告，于2025年10月16日斥资7639.78万英镑回购773.65股股份; 斥资2.14亿港元回购209.48万股股份。 ...

智通财经APP讯，佳辰控股(01937)发布公告，朱文已获委任为执行董事，自2025年10月17日起生效。 ...

第二季度为公司业务的重要转捩点。期内，受惠于定价产品的强劲增长势头及计价黄金产品的改善趋 势，中国内地以及香港及澳门的同店销售增长均全面回升。内地方面，直营店于季内的同店销售转为 7.6%正增长，而加盟店的同店销售则增长8.6%。若撇除钟表业务，期内直营店的同店销售增长9.9%。 香港及澳门的同店销售同比增长6.2%，其中香港上升3.2%，澳门则上升17.3%。 格隆汇10月17日丨周大福(01929.HK)公布，截至2025年9月30日止三个月("第二季度")，未经审核主要经 营数据，集团于期间内零售值同比增长4.1%，于中国内地的零售值同比增长3.0%；于中国香港、中国 澳门及其他市场的零售值则同比增长11.4%。。 ...

汇丰控股(00005.HK)公告，10月16日耗资2.1亿港元回购209.5万股。 ...

格隆汇10月17日丨吉利汽车(00175.HK)公告，董事会会议将于2025年11月17日(星期一)上午十一时，假 座香港湾仔港湾道23号鹰君中心23楼2301室举行，以审议及批准(其中包括)公司及其附属公司截至2025 年9月30日止9个月未经审核季度业绩。 ...

Core Viewpoint - Xiaomi Group-W (01810) has seen a decline of over 15% in its stock price this month, with a current drop of 3.82% to HKD 45.88, and a trading volume of HKD 10.359 billion [1] Group 1: Incident Impact - The ongoing controversy surrounding the Chengdu Xiaomi SU7 accident has raised concerns, particularly regarding the car door's inability to open from the outside post-collision, contradicting Xiaomi's customer service claims of "automatic unlocking after collision" [1] - The safety of the semi-hidden electric door handles of the Xiaomi SU7 has also come under scrutiny [1] Group 2: Regulatory Developments - The State Administration for Market Regulation announced the establishment of a reporting system for fire incidents involving new energy vehicles and a remote upgrade reporting system during the 2025 World Intelligent Vehicle Conference [1] - A pilot program for automotive safety sandbox regulation will also be initiated [1] Group 3: Market Analysis - According to a report from China International Capital Corporation, Xiaomi's stock price has been volatile this week due to multiple news events and market rumors, including the Chengdu SU7 accident, road testing of a third model in Xinjiang, and the readiness of the second phase factory in Beijing [1] - Despite the Xiaomi 17 series performing better than the Xiaomi 15 series, it is anticipated that the gross profit margin (GPM) for Xiaomi smartphones will hit a low point in the second half of this year [1]