撰文丨王聪 编辑丨王多鱼 排版丨水成文 2026 年伊始，国际顶尖学术期刊 Nature 上线了 35 篇研究论文，其中 14 篇来自华人学者 （包括通讯作者和第一作者） 。 1 月 7 日，香港 香港中文大学 吕海荣 、 香港科技大学 全杨健 作为共同通讯作者，在 Nature 期刊发表了题为： Electrochemical defluorinative Matteson- type homologation （ 电化学脱氟马特森型同系化反应 ） 的研究论文 【1】 。 1 月 7 日， 伦斯勒理工学院 Meng Xiangyi 作为第一作者，在 Nature 期刊发表了题为： Surface optimization governs the local design of physical networks （ 表面优化控制着物理网络的局部设计） 的研究论文 【2】 。 1 月 7 日， 马萨诸塞大学医学院 翁志萍 作为通讯作者，在 Nature 期刊发表了题为： An expanded registry of candidate cis-regulatory elements （ 候选顺 式调控元件的 ...

Core Viewpoint - China is enhancing its mineral exploration efforts by integrating land and sea strategies, focusing on deep-sea resource investigation to secure critical metal supplies for its economy and technological advancement [1][2]. Group 1: Importance of Deep-Sea Mining - The demand for key metals such as nickel, cobalt, and copper is surging globally, making deep-sea mining a new frontier for technological and strategic competition among nations [2]. - China's reliance on foreign sources for certain metals is high, with cobalt dependency reaching nearly 99% and copper at 77%, highlighting the need for domestic resource security [4]. - The economic value of deep-sea mining is significant, with the potential value of metals extracted from seabed nodules estimated at 6,000 to 7,000 yuan per ton, compared to much lower values for land-based sources [4]. Group 2: Technological and Environmental Challenges - Deep-sea mining presents challenges in technology, environmental impact, and cost, requiring advanced solutions for stable and reliable operations in extreme underwater conditions [6][7]. - Recent breakthroughs in deep-sea mining technology, such as the "Kai Tuo No. 2" mining vehicle, demonstrate China's growing capabilities in this field, achieving operational depths of 4,000 meters [7]. - Environmental concerns arise from insufficient understanding of deep-sea ecosystems, with mining activities potentially causing unpredictable disturbances [8]. Group 3: Strategic Development and Future Directions - The Chinese government is planning a long-term roadmap for deep-sea mining, emphasizing the need for sustainable practices and international cooperation in technology development [9][10]. - Local initiatives, such as those in Qingdao, are focusing on enhancing deep-sea mining capabilities and integrating marine industries [9]. - The future of deep-sea mining in China will depend on solidifying foundational technologies, reducing uncertainties, and establishing responsible supply chain standards [10].

Core Viewpoint - The research reveals the atomic structure of pathological human islet amyloid polypeptide (hIAPP) fibrils, providing a significant foundation for understanding the mechanisms of type 2 diabetes (T2D) and developing treatment strategies [7]. Group 1: Research Findings - The study analyzed hIAPP fibrils extracted from pancreatic tissues of three T2D patients using cryo-electron microscopy (cryo-EM) [4]. - The hIAPP fibrils exhibited a uniform morphology, consisting of two symmetrical protofibrils, containing amino acid residues 2-37, and forming an Ω-shaped spatial fold [4]. - Additional electron density observed in pancreatic hIAPP fibrils suggests potential ligand binding, which may significantly impact the pathogenesis of T2D [4][5]. Group 2: Structural Insights - The core findings include the atomic structure of hIAPP fibrils derived from T2D patients [5]. - The hIAPP fibrils display an unprecedented Ω-shaped folding structure with a conserved core region [5]. - Structural similarities were observed between pathological hIAPP fibrils and Aβ fibrils [5].

国家知识产权局信息显示，中国重汽集团济南动力有限公司与上海交通大学取得一项名为"考虑焊接工 况的焊点熔透率在线检测方法及系统"的专利，授权公告号CN116202409B，申请日期为2022年11月。 声明：市场有风险，投资需谨慎。本文为AI基于第三方数据生成，仅供参考，不构成个人投资建议。 财经频道更多独家策划、专家专栏，免费查阅>> ...

Core Insights - The article discusses the increasing global demand for critical metals such as nickel, cobalt, and copper, leading to a strategic focus on deep-sea mining as a new frontier for resource exploration and technological competition among nations [2][4]. Group 1: Deep-Sea Mining Overview - Deep-sea mining involves both the exploration and development of resources on a nation's continental shelf and in international seabed areas regulated by the International Seabed Authority [3]. - The primary types of deep-sea metal deposits include polymetallic nodules, cobalt-rich crusts, metal sulfides, and deep-sea rare earths, which are essential for various industries, particularly the renewable energy sector [4]. Group 2: Strategic Importance - China's high dependency on foreign sources for certain metals, such as cobalt (99% dependency) and copper (77% dependency), underscores the importance of deep-sea mining for ensuring a stable supply chain for strategic resources [4]. - The economic value of deep-sea mining is significant, with the potential value of extracted materials from seabed nodules estimated to be between 6,000 to 7,000 yuan per ton, compared to much lower values for land-based mining [4]. Group 3: Technological and Environmental Challenges - The challenges of deep-sea mining include technological difficulties, environmental concerns, and high operational costs, with a focus on achieving reliable, unmanned operations in extreme underwater conditions [6][8]. - Recent advancements in deep-sea mining technology, such as the "Kai Tuo No. 2" mining vehicle, demonstrate China's progress in this field, achieving significant milestones in deep-sea operations [8]. Group 4: Future Development and Collaboration - The Chinese government has outlined a long-term roadmap for deep-sea mining, emphasizing the need for coordinated efforts in resource exploration and environmental protection [10]. - Future development should focus on building a sustainable framework for deep-sea mining, enhancing global cooperation, and establishing responsible supply chain standards [10][12].

Core Insights - The delayed blooming of osmanthus in Shanghai in 2025, occurring approximately three weeks later than previous years, signals the impact of climate change on plant life cycles and ecological systems [1][2]. Group 1: Phenological Anomalies and Climate Impact - The flowering of plants like osmanthus is controlled by an intricate balance between internal biological clocks and external environmental signals, with temperature playing a crucial role in breaking dormancy [2]. - In 2025, Shanghai experienced an extended summer with high temperatures, causing the flowering process of osmanthus to be delayed until a significant drop in temperature was observed in late October [2]. - Research indicates that climate warming has led to earlier spring phenology, affecting the timing of plant growth and carbon absorption [2][3]. Group 2: Tree Growth and Carbon Dynamics - Observations in a forest on Chongming Island revealed that while trees begin to leaf out earlier due to warming, their radial growth lags behind, indicating a disconnect between carbon absorption and storage under climate stress [3][4]. - The phenomenon of "source-sink decoupling" suggests that despite prolonged growth periods, actual carbon storage may not increase proportionately, complicating assessments of forest carbon functions [4]. Group 3: Resilience and Ecological Strategies - Diverse plant communities exhibit lower sensitivity to climate warming, suggesting that biodiversity can buffer against the impacts of climate change on phenology [5]. - Urban areas, experiencing the "urban heat island" effect, face unique challenges in plant species composition and phenological responses, necessitating careful selection of tree species for urban greening [5][6]. - The need for real-time monitoring and advanced ecological sensing technologies is emphasized to protect urban vegetation and ecosystems under climate change [6][7]. Group 4: Future Directions and Knowledge Integration - The integration of new knowledge regarding biodiversity, carbon cycling, and climate stress mechanisms into future Earth system models is crucial for accurately simulating urban ecological changes [7]. - Long-term observations and research are vital for understanding ecological changes and guiding effective management practices for urban vegetation [7].

Core Insights - Shanghai Jiao Tong University has announced multiple government procurement intentions, summarizing 40 items of instrument and equipment with a total budget of 131 million yuan [1][9][10]. Procurement Overview - The procurement involves high-resolution laser confocal microscopes, high-sensitivity seabed electromagnetic instruments, atomic force microscopes, ultra-low temperature strong magnetic field scanning tunneling microscopes, and high-power femtosecond solid-state lasers, with expected procurement time from October 2025 to January 2026 [2][10]. Detailed Procurement List - The procurement includes various systems such as: - Micro-nano sample sorting system with a budget of 2.95 million yuan, expected in December 2025 [11]. - Biological cell interaction and omics analysis system with a budget of 2.85 million yuan, expected in December 2025 [11]. - Cross-domain optical communication system with a budget of 1.98 million yuan, expected in October 2025 [11]. - Gravity module for underwater magnetic measurement with a budget of 4.3 million yuan, expected in October 2025 [11]. - High-sensitivity seabed electromagnetic instrument with a budget of 4 million yuan, expected in October 2025 [11]. - Atomic force microscope with a budget of 1.5 million yuan, expected in November 2025 [11]. - Ultra-low temperature strong magnetic field scanning tunneling microscope with a budget of 12 million yuan, expected in October 2025 [11].

特别提示 微信机制调整，点击顶部"仪器信息网" → 右上方"…" → 设为 ★ 星标，否则很可能无法看到我 们的推送。 摘要 ： 近日，上海交通大学发布多批政府采购意向，仪器信息网特对其中的仪器设备品目进行梳理，统 计出40项仪器设备采购意向，预算总额达1.31亿元。 近日， 上海交通大学发布 4 0 项仪器设备采购意向，预算总额达 1 . 3 1 亿 元，涉及高分辨率激 光共聚焦显微镜 、高灵敏海底大地电磁仪、原子力显微镜、极低温强磁场扫描隧道显微镜 、 高功率飞秒固体激光器 等，预计采购时间为2 0 2 5 年 1 0月~2 0 2 6年1 月。 详细采购清单： 上海交通大学2 0 2 5年1 0月~ 2 0 2 6年 1月 仪器设备采购 意向汇总表 | 采购 | | 预算 | 采购 | | --- | --- | --- | --- | | | 需求概况 | | | | 项目 | | 万元 | 时间 | | | 基于压电喷射技术，可精确地在皮升体积水平喷射各种生 | | | | 微纳 | 物类样本，如核酸，蛋白，细胞，微纳米颗粒等。得益于 | | 2025 | | 样本 | | | | | | 其非接触 ...

Core Viewpoint - The research highlights the role of extracellular proteins in supporting T cell immunity, particularly in the context of aging and its impact on immune response [2][4][7]. Group 1: Research Findings - The study published in Cell Reports reveals that even healthy elderly individuals with normal albumin levels (>25g/L) may experience limited T cell functionality during acute viral infections due to relatively lower albumin concentrations [2]. - Activated T cells can internalize extracellular proteins like albumin, degrade them in lysosomes, and release free amino acids such as leucine, which are crucial for maintaining mTORC1 activity and cytokine production, thereby enhancing antiviral and antitumor immunity [4][5]. - The transcription factor TFE3 plays a central regulatory role in this process, with its expression being specifically upregulated during T cell activation, promoting lysosomal biogenesis and protein degradation capabilities [4][5]. Group 2: Clinical Implications - The clinical significance of this pathway has been validated in elderly lung cancer patients, where tumor-infiltrating CD8⁺ T cells showed significantly reduced lysosomal degradation capacity and cytokine secretion compared to middle-aged patients [5]. - The study suggests that the activation of mTORC1 is regulated by both rapid signals from extracellular free amino acids and sustained amino acid signals from lysosomal degradation of extracellular proteins, which may influence the differentiation balance between effector T cells and memory T cells [5][7]. - The functional impairment of elderly T cells arises from both intrinsic lysosomal dysfunction and extrinsic declines in plasma albumin levels [5][7].

Core Viewpoint - Shanghai Jiao Tong University has established the "Tang Ye Education Fund" with a donation of 1 million shares of stock from Baichu Electronics, valued at approximately 130 million yuan, to support various academic and research initiatives [3][4]. Group 1: Donation and Fund Purpose - The "Tang Ye Education Fund" will focus on supporting the development of schools and colleges related to shipbuilding, machinery, integrated circuits, and future technologies, enhancing talent cultivation and research innovation [3][4]. - The donation agreement was signed by Tang Ye and Yang Zhenbin, marking a significant contribution to the university as it approaches its 130th anniversary [3]. Group 2: Strategic Cooperation - A strategic cooperation agreement was signed between Shanghai Jiao Tong University and Baichu Electronics, establishing the "Baichu-Jiao Da Intelligent Base for Industry-Education Integration" [4]. - The collaboration will focus on three key areas: joint research in intelligent sensing, AI-industry integration, and precision manufacturing; market-oriented transformation of research results; and dual empowerment in talent cultivation through joint training programs and practical training centers [4].