Core Viewpoint - Zhaoyan New Drug has announced a significant increase in its 2025 annual performance forecast, with a minimum increase of 945% in net profit excluding non-recurring items, despite a projected decrease in revenue [1][2]. Group 1: Financial Performance - The company expects to achieve an operating income of approximately 1.573 billion to 1.738 billion yuan in 2025, representing a decrease of about 13.9% to 22.1% compared to 2024 [2]. - The projected net profit for 2025 is estimated to be between 233 million to 349 million yuan, an increase of approximately 214% to 371% year-on-year [2]. - The net profit excluding non-recurring items is expected to be between 246 million to 370 million yuan, reflecting an increase of approximately 945.2% to 1467.7% compared to 2024 [2]. Group 2: Asset Valuation and Pricing - The increase in net profit is attributed to the positive change in the fair market value of biological assets, contributing approximately 452 million to 499 million yuan to net profit [2]. - The biological assets primarily consist of experimental models used for non-clinical research, with a significant price increase expected in the second half of 2025 [3]. - The average procurement price for non-human primate experimental animals reached a high of 150,000 to 200,000 yuan per unit in the second half of 2022, but declined to 70,000 to 100,000 yuan per unit by the second half of 2024 [3]. Group 3: Shareholder Actions - Following the strong performance of the stock, the actual controller of Zhaoyan New Drug, Zhou Zhiwen, has initiated a share reduction plan, having already sold over 10 million shares for more than 370 million yuan [1][4]. - As of January 26, 2026, the closing price of Zhaoyan New Drug was 41.39 yuan, with a market capitalization of approximately 31.02 billion yuan [4]. - Zhou Zhiwen plans to reduce his holdings by up to 14.98 million shares, which is about 1.99873% of the total share capital [4].

昭衍新药于2026年1月22日至2026年1月23日期间的加权均价为40.896元/股，以此计算，周志文本次合 计减持上市公司股份1,010.37万股，合计减持金额约为41,320.09万元。 据新浪财经，周志文从2020年11月5日起，第一次减持昭衍新药股份，迄今为止，累计减持公司股票 1411.32万股，累计套现约9.15亿元。 中国经济网北京1月26日讯昭衍新药（603127）(603127.SH)近日发布关于持股5%以上股东权益变动触 及1%刻度的提示性公告。 昭衍新药表示，公司于2026年1月23日收到公司实际控制人之一周志文减持公司股份通知，周志文于 2026年1月22日至2026年1月23日期间，通过上海证券交易所分别以集中竞价方式累计减持415.37万股， 占公司当前总股本的0.55%；大宗交易方式累计减持595万股，占公司当前总股本的0.79%。本次权益变 动后，实际控制人周志文及冯宇霞的持股比例由32.27%减少至30.93%，权益变动触及1%刻度。 ...

Investment Rating - The report assigns a "Buy" rating to several companies in the pharmaceutical sector, indicating a potential upside of over 15% in their stock prices over the next 12 months [29]. Core Insights - The MSCI China Healthcare Index has increased by 9.2% since the beginning of 2026, outperforming the MSCI China Index, which rose by 5.6% [1]. - The pharmaceutical industry has seen significant growth, driven by strong institutional investor interest and the ongoing trend of innovative drugs going global [1]. - The report emphasizes the importance of clinical progress and data validation for pipelines that have already gone overseas, suggesting that this trend will continue in the long term [1]. Summary by Sections Industry Overview - The report highlights a robust trend in the outbound licensing of innovative drugs, with multiple business development (BD) transactions occurring at the start of 2026, reflecting a high level of activity in the sector [4]. - Key transactions include significant upfront and milestone payments for various drugs, indicating strong market interest and potential for future growth [4]. Company Ratings and Valuations - The report provides detailed valuations for several companies, including: - **Sangfor Technologies (1530 HK)**: Market cap of $7,598.4 million, target price of $37.58, with a 54% upside potential [2]. - **Gusongtang (2273 HK)**: Market cap of $963.3 million, target price of $44.95, with a 46% upside potential [2]. - **WuXi AppTec (2268 HK)**: Market cap of $10,551.0 million, target price of $88.00, with a 28% upside potential [2]. - **China National Pharmaceutical Group (1177 HK)**: Market cap of $15,951.4 million, target price of $9.40, with a 42% upside potential [2]. Market Trends - The report notes that the competition in the PD-(L)1/VEGF space is intensifying, with several companies advancing their clinical trials and aiming for first-line indications [4]. - The report suggests that the efficiency and breadth of clinical trials, as well as the richness of combination therapies, will be critical factors in determining success in this competitive landscape [4].

- The report introduces a "Total Heat Index" indicator, which is defined as the sum of a stock's browsing, watchlist additions, and click counts, normalized as a percentage of the total market on the same day, and then multiplied by 10,000. The value range of the indicator is [0, 10,000][7] - A rotation strategy is constructed based on the weekly rate of change of the heat index (MA2). At the end of each trading week, the strategy involves buying the broad-based index with the highest MA2 rate of change. If the "Others" group has the highest rate of change, the strategy remains in cash. The strategy has achieved an annualized return of 8.74% since 2017, with a maximum drawdown of 23.5%, and a return of 3.6% in 2026[13][16] - The report also constructs two simple portfolios based on concept heat indices. The first portfolio (TOP) selects the top 10 stocks with the highest total heat index from the top 5 concepts with the highest heat index changes each week, while the second portfolio (BOTTOM) selects the bottom 10 stocks with the lowest total heat index from the same concepts. The BOTTOM portfolio has historically achieved an annualized return of 15.71% with a maximum drawdown of 28.89%[30][32]

Investment Rating - The report maintains a positive investment rating for the pharmaceutical sector [5] Core Views - The report emphasizes three main investment themes for 2026: innovation, overseas expansion, and turnaround impulses, with a focus on BD2.0, small nucleic acids, and supply chain (CXO and upstream) [2][3] - The report suggests that the pharmaceutical sector is currently experiencing a rotation in investment focus, particularly in areas such as brain-computer interfaces, AI integration, small nucleic acids, and medical robotics [3] Summary by Sections Public Fund Holdings Update for Q4 2025 - Overall, the market value of public funds holding pharmaceutical stocks has decreased, with a total market value of 217.6 billion yuan, down by 51 billion yuan from the previous quarter [14] - The pharmaceutical sector's allocation in public funds is 7.96%, a decrease of 1.74 percentage points [19] - Chemical preparations remain the most heavily weighted sub-industry, while allocations to medical devices have increased [14][25] Market Review and Analysis - The pharmaceutical and biotechnology index decreased by 0.39% week-on-week, outperforming the CSI 300 index but underperforming the ChiNext index [1] - The total trading volume in the pharmaceutical sector was 554.24 billion yuan, accounting for 4.00% of the total trading volume in the Shanghai and Shenzhen markets [1] Investment Opportunities - The report identifies specific companies for potential investment, including: - CXO and innovative drug companies such as Tigermed, Zhaoyan New Drug, and Hai Si Ke, which have seen significant increases in fund holdings [16][38] - AI innovative drug companies like Jingtai Holdings and small nucleic acid firms such as Frontier Biotech and Yuyuan Pharmaceutical [3][38] - The report also highlights the importance of exploring CROs, essential drugs, and companies showing signs of bottoming out [3]

Core Insights - A-share listed companies are accelerating the disclosure of performance forecasts for 2025, with 710 companies having reported, of which 284 are optimistic, resulting in a positive forecast ratio of 40% [1] Group 1: Performance Forecasts - Among the 710 companies that disclosed forecasts, 43 expect slight increases, 57 have turned losses into profits, 4 will maintain profitability, and 180 anticipate profit growth [2] - 295 companies expect a net profit growth of over 10%, with 237 expecting over 30%, 183 over 50%, and 67 over 100% [2] - Notable companies with high expected net profit growth include Southern Precision, Shanghai Yizhong, and SAIC Motor, with Southern Precision projecting a net profit of 300 million to 370 million yuan, representing a year-on-year increase of 1130% to 1417% [2] Group 2: Industry Performance - The industries showing strong performance include non-ferrous metals, biomedicine, semiconductors, hardware equipment, chemicals, and automotive parts [4] - In the non-ferrous metals sector, companies like Xianglu Tungsten, Zijin Mining, and Northern Rare Earth are performing well due to rising product prices and improved downstream demand [4] - Xianglu Tungsten expects a net profit of 12.5 million to 18 million yuan, significantly turning losses into profits, supported by rising tungsten prices and improved market conditions [4] Group 3: Specific Company Insights - WuXi AppTec anticipates a revenue of approximately 45.456 billion yuan, a year-on-year increase of about 15.84%, and a net profit of around 19.15 billion yuan, reflecting a growth of approximately 102.65% [3] - Zhongke Blue News expects a revenue of 1.83 billion to 1.85 billion yuan, with a net profit growth of 366.51% to 376.51% [5] - Shanghai Yizhong forecasts a net profit of 60 million to 70 million yuan, a year-on-year increase of 760.18% to 903.54%, driven by the inclusion of its core product in the national medical insurance directory [6] Group 4: Underperforming Industries - The real estate, textile and apparel, and photovoltaic industries are facing performance pressures, with only one out of 31 real estate companies reporting profits [7] - In the photovoltaic sector, companies like Tongwei Co., TCL Zhonghuan, and Trina Solar are expected to incur losses due to rising costs of key raw materials [7] - Retail companies are experiencing significant performance divergence, with many optimizing store layouts and closing unprofitable locations to enhance overall profitability [7]

Core Viewpoint - The company announced that its actual controller, Zhou Zhiwen, reduced his shareholding in the company, impacting the overall ownership structure [1] Group 1: Shareholding Changes - Zhou Zhiwen reduced his shareholding by a total of 4.1537 million shares through centralized bidding, accounting for 0.55% of the company's total share capital [1] - Additionally, he reduced his shareholding by 5.95 million shares through block trading, representing 0.79% of the company's total share capital [1] - Following these transactions, the combined shareholding of Zhou Zhiwen and Feng Yuxia decreased from 32.27% to 30.93%, crossing the 1% threshold for equity changes [1]

Core Viewpoint - The company announced that its actual controller, Zhou Zhiwen, reduced his shareholding in the company, impacting the overall ownership structure [1] Shareholding Changes - Zhou Zhiwen reduced his shareholding by a total of 4.1537 million shares through centralized bidding, representing 0.55% of the company's total share capital [1] - Additionally, he reduced his holdings by 5.95 million shares through block trading, accounting for 0.79% of the total share capital [1] - Following these transactions, the combined shareholding of actual controllers Zhou Zhiwen and Feng Yuxia decreased from 32.27% to 30.93%, marking a change that touches the 1% threshold [1]

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不 負 責，對 其 準 確 性 或 完 整 性 亦 不 發 表 任 何 聲 明，並 明 確 表 示，概 不 對 因 本 公 告 全部或任何部分內容而產生或因倚賴該等內容而引致的任何損失承擔任何責 任。 JOINN LABORATORIES (CHINA) CO., LTD. 北京昭衍新藥研究中心股份有限公司 （於 中 華 人 民 共 和 國 註 冊 成 立 的 股 份 有 限 公 司） （股 份 代 號：6127） 海外監管公告 本公告乃北京昭衍新藥研究中心股份有限公司（「本公司」）根據香港聯合交易 所有限公司證券上市規則第13.10B條 而 作 出。 茲 載 列 本 公 司 於 上 海 證 券 交 易 所 網 站 刊 登 公 告 如 下，僅 供 參 閱。 承董事會命 北京昭衍新藥研究中心股份有限公司 馮宇霞 董事長 中 國 北 京，2026年1月23日 一、信息披露义务人及其一致行动人的基本信息 1、身份类别 | | ☑控股股东/实际控制人及其一致行动人 | | --- | --- | | | □其他 5%以上大股东及其一致行动人 | | 投资 ...

股东周志文及冯宇霞保证向本公司提供的信息真实、准确、完整，没有虚假记 载、误导性陈述或重大遗漏。 本公司董事会及全体董事保证公告内容与信息披露义务人提供的信息一致。 重要内容提示： | 权益变动方向 | 比例增加□ | | 比例减少☑ | | --- | --- | --- | --- | | 权益变动前合计比例 | 32.27% | | | | 权益变动后合计比例 | 30.93% | | | | 本次变动是否违反已作出的 承诺、意向、计划 | 是□ | 否☑ | | | 是否触发强制要约收购义务 | 是□ | 否☑ | | 一、信息披露义务人及其一致行动人的基本信息 证券代码：603127 证券简称：昭衍新药 公告编号：2026-004 北京昭衍新药研究中心股份有限公司 关于持股 5%以上股东权益变动触及 1%刻度的提示性公告 1、身份类别 | | ☑控股股东/实际控制人及其一致行动人 | | --- | --- | | | □其他 5%以上大股东及其一致行动人 | | 投资者及其一致行动人的身份 | □合并口径第一大股东及其一致行动人（仅 | | | 适用于无控股股东、实际控制人） | | | □其他_ ...