Core Viewpoint - The incidence and mortality rates of acute myocardial infarction (AMI) are increasing annually in China, particularly during the autumn and winter seasons when cardiovascular diseases are more prevalent due to lower temperatures, which heighten the risk of heart attacks [1]. Group 1: Symptoms of Acute Myocardial Infarction - Typical symptoms include severe chest pain lasting more than 15 minutes, which does not improve with rest or nitroglycerin [6]. - Chest pressure sensation, described as feeling like a heavy weight on the chest, may persist for several minutes or recur [7]. - Atypical symptoms may include radiating pain to the left shoulder, arm, jaw, or teeth, with women more likely to experience these non-typical symptoms [8]. - Other symptoms can include dizziness, weakness, cold sweats, pale complexion, difficulty breathing, nausea, and vomiting [10][11]. Group 2: Emergency Response Measures - Immediate actions include stopping all activities, lying down, and loosening tight clothing to calm down and improve oxygen supply to the heart [14]. - It is crucial to call emergency services promptly and provide accurate information about the patient's condition and medical history [15]. - If chest pain persists and blood pressure is stable, sublingual nitroglycerin may be administered; otherwise, alternative medications should be considered [16]. Group 3: Risk Factors and Causes - Risk factors for AMI include age, smoking, diabetes, hypertension, and a family history of heart disease [25]. - Common triggers for heart attacks include physical exertion, emotional stress, and unhealthy dietary habits [25]. - Atherosclerotic plaque rupture and coronary artery spasm due to various stimuli can lead to acute myocardial infarction [19][20]. Group 4: Prevention and Lifestyle Adjustments - Dietary recommendations emphasize low saturated fat and cholesterol intake, with a focus on fresh vegetables and whole grains [27]. - Maintaining a positive mindset and engaging in regular physical activity can benefit heart health [28]. - Avoiding excessive strain, monitoring high-risk factors, and adhering to prescribed medication regimens are essential for prevention [30][31][33].

Core Insights - The article discusses a groundbreaking study on cardiovascular disease, highlighting the limitations of existing laboratory models in accurately replicating the complex environment of human arteries [2][5] - The research introduces a novel extrusion-on-demand (EoD) bioprinting technology that creates arterial models with micron-level structural fidelity and customizable macro geometries, enabling better understanding of vascular disease mechanisms and personalized treatment approaches [3][8] Summary by Sections Research Background - Cardiovascular disease is the leading cause of death globally, yet research has been hindered by inadequate laboratory models that fail to replicate the intricate interactions involved in vascular diseases [2] - Current models are either overly simplified (2D) or lack the necessary structural and functional complexity (3D), leading to unresolved mechanisms and ineffective drug trials [2] Technological Innovation - The EoD bioprinting technology developed in this study allows for the construction of arterial models that accurately reflect the microenvironment of vascular diseases, including specific gene/protein expressions that enhance endothelial function and barrier integrity [5][6] - This technology bridges the gap between simplified in vitro systems and the complex in vivo environments, providing a biomimetic platform for disease mechanism analysis and therapy evaluation [5][9] Key Findings - The printed arterial models successfully replicate hallmark processes of vascular diseases, such as endothelial dysfunction, immune cell infiltration, and foam cell formation under physiologically relevant flow and inflammatory conditions [8][9] - The response of these models to drugs mirrors in vivo results, establishing their value for preclinical testing and therapeutic discovery [8] Implications for Future Research - This research not only presents a sophisticated vascular model but also offers a blueprint for engineering complex disease environments, paving the way for decoding vascular disease progression, identifying therapeutic targets, and accelerating precision medicine [9]

Core Insights - The rising incidence of cardiovascular diseases (CVD) among young people necessitates the identification of high-risk groups for targeted preventive measures [2][4] - Maternal diabetes is linked to an increased risk of early-onset cardiovascular diseases in male offspring, while female offspring are not affected [11][12] Group 1: Research Findings - A study published by a team from Karolinska Institute confirmed that sons of mothers with type 1 diabetes are at higher risk for early endothelial dysfunction and related cardiovascular diseases, independent of metabolic disorders [2][6][11] - The research utilized a mouse model to demonstrate that maternal hyperglycemia specifically leads to early endothelial dysfunction in male offspring, with oxidative stress and arginase-1 signaling pathways identified as potential mechanisms [6][11] - Epidemiological studies in Denmark and Sweden corroborated these findings, showing that sons of mothers with type 1 diabetes have an increased risk of early cardiovascular diseases associated with endothelial dysfunction [6][8][11] Group 2: Implications - The study highlights a previously underappreciated risk group for early cardiovascular disease, emphasizing the impact of maternal health on offspring cardiovascular health [12] - The findings suggest a need for future preventive strategies targeting this specific demographic, particularly focusing on the health of mothers with diabetes [11][12]

Core Viewpoint - The article highlights the increasing risk of cardiovascular diseases (CVD) during the autumn and winter seasons, particularly among vulnerable populations such as the elderly and those with pre-existing health conditions. It emphasizes the importance of awareness regarding early symptoms and preventive measures to mitigate risks associated with cold weather and lifestyle factors. Group 1: Cardiovascular Disease Statistics - In 2021, CVD was the leading cause of death among urban and rural residents in China, accounting for 48.98% and 47.35% of deaths respectively [3] - The crude incidence rate of CVD among residents aged 18 and above in 2023 was 620.33 per 100,000, with males at 717.36 and females at 519.64, showing a significant increase with age [3] Group 2: Seasonal Impact on Cardiovascular Health - Cold weather poses a direct challenge to blood vessels, leading to constriction and increased blood pressure, which heightens the heart's workload [4] - The autumn and winter seasons coincide with a rise in respiratory infections, which can indirectly harm the cardiovascular system and increase the risk of acute myocardial infarction [6] Group 3: High-Risk Populations - Elderly individuals and young professionals under high stress are identified as high-risk groups for cardiovascular events during the colder months [6][9] - Lifestyle factors such as obesity, hypertension, and sedentary behavior contribute to the increasing prevalence of CVD among younger populations [9] Group 4: Early Symptoms and Misdiagnosis - Common early symptoms of cardiovascular issues include fatigue, chest discomfort, palpitations, and sleep disturbances, which are often overlooked or misdiagnosed as gastrointestinal problems [7] - Patients frequently visit other medical departments without receiving appropriate cardiovascular care, highlighting the need for better awareness and education [8] Group 5: Preventive Measures and Lifestyle Recommendations - Maintaining a healthy lifestyle, including a balanced diet low in salt and high in fruits and vegetables, is crucial for preventing cardiovascular diseases [10] - Regular physical activity, stress management, and adequate sleep are essential components of cardiovascular health [11] - During cold weather, individuals are advised to dress warmly and engage in moderate exercise to adapt to temperature changes [11]

Core Insights - The recent drop in temperatures across the country has led to a significant increase in heart attack patients visiting hospitals, particularly among those with pre-existing cardiovascular conditions [1][2] Group 1: Cardiovascular Disease Risks - Cold weather causes blood vessels to constrict, leading to increased blood pressure and added strain on the heart, which can trigger coronary artery spasms and worsen existing conditions [2] - Symptoms of heart issues can manifest in various forms, including chest pain, dizziness, and discomfort in different body parts, necessitating immediate medical attention [2][3] - The incidence of heart attacks is rising among younger individuals due to lifestyle factors such as obesity, stress, and smoking, highlighting the need for regular blood pressure monitoring and medical guidance [3] Group 2: Stroke Awareness and Prevention - A decrease in temperature by 1 degree Celsius increases the risk of stroke by 1.13%, with winter diets high in calories potentially raising cholesterol and blood lipid levels [4] - Recognizing stroke symptoms is crucial, with immediate treatment within a 4.5-hour window being vital for minimizing brain damage [4] - Establishing emergency protocols in hospitals for stroke treatment is essential, including ensuring airway clearance and timely emergency calls [4] Group 3: Lifestyle Recommendations - Adopting a healthy lifestyle, including proper hydration, balanced diet, and regular exercise, can significantly reduce the risk of stroke [5] - Maintaining good mental health and adequate sleep is important, as stress can contribute to immune issues and blood clot formation [5] - Engaging in consistent physical activity, even at home, can enhance overall cardiovascular health and reduce the likelihood of thrombus formation [5]

Group 1 - The risk of cardiovascular diseases increases during autumn due to significant temperature fluctuations, prompting medical professionals to advise immediate medical attention for symptoms like chest pain, shortness of breath, and sudden weakness [1] - Common cardiovascular diseases include hypertension, coronary heart disease, myocardial infarction, and heart failure, which can be exacerbated by cold weather leading to blood vessel constriction and increased heart strain [1] - Patients with cardiovascular disease or risk factors are advised to take protective measures such as dressing appropriately for the weather, maintaining a balanced diet low in salt, oil, and sugar, and engaging in moderate exercise [1] Group 2 - Coronary heart disease patients are recommended to use antiplatelet medications under medical guidance to prevent thrombosis and statins to stabilize plaques and lower lipid levels [2] - Severe cases of coronary artery disease require evaluation by specialists to assess the severity of the condition and improve heart function for better prognosis [2]

Core Viewpoint - The prevalence of hypertension is increasing among young and middle-aged individuals, previously considered an "elderly disease," highlighting a growing health concern in this demographic [1][2]. Group 1: Characteristics and Causes of Hypertension - Many young patients do not exhibit typical symptoms like dizziness or headaches, often discovering high blood pressure incidentally during check-ups, leading to a lack of awareness [2]. - A significant portion of young patients, approximately 60%, also suffer from obesity, high blood lipids, or high blood sugar, which exacerbates hypertension [2]. - The rise in hypertension among younger individuals is attributed to unhealthy lifestyles, including high sodium intake, consumption of fried foods, and habits like smoking and drinking [2]. Group 2: Diagnosis and Global Statistics - Hypertension can be diagnosed if blood pressure exceeds 140/90 mmHg on three separate occasions without medication [4]. - According to the World Health Organization, by 2024, there will be 1.4 billion hypertension patients globally, with only about 20% effectively managing their condition through medication or lifestyle changes [4]. - In China, approximately 29% of adults aged 30 to 79 are expected to have hypertension by 2024, with only 57% aware of their condition and just 18% achieving effective control [4]. Group 3: Prevention and Lifestyle Recommendations - Interventions during the young and middle-aged stages can help control blood pressure and prevent cardiovascular diseases, emphasizing the importance of a healthy diet and lifestyle [4][5]. - Dietary recommendations include limiting salt intake to no more than 5 grams per day and adopting a low-salt, low-fat, high-fiber diet rich in fresh vegetables, fruits, and whole grains [4][5]. - Maintaining a regular sleep schedule of 7 to 9 hours and engaging in suitable physical activities like walking, jogging, or swimming are crucial for weight management and overall health [5].

Core Insights - Cardiovascular diseases have become the leading cause of death among residents in China, as reported by the National Center for Cardiovascular Diseases on World Heart Day [1] Industry Summary - The current health check-up season has led many individuals to discover atherosclerotic plaques in their reports, prompting varied reactions regarding the necessity of intervention [1] - There is a divide in public perception, with some viewing plaques as a normal part of aging, while others see them as a warning sign for potential heart attacks [1]

Core Insights - Cardiovascular diseases are increasingly affecting younger populations, with stress and anxiety identified as significant risk factors for heart health [1][5] - Obstructive Sleep Apnea (OSA) is a rising concern, with an estimated 1.76 billion people in China affected, making it a critical health issue [1][2] - The diagnosis rate of OSA is alarmingly low, with less than 1% in China and only 20% in the U.S., highlighting the need for increased awareness and screening [4] Group 1: Cardiovascular Health - Cardiovascular diseases are the leading cause of death, with a notable increase in cases among younger individuals [1] - Emotional factors, particularly stress and anxiety, are significant contributors to cardiovascular risks in young people [5] - The theme for World Heart Day 2023 is "Rhythm Never Stops," emphasizing the importance of continuous heart health awareness [1] Group 2: Obstructive Sleep Apnea (OSA) - OSA is often misperceived as mere snoring, but it can lead to serious complications such as hypertension, with over 47% of OSA patients in China suffering from high blood pressure [2][4] - The prevalence of OSA is expected to rise, with projections indicating that the number of affected individuals in China could exceed 200 million this year [1] - Diagnosis of OSA typically involves sleep monitoring, which can be conducted in hospitals or at home using portable devices [4]

Company Overview - The founder of Yunnan Yunhaiyao Restaurant Management Co., Ltd., Zhao Han, passed away due to a sudden heart attack at the age of 40, which has garnered widespread attention [5]. - Zhao Han was instrumental in establishing the brand, opening over 100 restaurants in major cities such as Beijing, Shanghai, Guangzhou, and Shenzhen within a decade [5]. Leadership Changes - Following Zhao Han's passing, the company's board underwent adjustments, with Zhu Haiqin taking over as Chairman and CEO, assuming full responsibility for company decisions and management [3]. Industry Context - The restaurant industry has faced numerous challenges in recent years, prompting Yunhaiyao to explore various strategies, including brand collaborations and partnerships with popular media to attract new customers [3].