编辑丨王多鱼 排版丨水成文 撰文丨王聪 心血管疾病 （CVD） 是全球头号致死病因，其临床症状多样，包括中风、心绞痛、心肌梗死和/或猝死。 新出现的证据表明，涉及炎症和代谢途径的宿主-微生物群相互作用可能有助于心血管疾病风险因素的发 展，肠道微生物群的变化可能在心血管疾病中发挥作用 。鉴于肠道微生物群及其代谢产物与心血管疾病 （CVD） 存在显著关联，从临床角度来看，它们可能是心血管疾病治疗的重要靶点。 棕榈酸 （PA） 是我们身体中最丰富的饱和脂肪酸，通常被认为来自饮食和内源性合成，并且与 心血管疾 病 （CVD） 呈负相关。然而，肠道微生物群是否调节循环系统中的棕榈酸并增强心血管疾病风险，目前尚 不清楚。 2025 年 7 月 31 日，中国科学院昆明动物研究所 赖仞 团队在 Cell 子刊 Cell Reports Medicine 上发表了 题为： High-fat diet increases circulating palmitic acid produced by gut Bacteroides thetaiotaomicron to promote thrombosis 的研究论文。 该研究证 ...

Core Viewpoint - There is a compelling link between gut microbiota and atherosclerosis, a disease characterized by cholesterol and inflammatory cell deposits in arterial walls, leading to potential health issues like stroke and heart attacks [1][5]. Group 1: Research Findings - A study published in Nature identified Imidazole Propionate (ImP), a metabolite produced by gut bacteria, as a driver of atherosclerosis, suggesting new targets for early detection and personalized treatment of cardiovascular diseases [2][10]. - The study highlights the necessity for early intervention in seemingly healthy populations due to rising morbidity and mortality rates associated with cardiovascular diseases [5]. - The research team found a strong correlation between ImP levels and the severity of atherosclerosis in both mouse models and human cohorts [7][10]. Group 2: Mechanism of Action - ImP promotes atherosclerosis through the activation of the imidazoline-1 receptor (I1R) in myeloid cells, indicating a specific signaling pathway that could be targeted for therapeutic purposes [8][10]. - Blocking the ImP-I1R signaling axis can inhibit the development of atherosclerosis induced by either ImP or a high-cholesterol diet, suggesting a potential intervention strategy [8][10]. Group 3: Implications for Treatment - The findings open new avenues for the early diagnosis and personalized treatment of atherosclerosis, emphasizing the importance of understanding gut microbiota's role in cardiovascular health [10].

Core Viewpoint - A groundbreaking study conducted by Xi'an Jiaotong University and Harvard University provides authoritative guidance on beverage choices for diabetes patients, revealing significant differences in health impacts among various drinks [6][9]. Group 1: Research Overview - The study tracked 15,486 type 2 diabetes patients over 38 years, utilizing validated food frequency questionnaires to assess beverage intake and its correlation with all-cause mortality and cardiovascular outcomes [6][12]. - The research highlights the urgent need for dietary interventions in diabetes management, given the rising global diabetes prevalence, projected to reach 783 million by 2045 [9]. Group 2: Key Findings - High intake of sugar-sweetened beverages (SSBs) is significantly associated with increased all-cause mortality and adverse cardiovascular outcomes, while coffee, tea, plain water, and low-fat milk show protective effects [6][10]. - Specifically, the highest consumption group of SSBs had a 20% higher risk of all-cause mortality compared to the lowest intake group, while coffee drinkers had a 26% lower risk [13]. Group 3: Clinical Implications - The study suggests that reducing SSB intake and increasing consumption of healthier beverages like coffee, tea, or plain water could be a viable strategy for improving long-term outcomes and reducing mortality risk in type 2 diabetes patients [14]. - The findings provide high-quality evidence for personalized dietary guidance, emphasizing the importance of beverage choices in diabetes management [14].

Core Viewpoint - The article discusses the rising prevalence of non-alcoholic fatty liver disease (NAFLD) in China, particularly among young adults, and highlights the associated health risks and lifestyle factors contributing to this condition [3][4][7]. Group 1: Prevalence and Demographics - NAFLD has overtaken viral hepatitis as the leading chronic liver disease in China, with the prevalence of non-alcoholic fatty liver disease reaching 21.36% by 2021 [7][10]. - A study from Wuhan University indicates that the overall prevalence of NAFLD in China approached 30% from 1999 to 2018, suggesting that nearly 3 out of 10 individuals may be affected [10]. - The disease disproportionately affects the obese population, with approximately two-thirds of obese individuals diagnosed with NAFLD [11]. - Alarmingly, about 40% of NAFLD patients globally are not obese, and in China, nearly a quarter of non-obese individuals are also affected [12][13]. - The incidence of NAFLD among young adults aged 20-24 increased by 18.34% from 2011 to 2021, the highest growth rate across all age groups [16]. Group 2: Causes and Mechanisms - The root cause of NAFLD is metabolic dysfunction rather than just dietary habits, as the liver becomes overloaded with excess fat due to metabolic disturbances [18][19]. - The latest medical guidelines have redefined NAFLD as "metabolism-related fatty liver disease," emphasizing the connection between metabolic disorders and liver health [20]. - Conditions such as obesity, high blood lipids, and diabetes significantly increase the risk of developing NAFLD, with individuals exhibiting metabolic syndrome having over four times the risk compared to the general population [20][23]. Group 3: Health Risks and Complications - NAFLD is linked to increased risks of cardiovascular diseases, with over half of NAFLD patients also facing atherosclerosis [31]. - The risk of extrahepatic malignancies, including thyroid cancer and other gastrointestinal cancers, is significantly elevated in NAFLD patients, with the incidence of non-liver cancers reaching approximately 10.58 cases per 1,000 individuals [37]. - The mortality rates from liver cirrhosis and liver cancer due to NAFLD have been rising, with cirrhosis mortality increasing from 0.36 to 0.45 per 100,000 and liver cancer mortality more than doubling from 0.35 to 0.73 per 100,000 between 1990 and 2021 [25]. Group 4: Lifestyle Interventions - Weight loss of 3% to 5% can effectively reduce liver fat accumulation, while a 5% to 7% reduction can significantly lower liver inflammation [38]. - A combination of dietary changes, such as reducing sugar and fat intake, along with regular physical activity, is essential for managing and potentially reversing NAFLD [39]. - Individuals diagnosed with NAFLD often experience a cycle of anxiety and lifestyle regression, emphasizing the need for sustained lifestyle changes to prevent further health deterioration [39].

Group 1 - High temperatures, high humidity, and low pressure are significant contributors to cardiovascular diseases, with an increase in heart attack patients reported in Hangzhou [1] - The director of the cardiology department at Zhejiang University Second Hospital noted that over 20 heart attack patients have been treated in the past month due to the heat [1] - Factors such as skin blood vessel dilation, increased blood viscosity, and emotional stress during hot weather can elevate the risk of heart attacks [1] Group 2 - Patients with hypertension, diabetes, and hyperlipidemia are advised to monitor their blood pressure daily and adhere strictly to medication regimens [2] - Recommendations include drinking warm water in small amounts, avoiding cold drinks, and exercising during cooler times of the day [2] - Immediate medical attention is crucial if symptoms like chest pain, shortness of breath, or dizziness occur, as these may indicate serious conditions like heart failure or stroke [2]

Core Viewpoint - The consumption of rice versus wheat-based foods has significant implications for cardiovascular health, with a study indicating that those who primarily consume wheat have a 40.8% higher risk of cardiovascular diseases compared to rice consumers [3][6]. Group 1: Study Overview - The study included over 16,000 healthy elderly individuals aged 65 and above, tracking their dietary habits over 7.38 years, during which 1,757 developed cardiovascular diseases [6]. - The risk of cardiovascular diseases was found to be particularly pronounced in men aged 65-79 and those without hypertension, with a risk increase of 89.1% associated with wheat consumption [6]. Group 2: Dietary Implications - The research suggests a U-shaped relationship between wheat intake and cardiovascular disease risk, with the lowest risk occurring at a daily intake of 375 grams of cooked wheat, aligning with dietary guidelines [6]. - Compared to rice, wheat has higher fat and sodium content, lacks cholesterol, and has a higher glycemic index, which may contribute to increased oxidative stress and insulin resistance [8]. Group 3: Nutritional Recommendations - The study emphasizes the importance of high-quality carbohydrates, such as whole grains, legumes, vegetables, and fruits, which are beneficial for health and anti-aging [9][11]. - High-quality carbohydrates are characterized by high dietary fiber, low glycemic index, and high nutrient density, providing significant health advantages [11].

Group 1 - The core viewpoint is that the COVID-19 pandemic in China has been on a steady decline since late May, with no significant impact on medical resources or daily life [1][2] - Other respiratory infectious diseases, including influenza, are currently at low levels of prevalence [2] - Public health recommendations include personal protective measures during travel, especially for vulnerable populations [2][3] Group 2 - There is an increase in the risk of gastrointestinal issues, particularly diarrhea, during the summer months, which can be caused by various factors, not just food [4][5] - Preventive measures against diarrhea include avoiding drinking tap water and ensuring food hygiene [4][5] - Severe cases of diarrhea require immediate medical attention, especially if dehydration symptoms are present [4][5] Group 3 - The risk of cardiovascular diseases increases in summer, particularly for older adults, who should be aware of warning signs such as sudden dizziness or chest discomfort [6][7] - Recommendations for older adults include maintaining adequate sleep, moderate exercise, and regular monitoring of health indicators like blood pressure and blood sugar [7]

Core Viewpoint - The article highlights the health risks associated with frequent consumption of takeout food, emphasizing the negative impact of unhealthy ingredients and plastic packaging on cardiovascular health [1][2][3]. Group 1: Health Risks of Takeout Food - A case study of a 34-year-old man who consumed takeout 2.5 times daily revealed severe health issues, including high blood pressure and elevated "bad cholesterol" levels, leading to a need for lifelong medication [2]. - Research indicates that frequent exposure to plastic products, such as takeout containers, is linked to a 13% increased risk of congestive heart failure, and animal studies show that these containers can alter gut microbiota, causing inflammation and oxidative stress [2][4]. - Long-term exposure to chemicals from plastic packaging can lead to chronic inflammation in blood vessels, increasing the incidence of carotid plaques by 1.8 times compared to the normal population [5]. Group 2: Nutritional Concerns - Takeout meals often contain excessive amounts of fats, with an average of 45 grams of oil per serving, exceeding daily recommended limits by 50%, which can promote the accumulation of "bad cholesterol" [6]. - High sodium content in takeout food, such as 8.6 grams of salt in a bowl of spicy sour noodles, can lead to increased blood pressure and a 30% higher risk of stroke for every 10 mmHg increase [6]. - The lack of vegetables in takeout orders, with leafy greens making up less than 12% of total orders, results in a significant deficiency of heart-protective nutrients like magnesium and potassium [7]. Group 3: Mitigation Strategies - The article proposes a "three-tier defense system" to minimize health risks when consuming takeout food, including choosing lower oil and salt options, rinsing oily dishes, and preparing meals at home on weekends [9]. - It is recommended to select takeout items labeled as "low oil" or "light salt," and to request separate packaging for sauces to reduce hidden sodium intake [9]. - For high-risk individuals, using wearable devices to monitor heart rate fluctuations after meals is advised [9].

Group 1 - Cardiovascular diseases are recognized as the leading health threat to residents in China, yet there are significant misconceptions among the public regarding these conditions [1] - Two major blind spots in public understanding of cardiovascular diseases include the belief that "no pain means no heart attack" and the misattribution of atypical symptoms to other diseases, which can lead to misdiagnosis [2] - There is a strong emphasis on the importance of early detection and prevention through individualized health screenings, which can more accurately assess individual health risks compared to traditional screening methods [2] Group 2 - Individualized health screenings can identify potential risk groups for high blood lipids and high blood sugar, allowing for targeted health management recommendations [2] - For individuals with elevated blood lipids or blood sugar that do not yet meet diagnostic criteria, lifestyle changes such as a balanced diet, regular exercise, and good sleep hygiene are recommended to prevent disease progression [2]