整理 | GLP1减重宝典内容团队 ▍ 一半的人在一年内停止治疗 与安慰剂对照组相比，GLP-1 受体激动剂（如司美格鲁肽和替尔泊肽）分别在治疗 68 周和 72 周后导致体重减轻15%-20%。尽管多项 研究报告了这些减肥药的积极作用， 但由于其不良的胃肠道影响和高成本，长期坚持这些治疗很困难 。多达一半的人在处方的第一年 内停止治疗。 肥胖是一种与体内多余脂肪堆积有关的健康状况。多项研究表明， 肥胖不仅对健康造成多系统性损害，还与多种并发症和合并症密切 相关 ，包括代谢紊乱（如脂肪肝、胆结石、不孕、心脑血管疾病等）、躯体异常（如哮喘、胃食管反流、关节炎等）以及精神健康问 题（如抑郁、焦虑等）。近年来，已经开发出许多治疗方法和减肥计划来减少肥胖。例如，GLP-1 受体激动剂已获得全球监管机构批 准用于治疗肥胖和 2 型糖尿病。已证明 GLP-1 受体激动剂可以减少食欲，从而减少食物摄入量。 减肥的最大挑战之一是维持减肥效果。尽管这些新疗法很有效，但仍然看到很多人在停止治疗后体重反弹。许多研究表明，停用 GLP- 1 受体激动剂会导致体重增加。这些观察结果强调了继续使用 GLP-1 受体激动剂作为长期有利效果 ...

Core Viewpoint - Obesity is a health condition associated with excess fat accumulation, leading to various complications and comorbidities. GLP-1 receptor agonists have been developed and approved for obesity treatment, demonstrating effectiveness in appetite reduction and weight loss [1][2][4]. Summary by Sections Treatment Efficacy - GLP-1 receptor agonists, such as semaglutide and tirzepatide, have shown weight loss of 15%-20% after 68 to 72 weeks compared to placebo [2]. - A clinical trial indicated that participants lost an average of 10.6% of their body weight during 20 weeks of semaglutide treatment, with those continuing the drug losing an additional 7.9% over 48 weeks [5]. Challenges in Weight Maintenance - One of the biggest challenges in weight loss is maintaining the results, as many individuals experience weight regain after stopping treatment. Studies show that stopping GLP-1 receptor agonists can lead to significant weight gain [4][5]. - After one year of stopping semaglutide, approximately two-thirds of the weight lost can be regained [5]. Medication Management - It is recommended to continue GLP-1 receptor agonist treatment for at least 12 weeks to see significant effects, with a suggested continuation of 9 months to 1 year for consolidation [6]. - Users may experience increased satiety and reduced food intake initially, with weight loss typically ranging from 0.5 to 2 pounds per week [9]. Discontinuation Strategies - Gradual dose reduction is advised when stopping the medication to mitigate increased hunger, with specific recommendations for both non-diabetic and diabetic patients [10][12]. - Maintaining healthy eating habits and regular exercise is crucial post-discontinuation to prevent weight rebound [12]. Dietary and Lifestyle Recommendations - Key strategies to prevent weight regain include altering dietary habits by reducing high-calorie foods and increasing protein and fiber intake [13]. - Incorporating strength training and ensuring adequate sleep (7-9 hours per night) are also essential for maintaining weight loss and improving metabolic health [15].

Core Viewpoint - The article discusses the challenges of weight management and the phenomenon of weight regain after dieting, emphasizing the need for innovative solutions in the weight loss industry to combat this issue [1][2][6]. Group 1: Weight Management Initiatives - The National Health Commission of China has launched a three-year "Weight Management Year" initiative aimed at reducing weight and controlling chronic diseases [1]. - The concept of "metabolic memory" explains why individuals often regain weight after losing it, as the body tends to remember previous weight levels [2][6]. Group 2: Current Market Dynamics - The weight loss market is seeing significant sales, with drugs like semaglutide generating annual revenues of $28.3 billion [3]. - Major pharmaceutical companies, including Novo Nordisk and Eli Lilly, are focusing on developing new mechanisms and improving existing products to address muscle loss and weight regain during weight loss [2][10]. Group 3: Challenges in Weight Loss - Many weight loss methods lead to muscle loss, which can decrease the basal metabolic rate and exacerbate weight regain after stopping treatment [10]. - A study published in the Journal of the American Medical Association indicated that participants who stopped taking the weight loss drug tirzepatide regained an average of 14% of their lost weight within a year [8]. Group 4: Innovative Solutions and Research - Companies are exploring new drug targets and combination therapies to enhance weight loss while preserving muscle mass [10][11]. - The UK company NodThera is investigating an anti-inflammatory approach to weight loss, which has attracted interest from major players like Novo Nordisk [11]. Group 5: Long-term Weight Management Strategies - Experts recommend sustainable lifestyle changes, including balanced diets and regular exercise, as more effective long-term strategies for weight management compared to quick fixes [12][13]. - A comprehensive approach to weight management may involve a treatment cycle lasting over 20 months, focusing on identifying causes of obesity and designing personalized weight loss strategies [12].