Core Insights - Novo Nordisk's new weight loss drug CagriSema shows promising results in weight reduction and metabolic improvement, but has a higher incidence of gastrointestinal side effects compared to the placebo group [1][2] - The company recently experienced a leadership change with the dismissal of CEO Lars Fruergaard Jorgensen [1] - CagriSema demonstrated an average weight loss of approximately 23% in overweight or obese non-diabetic patients and 15.8% in overweight patients with type 2 diabetes over a 68-week clinical trial [1] - The drug's efficacy data is comparable to Eli Lilly's Tirzepatide, which achieved a 22% weight loss in a 72-week trial [1] Safety and Side Effects - 79.6% of CagriSema users reported gastrointestinal reactions such as nausea, vomiting, and constipation, compared to 39.9% in the placebo group [2] - The incidence of serious adverse events was 9.8% in the CagriSema group, higher than the 6.1% in the placebo group, although most side effects were mild to moderate and transient [2] - 6% of CagriSema participants discontinued treatment due to adverse events, compared to 3.7% in the placebo group [2] Future Plans and Market Position - Novo Nordisk plans to submit a marketing application for CagriSema in Q1 2026, with expectations for approval in early 2027 [3] - The company is also conducting additional research on cardiovascular benefits beyond weight loss indications [3] - A flexible dosing adjustment strategy will be a key focus in clinical application, allowing for controlled weight loss rates while minimizing side effects [3] - The global obesity treatment market is highly competitive, and CagriSema will directly compete with Eli Lilly's GLP-1/GIP dual-target drug if successfully launched [3]

诺和诺德正在积极推进其为使amycretin获得批准所需的研究项目，并表示本月将对该化合物进行口服和 注射两种剂型的测试。后期试验将于明年年初开始招募患者。诺和诺德负责药物研发的Martin Holst Lange在接受采访时表示，目前公司对amycretin的减肥效果和安全性潜力已经有了"较为乐观的判断"。 智通财经APP获悉，诺和诺德公司(NVO.US)最新研发的减肥药物在一项小型研究中帮助患者成功减重 达 24.3%。这一成果表明，该药物有望在竞争激烈的市场中成为新一代的治疗药物。研究人员在《柳叶 刀》杂志上发表的两份试验报告中称，一种名为amycretin的药物显示出能够改善血糖水平的迹象，其副 作用与其他强效的减肥药大致相同。该试验结果将于在芝加哥举行的美国糖尿病协会会议上公布。在针 对该化合物注射剂型的试验中，参与者在 36 周内体重减轻了 24.3%。 这家丹麦制药公司若要取得成功并能在竞争对手礼来公司(LLY.US)的产品组合中脱颖而出，就必须推出 一款像amycretin这样的药物。诺和诺德的当前畅销产品Wegovy在关键的美国市场已被礼来的Zepbound 超越，而其下一代候选药物Cagr ...

整理 | GLP1减重宝典内容团队 礼来公司的一款实验性减重药物在初步研究中显示出良好的效果，副作用较少，这表明该公司在竞争激烈的减肥治疗市场上又迈出了一步。 这款药物名为 eloralintide，根据周五发布的一份摘要，在为期三个月的试验中，有部分参与者的体重下降超过11%。这一摘要是在芝加哥举行 的美国糖尿病协会（ADA）年会前夕公布的。该药物正进入下一阶段的研发，研究人员将在下周的会议上公布有关安全性和剂量的更多数据。 "这些数据看起来非常有前景，有望重新激发投资者对该项目的关注，"Cantor Fitzgerald 分析师 Prakhar Agrawal 在一份客户报告中写道。 此前，礼来对 eloralintide 的信息披露极少，因为该药物仍处于早期试验阶段。它属于一类模拟胰淀素激素的药物。胰淀素可减缓胃排空速度， 让人更长时间感到饱足。相比目前已上市的注射类药物，如 Zepbound 和 Wegovy，这类药物被认为是一种副作用较轻的减肥选择。目前常见 的不良反应包括恶心和呕吐。 版权声明：所有「GLP1减重宝典」的原创文章，转载须联系授权，并在文首/文末注明来源、作者、微信ID，否则减重宝典 ...