Company Strategy & Market Opportunity - Lilly aims to provide freedom from diabetes, eliminate serious health issues caused by obesity, and reduce cardiovascular deaths[10] - The company estimates a significant addressable market of over 170 million patients by 2030 for obesity and related conditions[13] - Outside of the US, the addressable market is expected to be approximately 1 billion patients[15] Orforglipron Development Program - Orforglipron, a GLP-1 small molecule, has a broad development plan including studies for Type 2 Diabetes, obesity, hypertension, and obstructive sleep apnea[20] - In the ACHIEVE-1 trial, all three doses of orforglipron achieved superiority versus placebo in reducing HbA1c levels in patients with Type 2 Diabetes[27] - ACHIEVE-1 trial data showed significant reductions in HbA1c observed as early as 4 weeks, with approximately 3/4 of patients achieving an ADA HbA1c target of less than 7%, and 2/3 reaching HbA1c ≤6.5%[27] - ACHIEVE-1 trial also demonstrated dose-dependent reduction in body weight, with approximately 2/3 of patients achieving ≥5% weight reduction and approximately 1/3 achieving ≥10% weight reduction[30] - Topline results for ATTAIN-1, an orforglipron trial in obesity, are expected in Q3 2025[39] Retatrutide Development Program - Retatrutide is undergoing global development with the TRIUMPH program for obesity and related complications, and the TRANSCEND program for Type 2 Diabetes[41] - Topline results for TRIUMPH-4, a retatrutide trial in knee osteoarthritis pain and overweight or obesity, are expected in Q4 2025[48] Tirzepatide & Early Phase Pipeline - The SURPASS-CVOT trial is designed to evaluate tirzepatide against dulaglutide in patients with established cardiovascular disease[51] - Eloralintide, a selective amylin receptor agonist, showed weight loss up to 11.3% in Phase 1 trials and is well-tolerated with less than 10% incidence of GI side effects[60]

证券研究报告·行业跟踪周报·医药生物 医药生物行业跟踪周报 2025ADA 重磅数据披露，关注减脂增肌、 Amylin 及口服赛道 增持（维持） [Table_Tag] [Table_Summary] 投资要点 2025 年 06 月 29 日 证券分析师 朱国广 执业证书：S0600520070004 zhugg@dwzq.com.cn 行业走势 -9% -5% -1% 3% 7% 11% 15% 19% 23% 27% 2024/7/1 2024/10/29 2025/2/26 2025/6/26 医药生物 沪深300 相关研究 《科研服务拐点已至，关注皓元医药、 毕得医药、百奥赛图等》 2025-06-23 《线上 618 大促收官+国补持续，关注 国产家用医疗器械放量机遇》 2025-06-21 东吴证券研究所 1 / 27 请务必阅读正文之后的免责声明部分 ◼ 本周、年初至今 A 股医药指数涨幅分别为 1.6%、6.2%，相对沪深 300 的超额收益分别为-0.4%、6.6%；本周、年初至今 H 股生物科技指数涨 跌幅分别为 2.7%、52.7%，相对于恒生科技指数跑赢-1.5%、32.2%； 本周 ...

Investment Rating - The investment rating for the pharmaceutical and biotechnology industry is "Positive" (maintained) [2] Core Insights - The report highlights the emergence of multiple promising weight loss drugs showcased at the 2025 ADA conference, focusing on AMYR and ActRII target drugs, which exhibit excellent clinical data and are expected to become core targets for future weight loss drug development [6][15] - The report emphasizes the potential of oral and ultra-long-acting drugs in the weight loss and glycemic control market, which are anticipated to open new incremental market opportunities [8][31] - The report recommends several pharmaceutical and biotechnology companies as investment targets, including Heng Rui Medicine, East China Medicine, and others across various segments such as CXO, research services, traditional Chinese medicine, raw materials, medical devices, and retail pharmacies [9] Summary by Sections 1. Weight Loss Drug Developments - The 2025 ADA conference showcased several potential pipeline drugs for weight loss, with a focus on AMYR and ActRII target drugs, which are expected to lead future developments in this area [15] - AMYR-targeted drugs, such as eloralintide from Eli Lilly, demonstrated superior efficacy and safety compared to GLP-1 drugs, indicating a promising future for this class of drugs [16][18] - ActRII-targeted drugs, particularly Bimagrumab, showed significant weight loss results, with 100% of weight loss coming from fat, suggesting a new standard for high-quality weight loss therapies [28][29] 2. Oral and Ultra-Long-Acting Drugs - The report identifies oral GLP-1RA drugs as a new trend in the weight loss and glycemic control market, with several companies presenting promising clinical data at the 2025 ADA conference [31][32] - The ultra-long-acting drug Maridebart cafraglutide demonstrated effective weight loss results with extended dosing intervals, enhancing patient compliance and treatment simplicity [33][34] 3. Recommended Investment Targets - The report lists various companies across different segments as recommended investment targets, including pharmaceutical and biotechnology firms, CXO companies, research service providers, traditional Chinese medicine manufacturers, raw material suppliers, medical device companies, and retail pharmacies [9]

In this articleNOVO.B-DKLLYA sign with the company logo sits outside of the headquarters of Eli Lilly in Indianapolis, Indiana, on March 17, 2024.Scott Olson | Getty ImagesA version of this article first appeared in CNBC's Healthy Returns newsletter, which brings the latest health-care news straight to your inbox. Subscribe here to receive future editions.Competition in the blockbuster weight loss drug market is ramping up, as drugmakers share fresh data on new and existing treatments. The annual American D ...

高盛认为在"下一代减肥药物" MariTide相关的重大催化之下，安进有望踏上价值重估轨迹，其股价上行 空间相比于同行可能更加广阔。高盛表示，安进当前仅仅14x的2025年预期PE显著低于其所处的生物科 技板块均值(22x)，目标价400美元对应该公司股价大约40%上行空间。 智通财经APP获悉，美国生物科技巨头安进公司(AMGN.US)将在2025年6月23日举行的美国糖尿病学会 (ADA) 年会上公布"下一代减肥药物" MariTide 在肥胖症适应症中的II 期(第一部分)完整临床数据。该试 验针对肥胖或超重且无Ⅱ型糖尿病的患者开展，为期52周，管理层虽然表示，2024年11月公布的顶线数 据已经涵盖了大部分关键数据，但高盛预计本次完整数据披露仍将成为安进乃至整个减肥药领域公司的 重要股价上行催化剂，安进将能够提供此前摘要数据中未涵盖的细节和洞见。 高盛在最新发布的研报中表示，一项关于MariTide的I期药代动力学剂量递增研究结果也将同期发布， 这些新增数据有望进一步澄清 MariTide 的临床特性。高盛预计MariTide实现"双面突破"的可能性非常大 ——即减肥药物的巨大潜力与临床争议的平衡均取 ...

整理 | GLP1减重宝典内容团队 礼来公司的一款实验性减重药物在初步研究中显示出良好的效果，副作用较少，这表明该公司在竞争激烈的减肥治疗市场上又迈出了一步。 这款药物名为 eloralintide，根据周五发布的一份摘要，在为期三个月的试验中，有部分参与者的体重下降超过11%。这一摘要是在芝加哥举行 的美国糖尿病协会（ADA）年会前夕公布的。该药物正进入下一阶段的研发，研究人员将在下周的会议上公布有关安全性和剂量的更多数据。 "这些数据看起来非常有前景，有望重新激发投资者对该项目的关注，"Cantor Fitzgerald 分析师 Prakhar Agrawal 在一份客户报告中写道。 此前，礼来对 eloralintide 的信息披露极少，因为该药物仍处于早期试验阶段。它属于一类模拟胰淀素激素的药物。胰淀素可减缓胃排空速度， 让人更长时间感到饱足。相比目前已上市的注射类药物，如 Zepbound 和 Wegovy，这类药物被认为是一种副作用较轻的减肥选择。目前常见 的不良反应包括恶心和呕吐。 版权声明：所有「GLP1减重宝典」的原创文章，转载须联系授权，并在文首/文末注明来源、作者、微信ID，否则减重宝典 ...