智通财经APP获悉，瑞博生物-B(06938)首挂上市，公告显示，每股定价57.97港元，共发行3161.04万股 股份，每手200股，所得款项净额约17.02亿港元。截至发稿，涨29.38%，报75港元，成交额2.49亿港 元。 除核心产品RBD4059外，公司还在推进其他临床阶段产品，包括RBD5044和 RBD1016。RBD5044是全 球第二款进入临床开发的靶向APOC3(一种参与脂质代谢的蛋白)的siRNA药物。RBD1016通过对HBsAg 的作用，旨在实现CHB的功能性治癒，同时也是一款针对CHD的差异化siRNA候选药物。在临床管线之 外，公司还拥有20多个临床前项目，计划将其推进至临床开发阶段。 公开资料显示，瑞博生物是一家从事小核酸药物研究和开发，尤其专注于siRNA疗法的生物制药公司。 公司拥有一款用于治疗血栓性疾病的核心产品RBD4059(靶向FXI 的siRNA)，研发管线中共有七款自研 药物资产处于临床试验阶段，涉及心血管、代谢类、肾脏和肝脏疾病的七种适应症，其中四款处于2期 临床试验中。 ...

智通财经APP获悉，1月5日，中国证监会公布《境外发行上市备案补充材料要求(2025年12月29日— 2026年1月4日)》。其中，中国证监会要求靖因药业补充说明关于搭建离岸架构及返程并购的合规性等 事项。据港交所2025年9月28日披露，靖因药业向港交所主板提交上市申请书，高盛、海通国际、 HSBC为其联席保荐人。 中国证监会请靖因药业补充说明以下事项，请律师核查并出具明确的法律意见： 一、关于搭建离岸架构及返程并购的合规性，请说明：(1)你公司搭建离岸架构和返程投资涉及的外汇 管理、境外投资、外商投资、税务管理等监管程序具体履行情况，并说明是否符合当时有效监管规定的 结论性意见;(2)境内运营实体靖因上海设立及历次股权变动是否合法合规的结论性意见。 二、请说明你公司境内运营实体所占你公司财务报表相关数据的具体比例，注册资本未缴足是否会对正 常业务开展及债务偿付能力产生不利影响，并就其经营范围及实际业务是否涉及限制或禁止外商投资领 域出具明确结论性意见。 三、请对照《监管规则适用指引——境外发行上市类第2号：备案材料内容和格式指引》要求，完善说 明发行上市方案。 招股书显示，靖因药业是一家全球临床阶段生物技 ...

股票申购期将持续至1月6日，交易首日定于1月9日。 成立于2007年的瑞博生物一直专注于小核酸药物，尤其是siRNA疗法的研发，目前已建成全球最大的siRNA药物管线之一，有七款自研药物处于临床试验阶段， 涉及心血管、代谢类、肾脏和肝脏疾病的7种适应症，当中有4款药物正在进行二期临床试验，另有超过20个临床前项目储备。 近年，RNA（核糖核酸）领域连续获得诺贝尔奖认可，mRNA和miRNA的相关发现分别在2023年、2024年获奖，其科学价值与产业潜力备受关注。以RNA为基础 的小核酸药物凭借其靶点选择范围广、临床开发成功率相对较高、作用持久等优势，有望成为继小分子药物、抗体药物之后，现代新药第三次浪潮的引领者。如 今，国际投资者即将可以参与投资中国小核酸药物领域的领军企业。 在小核酸药物领域深耕18年的苏州 瑞博生物 技术股份有限公司，自我定位是siRNA（小干扰核糖核酸）疗法领域的世界领先者。 瑞博生物于2025年12月31日启动香港主板IPO。计划发行股份数量约为2750万股，发行价57.97港元，计划募资约15.9亿港元（约2.05亿美元）。此次上市由中金公 司和花旗银行担任联席保荐人。 这家小核酸药 ...

瑞博生物-B(6938.HK)正式启动招股，拟全球发售2748.74万股H股，此次招股于2025年12月31日至2026年1月6日招股进行，发售价将为每股H股57.97港元， H股的每手买卖单位将为200股，预计H股将于2026年1月9日在联交所开始买卖。下面将通过一图看懂瑞博生物-B(6938.HK)IPO。 招股信息及公司介绍 〔三〕 发行股份 27.487官方股 cisis 上市日期 E 1月9日 发售价 ] 57.97港元/股 瑞博主物创立于2007年，是一家从事小核酸药 物研究和开发,尤其专注于siRNA疗法的主物制药公 司。公司拥有一款用于治疗血栓性疾病的核心产品 RBD4059 (靶向FXI的siRNA),研发营线中共有7款 自研药物资产处于临床试验阶段，涉及心血管、代谢 类、肾脏和肝脏疾病的7种适应症,其中4款处于l期 临床试验中。 > 丰富的产品管线 自研药物资产 处于临床试验 7款 涉及心血管、代谢类 肾脏和肝脏疾病 7种适应症 临床前 申报试验 化合物 话应症 临床前 1期 2期 ¥ RBD4059 血栓性疾病 川 高官湘 RBD5044 三酯血病 管 高胆固醇 RBD7022 IIII ...

公司创立于2007年，是一家从事小核酸药物研究和开发，尤其专注于siRNA疗法的生物制药公司。公司 拥有一款用于治疗血栓性疾病的核心产品RBD4059(靶向FXI的siRNA)，研发管线中共有七款自研药物 资产处于临床试验阶段，涉及心血管、代谢类、肾脏和肝脏疾病的七种适应症，其中四款处于2期临床 试验中。 格隆汇12月31日丨瑞博生物-B(06938.HK)发布公告，公司拟全球发售2748.74万股H股，中国香港发售股 份274.88万股，国际发售股份2473.86万股(以上可予重新分配及视乎发售量调整权及超额配股权行使与 否而定)；2025年12月31日至2026年1月6日招股；发售价将为每股H股57.97港元，H股的每手买卖单位 将为200股，中金公司及花旗为联席保荐人；预计H股将于2026年1月9日在联交所开始买卖。 基于每股股份57.97港元的发售价并假设发售量调整权及超额配股权未获行使，公司估计公司将从全球 发售获得所得款项净额约14.736亿港元。公司目前计划将所得款项净额用于以下用途：(i)约37.4%将用 于核心产品RBD4059的研发；(ii)约19.6%将用于RBD5044的研发；(iii ...

我们与基石投资者Arc Avenue、Bright Stone、华夏基金、大成国际及大成基金、Erik Selin Fastigheter AB、Himension Fund、IvyRock、Mingxin Growth Ventures、Springs Capital(Hong Kong)、泰康人寿及拾 贝能信、自然拾贝及Huatai Capital Investment Limited(关于华泰场外掉期)订立基石投资协议，基石投资 者已同意在满足若干条件的情况下，按发售价认购或促使其指定实体认购以总金额约1亿美元可购买的 相关数目的发售股份。 我们认为，基石配售体现了我们的基石投资者对本公司及其业务前景的信心，并且基石配售将有助于提 升本公司的形象。除Ribocure AB的主要股东Erik Selin Fastigheter Aktiebolag(Erik Selin Fastigheter AB) 外，我们经由全球发售的整体协调人介绍结识了各基石投资者。 基于每股股份57.97港元的发售价并假设发售量调整权及超额配股权未获行使，估计我们将从全球发售 获得所得款项净额约14.74亿港元。其中，约37.4 ...

Investment Rating - The industry investment rating is "Outperform" compared to the market, indicating an expected performance greater than the CSI 300 index by more than 5% over the next six months [49]. Core Insights - Alnylam has shown strong revenue growth, with total revenue reaching $1.249 billion in Q3 2025, a year-over-year increase of 149%. Net product revenue was $851 million, up 103%, and revenue from collaborations and royalties surged by 393% to $398 million [2][7]. - The TTR product line is experiencing rapid growth, with Q3 2025 revenue of $724 million, a 135% increase year-over-year. The company has raised its full-year revenue guidance for TTR products to between $2.475 billion and $2.525 billion [16][29]. - Alnylam's research pipeline is robust, with seven drugs in Phase 3 clinical trials, including Nucresiran, which is expected to offer a better dosing regimen. The company is also exploring siRNA therapies in chronic disease areas [38][40]. Summary by Sections 1. Q3 2025 Performance Overview - In Q3 2025, Alnylam's total revenue was $1.249 billion, reflecting a 149% increase from the previous year. The net product revenue was $851 million, up 103%, while collaboration and royalty revenues reached $398 million, a 393% increase [2][7]. 2. Rapid Growth of TTR Products - The TTR product revenue for Q3 2025 was $724 million, marking a 135% year-over-year increase. The company has adjusted its full-year revenue guidance for TTR products to $2.475 billion to $2.525 billion, up from the previous estimate of $2.175 billion to $2.275 billion [16][29]. 3. Rich R&D Pipeline - Alnylam has a diverse R&D pipeline with seven drugs in Phase 3 trials. Nucresiran, a new generation TTR product, is expected to provide a more effective dosing schedule. The company is also advancing siRNA therapies in chronic disease management [38][40].

Summary of Alector Therapeutics Conference Call Company Overview - Alector is focused on neurodegeneration, developing therapeutics for Alzheimer's disease, Parkinson's disease, and other neurodegenerative disorders [5][6][24] - The company has five drugs in clinical trials and multiple preclinical programs utilizing proprietary blood-brain barrier technology [5][6] Clinical Programs and Pipeline - **Progranulin-elevating drug**: In collaboration with GSK, targeting Alzheimer's disease with an interim analysis expected in the first half of next year [5][6] - **Anti-amyloid beta antibody**: Expected to enter the clinic next year, leveraging blood-brain barrier technology for enhanced delivery [6][10] - **GCase enzyme replacement therapy**: Targeting Parkinson's disease and Lewy body dementia, with over 10% of Parkinson's patients linked to loss of function mutations in this enzyme [6][36] - **siRNA programs**: Targeting Tau, alpha-synuclein, and NLRP3, aiming for safer and more effective delivery to the brain [6][7][45] Blood-Brain Barrier Technology - Alector's technology allows for the delivery of large molecules to the brain at 10- to 50-fold higher concentrations, enhancing efficacy and safety [9][10] - The use of transferrin technology as a "Trojan horse" to transport drugs across the blood-brain barrier is a key differentiator [12][13] - Alector claims to achieve 10-12 fold higher concentrations of drugs in the brain compared to competitors, potentially allowing for lower doses and subcutaneous delivery [14][24] Competitive Landscape - Current anti-amyloid beta drugs (e.g., lecanemab, aducanumab) show modest clinical benefits (25%-30% slowdown in cognitive decline) but have significant adverse effects [22][23] - Alector's anti-amyloid beta drug aims to reduce adverse effects like ARIA (e.g., meningoencephalitis) and improve patient compliance through subcutaneous delivery [24][25] AL137 and AL101 Programs - **AL137**: Lead antibody with brain penetration 4-12 times higher than competitors, targeting subcutaneous delivery [28][29] - **AL101**: In partnership with GSK, focusing on amyloid beta removal and minimal ARIA, with interim analysis expected in the first half of 2026 [49][50] Financial Position - Alector has approximately $300 million in cash, providing a runway through 2027 to support multiple clinical programs and advance the ABC platform [54][58] Key Takeaways - Alector is positioned to potentially revolutionize treatment for neurodegenerative diseases through innovative drug delivery technologies and a robust pipeline of therapeutics [10][24] - The company is focused on addressing the limitations of existing therapies, particularly in terms of safety and delivery methods, which could enhance patient compliance and treatment outcomes [25][45]

Core Viewpoint - Sirius Therapeutics has submitted its listing application to the Hong Kong Stock Exchange, with a valuation of approximately $253 million after its Series B funding round in April 2025, backed by prominent investors [1][2]. Group 1: Company Overview - Sirius Therapeutics was established in 2021 and focuses on developing siRNA therapies [1]. - The company is co-founded by top healthcare investment firms OrbiMed Entities and Creacion Ventures, holding over 40% of shares, with Tencent's investment arm holding 8.14% and Hancan Capital holding over 13% [1]. - The company reported a net loss of 309 million yuan and 342 million yuan for 2023 and 2024, respectively, totaling 651 million yuan in losses [3]. Group 2: Financial Performance - In the first half of 2025, Sirius Therapeutics achieved a net profit of 34.46 million yuan, marking its first profitable period, primarily driven by non-recurring income [3][4]. - The company generated 144 million yuan in other income, a significant increase from 4.51 million yuan in the same period last year, largely due to a strategic partnership with CRISPR Therapeutics [3][4]. Group 3: Product Pipeline and Challenges - The core product, SRSD107, is in Phase II clinical trials for venous thromboembolism, while two key products, SRSD216 and SRSD384, are also in various stages of development [5][6]. - The company faces significant competition in the FXI/FXIa inhibitor space, with several competitors already in Phase III trials, including drugs from Novartis, Bayer, and Johnson & Johnson [7][8]. - Sirius Therapeutics has 65 patents and applications, but only one has been granted, with 32 critical patents pending, posing potential risks in a competitive biopharmaceutical landscape [9].

Group 1: Industry Overview - The small RNA drug sector has gained significant attention in recent years, with Alnylam (ALNY) seeing a stock price increase of over 60 times since its IPO, reaching a market capitalization of $55.9 billion [1] - Major pharmaceutical companies like Novartis and Roche are increasing their investments in this field [1] - Several domestic companies in China, including Yuyuan Pharmaceutical, Hengrui Medicine, and others, are also developing small RNA drugs [1] Group 2: Company Profile - Sirius Therapeutics - Sirius Therapeutics, founded in 2021, is a global clinical-stage biotechnology company focused on siRNA therapies for chronic diseases, with a dual headquarters in San Diego and Shanghai [3][8] - The company has completed three rounds of financing, raising approximately $144 million, with major investors including OrbiMed Entities and Creacion Ventures [3] - As of April 2025, the company's post-investment valuation is approximately $253 million [4] Group 3: Product Pipeline - The core product, SRSD107, is a siRNA drug targeting coagulation factor XI, currently in Phase II clinical trials in Europe, with plans for additional trials in China and Australia/New Zealand [16][19] - SRSD216, another key product, targets Lp(a) to lower its levels, addressing a significant unmet need in cardiovascular disease management [22][23] - SRSD384 is a candidate drug targeting obesity, currently advancing towards IND application [17] Group 4: Financial Performance - Sirius Therapeutics has not generated any revenue from product sales, with other income primarily from bank interest and investment returns [24] - The company reported losses of approximately 616 million yuan over two and a half years, mainly due to R&D expenditures [25] - As of June 2025, the company had cash and cash equivalents of 618 million yuan, estimated to sustain operations for 30 months [27] Group 5: Market Potential - The global siRNA therapy market is projected to reach $2.4 billion in 2024, with an expected growth to $50.3 billion by 2040, reflecting a compound annual growth rate of 20.9% [13] - Since the approval of the first siRNA drug, Onpattro, in 2018, significant clinical and commercial validation has been achieved, with seven siRNA products currently approved in major markets [12]