10% 医药生物 沪深300 医药生物行业 -5% 0% 5% 10% 医药生物 沪深300 超配（维持） 医药生物行业双周报（2025/12/5-2025/12/18） 29 省耗材联盟集采启动 投资要点： 本报告的风险等级为中高风险。 本报告的信息均来自已公开信息，关于信息的准确性与完整性，建议投资者谨慎判断，据此入市，风险自担。 请务必阅读末页声明。 行 业 研 医药生物（申万）指数走势 -35% 资料来源：iFind，东莞证券研究所 -40% -20% 0% 20% 22-03 22-05 22-07 22-09 22-11 23-01 23-03 相关报告 -30% -25% -20% -15% -10% -5% 0% 5% 10% 医药生物 沪深300 -35% -30% -25% -20% -15% -10% 5% -35% -30% -25% -20% -15% -10% -5% 0% 医药生物 沪深300 -35% -30% -25% -20% -15% -10% -5% 0% 5% 10% 医药生物 沪深300 2025 年 12 月 19 日 分析师：谢雄雄 SAC 执业证书编号： S0 ...

Group 1 - The core viewpoint of the news is that Tigermed has experienced fluctuations in its stock price, with a recent increase of 2.03% and a total market capitalization of 44.196 billion yuan [1] - As of September 30, 2025, Tigermed reported a revenue of 5.026 billion yuan, a year-on-year decrease of 0.82%, while the net profit attributable to shareholders increased by 25.45% to 1.02 billion yuan [2] - The company has distributed a total of 2.458 billion yuan in dividends since its A-share listing, with 1.154 billion yuan distributed in the last three years [3] Group 2 - Tigermed operates in the medical and biological sector, specifically in medical research outsourcing, and is involved in various concept sectors including CRO, medical devices, and internet healthcare [2] - The company has seen a decrease in the number of shareholders, with 48,400 shareholders as of September 30, 2025, a reduction of 6.01% from the previous period [2] - The top shareholders include Hong Kong Central Clearing Limited and several ETFs, with notable changes in their holdings compared to the previous period [3]

Core Viewpoint - Zhaoyan New Drug's stock price has shown significant volatility, with a year-to-date increase of 110.72%, but a recent decline in the last 60 days by 12.90% [1] Group 1: Stock Performance - As of December 19, Zhaoyan New Drug's stock price was 34.98 CNY per share, with a market capitalization of 26.217 billion CNY [1] - The stock has experienced a net inflow of 6.0604 million CNY from major funds, with large orders accounting for 22.37% of purchases and 20.10% of sales [1] - The stock has been on the "龙虎榜" three times this year, with the most recent occurrence on September 15 [1] Group 2: Financial Performance - For the period from January to September 2025, Zhaoyan New Drug reported a revenue of 985 million CNY, a year-on-year decrease of 26.23%, while net profit attributable to shareholders increased by 214.79% to 80.7061 million CNY [2] - The company's main business revenue composition includes 95.59% from non-clinical research services, 4.34% from clinical services, and 0.07% from experimental model supply [1] Group 3: Shareholder Information - As of September 30, 2025, the number of shareholders increased by 57.61% to 96,500, with an average of 0 shares per shareholder [2] - Among the top ten circulating shareholders, notable changes include a decrease in holdings by Huabao Zhongzheng Medical ETF and new entries from Guangfa Small Cap Growth Mixed Fund [3]

Group 1 - The core viewpoint of the news is that BaiO Technology's stock has experienced a significant decline this year, with a drop of 21.72% and a recent 5-day decline of 11.54% [1] - As of December 19, BaiO Technology's stock price was 51.51 CNY per share, with a market capitalization of 23.02 billion CNY [1] - The company experienced a net outflow of main funds amounting to 6.38 million CNY, with large orders showing a buy of 22.73 million CNY and a sell of 28.98 million CNY [1] Group 2 - BaiO Technology, established on November 13, 2009, is located in the Daxing District of Beijing and specializes in antibody drug research and preclinical research services [2] - The company operates five divisions, including gene editing services, preclinical pharmacology and efficacy evaluation, model animal sales, antibody development, and innovative drug development focusing on oncology and autoimmune diseases [2] - BaiO Technology is categorized under the pharmaceutical and biological industry, specifically in medical services and medical research outsourcing, with concepts including innovative drugs, cell therapy, and CRO [2]

Core Viewpoint - The stock of Haoyuan Pharmaceutical has experienced a decline of 2.05% on December 18, 2023, despite a year-to-date increase of 100.54% [1] Group 1: Company Overview - Haoyuan Pharmaceutical, established on September 30, 2006, and listed on June 8, 2021, is located in Shanghai and specializes in the research and development of small molecule drug discovery, including molecular building blocks and tool compounds [2] - The company's main business revenue composition includes molecular building blocks and tool compounds (68.97%), with product sales contributing 63.42%, raw materials and intermediates 30.46%, and technical services 5.55% [2] - As of September 30, 2023, the number of shareholders is 12,000, a decrease of 6.34% from the previous period, with an average of 17,647 circulating shares per person, an increase of 6.77% [2] Group 2: Financial Performance - For the period from January to September 2023, Haoyuan Pharmaceutical achieved a revenue of 2.059 billion yuan, representing a year-on-year growth of 27.18%, and a net profit attributable to shareholders of 237 million yuan, up 65.09% year-on-year [2] - The company has distributed a total of 160 million yuan in dividends since its A-share listing, with 120 million yuan distributed over the past three years [3] Group 3: Stock Market Activity - On December 18, 2023, Haoyuan Pharmaceutical's stock price was reported at 71.13 yuan per share, with a trading volume of 111 million yuan and a turnover rate of 0.73%, resulting in a total market capitalization of 15.087 billion yuan [1] - The stock has seen a net outflow of 2.4429 million yuan from major funds, with significant buying and selling activities recorded [1] - The stock has appeared on the "Dragon and Tiger List" once this year, with the last occurrence on May 30, 2023, where it recorded a net purchase of 10.336 million yuan [1]

Company Overview - Yinos Bio is located in the China (Shanghai) Pilot Free Trade Zone and was established on May 12, 2010. The company specializes in providing non-clinical research services in the biopharmaceutical sector, primarily as a Contract Research Organization (CRO) [1] - The company's revenue composition is as follows: non-clinical services account for 96.31%, clinical services for 3.42%, and other services for 0.27% [1] Stock Performance - As of December 18, Yinos Bio's stock price increased by 2.03%, reaching 51.36 CNY per share, with a total market capitalization of 7.241 billion CNY [1] - Year-to-date, the stock price has risen by 45.95%, with a 19.16% increase over the last five trading days, a 10.64% increase over the last 20 days, and a 9.63% increase over the last 60 days [1] Financial Performance - For the period from January to September 2025, Yinos Bio reported a revenue of 571 million CNY, representing a year-on-year decrease of 35.33%. The net profit attributable to shareholders was -14.7881 million CNY, a decline of 111.14% compared to the previous year [2] Shareholder Information - As of September 30, the number of shareholders for Yinos Bio was 4,849, a decrease of 9.97% from the previous period. The average number of circulating shares per person increased by 257.28% to 18,703 shares [2] - The company has distributed a total of 45.1135 million CNY in dividends since its A-share listing [3] - Notable changes in institutional holdings include new entries from Huatai-PineBridge Healthcare Mixed Fund and Huaxia Stable Growth Mixed Fund among the top ten circulating shareholders [3]

Core Viewpoint - The stock of Zhaoyan New Drug (06127) has risen over 8%, currently trading at HKD 22.14, with a transaction volume of HKD 39.86 million, driven by increasing demand for experimental monkeys used in preclinical safety evaluations [1] Group 1: Market Dynamics - Recent reports indicate a significant increase in the price of experimental monkeys, reaching approximately HKD 140,000 each as of December 9, 2025, due to rising demand and limited supply [1] - According to a report from Founder Securities, the demand for experimental monkeys is expected to rise as preclinical CRO orders recover, while supply-side expansion remains challenging [1] - Some monkey breeding facilities have indicated that their production capacity is already booked until the first quarter of 2026, suggesting a sustained tight supply situation [1] Group 2: Financial Implications - Founder Securities estimates that the fair value of experimental monkeys could increase from an average of HKD 84,900 per monkey in 2024 to HKD 140,000 by Q4 2025, with a projected output rate of 17% from breeding facilities [1] - Based on the known quantity of 23,200 monkeys, the estimated additional fair value for 2025 could reach approximately HKD 220 million, not accounting for new additions or the impact of juvenile and aging monkeys [1]

Core Viewpoint - The company, Jinkai (Liaoning) Life Science Technology Co., Ltd., specializes in providing custom development and production services for small molecule drug intermediates and a small amount of raw materials for global pharmaceutical companies, with a focus on fluorinated and non-fluorinated CDMO businesses [2][8]. Group 1: Business Overview - The main business involves providing small molecule drug intermediates and limited raw materials for new drug development projects for globally recognized pharmaceutical companies [2][8]. - The company has a significant focus on fluorinated CDMO services, including specialized fluorination agents and other fluorinated products [3][8]. - As of the 2024 annual report, overseas revenue accounts for 61.18% of total revenue, benefiting from the depreciation of the RMB [4]. Group 2: Financial Performance - For the period from January to September 2025, the company achieved a revenue of 488 million yuan, representing a year-on-year growth of 25.96%, and a net profit attributable to the parent company of 103 million yuan, reflecting a substantial increase of 163.24% [8]. - The company has distributed a total of 117 million yuan in dividends since its A-share listing [9]. Group 3: Market Activity - On December 16, the company's stock price fell by 2.50%, with a trading volume of 39.89 million yuan and a turnover rate of 2.15%, resulting in a total market capitalization of 3.896 billion yuan [1]. - The stock has shown no clear trend in major capital inflows, with a net outflow of 4.2829 million yuan today, ranking 27th out of 52 in its industry [5][6].

Investment Rating - The report maintains an "Overweight" rating for the CXO industry, indicating a positive outlook for investment opportunities in this sector [7]. Core Insights - The CXO industry is entering a new high prosperity cycle driven by external factors such as overseas interest rate cuts, domestic recovery, and industrial upgrades. The worst period for the industry is considered to be over, with a significant improvement in sentiment and operational conditions [1][2][17]. - The report emphasizes the competitive advantages of Chinese CXO companies, including efficiency, cost, quality, and rapid expansion capabilities, which are expected to maintain their global standing in the short to medium term [1][3][22]. - The emergence of new molecular drugs, such as peptides and oligonucleotides, is driving growth in the CRDMO sector, with Chinese suppliers positioned to lead globally due to their production capabilities and cost advantages [3][22][28]. Summary by Sections New Cycle - The CXO industry has transitioned from a prolonged adjustment period (2H21-1H24) to a new upward cycle, supported by recovering overseas financing and a favorable domestic IPO environment. The demand for CXO services is expected to increase significantly starting in 2026 [2][17]. New Molecules - New molecular CRDMO services are characterized by higher demand and technical barriers. Chinese companies are leading in areas like TIDES and ADC, achieving higher growth rates and maintaining robust profit margins [3][22][28]. New Landscape - The domestic CXO market is undergoing a restructuring, with market share increasingly concentrated among leading firms. The report highlights that smaller companies may struggle to survive due to heightened quality and sustainability demands from pharmaceutical clients [4][22][28]. Key Recommendations - The report recommends investing in leading companies with strong positions in the new molecular space, such as WuXi AppTec, WuXi Biologics, and others, which are expected to benefit from the ongoing industry upgrades and demand recovery [1][9][22].

智通财经记者 | 李科文 智通财经编辑 | 谢欣 12月12日晚间，睿智医药公告，公司董事会秘书高莹莹因工作职务调整，申请辞去董事会秘书职务，辞职报告自送达董事会之 日起生效。 值得注意的是，自就任睿智医药董事会秘书至辞职，高莹莹任职时间仅为11天。高莹莹此前并无上市公司董秘从业经历，职业 背景主要来自地方广播电视系统。 据履历信息，2016年7月至2020年3月，高莹莹在阳江广播电视台任策划、主持人、编导、编辑；2020年3月至2022年9月，在中 山广播电视台担任主持人、栏目策划及编导。其间，她曾与双胞胎姐姐高晶晶共同主持《晶莹睇透》《晶莹宝贝》《文学悦 听》《水上冲关》等节目。 12月15日，智通财经致电睿智医药董秘办，询问高莹莹离任是否与近期网络舆情有关。睿智医药投资者关系相关工作人员向智 通财经回应称，相关变动原因以公告披露内容为准。 睿智医药是国内较早成立的合同研究组织（CRO）公司。其前身睿智化学成立于2003年，在行业起步阶段，一度与如今的A股 医药合同研发生产组织（CDMO）龙头药明康德平齐。 胡瑞连曾是睿智化学的财务投资者。2017年5月，胡瑞连控制的Mega Star受让睿智化学23.5 ...