Core Viewpoint - The innovation drug sector has seen a continuous rise in popularity this year, with various indices related to innovation drugs in both Hong Kong and A-shares showing strong performance [1] Index Comparison - The Hang Seng Hong Kong Stock Connect Innovation Drug Index focuses on Hong Kong stocks related to innovation drug research, development, and production, while the CSI Innovation Drug Industry Index targets A-share companies involved in innovation drug R&D, selecting up to 50 representative stocks [2] - The Hang Seng index excludes contract research organizations (CROs) and selects stocks based on their relevance to innovation drug business, while the CSI index does not exclude CROs and selects the largest 50 stocks by market capitalization [2] Industry Distribution - The CSI Innovation Drug Industry Index has a higher weight in chemical preparations (46.6%) and medical R&D outsourcing (21.3%), while the Hang Seng index has a greater focus on chemical preparations (48.9%) and other biological products (41.1%) [5] - The Hang Seng index excludes medical outsourcing companies, leading to a different industry distribution compared to the CSI index, which includes this segment [5] Component Stock Concentration - The Hang Seng index has a higher concentration of component stocks, with the top ten stocks accounting for approximately 75% of the index, while the CSI index's top ten stocks account for less than 50% [9] - Major stocks in the CSI index include WuXi AppTec (13.09% weight) and Hengrui Medicine (10.19% weight), while the Hang Seng index features CSPC Pharmaceutical (10.75% weight) and China National Pharmaceutical (10.31% weight) [11] Summary - Both indices focus on the innovation drug industry but differ in their compilation rules, industry distribution, and component stocks, which investors should consider based on their investment goals and risk tolerance [12]

Group 1 - The core viewpoint of the news highlights the performance of various healthcare indices, with the CSI Hong Kong Stock Connect Healthcare Index rising by 2%, the CSI 300 Healthcare Index increasing by 1.7%, and the Hang Seng Hong Kong Stock Connect Innovative Drug Index up by 1.5% [1][4][11] - The CSI Hong Kong Stock Connect Healthcare Index focuses on leading companies in the Hong Kong healthcare sector, comprising 50 stocks from medical devices, biopharmaceuticals, chemical drugs, and other healthcare-related industries [3] - The CSI Innovative Drug Industry Index targets leading A-share innovative drug companies, consisting of no more than 50 stocks involved in innovative drug research and development [6] - The CSI Biotechnology Theme Index centers on leading A-share biotechnology companies, including no more than 50 stocks related to gene diagnostics, biopharmaceuticals, blood products, and other human biotechnology [8] - The CSI 300 Healthcare Index encompasses leading A-share healthcare companies, covering segments such as chemical pharmaceuticals, medical services, and medical devices [10]

Group 1 - The National Healthcare Security Administration has issued guidelines for the adjustment of the basic medical insurance catalog and the commercial health insurance innovative drug catalog for 2025, marking the first inclusion of commercial health insurance innovative drug catalog in the adjustment plan [1] - The Hang Seng Innovative Drug ETF (159316) has shown impressive performance, with a year-to-date increase of 67%, following the completion of a "purity revolution" that removed five CXO companies, focusing entirely on leading innovative drug firms [1][2] - The new index ensures "purity" through a three-tier screening process: excluding CXO companies, scoring based on R&D investment, and semi-annual rebalancing [1] Group 2 - The policy environment is favorable, with accelerated pilot programs for Class B medical insurance catalogs and CAR-T drugs included in "Huibao" for three consecutive years, with a maximum reimbursement of 500,000 yuan; nearly 40 innovative drugs are expected to be approved in the first half of 2025, potentially exceeding 50 for the entire year [2] - In the first five months of 2025, the total amount of license-out transactions by Chinese innovative drug companies reached 45.5 billion USD, surpassing the total for the first half of 2024, indicating a global revaluation of innovative drug value [2] Group 3 - The Hang Seng Innovative Drug ETF (159316) has significant holdings in companies like BeiGene and CanSino Biologics, with recent net inflows exceeding 17 million yuan and a 120% year-on-year increase in overseas sales for its holdings [3] - The EasyGo Innovative Drug ETF (516080) covers leading firms like HengRui Medicine, with a scale exceeding 400 million yuan, while the Medical ETF (512010) has a scale of over 20 billion yuan, with 35% allocated to innovative drugs, suitable for conservative investors [3] Group 4 - The innovative drug development success rate is below 10%, and some individual stocks may experience increased volatility due to speculative trading [4] - A "core + satellite" strategy is recommended, focusing 60%-70% on the Hang Seng Innovative Drug ETF and EasyGo Innovative Drug ETF, complemented by a diversified approach through the Hong Kong Stock Connect Medical ETF [4] - The combination of policy support and industry upgrades presents a historic opportunity for innovative drugs in 2025, with EasyGo providing efficient access for investors to participate in this transformation [4]

Core Insights - The Hang Seng Hong Kong Stock Connect Innovative Drug Index has seen a remarkable increase of over 60% year-to-date, highlighting the significant development of China's innovative drug sector and attracting interest from overseas pharmaceutical companies [1][8] - The index has revised its compilation scheme to exclude CXO companies, focusing solely on innovative drug companies, thus becoming the first index with a "purity" of 100% in tracking innovative drugs [1][2] Index Revision Details - Five CXO companies will be removed from the Hang Seng Hong Kong Stock Connect Innovative Drug Index, resulting in a composition entirely made up of innovative drug firms [2] - The previous weight of the excluded CXO companies was approximately 20%, and their performance lagged behind the overall index [3][5] Performance Metrics - The revised index has shown better performance since its announcement, with an annualized return exceeding 30% and a higher Sharpe ratio compared to the original index [5][7] - The annualized volatility of the revised index is 37.7%, while the original index had a volatility of 40.0% [7] Market Trends - Multinational pharmaceutical companies have significantly increased their procurement of innovative drug patents from China, with procurement amounts nearing the total for the entire year of 2024 within the first five months of this year [8] - The trend of multinational companies sourcing innovative drug patents from China is expected to continue, driven by pressures such as drug price reductions and patent expirations [8] Investment Opportunities - The Hang Seng Innovative Drug ETF (159316) is currently the only product tracking the Hang Seng Hong Kong Stock Connect Innovative Drug Index, providing investors with a convenient way to access leading innovative drug companies in Hong Kong [9] - Other investment products, such as the E Fund Innovative Drug ETF (516080), also cover the entire innovative drug industry chain, including major players like Hengrui Medicine and Fosun Pharma [9][10]