根据协议，希华医药及韩美会将encequidar在病毒学领域的全球独家权利授予 Gilead。此外，希华医药 及韩美亦将提供药物供应、分享技术知识，并以主要伙伴身份参与项目。待于协议期内达成若干条件及 里程碑后，希华医药将获支付1000万美元首付款，日后有权获得的潜在价款可达最高约7250万美元，并 可按低个位数比率在销售净额中抽取使用权费。 希玛医疗(03309)发布公告，于2025年9月29日，希华医药有限公司的一间附属公司与Gilead Sciences, Inc.及韩美药品工业株式会社就病毒学领域首款P-糖蛋白抑制剂encequidar(希华医药拥有该款药物在韩 国以外的全球独家权利)订立三方全球授权及合作协议。 希华医药主要从事肿瘤学领域的创新药开发项目，目前正在多个领域研究以 encequidar开发口服药配 方。希华医药正研究在肿瘤学领域以口服紫杉醇结合 encequidar治疗转移性乳癌，以取代在化疗中经静 脉注射紫杉醇，是该公司最前沿的项目。希华医药正准备就口服紫杉醇结合encequidar的转移性乳癌疗 程展开第3阶段全球临床研究，有关研究计划于2025年底在美国、香港及纽西兰的多个中心进 ...

格隆汇9月29日丨希玛医疗(03309.HK)宣布，于2025年9月29日，希华医药有限公司的一间附属公司与 Gilead Sciences,Inc. "Gilead"及韩美药品工业株式会社"韩美"就病毒学领域首款P－糖蛋白"P-gp"抑制剂 encequidar(希华医药拥有该款药物在韩国以外的全球独家权利)订立三方全球授权及合作协议。 根据协议，希华医药及韩美会将encequidar在病毒学领域的全球独家权利授予Gilead。此外，希华医药 及韩美亦将提供药物供应、分享技术知识，并以主要伙伴身份参与项目。待于协议期内达成若干条件及 里程碑后，希华医药将获支付1000万美元首付款，日后有权获得的潜在价款可达最高约7250万美元，并 可按低个位数比率在销售净额中抽取使用权费。 希华医药主要从事肿瘤学领域的创新药开发项目，目前正在多个领域研究以encequidar开发口服药配 方。希华医药正研究在肿瘤学领域以口服紫杉醇结合encequidar治疗转移性乳癌，以取代在化疗中经静 脉注射紫杉醇，是该公司最前沿的项目。希华医药正准备就口服紫杉醇结合encequidar的转移性乳癌疗 程展开第3阶段全球临床研究，有关研 ...

Group 1 - The core point of the news is that Hema Medical (希华医药) has entered into a global licensing and collaboration agreement with Gilead Sciences, Inc. and Hanmi Pharmaceutical Co., Ltd. for the antiviral drug encequidar, which Hema Medical holds exclusive global rights outside of South Korea [1] - Under the agreement, Hema Medical and Hanmi will grant Gilead exclusive global rights to encequidar in the field of virology, while also providing drug supply and sharing technical knowledge [1] - Hema Medical is set to receive an upfront payment of $10 million, with potential milestone payments reaching up to approximately $72.5 million, along with royalties based on a low single-digit percentage of net sales [1] Group 2 - Hema Medical is primarily focused on innovative drug development in the oncology field and is currently researching oral formulations of paclitaxel combined with encequidar for the treatment of metastatic breast cancer [2] - The company is preparing to initiate a Phase 3 global clinical study for the oral paclitaxel and encequidar regimen for metastatic breast cancer, with plans to conduct the study at multiple centers in the United States, Hong Kong, and New Zealand by the end of 2025 [2]

Core Viewpoint - The company reported its 1H25 performance, showing a slight decline in revenue but a significant increase in net profit, aligning with market expectations [1][2]. Financial Performance - Revenue for 1H25 was 4.356 billion yuan, a year-on-year decrease of 0.8% [1] - Net profit attributable to shareholders was 1.358 billion yuan, a year-on-year increase of 24.6% [1] - Adjusted net profit was 1.136 billion yuan, a year-on-year increase of 2.1%, meeting market expectations [1] Business Trends - Sales of core commercial products faced pressure in 1H25: - Revenue from Teva Australia was 2.371 billion yuan, down 4.2%, accounting for 54.4% of total revenue [1] - Revenue from Yibiao was 346 million yuan, down 12.1% [1] - Revenue from Cyber was 110 million yuan, down 10.4% [1] - Combined revenue from the above two products accounted for 10.5% of total revenue [1] - Revenue from the hair loss sector was 690 million yuan, up 23.8%, accounting for 15.8% of total revenue [1] - Revenue from Mandi was 682 million yuan, up 24.0% [1] - CDMO business achieved revenue of 101 million yuan, up 76.1% [1] - Revenue from Sanofi was 642 million yuan, up 7.6% [1] Research and Development - As of the end of 1H25, the company had a rich pipeline of 30 products under research, covering areas such as hematology, oncology, autoimmune diseases, and nephrology [2] - Notable products include: - SSGJ-706 (anti-PD-1/PD-L1 bispecific antibody) approved for two Phase II clinical trials [2] - SSGJ-705 (anti-PD-1/HER2 bispecific antibody) has received FDA approval for IND in the U.S. [2] - SSS59 (MUC17/CD3/CD28 trispecific antibody) has entered Phase I clinical trials for solid tumors [2] Collaborations and Partnerships - The company continues to engage in external collaborations: - Granted Pfizer global rights to SSGJ-707 (PD-1/VEGF bispecific antibody), receiving a $1.25 billion upfront payment and potential future milestone payments exceeding $4.8 billion [2] - Collaborated with Haihe Pharmaceuticals for oral paclitaxel, which is under preliminary review for inclusion in the 2025 National Medical Insurance Directory [2] - Partnered with Hanyu Pharmaceuticals for semaglutide injection, completing patient enrollment for Phase III clinical trials [2] - Signed a collaboration with Ying'en Bio for commercialization rights of DB-1303 (HER2 ADC) in mainland China, Hong Kong, and Macau [2] Profit Forecast and Valuation - The company raised its net profit forecasts for 2025 and 2026 by 186.5% and 138.3% to 6.249 billion yuan and 5.664 billion yuan, respectively [2] - The current stock price corresponds to 11.3x and 12.3x P/E ratios for 2025 and 2026 [2] - The target price was raised by 39.9% to 36.50 HKD, implying a 14.9% upside potential [2]

Core Viewpoint - CICC has raised the net profit estimates for 2025 and 2026 for Sangfor Pharmaceuticals (01530) by 186.5% and 138.3% to CNY 6.249 billion and CNY 5.664 billion respectively, reflecting a positive outlook on the company's BD revenue recognition [1] Group 1: Financial Performance - In 1H25, the company's revenue was CNY 4.356 billion, a slight decline of 0.8% year-on-year; however, the net profit attributable to the parent company increased by 24.6% to CNY 1.358 billion, and the adjusted net profit rose by 2.1% to CNY 1.136 billion, meeting market expectations [1] - The current stock price corresponds to a price-to-earnings ratio of 11.3x for 2025 and 12.3x for 2026, with a target price raised by 39.9% to HKD 36.50, implying a potential upside of 14.9% [1] Group 2: Product Sales Performance - The sales of the company's core commercial products faced pressure in 1H25, with revenue from Teva Australia declining by 4.2% to CNY 2.371 billion, accounting for 54.4% of total revenue; revenue from Yibiao fell by 12.1% to CNY 346 million, and revenue from Cyberol decreased by 10.4% to CNY 110 million, together representing 10.5% of total revenue [2] - Revenue from the hair loss sector grew by 23.8% to CNY 690 million, accounting for 15.8% of total revenue, with Mandai contributing CNY 682 million, a 24.0% increase [2] - The CDMO business achieved revenue of CNY 101 million in 1H25, a significant increase of 76.1% year-on-year, while Sangfor Guojian's revenue rose by 7.6% to CNY 642 million [2] Group 3: R&D Pipeline - As of the end of 1H25, the company has a rich pipeline of 30 products under research, covering areas such as hematology and oncology, autoimmune diseases, and nephrology [3] - Notable products include SSGJ-706 (anti-PD-1/PD-L1 bispecific antibody) which has received approval for two Phase II clinical trials, and SSGJ-705 (anti-PD-1/HER2 bispecific antibody) which is currently enrolling patients for Phase II trials in China [3] Group 4: External Collaborations - The company has continued its external collaborations, granting Pfizer global rights to SSGJ-707 (PD-1/VEGF bispecific antibody) for a total of USD 12.5 billion in upfront payments and potential milestone payments exceeding USD 4.8 billion, along with double-digit sales sharing [4] - The company is also collaborating with Haihe Pharmaceuticals for oral paclitaxel, which has entered the preliminary review list for the 2025 National Medical Insurance Directory adjustment [4] - Additionally, the company has partnered with Hanyu Pharmaceuticals for the completion of patient enrollment in the Phase III clinical trial of semaglutide injection for weight loss indications [4]

Group 1 - The core viewpoint of the report is that the net profit estimates for 2025 and 2026 for Sanofi Pharmaceutical have been raised significantly by 186.5% and 138.3% to 6.249 billion yuan and 5.664 billion yuan respectively, reflecting a positive outlook on the company's performance [1] - The current stock price corresponds to a price-to-earnings ratio of 11.3 times for 2025 and 12.3 times for 2026, indicating a favorable valuation [1] - The target price has been increased by 39.9% to 36.50 HKD, which implies a potential upside of 14.9% based on a price-to-earnings ratio of 13.0 times for 2025 and 14.2 times for 2026 [1] Group 2 - In the first half of 2025, the sales of the company's core commercial products faced pressure, with revenue from Teva Australia declining by 4.2% to 2.371 billion yuan, accounting for 54.4% of total revenue [2] - The revenue from the hair loss sector grew by 23.8% to 690 million yuan, representing 15.8% of total revenue, with the product Mandi contributing 682 million yuan, a 24.0% increase [2] - The CDMO business achieved a revenue of 101 million yuan, marking a significant growth of 76.1% [2] Group 3 - The company has a rich pipeline of 30 products under research, including areas such as hematology, oncology, autoimmune diseases, and nephrology [3] - Notable products in the pipeline include SSGJ-706, which has received approval for two Phase II clinical trials for gastrointestinal tumors and non-small cell lung cancer [3] - SSGJ-705 is currently enrolling patients for Phase II trials in China, with FDA approval for IND in the United States [3] Group 4 - The company continues to engage in external collaborations, having granted Pfizer global rights to SSGJ-707, receiving an upfront payment of 1.25 billion USD and potential milestone payments exceeding 4.8 billion USD [4] - The collaboration with Haihe Pharmaceuticals for oral paclitaxel has entered the preliminary review list for the 2025 National Medical Insurance Directory adjustment [4] - The partnership with Hanyu Pharmaceuticals for semaglutide injection has completed patient enrollment for Phase III clinical trials [4]

Group 1 - The core viewpoint of the article is that the investment by Huayi Family in Haihe Pharmaceutical is a strategic response to the pressures of transformation faced by traditional industries, supported by policy and market logic [1][4] - The "Six Merger Guidelines" issued by the CSRC in 2024 encourage listed companies to engage in cross-industry mergers to enhance industrial transformation and upgrade, providing institutional support for traditional enterprises [1][2] - Traditional industries, including real estate, are experiencing common issues of sluggish growth, with many companies facing performance declines, highlighting the urgent need for transformation [1][3] Group 2 - Compared to building teams to enter new fields, investing in or acquiring mature innovative companies is a more efficient choice, aligning with the "Six Merger Guidelines" that direct resources towards new productive forces [2] - Haihe Pharmaceutical possesses clear core value through its solid R&D capabilities and commercial progress, having undertaken significant national projects and achieved commercialization of several products [3] - Despite currently being in a loss-making state, Haihe Pharmaceutical's situation aligns with the characteristics of innovative pharmaceutical companies, which typically require substantial upfront R&D investments [3] Group 3 - The investment strategy reflects practicality, utilizing a "strategic financial investment" approach to minimize integration risks and allow for future collaboration [4] - The transaction complies with regulatory requirements, ensuring protection for minority investors by involving shareholder meetings and avoiding conflicts of interest [4] - Huayi Family's financial strength supports the feasibility of the operation, with sufficient cash reserves to accommodate the investment without jeopardizing ongoing operations [4]