Core Insights - The pharmaceutical companies listed on the Shanghai Stock Exchange have shown robust growth in the first half of 2025, driven by the implementation of the Healthy China strategy and global pharmaceutical innovation [1][4] - Jiangsu Hengrui Medicine Co., Ltd. has received approval for its innovative drug, Zemeituzhita Tablets, marking a significant advancement in China's hematological oncology drug development [1][2] - The overall trend indicates a shift towards increased R&D investment, with innovative drug sales becoming a larger portion of revenue and accelerated international market expansion [1][4] Company Summaries - **Hengrui Medicine**: Achieved revenue of 15.761 billion yuan and net profit of 4.450 billion yuan in the first half of 2025, representing year-on-year growth of 15.88% and 29.67% respectively. Innovative drug sales now account for 55% of main business revenue. The company has invested over 48 billion yuan in R&D and has 14 global R&D centers with a team of over 5,600 [2][3] - **Fosun Pharma**: Reported innovative drug revenue exceeding 4.3 billion yuan in the first half of 2025, a year-on-year increase of 14.26%, making up 31% of its pharmaceutical business revenue. The company has engaged in five innovative drug licensing transactions and has established a local team in the U.S. for commercialization efforts [2][3] - **WuXi AppTec**: Experienced a 24.2% year-on-year growth in revenue from continuing operations in the first half of 2025, with adjusted net profit increasing by 44.4%. The company has successfully synthesized and delivered over 440,000 new compounds in the past 12 months [3] Industry Trends - The pharmaceutical industry is actively exploring new growth points through digital transformation, green low-carbon development, and cross-industry innovation. Leading companies like Hengrui, Fosun, and WuXi AppTec are demonstrating the effectiveness of innovation-driven strategies and global market expansion [4]

Core Viewpoint - Fosun Pharma is divesting non-core assets to focus on its innovative drug business, with plans to transfer 100% equity of Shanghai Clon to a special fund for 1.256 billion yuan, using the proceeds to enhance investment in innovative drugs [2][5][7]. Group 1: Asset Disposal and Focus on Core Business - Fosun Pharma has signed agreements to dispose of over 2 billion yuan in non-core assets since 2025, including a recent sale of 1.24 million USD for a stake in Unicorn II and 26.54 million yuan for a stake in Shanghai Rehabilitation [7][11]. - The company aims to optimize its asset structure and accelerate cash flow by exiting non-strategic assets, as stated by Chairman Chen Yuqing [7][8]. Group 2: Investment in Innovative Drugs - Fosun Pharma's R&D investment totaled 173.76 billion yuan over the past three years, with 25.84 billion yuan spent in the first half of 2025, bringing the total R&D investment to 199.6 billion yuan over three and a half years [10][11]. - The company has received approvals for four innovative drugs with five indications in the first half of 2025, including treatments for high phosphorus levels in dialysis patients and various cancers [10][11]. Group 3: Financial Performance - In the first half of 2025, Fosun Pharma reported a net profit of 1.702 billion yuan, a year-on-year increase of 38.96%, despite a 4.63% decline in total revenue to 19.514 billion yuan [3][11]. - The revenue from innovative drugs reached 4.3 billion yuan, reflecting a 14.26% increase compared to the previous year, which helped mitigate the impact of centralized procurement on generic drugs [4][11].

Group 1: Changshan Pharmaceutical - The company is preparing for clinical trials of Aibennate peptide for weight loss, with no current plans for oral formulation development [1] - Aibennate peptide is a long-acting GLP-1 receptor agonist, developed through chemical modification of exenatide [1] - The marketing preparation includes team building, product knowledge training, and marketing strategy formulation [1] Group 2: Fosun Pharma - Four innovative drugs approved in the first half of the year are expected to gradually increase sales in the coming months [2] - Innovative drug revenue exceeded 4.3 billion yuan, a year-on-year increase of 14.26%, accounting for over 30% of total drug revenue [2] - The company is actively participating in negotiations for the inclusion of its innovative drugs in insurance and national basic medical insurance directories [2] Group 3: Tiantan Biological Products - The company has established an international cooperation department to enhance its global market presence [3] - Products such as tetanus immunoglobulin and rabies immunoglobulin have already been exported [3] - The company is focused on international certification and registration of key products [3] Group 4: Kangtuo Medical - The US-based subsidiary BIOPLATE has launched a local production line for PEEK plates [4] - The company has completed market access in nearly 40 countries and regions [4] - The marketing of "4D bioactive plates" and PEEK fixation systems is underway in the US [4] Group 5: Tailong Pharmaceutical - The company is focusing on the development of modified new drugs across various therapeutic areas including respiratory, digestive, and oncology [5] - Projects in progress include treatments for Alzheimer's disease and schizophrenia [5] Group 6: Heng Rui Pharmaceutical - The HRS-5635 injection has been included in the list of proposed breakthrough therapies [6][7] - Chronic hepatitis B infection affects approximately 257 million people globally, with a significant mortality rate [7] - There is a pressing need for more effective treatments to achieve functional cure for chronic hepatitis B [7]

Core Insights - The company is actively participating in the review phase for the inclusion of its innovative drug, Yikaida, in commercial insurance and national basic medical insurance directories, and will engage in subsequent negotiations and evaluations [1] - The revenue from innovative drugs showed steady growth, exceeding 4.3 billion yuan, representing a year-on-year increase of 14.26%, and accounting for over 30% of total drug revenue, indicating an optimized revenue structure [1] - The company has a positive outlook on the sales prospects of its innovative drugs, with four newly approved drugs initiating academic promotion and market education, expected to gradually increase their market presence in the coming months [1] Business Development - The company focuses its innovation strategy on three core therapeutic areas: solid tumors, hematological tumors, and immune inflammation, while also expanding into chronic disease areas such as cardiovascular, renal metabolism, and central nervous system [2] - In the solid tumor segment, the company has developed an innovative drug matrix represented by drugs like Surulitinib and Trastuzumab, with new approvals enhancing its treatment offerings for breast cancer and rare tumors [2] - The company is advancing its capabilities in antibody, ADC, cell therapy, and small molecule platforms, while also exploring cutting-edge technologies such as nuclear medicine, small nucleic acids, and peptides [2]

Core Viewpoint - Fosun International is leveraging macroeconomic trends and industry dynamics to drive steady growth through innovation and global operations, achieving total revenue of 87.28 billion RMB in the first half of 2025, with a net profit of 660 million RMB [1] Group 1: Financial Performance - Total revenue reached 87.28 billion RMB, with operational profit at 3.15 billion RMB and net profit at 660 million RMB [1] - The debt-to-capital ratio remained healthy at 53%, indicating a stable financial condition [1] - Standard & Poor's affirmed a "stable" outlook for the company's credit rating in May 2025 [1] Group 2: Globalization Strategy - Fosun's overseas revenue amounted to 46.67 billion RMB, accounting for 53% of total revenue, reflecting a deepened global operational phase [2] - The company operates in over 40 countries and regions, showcasing its robust cross-cycle operational capabilities [2] Group 3: Market Expansion and Innovation - Fosun Portugal Insurance has expanded into emerging markets like Brazil and Angola, with international business accounting for 28.2% of total operations [3] - Club Med achieved record global performance with revenue of 9.25 billion RMB, a 3.8% increase year-on-year, and operating profit of 1.27 billion RMB, an 11% increase [3] Group 4: Pharmaceutical Innovations - Fosun Pharma's subsidiary, Fuhong Hanlin, achieved global sales of 597.7 million RMB for its PD-1 monoclonal antibody, with approvals in multiple countries [4] - The company reported a 200% increase in overseas product profits, with cash inflows from business development contracts exceeding 1 billion RMB, a 280% year-on-year growth [4] Group 5: Strategic Collaborations - Fosun Pharma is collaborating with Fakeeh Care Group in Saudi Arabia to promote innovative treatment products [5] - The company is also partnering with Khaled Juffali Company to provide production line solutions for the electric vehicle industry in Saudi Arabia [5] Group 6: Technological Innovation - Fosun invested 3.6 billion RMB in R&D in the first half of 2025, focusing on creating a competitive product portfolio across various strategic sectors [7] - The company has established over 20 global innovation centers, enhancing its technological capabilities [7] Group 7: AI Integration - Fosun is implementing an "embrace AI" strategy to enhance operational efficiency and product innovation across its sectors [10] - The Pharm AID platform in the pharmaceutical sector improves decision-making efficiency by 50% [10] Group 8: Future Outlook - The company is positioned for sustainable growth with a strong financial foundation and innovative momentum across multiple sectors, including pharmaceuticals, consumer goods, and tourism [11] - The dual strategy of "globalization + innovation" is expected to drive future growth and value creation [11]

Core Viewpoint - Fosun Pharma reported a slight decline in revenue but a significant increase in net profit, indicating a strong performance in innovation and strategic development [1] Financial Performance - In the first half of 2025, Fosun Pharma achieved revenue of 19.514 billion yuan, a year-on-year decrease of 4.63% - The net profit attributable to shareholders reached 1.702 billion yuan, reflecting a year-on-year growth of 38.96% - Revenue from innovative drugs exceeded 4.3 billion yuan, marking a year-on-year increase of 14.26% [1] Innovation and R&D - Fosun Pharma invested 2.584 billion yuan in R&D during the first half of 2025 - The company is focusing on core therapeutic areas such as solid tumors, hematological tumors, and immune inflammation, while also exploring chronic diseases and neurological fields [1][2] Product Development - In the solid tumor sector, Fosun Pharma has developed a matrix of innovative drugs, including the approval of a new small molecule CDK4/6 inhibitor and a first self-developed small molecule drug for dual indications - The CAR-T product, Yikaida, is being promoted for accessibility and affordability, with inclusion in over 110 health insurance plans [2] Global Market Expansion - Fosun Pharma's overseas revenue reached 5.478 billion yuan, accounting for approximately 28.07% of total revenue - The company is enhancing its global business development through licensing and collaboration, focusing on unmet clinical needs [3] Sustainability and ESG - Fosun Pharma has improved its MSCI ESG rating to AA, reflecting its commitment to sustainable development [3]

Core Viewpoint - Shanghai Fosun Pharmaceutical Group Co., Ltd. reported a decrease in revenue but an increase in net profit for the first half of 2025, indicating a focus on innovation and operational efficiency despite challenges in the pharmaceutical market [4][5][6]. Financial Performance - The company's operating revenue for the first half of 2025 was approximately CNY 19.51 billion, a decrease of 4.63% compared to the same period last year [4]. - Total profit for the period was approximately CNY 2.72 billion, reflecting a 40.77% increase year-on-year [4]. - Net profit attributable to shareholders was approximately CNY 1.70 billion, up 38.96% from the previous year [4]. - The net cash flow from operating activities increased by 11.90% to approximately CNY 2.13 billion [4]. Business Overview - The company operates in pharmaceuticals, medical devices, and healthcare services, with a focus on innovative drugs and high-value medical equipment [6][7]. - The pharmaceutical segment remains the core business, emphasizing the development of innovative drugs targeting various diseases [6][7]. - The company has established a comprehensive manufacturing system, with all domestic production lines certified by GMP [7]. Industry Context - The Chinese pharmaceutical industry is undergoing a transformation towards high-quality development, supported by government policies aimed at fostering innovation [6][10]. - The market for medical devices is expanding due to policies promoting equipment updates and compliance with international standards [10]. - The healthcare sector is experiencing growth driven by an aging population and increasing demand for chronic disease management [6][10]. Innovation and R&D - The company is committed to developing "Best-in-class" and "First-in-class" products, with several innovative drugs approved for the Chinese market [11][12]. - The introduction of CAR-T cell therapy and other advanced treatments highlights the company's focus on cutting-edge medical solutions [12]. - The company has also made strides in AI, being recognized for its PharmAID decision-making platform [13]. Market Position - Shanghai Fosun Pharmaceutical ranked 5th in the 2024 China Pharmaceutical Industry Top 100 list, indicating a strong market presence [13]. - The company is actively expanding its international footprint, particularly in emerging markets [8][9]. ESG and Compliance - The company has joined the Pharmaceutical Supply Chain Initiative (PSCI) to enhance supply chain responsibility and align with international standards [13]. - It has received an upgraded MSCI ESG rating of AA, reflecting its commitment to environmental, social, and governance practices [13].

香港交易及結算所有限公司及香港聯合交易所有限公司對本公告的內容概不負責，對其準確性或完整性亦不 發表任何聲明，並明確表示，概不對因本公告全部或任何部份內容而產生或因倚賴該等內容而引致的任何損 失承擔任何責任。 上 海 復 星 醫 藥（ 集 團 ）股 份 有 限 公 司 Shanghai Fosun Pharmaceutical (Group) Co., Ltd.* （於中華人民共和國註冊成立的股份有限公司） （股份代號：02196） 海外監管公告 本公告乃根據香港聯合交易所有限公司證券上市規則第13.10B條而作出。 茲載列上海復星醫藥（集團）股份有限公司（「本公司」）在上海證券交易所網站刊登的《2025 年半年度報告》，僅供參閱。 承董事會命 上海復星醫藥（集團）股份有限公司 董事長 陳玉卿 中國，上海 2025 年8 月2 6 日 於本公告日期，本公司之執行董事為陳玉卿先生、關曉暉女士、文德鏞先生及王可心先生；本公司之非執 行董事為陳啟宇先生、潘東輝先生及吳以芳先生；本公司之獨立非執行董事為余梓山先生、王全弟先生、 Chen Penghui先生及楊玉成先生；以及本公司之職工董事為嚴佳女士。 * 僅供識別 ...

Group 1 - Company successfully issued China's first private pharmaceutical industry medium to long-term technology innovation bond with a scale of 1 billion RMB and a maturity of 2 years at a coupon rate of 2.70% [2] - The bond attracted enthusiastic subscriptions from various financial institutions, including bank wealth management, insurance, foreign banks, public funds, and securities firms [2] - Funds raised from this bond will support the company's layout in key technology innovation areas, accelerating the transformation and implementation of innovative results, and enhancing its global competitiveness in the pharmaceutical and health industry [2] Group 2 - Company has focused on innovation as its core development driver for over 30 years, with 12 self-developed and licensed innovative drugs approved since 2019 [3] - Four products with five indications have been approved in China and the EU since 2025, including the first self-developed small molecule innovative drug, which fills a gap in the rare tumor field [3] - The anti-PD-1 monoclonal antibody has become the first PD-1 monoclonal antibody approved in the EU for the treatment of extensive-stage small cell lung cancer, marking significant progress in international expansion [3]