丨2025年11月27日星期四丨 NO.1 欧林生物向港交所主板递交上市申请 11月26日，欧林生物发布公告，称公司于11月25日向香港联合交易所有限公司（简称"香港联交所"）递 交了境外公开发行股份（H股）并在香港联交所主板上市的申请，并于同日在香港联交所网站刊登了本 次发行上市的申请资料。 点评：OT-702获批上市，意味着在原研药之外，给中国患者提供更多药物选择。对于欧康维视生物， 该事件短期将提振股价情绪，长期则为公司估值提供业绩支撑，但具体效果能否落地需持续观察。 NO.4 罗氏回应流感特效药需求上升：已启动应对预案 11月26日，罗氏制药对《每日经济新闻》记者表示，面对流感高发季，罗氏已启动预案，调动速福达全 球供应链资源，尽最大努力加大生产，加速向中国市场供应。目前，速福达正按计划分批次抵达中国口 岸，持续供应中国市场。 点评：罗氏制药的回应反映出中国市场的重要性，也凸显出国内流感特效药供不应求的问题。近年来， 业内卷起"一次治疗"新战场，未来若有更多的中国药企研发出流感创新药物，将成为这一市场的破局关 键。 NO.5 博雅生物破伤风人免疫球蛋白在国内获批 点评：欧林生物递表港股是其资本化与国际 ...

北京商报讯（记者 王寅浩 宋雨盈）11月26日，博雅生物发布公告称，公司近日收到国家药品监督管理 局签发的破伤风人免疫球蛋白《药品注册证书》，药品注册标准编号：YBS00762025，剂型为注射剂， 规格为每瓶含破伤风抗体250IU（2.5ml）。 ...

格隆汇11月26日丨博雅生物(300294.SZ)公布，收到国家药品监督管理局签发的破伤风人免疫球蛋白 《药品注册证书》(证书编号：2025S03488)。截至目前，公司破伤风人免疫球蛋白累计研发投入975万 元。公司本次获得破伤风人免疫球蛋白《药品注册证书》，进一步丰富公司的产品管线，有助于提升公 司的研发积极性。 ...

博雅生物（300294）(300294.SZ)公告，公司收到国家药品监督管理局签发的破伤风人免疫球蛋白《药 品注册证书》。 ...

智通财经APP讯，博雅生物(300294.SZ)公告，公司收到国家药品监督管理局签发的破伤风人免疫球蛋白 《药品注册证书》。 ...

博雅生物公告，近日收到国家药品监督管理局签发的破伤风人免疫球蛋白《药品注册证书》(证书编 号：2025S03488)。破伤风人免疫球蛋白剂型为注射剂，规格为每瓶含破伤风抗体250IU（2.5ml）。公 司本次获得破伤风人免疫球蛋白《药品注册证书》，进一步丰富公司的产品管线，有助于提升公司的研 发积极性。 ...

Core Viewpoint - Shanghai Laishi (002252) has confirmed that several of its products have been included in the 2024 National Basic Medical Insurance, Work Injury Insurance, and Maternity Insurance Drug List [2] Group 1: Product Inclusion in Medical Insurance - The following products from Shanghai Laishi and its subsidiaries are included in the medical insurance directory: human albumin, intravenous human immunoglobulin (PH4), human fibrinogen, prothrombin complex, coagulation factor VIII, human immunoglobulin, tetanus human immunoglobulin, and rabies human immunoglobulin [2]

Group 1: Changshan Pharmaceutical - The company is preparing for clinical trials of Aibennate peptide for weight loss, with no current plans for oral formulation development [1] - Aibennate peptide is a long-acting GLP-1 receptor agonist, developed through chemical modification of exenatide [1] - The marketing preparation includes team building, product knowledge training, and marketing strategy formulation [1] Group 2: Fosun Pharma - Four innovative drugs approved in the first half of the year are expected to gradually increase sales in the coming months [2] - Innovative drug revenue exceeded 4.3 billion yuan, a year-on-year increase of 14.26%, accounting for over 30% of total drug revenue [2] - The company is actively participating in negotiations for the inclusion of its innovative drugs in insurance and national basic medical insurance directories [2] Group 3: Tiantan Biological Products - The company has established an international cooperation department to enhance its global market presence [3] - Products such as tetanus immunoglobulin and rabies immunoglobulin have already been exported [3] - The company is focused on international certification and registration of key products [3] Group 4: Kangtuo Medical - The US-based subsidiary BIOPLATE has launched a local production line for PEEK plates [4] - The company has completed market access in nearly 40 countries and regions [4] - The marketing of "4D bioactive plates" and PEEK fixation systems is underway in the US [4] Group 5: Tailong Pharmaceutical - The company is focusing on the development of modified new drugs across various therapeutic areas including respiratory, digestive, and oncology [5] - Projects in progress include treatments for Alzheimer's disease and schizophrenia [5] Group 6: Heng Rui Pharmaceutical - The HRS-5635 injection has been included in the list of proposed breakthrough therapies [6][7] - Chronic hepatitis B infection affects approximately 257 million people globally, with a significant mortality rate [7] - There is a pressing need for more effective treatments to achieve functional cure for chronic hepatitis B [7]

Core Viewpoint - The company is actively expanding its international market presence and enhancing its product offerings while addressing pricing strategies and production efficiency to meet annual targets [1][2]. Group 1: International Expansion and Product Development - The company has established an International Cooperation Department to focus on international market development and registration preparations, successfully exporting several immunoglobulin products [1]. - The company is advancing its key products towards international certification and registration, aiming to become a globally influential blood product enterprise [1]. Group 2: Pricing Strategy and Market Position - In response to investor concerns about declining gross margins due to falling prices of blood products, the management indicated that product prices have stabilized in 2025, although there was a decrease compared to the full year of 2024 [1]. - The company plans to implement multiple measures to achieve its annual goals, including increasing market share, boosting sales, and reducing inventory [1]. Group 3: Research and Development Progress - The company maintains a leading level of R&D investment in the industry, with over ten products under research, including blood products and gene-recombinant products [2]. - Two products have completed Phase III clinical trials and have submitted applications for marketing authorization, while others are progressing well in clinical trials [2]. Group 4: Production Capacity and Facility Development - The Yunnan project has completed key product registration inspections and is currently addressing inspection deficiencies, with plans to accelerate production site transfer for major products [2]. - The Yunnan facility is expected to commence production in 2026, focusing on human albumin, intravenous immunoglobulin, and prothrombin complex products [2].

Core Insights - Tian Tan Biological Products Co., Ltd. reported a revenue of 3.11 billion yuan for the first half of 2025, representing a year-on-year increase of 9.47%, while the net profit attributable to shareholders decreased by 12.88% to 633 million yuan [1] - The decline in net profit was attributed to a decrease in product sales prices compared to the previous year and reduced interest income due to changes in credit policies [1] Financial Performance - Revenue for the second quarter of 2025 reached 1.793 billion yuan, a quarter-on-quarter increase of 36.04% [1] - Net profit for the second quarter was 388 million yuan, reflecting a quarter-on-quarter increase of 59.09% [1] Business Operations - The company focuses on the research, production, and sales of blood products, including human albumin, intravenous immunoglobulin, and tetanus immunoglobulin [1] - Tian Tan Biological is actively expanding its market presence, enhancing blood source development, and accelerating product delivery processes [1] Research and Development - The company maintains a high level of investment in research and development, having obtained 2 authorized patents during the reporting period, including 1 invention patent and 1 utility model patent [2] - Efforts are being made to promote engineering projects and information technology construction, facilitating intelligent upgrades and industrial collaboration [2] International Strategy - Tian Tan Biological is implementing an international strategy, focusing on the development and registration of products in overseas markets [2] - The company is engaged in compiling product registration materials and initiating application processes for multiple target markets [2]