21世纪经济报道记者韩利明 新一轮寒潮正席卷我国。中国天气网消息显示，11日至13日，我国大部地区日平均气温将下降6至 10℃，局地降温将超14℃。降温过后，北方多地气温将创下半年来新低，最低气温0℃将抵达长江沿 线。降温的同时，立冬以来最大规模雨雪天气也将来袭，华北、黄淮中北部、内蒙古中部、东北地区中 南部等地有明显降雪，南方以降雨为主。 湿冷交织的冬季气候，为慢性病患者的健康防护带来严峻挑战。尤其对于庞大的糖尿病患者群体而言， 低温易引发血管收缩，进而导致血糖波动、免疫力下降，而带状疱疹这一"隐性健康威胁"更易趁虚而 入。 在日前一场以"糖疹联防，稳住血糖"为主题的科普活动上，同济大学附属东方医院内分泌科主任冯波解 释，糖尿病患者的免疫系统长期处于受损状态，"就像一栋长期不维护的房子，抗病能力会越来越 差。"在这种免疫力低下的状态下，潜伏在体内的水痘-带状疱疹病毒极易被激活。 值得关注的是，国家卫生健康委提出，在"十五五"期间，将以心脑血管疾病、癌症、慢性呼吸系统疾 病、糖尿病等慢性病为切入点，发展"防、治、康、管"的全链条服务。在此背景下，相关产业也在加速 布局、积极发力。 多病叠加风险高 中国疾病预防 ...

（原标题：专家提醒：当"三高"遇上"缠腰龙"，多病叠加风险不容小觑） 21世纪经济报道记者季媛媛 当前，我国正处于人口老龄化持续深化的关键时期。伴随这一进程，以高血压、高血糖、高血脂为代表 的"三高"慢性病患者基数已极为庞大，且发病呈现年轻化趋势。与此同时，慢性病人群罹患带状疱疹、 流感、肺炎球菌性疾病等感染性疾病的情况日益普遍。 近期，国家卫生健康委提出，在"十五五"期间，将以心脑血管疾病、癌症、慢性呼吸系统疾病、糖尿病 等慢性病为切入点，发展"防、治、康、管"的全链条服务，医防融合将发挥更大的作用。 "从传染病或感染性疾病的流行状况来看，当下正处在流感高发季节，呼吸道疾病呈现季节性波动和局 部聚集的特征，而一些新发突发感染性疾病的潜在风险仍然存在。更值得关注的是，带状疱疹、流感等 感染性疾病与基础疾病叠加的效应日益凸显。更为关键的是，许多慢性疾病患者并非单一患病，有的同 时患上两种甚至两种以上的疾病。"北京市人民政府参事、北京大学公共卫生学院长聘正教授刘民日前 在一场媒体沟通会上指出，这种一人多病的情况，使得传统单一疾病的管理模式有待改变，也让如何实 现多病协同管理成为公共卫生领域的核心课题。多病共管不仅 ...

Core Insights - The article discusses the competitive landscape of the shingles vaccine market in China, highlighting the unexpected price war initiated by GSK's vaccine, Shingrix, which is being promoted through a "buy one get one free" offer [1][2][4]. Market Dynamics - Shingrix's original price for two doses is 3,260 yuan, but with the promotion, the cost is reduced to 1,652 yuan, effectively a 50% discount [2]. - The vaccine has shown exceptional efficacy, reducing the risk of shingles by 97.2% in individuals aged 50 and above, and offers long-lasting immunity [2][7]. Competitive Landscape - Following GSK's price reduction, domestic competitor, Baike Biological, has also adjusted its pricing strategy, with its vaccine now priced around 1,400 yuan, and further discounts being offered [4]. - The domestic market for shingles vaccines has not met expectations, with Baike Biological reporting a significant drop in sales and revenue due to high return rates and low demand [8]. Consumer Behavior and Market Potential - Despite the high demand for shingles vaccines among the elderly population, the uptake has been low, with only 0.1% vaccination rate among those aged 50 and above in 2021 [9][11]. - The mismatch between the high cost of the vaccine and the financial capability of the target demographic is a significant barrier to market growth [11]. Challenges in Market Expansion - The competitive landscape in China is more fragmented compared to overseas markets, with both imported and domestic vaccines vying for market share, complicating the expansion efforts for Shingrix [11][13]. - There is a lack of awareness and understanding of the vaccine among the target demographic, which hinders its adoption [12][13].

Core Viewpoint - The article emphasizes the strategic opportunities in China's pharmaceutical and healthcare sector, particularly in the context of the "14th Five-Year Plan" and the upcoming "15th Five-Year Plan," highlighting the importance of health in national development and the need for enhanced public health initiatives [1]. Policy and Strategic Initiatives - The "15th Five-Year Plan" proposes a health-first development strategy, aiming to increase the average life expectancy in China from 79 years in 2024 to around 80 years [1]. - The 8th China International Import Expo (CIIE) showcased cutting-edge technologies and innovative products in the healthcare sector, indicating a strong response from the industry to policy initiatives [1]. Chronic Disease Management - Cardiovascular diseases remain a significant health threat in China, with over 330 million patients, and low awareness and treatment rates for blood lipid management [3]. - Collaborative efforts, such as the "Super Consultation" event by Tencent News and Novartis, aim to address public misconceptions about LDL-C and improve cardiovascular disease management [3]. Innovations in Disease Prevention - GSK is focusing on product innovation and health education to promote the prevention of diseases closely related to chronic conditions, such as shingles, which poses increased risks for patients with cardiovascular diseases [4][5]. - Bayer introduced a new product for chronic constipation management, addressing a prevalent health issue among adults in China [5]. Retail Health Services - The retail sector is crucial in connecting healthcare services with public health, with initiatives to extend health services from hospitals to homes [7]. - Novo Nordisk and the China Pharmaceutical Commerce Association launched a health management standard for obesity in retail pharmacies, aiming to enhance patient support [7][9]. AI in Healthcare - AI technology is increasingly integrated into healthcare, enhancing clinical diagnosis and patient management, as demonstrated by various companies at the CIIE [13]. - The launch of AI-driven platforms, such as Boston Scientific's medical knowledge graph, aims to improve clinical education and decision-making [13][14]. Ecosystem Collaboration - The CIIE serves as a platform for collaboration among healthcare companies, fostering partnerships that enhance innovation and market access [18]. - Companies like Merck and Medtronic are focusing on local partnerships to accelerate the introduction of innovative products in China [19][20]. Conclusion - The healthcare sector in China is undergoing significant transformation driven by policy support, technological advancements, and collaborative efforts among industry players, aiming to improve public health outcomes and enhance the overall healthcare ecosystem [1][18].

Core Insights - The Chinese healthcare sector is entering a strategic opportunity period, integrating deeply into the "Healthy China" initiative and the global biopharmaceutical competition landscape [1] - The "14th Five-Year Plan" has set a goal to increase the average life expectancy of the Chinese population from 79 years in 2024 to around 80 years by 2029, requiring multi-faceted efforts for achievement [1] - The 8th China International Import Expo (CIIE) showcased cutting-edge technologies and innovative products in the healthcare sector, emphasizing the importance of high-quality development in the pharmaceutical and medical device industries [1] Policy and Strategic Initiatives - The "15th Five-Year Plan" emphasizes a health-first development strategy, aiming to enhance public health and healthcare services [1] - The National Health Commission aims to improve public awareness and management of chronic diseases, particularly cardiovascular diseases, which affect over 330 million people in China [2][3] Disease Prevention and Management - Cardiovascular diseases remain a significant health threat, with a focus on improving public knowledge about blood lipid management to combat related health issues [2] - GSK is promoting a comprehensive management model that integrates chronic disease prevention, including shingles, which poses increased risks for patients with cardiovascular conditions [3][4] Retail Health Services - The retail sector is crucial in connecting healthcare services with public health, with initiatives to extend health services from hospitals to homes [5][6] - Novo Nordisk and other companies are collaborating with retail pharmacies to establish standardized obesity management services, addressing the rising obesity rates in China [5][6] AI in Healthcare - AI technology is increasingly being integrated into healthcare, enhancing clinical diagnosis, medical education, and consumer health management [8][9] - Companies like Philips and Boston Scientific are leveraging AI to improve healthcare delivery and patient outcomes, with significant acceptance among healthcare professionals and patients [11] Ecosystem Collaboration - The CIIE serves as a platform for collaboration among global and local companies, fostering innovation and resource sharing in the healthcare sector [12][13] - Bayer and other companies are utilizing the expo to introduce innovative medical products and enhance local partnerships, aiming to improve healthcare accessibility in China [12][13] Localized Innovation - Merck and Medtronic are focusing on local partnerships to accelerate the introduction of innovative healthcare solutions in China, reflecting the country's growing market potential [13][14] - The "Marco Polo Plan 3.0" by the Cassi Group aims to enhance collaboration across various sectors, promoting medical innovation and accessibility [14][15]

Core Viewpoint - The 8th China International Import Expo (CIIE) showcased GSK's commitment to the Chinese market with its innovative health solutions, particularly highlighting the newly approved shingles vaccine, which targets high-risk groups [1][2][3]. Group 1: GSK's Vaccine Innovations - GSK's shingles vaccine, Xinanlis, is the first and only shingles vaccine approved by the NMPA for high-risk adults aged 18 and above [1][3]. - The vaccine's approval for expanded indications aims to protect individuals with immune deficiencies or immunosuppression, reflecting a shift towards proactive immunization across all life stages [1][3]. - GSK emphasizes the integration of vaccine prevention into chronic disease management, particularly for high-risk groups such as those with hypertension, diabetes, and cardiovascular diseases [2][3][11]. Group 2: Market Potential and Growth - The adult vaccine market in China is projected to grow significantly, with the shingles vaccine market expected to reach 5.63 billion yuan by 2025 and exceed 10 billion yuan by 2031 [9]. - With over 500 million chronic disease patients in China, achieving a 5% to 10% vaccination rate could translate to a market size in the hundreds of billions [9][10]. - The increasing prevalence of chronic diseases and an aging population are key drivers for the growth of the adult vaccine market [9]. Group 3: Challenges and Strategies - Despite high awareness of shingles (80%-90%) and vaccine knowledge (60%-80%), the vaccination rate remains low at 1%-2% [5]. - GSK is addressing this "knowledge-action gap" by implementing "vaccine prescriptions" to enhance accessibility and conversion rates for vaccinations [5][6]. - The company is developing a multi-tiered adult vaccine management system, aiming to integrate vaccine management with chronic disease management [6][10]. Group 4: Future Directions - GSK plans to extend its focus from cardiovascular and diabetes management to include other chronic diseases like COPD, promoting a comprehensive approach to disease management [12]. - The company is committed to leveraging its innovative research and development capabilities to enhance public health in China, particularly through the introduction of new vaccines [12].

Core Insights - The China International Import Expo (CIIE) serves as a vital bridge for global trade resources and promotes the integration of domestic and international industries, showcasing China's market vitality and providing a stable development platform for global trade [1][3] Group 1: CIIE's Role and Impact - Since its inception in 2018, CIIE has transformed exhibits into commodities and exhibitors into investors, highlighting its role in international procurement, investment promotion, cultural exchange, and open cooperation [3] - GSK has participated in CIIE for eight consecutive years, evolving from a witness to a participant and promoter of China's economic development [3][5] - CIIE is recognized as a high-quality platform that reflects China's reform and opening-up achievements, enhancing the business environment for foreign enterprises like GSK [3][5] Group 2: GSK's Commitment to China - GSK views China as a core growth engine and a significant source of global innovation, particularly in biopharmaceuticals and artificial intelligence [5][10] - GSK's commitment to China includes establishing a global innovation center and aligning its product pipeline with China's health strategies [10][12] Group 3: Innovation and Collaboration - The Chinese innovative pharmaceutical sector has seen explosive growth, with domestic companies emerging as key players in global pharmaceutical innovation [6][11] - CIIE facilitates the rapid introduction of innovative drugs and medical solutions to Chinese patients, enhancing collaboration between international and domestic pharmaceutical resources [6][11] - GSK plans to showcase approximately 20 innovative products at this year's CIIE, focusing on respiratory, immunology, and oncology areas [8][10] Group 4: Strategic Partnerships - GSK collaborates with local partners to enhance the accessibility of its products and supports various health initiatives in China [11][12] - The company is actively exploring diverse collaboration models with local biopharmaceutical firms, including a recent agreement with Hengrui Medicine to co-develop up to 12 innovative drugs [12][13] Group 5: Future Outlook - CIIE exemplifies the deep integration of China with the global economy and serves as a platform for multinational companies to connect with Chinese market demands [13] - GSK is committed to increasing its investment in China, focusing on local innovation capabilities and creating a win-win industrial ecosystem [13]

Core Viewpoint - The China International Import Expo (CIIE) serves as a vital bridge for global trade resources and an important platform for deep integration of domestic and international industries, showcasing China's market vitality and promoting stable global trade development [1][3]. Group 1: CIIE's Role and Impact - Since its inception in 2018, CIIE has transformed exhibits into commodities and exhibitors into investors, highlighting its roles in international procurement, investment promotion, cultural exchange, and open cooperation [3]. - GSK has participated in CIIE for eight consecutive years, evolving from a witness to a participant and promoter of China's economic development [3]. - GSK's Vice President emphasized CIIE's high-quality platform advantage and its role as a significant showcase of China's reform, opening up, and high-quality development achievements [3]. Group 2: GSK's Commitment to China - GSK views China as a crucial strategic market and believes it has become a core growth engine and a significant source of global innovation [5]. - The rapid growth of China's innovative pharmaceutical sector has positioned the country as a key player in global pharmaceutical innovation, injecting new vitality into the industry [7]. - GSK's commitment to China includes establishing a global innovation center and aligning its product pipeline with China's health strategies [11]. Group 3: Innovation and Collaboration - CIIE provides a platform for GSK to showcase innovative products and solutions, facilitating deep communication with government and industry partners to accelerate the implementation of innovations in China [9]. - GSK plans to present around 20 innovative products at this year's CIIE, focusing on areas such as respiratory and immune diseases, infections, vaccines, and oncology [9]. - GSK is actively collaborating with local partners to enhance the accessibility of its products and to explore innovative healthcare models in China [12]. Group 4: Future Outlook - GSK anticipates that breakthroughs in biopharmaceuticals and artificial intelligence in China will have a profound impact on the global pharmaceutical industry [5]. - The company aims to deepen its engagement in high-quality industry discussions and expand its network to uncover more collaboration opportunities [11]. - GSK is committed to integrating global resources with local advantages to foster an open and win-win industrial ecosystem in China [13].

Core Viewpoint - The approval of the expanded indication for GSK's recombinant shingles vaccine, Shingrix (RZV), to include adults aged 18 and above with increased risk of shingles due to known diseases or treatments marks a significant advancement in the prevention of shingles in high-risk populations in China [1][2]. Group 1: Vaccine Approval and Market Impact - The National Medical Products Administration (NMPA) in China has officially approved the expanded indication for Shingrix, allowing its use in adults aged 18 and above who are at increased risk of shingles due to immunocompromising conditions [1]. - This approval expands the vaccine's protective coverage from the initial target group of adults aged 50 and above, thereby creating new growth opportunities for GSK in both the global and Chinese vaccine markets [1][5]. - The approval represents a breakthrough in the prevention of shingles for high-risk groups, as it is the first and only shingles vaccine approved for this demographic in China [2][4]. Group 2: Clinical Need and Disease Burden - Shingles, caused by the varicella-zoster virus, poses a significant disease burden, particularly among individuals aged 50 and above, with approximately 1.56 million new cases reported annually in this age group in China [3]. - The risk of shingles increases with age, and certain conditions such as HIV infection and malignancies further elevate this risk, with immunocompromised individuals facing a 2.3 to 4.0 times higher risk compared to the general population [3]. Group 3: Market Potential and Growth - The domestic shingles vaccine market in China is projected to grow significantly, with a market size of 3.73 billion yuan in 2022 expected to reach 5.63 billion yuan by the end of 2025, reflecting a compound annual growth rate (CAGR) of 16.4% [6]. - GSK's Shingrix vaccine targets a population of approximately 340 million people aged 50 and above in China, with potential market space estimated at around 65 billion yuan if penetration rates reach 10% [6][7]. - The newly approved indication for high-risk adults represents an untapped market segment with substantial growth potential, driven by a large patient base and a strong demand for preventive measures [6][8]. Group 4: Competitive Landscape - Currently, there are two approved shingles vaccines in China: GSK's Shingrix and Baike Biotech's vaccine, which utilize different technological approaches [9]. - Shingrix has established itself as a core growth engine for GSK's vaccine business, demonstrating strong revenue stability with sales of 3.364 billion pounds in 2024 [9][10]. - Continuous investment in research and development is crucial for maintaining the competitive edge of Shingrix, with GSK planning further studies to assess the vaccine's efficacy and safety in high-risk populations [10].

Group 1 - XuanZhu Biotech officially listed on the Hong Kong Stock Exchange on October 15, raising a total of HKD 780 million by issuing 67.33 million shares at an offering price of HKD 11.60 per share [1] - On its first trading day, XuanZhu Biotech's stock price surged to HKD 26.30 per share, marking a daily increase of 126.72% [1] - The strong market reception indicates investor confidence in high-quality innovative pharmaceutical companies, with XuanZhu Biotech poised to benefit from ongoing industry trends through accelerated R&D funded by the raised capital [1] Group 2 - GlaxoSmithKline's recombinant shingles vaccine, Shingrix, received approval for a new indication from the National Medical Products Administration in China [2] - The new indication allows the vaccine to be used for adults aged 18 and older who are at increased risk of shingles due to known diseases or treatments that cause immunodeficiency or immunosuppression [2] - This approval addresses the vaccine needs of high-risk groups and further solidifies GlaxoSmithKline's competitive position in the shingles vaccine market [2] Group 3 - Johnson & Johnson reported third-quarter revenue of USD 23.993 billion, reflecting a year-over-year growth of 6.8% [3] - For the first nine months of the year, Johnson & Johnson's total revenue reached approximately USD 69.6 billion, driven by growth in both its innovative pharmaceuticals and medical technology segments, which generated revenues of USD 44.638 billion and USD 23.669 billion, respectively [3] - The revenue growth demonstrates the company's operational resilience, supported by strong performance in both business segments [3]