21世纪经济报道记者季媛媛上海报道 芝加哥McCormick会展中心，第85届美国糖尿病协会科学年会(ADA)正在这里举行。诺和诺德、礼来两 大巨头的专题研讨会现场人头攒动，会议现场的技术交锋，也预示GLP-1(胰高血糖素样肽-1)类药物市 场的战争才刚刚升级。 今年ADA科学年会上，诺和诺德公布了针对不伴糖尿病的肥胖症患者的STEP UP3b期临床试验结果。 STEP UP试验表明，在第72周时，接受更高剂量的Wegovy(司美格鲁肽7.2mg)治疗的受试者相较于安慰 剂组实现平均21%的体重降幅，其中三分之一的受试者体重降幅达25%或以上。 礼来公布了3期临床研究ACHIEVE-1的详细结果。在所有剂量组中，在研药物orforglipron每日一次口服 实现2型糖尿病成人患者A1C平均降低1.3%至1.6%，且用药四周就可观察到改善。ACHIEVE-1研究的关 键次要终点显示，orforglipron最高剂量组在第40周时实现平均体重减轻7.3kg(7.9%)，且Orforglipron的安 全性与GLP-1RA类药物一致。 有券商医药行业分析师对21世纪经济报道记者指出，随着肥胖症在全球范围内的发病率不 ...

Investment Rating - The industry investment rating is "Overweight (Maintain)" [1] Core Viewpoints - The report highlights the significant rise in the global obesity population, with the adult overweight/obesity rate reaching 46% in 2025 and projected to rise to 54% by 2035. In China, the overweight/obesity population aged 25 and above reached 402 million by 2021, expected to exceed 627 million by 2050 [2] - The report emphasizes the increasing demand for treatments related to metabolic diseases, particularly the GLP-1 class of drugs, which is projected to surpass $50 billion in global sales by 2024, with semaglutide contributing $25 billion and tirzepatide $16 billion [2] - Domestic pharmaceutical companies are actively developing GLP-1 drugs, with several clinical research results expected to be presented at the upcoming ADA conference, showcasing advancements in obesity and diabetes treatments [3] Summary by Sections Industry Overview - The report notes that the ADA conference is expected to elevate the focus on GLP-1 drugs, with long-acting, oral, multi-target combination therapies, and fat loss without muscle loss being key areas of interest [4] Market Trends - The report indicates that the prescription volume of GLP-1 drugs in the U.S. has been rapidly increasing, with GLP-1 drugs accounting for over 50% of the total market share for weight loss medications as of April 2025 [2] Company Focus - The report suggests monitoring companies such as Heng Rui Medicine, Zhong Sheng Pharmaceutical, and Innovent Biologics, as they are well-positioned in the GLP-1 drug market [4]

证券研究报告·行业点评报告 2025 年 6 月 11 日 江海证券研究发展部 执业证书编号：S1410524050001 近十二个月行业表现 % 1 个月 3 个月 12 个月 相对收益 8.85 10.28 3.81 绝对收益 9.35 8.29 11.96 数据来源：聚源 注：相对收益与沪深 300 相比 业：中美关税缓和叠加医疗器械审批加速， 相关企业估值修复可期 – 2025.05.15 2. 江海证券-行业点评报告-医药生物行 业：药品关税问题悬而未决，美国药品"最 惠国定价"来袭，或将影响全球药品定价 体系重构与产业链转移 – 2025.05.15 3. 江海证券-行业点评报告-医药生物行 业：减肥药或将首次纳入基本药物目录 （EML），推动 GLP-1 类药物需求增长 – 2025.05.08 业：NIH 数据跨境管控升级对创新药影响 几何？ – 2025.04.11 5. 江海证券-行业点评报告-医药生物行 2025.04.09 医药行业研究组 分析师：吴春红 聚焦 ADA 会议催化剂，关注 GLP 产 业链相关投资机会 事件： 行业评级：增持（维持） 美国糖尿病协会（ADA）官网显示，其第 ...