撰文丨王聪 编辑丨王多鱼 排版丨水成文 阿尔茨海默病 （AD） 是最常见的神经退行性疾病，其病理特征是大脑中细胞外的 β- 淀粉样蛋白 （Aβ） 斑块的积累以及细胞内的磷酸化 tau 蛋白缠结的形成， 同时伴有突触功能障碍和神经炎症。临床上，阿尔茨海默病最重要的表现是进行性认知能力下降。尽管在阿尔茨海默病的早期诊断和治疗方面付出了巨大努力， 但目前临床上可用的疾病修正疗法 仍寥寥无几。 目前，人们已认识到 慢性神经炎症 是阿尔茨海默病的一个主要组成部分，在 β-淀粉样蛋白斑块周围经常能观察到活化的小胶质细胞和星形胶质细胞。最近，调 控这些神经炎症通路被认为是一种很有前景的阿尔茨海默病治疗策略。 在能够调节神经炎症的因素中， 饮食 是一种易于实施的干预手段。例如， 黑米饮食 （ black rice diet，BRD ） 富含 不饱和游离脂肪酸 ，被认为能对抗衰老过 程中的神经退行。同样，从鱼类和植物中增加 ω-3 脂肪酸和类胡萝卜素的摄入量与改善大脑功能和延缓认知能力下降有关。还有研究证据显示，来自鱼油和黑米 饮食的不饱和脂肪酸能够协同作用，并且呈剂量依赖性地增强认知健康老年人的工作记忆，似乎还能降低患阿尔茨 ...

Core Viewpoint - Clinique Holdings (08367) has announced a leasing agreement for office space in Shenzhen, indicating a strategic move to expand its operations in China [1] Group 1: Leasing Agreement Details - The leasing agreement is between Clinique's indirect wholly-owned subsidiary, Huading Zhichain Supply Chain (Shenzhen) Co., Ltd. (as tenant), and China Resources Land Qianhai (as owner) [1] - The lease term is set for three years, from November 15, 2025, to November 14, 2028, with a total estimated cost of approximately HKD 1.7 million, excluding government rates, management fees, air conditioning fees, and utility costs [1] - The monthly rent is HKD 56,000, and the leased property is located at 5035 Menghai Avenue, Nanshan District, Qianhai, Shenzhen, covering a total area of 341 square meters [1] Group 2: Strategic Rationale - The company is engaged in restaurant operations in Hong Kong and aims to develop its presence in China [1] - The board believes that the property is well-located for office use, and the terms of the lease, including the rent, were negotiated fairly based on current market rates and comparable properties in the vicinity [1] - The board considers the leasing agreement and its terms to be fair and reasonable, aligning with the overall interests of the company and its shareholders [1]

Core Insights - The 2025 Chongqing International Auto Show showcases the latest trends in the automotive industry, emphasizing smart and low-carbon transportation, with a total exhibition area of 160,000 square meters and participation from 117 brands [1][6] - Local brands such as Changan, Deep Blue, and Avita have gained significant attention, with Changan showcasing its strategic transformation into a smart low-carbon travel technology company [2][3] - The event highlights the increasing importance of technology and innovation in the automotive sector, with a focus on intelligent driving and the integration of various industries [6][8] Group 1 - The auto show features 1,046 exhibited models and 93 new car debuts, reinforcing its status as a major platform for the automotive industry [1] - Changan's new models, including the Q07 SUV and E07, have attracted considerable interest, showcasing advanced features such as a "smart cockpit" and a long-range battery [2][3] - Deep Blue's S09 SUV has received 21,000 pre-orders before its official launch, indicating strong market demand for innovative vehicle designs [3] Group 2 - Avita has established itself as a benchmark in the high-end smart electric vehicle market, with cumulative sales exceeding 150,000 units and an average price of over 270,000 yuan [3] - BYD has launched the Ocean Network's Seal 06 EV at the show, targeting young families with a price range of 109,800 to 129,800 yuan, and featuring advanced safety and driving assistance technologies [6][7] - The event emphasizes the collaboration between automotive and technology sectors, with a focus on smart driving and digital services as key competitive advantages for companies [6][8]