Core Viewpoint - Alzheimer's disease (AD) is characterized by the accumulation of β-amyloid plaques and tau protein tangles, leading to progressive cognitive decline. Current disease-modifying therapies are limited, and chronic neuroinflammation is recognized as a significant component of AD, making the regulation of neuroinflammatory pathways a promising treatment strategy [1][2]. Group 1: Dietary Interventions - Diet is an easily implementable intervention to regulate neuroinflammation, with black rice diet (BRD) being rich in unsaturated fatty acids that may combat neurodegeneration associated with aging [2][5]. - Increased intake of ω-3 fatty acids and carotenoids from fish and plants is linked to improved brain function and delayed cognitive decline [2]. Group 2: Research Findings - A study published in Nature Aging revealed that α-linolenic acid (ALA) and 11,14-eicosadienoic acid (EDA) from black rice can inhibit amyloid pathology in AD mouse models through allosteric activation of cell-type-specific GPR120, improving cognitive function and extending lifespan [3][10]. - The research demonstrated that BRD significantly prevents cognitive decline in two common AD mouse models, APP/PS1 and 5×FAD [5]. Group 3: Mechanisms of Action - ALA and EDA are identified as key mediators that reduce amyloid pathology and restore cognitive performance to wild-type levels by activating GPR120 in plaque-associated macrophages and activated microglia [7][8]. - The study elucidated the structural binding patterns of ALA and EDA with GPR120, enhancing the understanding of their allosteric effects and downstream signaling pathways [8]. Group 4: Implications for Treatment - The findings suggest that GPR120 activation has cell-type-specific functions in the brain, providing insights for the development of targeted therapies for Alzheimer's disease [10]. - While the actual intake of black rice may be challenging to achieve therapeutic concentrations, this research lays the groundwork for developing standardized therapeutic agents [11].

Core Viewpoint - Clinique Holdings (08367) has announced a leasing agreement for office space in Shenzhen, indicating a strategic move to expand its operations in China [1] Group 1: Leasing Agreement Details - The leasing agreement is between Clinique's indirect wholly-owned subsidiary, Huading Zhichain Supply Chain (Shenzhen) Co., Ltd. (as tenant), and China Resources Land Qianhai (as owner) [1] - The lease term is set for three years, from November 15, 2025, to November 14, 2028, with a total estimated cost of approximately HKD 1.7 million, excluding government rates, management fees, air conditioning fees, and utility costs [1] - The monthly rent is HKD 56,000, and the leased property is located at 5035 Menghai Avenue, Nanshan District, Qianhai, Shenzhen, covering a total area of 341 square meters [1] Group 2: Strategic Rationale - The company is engaged in restaurant operations in Hong Kong and aims to develop its presence in China [1] - The board believes that the property is well-located for office use, and the terms of the lease, including the rent, were negotiated fairly based on current market rates and comparable properties in the vicinity [1] - The board considers the leasing agreement and its terms to be fair and reasonable, aligning with the overall interests of the company and its shareholders [1]

Core Insights - The 2025 Chongqing International Auto Show showcases the latest trends in the automotive industry, emphasizing smart and low-carbon transportation, with a total exhibition area of 160,000 square meters and participation from 117 brands [1][6] - Local brands such as Changan, Deep Blue, and Avita have gained significant attention, with Changan showcasing its strategic transformation into a smart low-carbon travel technology company [2][3] - The event highlights the increasing importance of technology and innovation in the automotive sector, with a focus on intelligent driving and the integration of various industries [6][8] Group 1 - The auto show features 1,046 exhibited models and 93 new car debuts, reinforcing its status as a major platform for the automotive industry [1] - Changan's new models, including the Q07 SUV and E07, have attracted considerable interest, showcasing advanced features such as a "smart cockpit" and a long-range battery [2][3] - Deep Blue's S09 SUV has received 21,000 pre-orders before its official launch, indicating strong market demand for innovative vehicle designs [3] Group 2 - Avita has established itself as a benchmark in the high-end smart electric vehicle market, with cumulative sales exceeding 150,000 units and an average price of over 270,000 yuan [3] - BYD has launched the Ocean Network's Seal 06 EV at the show, targeting young families with a price range of 109,800 to 129,800 yuan, and featuring advanced safety and driving assistance technologies [6][7] - The event emphasizes the collaboration between automotive and technology sectors, with a focus on smart driving and digital services as key competitive advantages for companies [6][8]