整理 | GLP1减重宝典内容团队 7月初，博瑞医药在《Journal of Medicinal Chemistry》发表论文称，相比GLP-1药物，BGM1812的差异化优势体现在显著提升肌肉保留、具 更优的胃肠道耐受性，并通过增强饱腹感而非诱导食物厌恶来实现更符合生理的体重管理，可与GLP-1单靶点或多靶点治疗形成互补。 此前在ADA2025上公布的临床前海报显示，BGM1812具有高溶解度，且在不形成纤维的条件下保持稳定，这也提示其可与GLP-1/GIP激动剂 等协同作用机制药物组成复方制剂的潜力。相关进展仍以监管审评与后续公告为准。公司尚未披露具体入组时间表。 *本文仅 供医疗卫生专业人 士参考 版权声明：所有「GLP1减重宝典」的原创文章，转载须联系授权，并在文首/文末注明来源、作者、微信ID，否则减重宝典将向其追究法律责 任。部分文章推送时未能与原作者或公众号平台取得联系。若涉及版权问题，敬请原作者联系我们。合作事宜，请添加微信：andyxu365 药审中心信息显示，9月3日，博瑞制药的新型减重候选药BGM1812注射液的临床试验申请获受理。 BGM1812为博瑞医药基于AI/ML优化设计的胰淀素 ...

Group 1: Macro Economic Insights - The recent appreciation of the RMB against the USD may be seen as a "catch-up" due to a weaker dollar environment, with the RMB appreciating by approximately 2.3% compared to a 10% depreciation of the dollar index in the first eight months of 2025 [5][6][7] - The domestic equity market's recovery and dovish signals from the Federal Reserve are key triggers for the recent rise in the RMB exchange rate, despite weaker manufacturing PMI data [6][8] - The RMB is expected to continue appreciating, but short-term fluctuations may occur due to uncertainties in global economic policies, particularly in Japan [8][9] Group 2: ETF Market Dynamics - Since June, non-broad-based ETFs have seen rapid growth, with net inflows reaching 227.9 billion RMB, indicating a shift in retail investor preferences towards ETFs [11][12] - Broad-based ETFs have experienced significant net redemptions, suggesting that while overall ETF inflows may appear modest, retail funds are actively entering the market through non-broad-based ETFs [12][13] - The current bull market is characterized by a shift from actively managed funds to ETFs, driven by factors such as product variety, cost efficiency, and ease of access [13][14] Group 3: Power Equipment and New Energy Sector - The photovoltaic industry is facing severe overcapacity, with nominal production capacity exceeding 1200 GW, leading to significant price declines across the supply chain [18][19] - Recent government initiatives aim to curb internal competition and stabilize the market, with signs of price recovery in the polysilicon segment [19][20] - Despite ongoing losses in the main supply chain, specialized companies are performing better than integrated firms, indicating a potential for recovery as supply-demand dynamics improve [20][21] Group 4: Chemical Industry Performance - The chemical raw materials and products manufacturing sector reported a revenue of 4.46359 trillion RMB in H1 2025, a year-on-year increase of 1.4%, but profits fell by 9% to 181.46 billion RMB [23][24] - The basic chemical industry achieved a revenue of 1.1707 trillion RMB in H1 2025, with a profit of 73.17 billion RMB, reflecting a 3.5% revenue increase year-on-year [24][25] - The petrochemical sector, excluding major state-owned enterprises, saw a revenue decline of 7.3% in H1 2025, indicating challenges in profitability [25][26] Group 5: Pharmaceutical Sector Developments - Sunshine Nuohuo (688621.SH) reported a revenue of 590 million RMB in H1 2025, a 4.87% increase, with a significant Q2 performance showing a 15.73% year-on-year growth [28][29] - The company is advancing its innovative drug pipeline, with multiple projects in clinical trials, indicating a strong growth trajectory [29][30] - Haofan Bio (301393.SZ) achieved a revenue of 270 million RMB in H1 2025, reflecting a 20.10% increase, driven by strong demand for GLP-1 drugs [32][33] Group 6: Food and Beverage Sector Insights - Shanxi Fenjiu (600809.SH) reported a revenue of 23.96 billion RMB in H1 2025, a 5.4% increase, but faced pressure on profit margins due to changing consumer preferences [40][41] - Wuliangye (000858.SZ) achieved a revenue of 52.77 billion RMB in H1 2025, a 4.2% increase, but is navigating challenges in maintaining price stability amid competitive pressures [45][46]

Core Viewpoint - The company reported a significant decline in revenue and net profit for the first half of 2025, prompting a downward revision of profit forecasts for 2025-2026, while maintaining a "buy" rating due to a robust pipeline and rapid progress in drug development [1][2][3] Financial Performance - In the first half of 2025, the company achieved revenue of 537 million yuan, a year-on-year decrease of 18.28%, and a net profit attributable to shareholders of 17.17 million yuan, down 83.85% [1] - For Q2 2025, revenue was 288 million yuan, a year-on-year decline of 9.16%, with a net profit of 4 million yuan, down 90.04% [1] - The gross margin was 52.82%, a decrease of 0.47 percentage points, and the net margin was 2.19%, down 4.24 percentage points [1] Business Segment Performance - The company's product sales revenue for the first half of 2025 was 483 million yuan, down 21.31%, with raw material drug revenue at 407 million yuan, a decrease of 19.3% [2] - Revenue from antiviral products fell significantly by 66.18% year-on-year, while revenue from immunosuppressive products increased due to commercial demand [2] - The revenue from formulation products was 76 million yuan, down 30.57%, primarily due to declining demand and prices for oseltamivir formulations [2] - Equity income increased by 15.96% compared to the previous year [2] Research and Development - R&D investment for the first half of 2025 was 348 million yuan, an increase of 144.07%, accounting for 64.83% of operating revenue [3] - The BGM0504 injection for diabetes and weight loss is in Phase III clinical trials, with all patient enrollments completed and progressing as planned [3] - The US bridging clinical study for BGM0504 injection for weight loss has been completed, and the company is working on refining the Phase III clinical plan based on FDA recommendations [3] - An IND application for the BGM0504 injection for glucose-lowering has been approved in Indonesia, and Phase III clinical research has officially started [3] - An IND application for the oral BGM0504 tablet for weight loss has been submitted in China, with approval received in the US [3] - The innovative drug BGM1812 injection for weight loss has submitted IND applications in both China and the US, while the oral BGM1812 tablet is in preclinical research [3]

Investment Rating - The investment rating for the company is "Buy" (maintained) [1] Core Views - The company experienced fluctuations in performance in the first half of 2025, with significant progress in its weight loss and diabetes drug development [4] - Revenue for the first half of 2025 was 537 million yuan, a year-on-year decrease of 18.28%, while net profit attributable to shareholders was 17.17 million yuan, down 83.85% [4] - The company is actively advancing its BGM0504 drug through clinical trials, which is expected to contribute positively to future earnings [4] Financial Performance Summary - In the first half of 2025, the company achieved product sales revenue of 483 million yuan, a decline of 21.31%, with raw material drug revenue at 407 million yuan, down 19.3% [5] - R&D investment increased significantly to 348 million yuan, representing 64.83% of operating revenue, indicating a strong commitment to innovation [6] - The company has revised its profit forecasts for 2025-2026, now expecting net profits of 65 million yuan and 130 million yuan respectively, with a new forecast for 2027 at 207 million yuan [4] Valuation Metrics - The current price-to-earnings (P/E) ratios for 2025, 2026, and 2027 are projected at 594.8, 296.7, and 186.2 respectively [8] - The gross margin for the first half of 2025 was 52.82%, a slight decrease of 0.47 percentage points year-on-year [4] - The company’s total market capitalization is approximately 38.573 billion yuan [1]

Group 1: Company Highlights - Changchun High New has made breakthrough progress in using AI large models to design highly alkaline single-domain antibodies, successfully completing the development of a protein product that has entered 5000-liter scale production [1] - Zhongchuang Zhiling's subsidiary Zhengmeiji Shuyun Intelligent Technology has invested heavily in building a robotic welding laboratory, promoting the transition of welding technology from manual to intelligent [2] - BoRui Pharmaceutical has submitted IND applications for BGM0504 and BGM1812 for weight loss indications in both the US and China, with BGM0504 entering Phase I clinical trials approved by the FDA [3] - Xingqi Eye Medicine's SQ-22031 eye drops, an innovative drug for treating neurotrophic keratitis and dry eye syndrome, have completed Phase I clinical trials [4] - Sunshine Nuohe reported a revenue of 7.3371 million yuan from equity-sharing projects, a year-on-year increase of 119.73%, with clinical business revenue reaching 279 million yuan, a 29% increase year-on-year [5] Group 2: Investment Management Overview - Shanghai Danyi Investment Management Partnership, established in April 2015, has a paid-in capital of 10 million yuan and is registered with the Asset Management Association of China [5] - The core executives of the company have over ten years of investment research experience, having previously worked as investment managers or chief researchers at prominent institutions [5]

Group 1: BoRui Pharmaceutical - BGM0504 tablet for weight loss has submitted IND applications in both the US and China, with FDA approval for Phase I clinical trials and the first dosing group about to start [1] - BGM1812 injection for weight loss has also submitted IND applications in both countries, while the oral tablet is in preclinical research [1] - The company is developing multiple formulations based on GLP-1/GIP dual targets and mylin-like molecules to meet different weight loss population needs [1] Group 2: Weili Transmission - As of August 29, 2025, the company has invested 123.12 million yuan in the wind power gearbox smart factory, with construction completed and equipment arriving [2] - The factory is in the initial capacity ramp-up phase, with ongoing optimization of production team proficiency and equipment debugging [2] - The decline in profits in the first half of 2025 is mainly due to increased period expenses, with labor costs rising by 75.45% year-on-year [2] Group 3: Sanfu Outdoor - X-BIONIC brand saw a growth rate of 28.07% in the first half of the year, with expectations for increased growth in the second half due to the winter peak season [3] - HOUDINI brand experienced a remarkable growth rate of 187.87%, expected to maintain high growth [3] - The company plans to enhance market investment in trail running and skiing, and will open new stores in the second half of the year [3] Group 4: Kaiying Network - In the first half of 2025, the company achieved revenue of 2.578 billion yuan, a year-on-year increase of 0.89%, and a net profit of 950 million yuan, up 17.41% [4] - Overseas revenue reached 202 million yuan, growing by 59.57%, with multiple products topping overseas charts [4] - The company launched an AI development platform and plans to introduce an AI toy brand in 2025 [4] Group 5: Focus Technology - In the first half of 2025, the company reported revenue of 915 million yuan, a year-on-year increase of 15.91%, and a net profit of 295 million yuan, up 26.12% [5] - The number of paid members on China Manufacturing Network reached 28,699, with I-Maike members exceeding 13,000 [5] - The company is enhancing AI capabilities to improve multilingual reception and system stability [5]

Group 1 - The core viewpoint of the news is that the company BoRui Pharmaceutical is advancing its weight loss drug candidates BGM0504 and BGM1812, with IND applications submitted in both the US and China, and BGM0504's Phase I clinical trial approved by the FDA [1] - BGM0504 tablet for weight loss has received IND approval in the US and China, with the first dose group about to start administration [1] - BGM1812 injection for weight loss has also submitted IND applications in both countries, while the oral tablet is in preclinical research [1] Group 2 - The company is developing multiple formulations based on GLP-1/GIP dual targets and mylin-like molecules to meet the needs of different weight loss populations [1] - BGM0504 injection has completed US bridging clinical trials and is preparing for Phase III trials, with domestic collaboration with China Resources Sanjiu for R&D and commercialization [1] - The oral formulation of BGM1812 aims for efficient transmembrane delivery and rapid absorption, with advantages pending clinical pharmacokinetic data verification [1] Group 3 - BGM2101 combines BGM0504 with weekly insulin for diabetes treatment, while BGM2102 is a dual-drug combination exploring significant weight loss or low-dose safety, currently in preclinical stages [1] - The company is focusing on new targets such as Myostatin and MC4R, planning to develop long-acting formulations in conjunction with GLP-1 drugs [1] - The oral technology platform is collaborating with Aoli Bio to optimize multi-stage delivery efficiency for the development of BGM0504 and BGM1812 oral tablets [1]

Core Viewpoint - The article discusses the financial performance and strategic direction of Borui Pharmaceutical, highlighting its revenue fluctuations, R&D investments, and innovative drug development efforts, particularly in the GLP-1 and GIP receptor agonist space. Financial Performance - In the first half of 2025, Borui Pharmaceutical reported total revenue of 537 million RMB, a year-on-year decline of 18.28%, and a net profit of 17.17 million RMB, down 83.85% year-on-year [8][16]. - The revenue decline is attributed to high base effects from previous flu outbreaks affecting the demand for antiviral raw materials and formulations [8][11]. - The company experienced a 16% quarter-on-quarter growth in Q2, with antiviral raw material revenue dropping over 60% compared to the previous year [8][13]. R&D Investment - Borui Pharmaceutical's R&D expenditure reached 348 million RMB in the first half of 2025, a 144.07% increase year-on-year, representing approximately 65% of total revenue [17][20]. - The company is focusing its R&D efforts on innovative drugs, with over 90% of the investment directed towards new drug development and inhalation formulations [20][22]. Innovative Drug Development - The company is advancing its proprietary GLP-1 and GIP receptor dual agonist, BGM0504, which is currently in Phase III clinical trials for type 2 diabetes and weight management [22][23]. - BGM0504 has shown promising results in clinical trials, demonstrating better glycemic control compared to Semaglutide and significant weight management potential [22][26]. - Borui Pharmaceutical is also developing additional innovative drugs, including BGM1812 and BGM2102, which are in preclinical stages and aim to enhance metabolic regulation and treatment efficacy [24][27][31]. Market Potential - The global market for GLP-1 drugs is projected to grow from 51.8 billion USD in 2024 to 88.1 billion USD by 2030, indicating significant commercial opportunities for Borui Pharmaceutical's innovative products [31][33]. - The company is strategically positioned to capitalize on this market growth through its diverse product pipeline and strong R&D focus [32][33].

Macro Strategy - In Q2 2025, the overall scale of fixed income + funds showed net subscriptions, with significant growth in primary and secondary bond funds, while convertible bond fund scale decreased noticeably [1][9] - The allocation of major asset classes indicates a reduction in the proportion of rights-bearing positions, with an increase in bond and cash assets, while flexible allocation funds increased their stock and convertible bond positions [1][9] - The overall position of public funds in convertible bonds slightly decreased by 0.08 percentage points, while fixed income + funds decreased by 0.54 percentage points, with only convertible bond funds increasing by 0.77 percentage points [1][9] - The concentration of holdings in fixed income + funds decreased, with overweights in basic chemicals, automobiles, non-ferrous metals, agriculture, forestry, animal husbandry, and transportation [1][9] - Fixed income + funds continued to overweight equity bonds, increasing allocations to balanced bonds and large-cap AAA-rated bonds [1][9] Fixed Income Engineering - Key factors influencing the growth rate of bond ETFs include yield, maximum drawdown, Sharpe ratio, market duration preference, and index tracking accuracy [2][10] - The correlation between bond ETF scale growth and yield is positive, indicating that higher yields generally lead to higher scale growth [10][12] - Maximum drawdown and Sharpe ratio also show significant correlations with bond ETF scale growth, suggesting that better risk management and performance lead to increased inflows [10][12] Company Analysis: 瑞鹄模具 (002997) - In H1 2025, the company reported revenue of 1.662 billion yuan, a year-on-year increase of 48.30%, and a net profit of 227 million yuan, up 40.33% [4][12] - The automotive manufacturing equipment business contributed significantly, with a backlog of orders amounting to 4.38 billion yuan, a 13.59% increase from the previous year [4][12] - The company plans to issue 880 million yuan in convertible bonds to expand its R&D and production capacity in lightweight components for new energy vehicles [4][12] Company Analysis: 中国汽研 (601965) - The company is a leading automotive technology research and service platform, with a projected revenue of 5.47 billion yuan in 2025, reflecting a 17% year-on-year growth [5][13] - The implementation of L2 national standards is expected to significantly expand the market for mandatory vehicle inspections, potentially increasing the market size by 50% [5][14] - The company has invested over 2.3 billion yuan in its headquarters and plans to enhance its testing capabilities to capture more market share in the third-party testing certification field [5][14] Company Analysis: 科达利 (002850) - The company anticipates a net profit of 1.8 to 2.1 billion yuan for 2025, reflecting a year-on-year growth of 22% to 20% [6][15] - The company is expanding its product line in robotics and has established a joint venture to produce harmonic reducers, which are expected to contribute significantly to future revenue [6][15] - The company maintains a "buy" rating based on its operational advantages and the potential growth of its robotics business [6][15] Company Analysis: 博瑞医药 (688166) - The company is focusing on the development of oral peptide formulations, with its BGM0504 injection showing promising results in clinical trials [7][16] - The company has extended the lock-up period for its major shareholder's capital increase to 48 months, indicating confidence in its future prospects [7][16] - The projected net profit for 2025 is 260 million yuan, with a strong emphasis on the potential of its oral formulations to capture market share [7][16]