来源：新浪证券 对少数核心产品的依赖度高意味着抗风险能力较为薄弱，尤其是原料药业务受政策影响较大，随着带量 采购政策的深入推进，下游仿制药企业面临终端价格下降的压力或将持续传导至原料药供应商，业绩承 压压力可能长期存在。 近日，博瑞生物医药（苏州）股份有限公司正式向港交所递交招股书，拟于主板挂牌上市。这是继今年 4月首次递表失效后的二次冲刺。博瑞医药此次谋求A+H双平台上市，表面理由是加快国际化战略及海 外业务布局，但其背后，却是业绩骤降、现金流紧绷、定增告吹后的融资困局。 值得关注的是，公司自上市以来已通过多种方式融资超过12亿元，却依然面临资金链紧张的局面，"融 资-研发-再融资"的发展模式难免引发市场对其可持续性的质疑。而其频繁的监管警示、高度依赖原料 药的营收结构、尚未兑现的创新管线，更让此次港股IPO充满悬念。 财务成本持续走高 核心产品研发进度落后 从财务数据看，博瑞医药2022至2024年收入分别为10.17亿元、11.8亿元、12.83亿元，虽保持低速增 长，但净利润已从2.4亿元降至1.89亿元，呈现出增收不增利的尴尬局面。 2025年前三季度，公司营收8.74亿元，同比下降10.5%；净利 ...

Core Viewpoint - 博瑞医药 has submitted an application for a dual listing on the Hong Kong Stock Exchange, marking a significant step in its global strategy and capital market internationalization [2][3] Group 1: Listing and Financial Strategy - The company aims to use the funds raised from the H-share issuance for three main purposes: supporting research and development of existing and future innovative drug candidates, building new production and R&D facilities, and supplementing operational funds [2] - The IPO is expected to enhance 博瑞医药's brand influence in the global pharmaceutical industry and provide new financing channels, optimizing its capital structure [3] Group 2: Financial Performance - 博瑞医药's revenue has shown consistent growth over the past three years, with revenues of RMB 1.017 billion, RMB 1.164 billion, and RMB 1.254 billion for the years ending December 31, 2022, 2023, and 2024, respectively [4] - The company's R&D expenditure for the first half of 2025 reached RMB 138 million, with a year-on-year increase of 144.07%, accounting for 64.83% of its operating revenue [4] Group 3: Innovation Pipeline - 博瑞医药 is advancing multiple innovative drug candidates, including BGM0504, which is a leading candidate in the global clinical stage for treating metabolic diseases [5][10] - The company is also developing BGM2102 and BGM1812, targeting comprehensive blood sugar control and weight management for Type 2 Diabetes Mellitus (T2DM) patients [6][8] Group 4: Market Potential - The global market for T2DM and obesity is substantial, with an estimated 542.9 million T2DM patients and 2.6387 billion obesity patients worldwide by 2024 [9] - The global sales of GLP-1 receptor agonists are projected to reach USD 154.2 billion by the end of 2035, indicating a lucrative market for 博瑞医药's innovative therapies [9] Group 5: Strategic Collaborations and Future Outlook - 博瑞医药's success in innovation is supported by strong technical platforms and strategic partnerships, enhancing its competitive edge in both domestic and global markets [11] - The company's ongoing development in respiratory diseases, with seven drugs in the pipeline, further diversifies its growth potential [11]

Core Viewpoint - 博瑞医药 is a leading high-end generic and innovative drug developer in China, with a strong industry position and full supply chain advantages [1] Financial Performance - In Q3 2025, 博瑞医药 achieved revenue of 874 million yuan, ranking 20th among 47 companies in the industry, while the industry leader, 普洛药业, reported revenue of 7.764 billion yuan [2] - The company's net profit for the same period was 31.39 million yuan, placing it 29th in the industry, with the top performer, 浙江医药, reporting a net profit of 867 million yuan [2] Profitability and Debt - As of Q3 2025, 博瑞医药's debt-to-asset ratio was 52.77%, higher than the industry average of 27.75%, indicating significant debt pressure [3] - The gross profit margin was 51.40%, which, despite a decrease from 58.00% year-on-year, remains above the industry average of 35.38% [3] Management and Shareholder Structure - The chairman, 袁建栋, received a salary of 1.9114 million yuan in 2024, a slight decrease from the previous year [4] - As of June 30, 2025, the number of A-share shareholders decreased by 10.11%, while the average number of shares held per shareholder increased by 11.32% [5] Innovation Pipeline - 博瑞医药's BGM0504 oral tablet has received Phase I clinical trial approval in the U.S., showcasing significant advantages in bioavailability and safety [5] - The company has a rich pipeline with multiple products progressing towards clinical stages, enhancing its competitiveness in international markets [5][6] Market Outlook - Despite a temporary decline in revenue and net profit due to reduced demand for antiviral products, the company is expected to improve its performance with ongoing innovation and clinical advancements [6]

Core Viewpoint - 博瑞医药 has decided to terminate its plan for a private placement of A-shares, citing challenges such as declining performance, increased R&D investment, and financial pressure [1][2]. Financial Performance - The company has experienced a continuous decline in net profit for three and a half years, with net profits of 240 million, 203 million, and 189 million yuan from 2022 to 2024, representing year-on-year declines of 1.77%, 15.51%, and 6.57% respectively [2]. - In the first half of 2025, 博瑞医药 reported a revenue of 537 million yuan, a decrease of 18.28% year-on-year, and a net profit of 17.17 million yuan, down 83.85% year-on-year [2]. Financial Pressure - The company's cash reserves have been declining, with cash balances of 1.18 billion, 969 million, and 765 million yuan at the end of 2022, 2023, and 2024 respectively. As of June 30, 2025, cash reserves were 740 million yuan, with total liabilities of 2.798 billion yuan and a debt-to-asset ratio of 52% [3]. - Interest expenses have been increasing, with amounts of 23.71 million, 44.42 million, 52.43 million, and 29.03 million yuan recorded from 2022 to the first half of 2025, impacting profitability [3]. R&D Investment - 博瑞医药's R&D expenses have surged, with amounts of 207 million, 249 million, and 297 million yuan from 2022 to 2024, accounting for 20.35%, 21.08%, and 23.19% of revenue respectively. In the first half of 2025, R&D expenses reached 344 million yuan, a 144.07% increase year-on-year, representing 64.83% of revenue [4]. - The company is focusing on the development of innovative drugs, with 91.22% of R&D investment directed towards new drugs and inhalation formulations, showing a significant increase in investment for core product BGM0504 [4]. Financing and Future Plans - 博瑞医药 has completed three rounds of financing since its listing, raising 521 million, 465 million, and 227 million yuan in 2019, 2021, and 2022 respectively. The company also plans to list in Hong Kong to enhance its international strategy and financing capabilities [5].

Core Viewpoint - 博瑞医药 plans to issue H-shares and list on the Hong Kong Stock Exchange to enhance its international strategy and overseas business layout, aiming to improve its capital strength and competitiveness [1] Group 1: H-share Issuance and Listing - 博瑞医药 has announced its intention to issue H-shares and list on the Hong Kong Stock Exchange, with the board approving relevant proposals [1] - The company is currently discussing the issuance with relevant intermediaries, but specific details are yet to be finalized [1] - The timing and window for the issuance will be chosen based on market conditions and shareholder interests within a 24-month period after shareholder approval [1] Group 2: Stock Price Volatility - 博瑞医药's stock has experienced significant volatility, with a cumulative drop of 50% over 10 consecutive trading days, qualifying as severe abnormal trading [2] - As of October 9, 2025, the closing price was 57.57 yuan per share, down 53.04% from its peak of 122.59 yuan on August 6, 2025 [2] - The company's rolling P/E ratio is 243.45, significantly higher than the industry average of 30.82 [2] Group 3: Fundraising Activities - 博瑞医药 has raised a total of 1.213 billion yuan through three fundraising activities since its listing [5] - The latest fundraising involves issuing shares to specific investors, with a total amount not exceeding 50 million yuan, aimed at replenishing working capital and repaying bank loans [2][3] - The issuance price for the new shares is set at 22.36 yuan per share, with the controlling shareholder participating in the cash subscription [3] Group 4: Product Development and Market Competition - 博瑞医药 is focusing on the development of its core product BGM0504 for type 2 diabetes and obesity, which is currently in phase III clinical trials [7] - The competitive landscape for GLP-1 receptor agonists in China is intensifying, with several companies developing similar products, leading to concerns about product differentiation [8] - Currently, there are 11 GLP-1 drugs approved globally for type 2 diabetes, with five available in China, indicating a crowded market [8]

Group 1 - 2025 marks a significant year for the development of innovative drugs in China, with 43 innovative drugs approved in the first half, 40 of which are developed by domestic companies [1] - The National Medical Products Administration (NMPA) has approved a total of 210 innovative drugs and 269 innovative medical devices during the 14th Five-Year Plan period, indicating a trend of accelerated growth [1] - Continuous policy support from the government has provided a strong impetus for the development of innovative drugs, creating a transparent and stable policy environment [2][3] Group 2 - Companies like China Resources Sanjiu have adopted a "brand + innovation" dual-drive strategy, significantly increasing their focus on innovation in response to national policies and market demands [3] - China Resources Sanjiu reported obtaining 8 drug registration certificates and has 205 ongoing research projects, covering various fields including cardiovascular and oncology [3] - Other notable companies in the innovative drug sector include Teva Pharmaceutical, Tai Chi Group, and Yiling Pharmaceutical, all of which are enhancing their competitiveness through increased R&D investment and talent acquisition [4][5] Group 3 - The number of innovative traditional Chinese medicine (TCM) drugs is on the rise, with 5 TCM innovative drugs approved in the first half of 2025, reflecting a growing trend in this sector [5] - As of July 31, 2025, there are 147 TCM innovative drugs in clinical stages or above, a threefold increase compared to 2020, indicating a significant expansion in TCM innovation [5] - The Chinese innovative drug industry has made remarkable breakthroughs in quantity, quality, and technology over the past decade, entering a new development phase with promising future prospects [5]

Core Viewpoint - The article discusses the recent announcement by Borui Pharmaceutical regarding its plan to issue H-shares and list on the Hong Kong Stock Exchange, while emphasizing the company's commitment to balancing shareholder interests with market conditions [2]. Product Portfolio - Borui Pharmaceutical has a diverse product line covering multiple therapeutic areas, including metabolism, antiviral, antifungal, immunosuppressive, respiratory, and oncology. Key innovative drugs in the metabolism category include BGM0504 and BGM1812, while antiviral products include Entecavir and Oseltamivir. The antifungal category features Caspofungin and Micafungin Sodium, among others [3]. Financial Performance and R&D Progress - In the first half of 2025, Borui Pharmaceutical reported a revenue of 537 million yuan and a net profit of 14.36 million yuan after deducting non-recurring items. The company is focusing on multi-target metabolic drugs containing GLP-1 and exploring new administration routes beyond injections for chronic metabolic diseases. The self-developed peptide-based hypoglycemic drug BGM0504, a dual receptor agonist for GLP-1 and GIP, shows potential in controlling blood sugar, weight loss, and treating non-alcoholic fatty liver disease (NASH). Currently, BGM0504 has completed patient enrollment for phase III clinical trials in China for both type 2 diabetes and weight loss indications, with progress being reported as smooth [5]. Industry Engagement - The "GLP-1 Club" has established a network of hundreds of professionals, providing a platform for industry insights and discussions related to the GLP-1 drug development and its applications in weight loss and diabetes management [9]. GLP-1 Drug Overview - GLP-1 (Glucagon-like peptide-1) is a hormone produced by intestinal L cells, classified as an incretin. GLP-1 receptor agonists are a new class of hypoglycemic drugs that enhance insulin secretion in a glucose-dependent manner, suppress glucagon secretion, and delay gastric emptying, leading to reduced food intake and lower blood sugar levels [13].

Group 1 - BioBAY company, Borui Pharmaceutical, announced plans to issue H-shares and list on the Hong Kong Stock Exchange [1] - The company will consider the interests of existing shareholders and market conditions when choosing the timing for the issuance [1] Group 2 - Borui Pharmaceutical's product portfolio covers various therapeutic areas including metabolism, antiviral, antifungal, immunosuppressive, respiratory, and oncology [2] - Key products in the metabolism area include innovative drugs BGM0504 and BGM1812, while antiviral products include Entecavir and Oseltamivir [2] Group 3 - In the first half of 2025, Borui Pharmaceutical reported revenue of 537 million yuan and a net profit of 14.36 million yuan [3] - The company is focusing on multi-target drugs in the metabolism field, particularly exploring new administration methods beyond traditional injections [3] - The peptide-based hypoglycemic drug BGM0504 is a dual agonist of GLP-1 and GIP receptors, showing potential for treating various metabolic diseases [3] - Phase III clinical trials for BGM0504 for type 2 diabetes and weight loss have completed patient enrollment and are progressing as planned [3] - An IND application for BGM0504's hypoglycemic indication has been approved in Indonesia, and Phase III clinical research has officially commenced [3]

Core Viewpoint - The pharmaceutical industry is experiencing a surge in IPO activities in the Hong Kong stock market, with companies like Nanjing Inpai Pharmaceutical, Guangdong Runtai Pharmaceutical, and A-share listed Borui Pharmaceutical all submitting their listing applications simultaneously, reflecting a recovery in the capital market for biopharmaceuticals and the attractiveness of Hong Kong as a financing platform [1][7]. Group 1: Company Developments - Nanjing Inpai Pharmaceutical focuses on developing precision cancer drugs based on synthetic lethality mechanisms and has a robust pipeline of DNA damage repair products [3]. - Guangdong Runtai Pharmaceutical is the fourth largest provider of marketing and supply chain solutions in China's outpatient pharmaceutical market and aims to enhance its digital marketing and supply chain through IPO funding [4][6]. - Borui Pharmaceutical is transitioning from raw material production to innovative drug development, with plans to use IPO proceeds for research and international expansion [2][8]. Group 2: Financial Highlights - Borui Pharmaceutical's revenue from raw materials reached 885 million yuan in 2023, with a 170% year-on-year increase in antiviral product sales [2]. - The company has invested 380 million yuan in its core product BGM0504, which is in the clinical trial phase for type 2 diabetes and weight loss indications, representing 60% of its total R&D investment [2]. - Runtai Pharmaceutical's business model involves purchasing products from upstream pharmaceutical companies and selling them through various e-commerce platforms, indicating a clear revenue generation strategy [6]. Group 3: Market Trends and Challenges - The current environment of improving overseas liquidity and a favorable financing climate for the biopharmaceutical sector has led to increased IPO activities [7]. - The Hong Kong market's regulatory framework allows unprofitable biotech companies to list, providing early capital access for firms like Inpai Pharmaceutical [9]. - Despite the positive trends, liquidity issues in the Hong Kong market remain a concern, with analysts noting that the enthusiasm for biopharmaceuticals in the primary market is still not sufficiently high [10][11].

Core Viewpoint - The innovative drug sector has emerged as one of the brightest segments in the Hong Kong stock market this year, with significant recognition from international capital reflected in the performance of the Hong Kong innovative drug ETF, which has seen a year-to-date increase of over 100% and a maximum increase exceeding 130% [3][4]. Group 1: Market Performance and Investor Dynamics - The Hong Kong stock market, primarily driven by institutional investors, has benefited from deep international capital participation, enhancing pricing efficiency and aligning stock prices closer to intrinsic values [4]. - The continuous inflow of southbound funds has strengthened the correlation between Hong Kong and A-share markets, providing important value references for A-shares [4]. - Notable companies like 恒瑞医药 (Hengrui Medicine) and 宁德时代 (CATL) have seen their H-shares trading at significantly higher prices than their A-shares, indicating a willingness in the Hong Kong market to pay higher valuation premiums for quality enterprises [5]. Group 2: Company-Specific Developments - 博瑞医药 (Borui Medicine) has announced plans to issue H-shares and list on the Hong Kong Stock Exchange, marking a step towards deeper engagement with international capital [5][6]. - The anticipated use of funds from the H-share issuance is likely focused on drug research and development, particularly for the GLP-1 series innovative drugs, with significant ongoing clinical trials [6][7]. - In the first half of the year, 博瑞医药's R&D investment reached 348 million, a year-on-year increase of 144.07%, representing approximately 65% of its total revenue for that period [7][10]. Group 3: R&D Strategy and Pipeline - 博瑞医药's current pipeline includes several innovative drugs targeting weight loss and diabetes, with the BGM0504 injection having entered Phase III clinical trials [6][21]. - The company is actively pursuing an integrated strategy for raw materials and formulations, necessitating substantial capital investment to maintain its competitive edge in GLP-1 research and development [13][24]. - The R&D intensity of 博瑞医药 is comparable to many innovative pharmaceutical companies that have not yet commercialized their products, indicating a strong focus on future growth despite current financial pressures [8][11]. Group 4: Competitive Landscape - 博瑞医药's product matrix is strategically designed to address different patient demographics, with specific formulations targeting both low and high weight loss needs [21]. - The company aims to differentiate itself in the competitive GLP-1 market by developing unique formulations and leveraging advanced technologies for oral drug delivery, which could significantly enhance patient compliance and treatment outcomes [22][23]. - Clinical data from 博瑞医药's BGM0504 injection shows promising results, with a weight reduction of 18.5% and a significant percentage of patients achieving substantial weight loss [22].