华夏时报记者 于娜 见习记者 赵文娟 北京报道 科创板上市药企博瑞医药近期发布公告，宣布拟发行H股股票并在香港联交所主板上市。据公告内容，此次资本动作的核心诉求明确，既是为了加快推进 公司国际化战略落地、完善海外业务布局，也是为了增强境外融资能力，通过拓宽资本渠道进一步提升公司资本实力与综合竞争力。在资金用途上，扣除 发行费用后的募集资金，将重点投向在研管线的研发活动、扩增生产管线、战略性投资与收购、补充营运资金及一般企业用途等。 新金融专家余丰慧告诉《华夏时报》记者，"博瑞医药选择在此时启动H股发行，深层动机在于通过资本市场融资来缓解当前面临的经营困境和财务压 力。"回溯2025年以来的发展轨迹，公司经历了多重压力考验，此前凭借"减肥药概念股"光环获得市场关注，但其股价随后上演"过山车"行情，最新价较 年内最高价跌幅超50%；业绩端同样承压，2025年上半年净利润同比下滑83.85%，核心的原料药业务增长乏力；而被寄予厚望的创新药，目前仍处于三期 临床阶段，商业化进程尚需时间，短期内无法为业绩提供有效支撑。多重挑战下，赴港上市成为公司缓解当前压力、寻求发展突破的关键选择。 | 主要会计数据 | 本报告期 ( ...

科创板上市药企博瑞医药近期发布公告，宣布拟发行H股股票并在香港联交所主板上市。据公告内容， 此次资本动作的核心诉求明确，既是为了加快推进公司国际化战略落地、完善海外业务布局，也是为了 增强境外融资能力，通过拓宽资本渠道进一步提升公司资本实力与综合竞争力。在资金用途上，扣除发 行费用后的募集资金，将重点投向在研管线的研发活动、扩增生产管线、战略性投资与收购、补充营运 资金及一般企业用途等。 新金融专家余丰慧告诉《华夏时报》记者，"博瑞医药选择在此时启动H股发行，深层动机在于通过资 本市场融资来缓解当前面临的经营困境和财务压力。"回溯2025年以来的发展轨迹，公司经历了多重压 力考验，此前凭借"减肥药概念股"光环获得市场关注，但其股价随后上演"过山车"行情，最新价较年内 最高价跌幅超50%；业绩端同样承压，2025年上半年净利润同比下滑83.85%，核心的原料药业务增长乏 力；而被寄予厚望的创新药，目前仍处于三期临床阶段，商业化进程尚需时间，短期内无法为业绩提供 有效支撑。多重挑战下，赴港上市成为公司缓解当前压力、寻求发展突破的关键选择。 本报（chinatimes.net.cn）记者于娜 见习记者 赵文娟 北京 ...

文 | 医药研究社 辉瑞"买买买"，竟让博瑞医药遭罪了。 博瑞医药最新公告显示，公司股票连续30个交易日内收盘价格跌幅偏离值累计达到70%，根据《上海证 券交易所交易规则》《上海证券交易所科创板股票异常交易实时监控细则》的有关规定，这属于股票交 易严重异常波动情形。 9月22日至23日，博瑞医药股价两日累计跌幅就高达30%。另外，根据中证指数有限公司发布的数据， 截至2025年9月23日，博瑞医药最新滚动市盈率为313.01倍，显著高于医药制造业最近一个月31.43倍的 平均滚动市盈率。 而经核实，博瑞医药不存在应披露而未披露的重大事项，日常经营情况正常。引发股价暴跌的外界因素 显然占了大成。 一笔重大外资收购交易值得关注。9月22日，辉瑞宣布将收购纳斯达克上市公司Metsera，交易总价值最 高可达73亿美元。有业内人士认为，博瑞医药受到了这笔交易波及。 辉瑞收购Metsera，国内市场预期落空？ 博瑞股价下跌与辉瑞收购是怎么联系到一起的？要留意到一个关键因素——GLP-1产品布局。 据公开资料，辉瑞此次收购的Metsera是一家临床阶段生物制药公司，致力于开发下一代肥胖与心脏代 谢疾病治疗药物，目前拥有两 ...

Group 1: Pharmaceutical Industry - The domestic raw material pharmaceutical industry is at the bottom of the cycle, with some companies actively transitioning to innovative drug development, which may lead to a harvest period [1] - The raw material drug sector has experienced a four-year downward cycle, with prices of various products, including sartans and heparins, reaching historical lows, resulting in some leading companies operating at a loss [1] - Companies like Huahai Pharmaceutical and Borui Pharmaceutical are focusing on innovative drugs in oncology and autoimmune fields, with several products in various clinical trial stages [2] Group 2: Vaccine and Blood Products Sector - The vaccine industry is facing a continuous decline in performance due to a decrease in newborn numbers and changes in the competitive landscape, although some companies are gradually adopting new technologies and products [3] - The blood products sector is also at the bottom of the cycle, with revenue and net profit expected to decline in 2025 due to inventory levels and demand suppression from medical insurance [3] - The consolidation of leading companies in the blood products industry is expected to increase industry concentration and stabilize pricing [3] Group 3: Medical Services Sector - The medical services sector is experiencing a decline in performance due to DRGs and the consumption environment, with a shift towards utilizing AI technology to enhance the capabilities of primary doctors [4] - The core competitiveness of the medical services industry lies in acquiring and training quality doctors and hospital management, with AI expected to improve patient coverage and diagnostic capabilities [4]

相关研究报告 《集采优化叠加创新驱动，Pharma 迎 来 发 展 新 阶 段 — 行 业 点 评 报 告 》 -2025.9.22 医药生物 2025 年 09 月 24 日 投资评级：看好（维持） 行业走势图 数据来源：聚源 0% 12% 24% 36% 48% 60% 2024-09 2025-01 2025-05 2025-09 医药生物 沪深300 《创新药行业进入快速成长期，关注 未来 6-12 个月投资机会—行业周报》 -2025.9.14 《中药及医药商业 2025H1 复盘：短期 承压，静待花开—行业点评报告》 -2025.9.8 原料药公司加速创新药布局，AI+医疗布局逐步深化 ——行业深度报告 | 余汝意（分析师） | 阮帅（分析师） | | --- | --- | | yuruyi@kysec.cn | ruanshuai@kysec.cn | | 证书编号：S0790523070002 | 证书编号：S0790524040007 | 原料药板块：创新转型正当时 原料药行业经历近 4 年周期下行，各类产品价格跌至部分龙头企业处于亏损的阶段， 行业整体处于底部区域，其中沙坦类、肝素类、动 ...

Investment Rating - The investment rating for the company is "Accumulate" with a target price of 40.12 CNY [7][12]. Core Views - The company's core CHC segment performance has been under pressure due to a decrease in flu incidence and channel adjustments, but its leading brand position in the traditional Chinese medicine OTC sector remains intact, indicating potential for sustained growth through both organic and external drivers [2][12]. - The company reported a revenue of 14.81 billion CNY for the first half of 2025, a year-on-year increase of 4.99%, while the net profit attributable to the parent company was 1.815 billion CNY, a decline of 24.31% [12]. - The company completed the consolidation of Tianshili, a traditional Chinese medicine innovative drug enterprise, enhancing its competitive edge in the innovative Chinese medicine sector [12]. Financial Summary - Total revenue projections are as follows: 24,739 million CNY for 2023, 27,617 million CNY for 2024, 30,418 million CNY for 2025, 32,406 million CNY for 2026, and 34,504 million CNY for 2027, reflecting growth rates of 36.8%, 11.6%, 10.1%, 6.5%, and 6.5% respectively [5][13]. - Net profit attributable to the parent company is projected to be 2,853 million CNY for 2023, 3,368 million CNY for 2024, 3,423 million CNY for 2025, 3,818 million CNY for 2026, and 4,287 million CNY for 2027, with growth rates of 16.5%, 18.1%, 1.6%, 11.5%, and 12.3% respectively [5][13]. - The earnings per share (EPS) estimates are 1.71 CNY for 2023, 2.02 CNY for 2024, 2.06 CNY for 2025, 2.29 CNY for 2026, and 2.58 CNY for 2027 [5][13]. Market Performance - The company's stock price has shown a 52-week range of 29.25 CNY to 51.82 CNY, with a current price of 29.50 CNY [8][12]. - The total market capitalization is approximately 49,096 million CNY [8]. Business Segments - The CHC business revenue for the first half of 2025 was 6.08 billion CNY, a year-on-year decrease of 18.4%, while the prescription drug revenue was 2.78 billion CNY, reflecting a growth of 15.2% [12]. - The gross margin for the CHC business was 59.9%, down by 2.43 percentage points year-on-year, while the gross margin for prescription drugs increased by 1.89 percentage points to 49.0% [12]. Research and Development - The company continues to invest in R&D, with notable projects including a joint development project for HiCM-188, which is the first innovative drug for heart failure regeneration therapy approved for clinical use in both China and the U.S. [12]. - A collaboration with Borui Pharmaceutical for a dual-target weight loss drug BGM0504 is also underway, with the product currently in Phase III clinical trials [12].

Core Insights - 博瑞医药's financial performance for the first half of 2025 shows a significant decline in revenue and profit, with total revenue at 537 million yuan, down 18.28% year-on-year, and net profit at 17.17 million yuan, down 83.85% [1] - The company's gross margin decreased to 48.71%, a drop of 11.91% year-on-year, while the net profit margin fell to 0.31%, down 97.53% [1] - The increase in operating expenses, particularly financial, sales, and management costs, has led to a total of 130 million yuan, representing 24.21% of total revenue, an increase of 39.33% year-on-year [1] Financial Performance - Total revenue for Q2 2025 was 288 million yuan, a decrease of 9.16% year-on-year, with net profit for the quarter at 4.21 million yuan, down 90.04% [1] - The company's return on invested capital (ROIC) for the previous year was 3.93%, indicating weak capital returns, with a historical median ROIC of 10.88% since its listing [2] - The cash flow situation is concerning, with cash and cash equivalents to current liabilities ratio at 73.67% [2] Business Model and Strategy - 博瑞医药's business relies heavily on R&D and capital expenditures, necessitating careful evaluation of capital projects and their financial viability [2] - The company is considering partnerships for the commercialization of its product BGM0504, with a preference for collaborating with firms that have strong market sales capabilities, such as 华润三九 [4] Market Position and Fund Holdings - The largest fund holding 博瑞医药 is 富国优化增强债券A/B, with a scale of 1.999 billion yuan and a recent net value increase of 0.33% [3] - Several funds have newly entered the top ten holdings of 博瑞医药, indicating growing interest from institutional investors [3]

Investment Rating - The report maintains an investment rating of "Outperform" [4] Core Insights - Novo Nordisk's semaglutide has received FDA approval for a new indication for the treatment of Metabolic Dysfunction-associated Steatotic Liver Disease (MASH), which is expected to increase the sales scale of GLP-1 drugs beyond diabetes and weight loss indications [21][24] - The report highlights the significant market potential for GLP-1 drugs and the deep positioning of domestic companies in this field, particularly regarding overseas licensing opportunities for domestic GLP-1 products [25] Summary by Sections Weekly New Drug Market Review - From August 11 to August 17, 2025, the top five gainers in the new drug sector were: Beihai Kangcheng (+35.6%), Basilea Pharmaceutica (+32.6%), Deqi Pharmaceuticals (+30.2%), Heyu Biotech (+30.1%), and Gilead Sciences (+29.7%). The top five losers were: Boan Biologics (-11.6%), Laika Pharmaceuticals (-3.9%), Ailis (-3.2%), Nossland (-1.2%), and CanSino Biologics (-1.1%) [16][18] Recommended Stocks - The report suggests focusing on domestic GLP-1 products for overseas licensing, including: 1. RAY1225 from Zhongsheng Pharmaceutical for GLP-1/GIP dual weekly administration 2. ASC30 from Gilead Sciences for oral GLP-1 small molecules 3. BGM0504 from Borui Pharmaceuticals and ZX2021 from Kangyuan Pharmaceuticals for multi-target GLP-1 receptor agonists 4. UBT251 from Lianfa Pharmaceuticals and HS-10535 from Hansoh Pharmaceutical for already licensed MNC products [20][25] Key Analysis of the New Drug Industry - The approval of semaglutide for MASH marks it as the first GLP-1 therapy approved for this condition, expanding treatment options for patients and potentially increasing market size [21][24] New Drug Application Approvals and Acceptances - This week, there were 6 new drug applications accepted, including semaglutide injection from Huisheng Biopharmaceutical and others [29][31] Clinical Application Approvals and Acceptances - This week, 18 new drug clinical applications were approved, and 39 new drug clinical applications were accepted [32][35]

Group 1: Market Overview - The A-share market is currently active, with brokerage analysts conducting extensive research on listed companies as half-year reports are being released [1] - A total of 162 listed companies have been researched by brokerages since August, covering popular sectors such as electronics, biomedicine, machinery, and power equipment [2] Group 2: Sector Focus - The electronics, biomedicine, and machinery sectors are the most researched, with 22, 21, and 20 companies respectively [2] - Notable companies in the electronics sector include Baiwei Storage, which attracted 37 brokerage firms for research, and companies like Jingfeng Mingyuan and Zhenlei Technology, which were researched by 24 and 13 firms respectively [2] - In the machinery sector, companies like Jerry Holdings and Zhejiang Huaye have also seen significant interest, with Jerry receiving 41 brokerage visits [2] Group 3: Company Highlights - Zhongchong Co., a leading company in the pet sector, attracted 61 brokerage firms for its recent earnings briefing, with its stock rising 66% this year [3][2] - Ninebot Company has also gained attention, with 47 brokerages researching its electric two-wheeler and robotic lawnmower business [3] - Jerry Holdings has been researched by 41 brokerages, focusing on its business structure and overseas development [3] Group 4: Biomedicine Sector - The biomedicine sector has become a focal point for brokerages, with over 65 reports published in August, including 10 deep-dive analyses [4] - Companies like Jiuzhou Pharmaceutical and Sanxin Medical have been heavily researched, with Jiuzhou reporting a net profit of 526 million yuan, a 10.7% increase year-on-year [4][5] - BoRui Pharmaceutical has seen its stock rise over 277% this year and is focusing on international expansion for its diabetes treatment product [5] Group 5: Rating Adjustments - Brokerages have raised ratings for seven companies since August, including Aisheng Co. and Huaneng International, with Huaneng reporting a net profit of 9.262 billion yuan, a 24.26% increase [6] - One stock, Fuling Pickles, had its rating downgraded from "Buy" to "Hold" due to slow sales recovery and increased cost pressures [7]

Investment Rating - The report maintains a rating of "Overweight" for the pharmaceutical and biotechnology industry [1] Core Insights - The report highlights the promising opportunities in the domestic oral weight-loss drug market, particularly recommending companies such as Borui Pharmaceutical and Gilead Sciences as key players [1][2] - The GLP-1 drug market is expected to see significant growth, with projections indicating a market size exceeding $150 billion by 2030, driven by increasing demand and new product approvals [6][12] - The report emphasizes the strong performance of innovative drugs, particularly GLP-1 and PD-1/VEGF dual antibodies, and suggests a focus on companies like Borui Pharmaceutical, Gilead Sciences, and others for investment [2][12] Summary by Sections Industry Performance - The A-share pharmaceutical index has shown a year-to-date increase of 21.3%, while the Hang Seng Biotechnology Index has surged by 87.2% [6][11] - Recent stock performance indicates a mixed trend, with notable gains in companies like Nanmo Biotechnology (+42%) and Haichen Pharmaceutical (+41%), while others like Nanxin Pharmaceutical (-19%) and Qizheng Tibetan Medicine (-16%) faced declines [11] Sub-industry Recommendations - The report ranks preferred sub-industries as follows: Innovative Drugs > Research Services > CXO > Traditional Chinese Medicine > Medical Devices > Pharmacies [2][12] - Specific stock recommendations include: - From the GLP-1 perspective: Borui Pharmaceutical, Gilead Sciences, and others [2][12] - From the PD-1/VEGF dual antibody perspective: Kangfang Biotech, Shenzhou Cell, and others [2][12] - From a low valuation perspective: Zoli Pharmaceutical, Dong'e Ejiao, and others [2][12] Market Dynamics - The report notes that the GLP-1 drug market is significantly underestimated, with companies like Borui Pharmaceutical and Gilead Sciences expected to emerge as major players with potential market capitalizations in the hundreds of billions [6][12] - The report also discusses the competitive landscape, highlighting the rapid growth of drugs like Eli Lilly's Mounjaro and Novo Nordisk's Wegovy, which have seen substantial sales increases [17][22] Financial Performance - Novo Nordisk reported a revenue of approximately $22.9 billion for the first half of 2025, reflecting an 18% year-on-year growth, driven by strong sales of its GLP-1 products [17][22] - Eli Lilly's revenue for the same period reached $28.3 billion, marking a 41% increase, with Mounjaro and Zepbound leading the sales growth [22][23]